Transcriptional networks and signaling pathways that govern vertebrate intestinal development

Current Topics in Developmental Biology

Volumn 90, Issue C, 2010, Pages 159-192

  Heath, Joan K ^a,b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cdx2; Crypt; Endoderm; Hedgehog; Hox; Intestinal epithelium; Villus; Wnt beta catenin

Indexed keywords

BONE MORPHOGENETIC PROTEIN; EPHRIN; HEPATOCYTE NUCLEAR FACTOR 4; HOMEODOMAIN PROTEIN; NOTCH RECEPTOR; TRANSCRIPTION FACTOR; WNT PROTEIN;

ANATOMY AND HISTOLOGY; ANIMAL; CELL POLARITY; CYTOLOGY; EMBRYOLOGY; ENDODERM; GENE REGULATORY NETWORK; GENETICS; GROWTH, DEVELOPMENT AND AGING; HOMEOSTASIS; HUMAN; INTESTINE; INTESTINE INNERVATION; INTESTINE MUCOSA; METABOLISM; MORPHOGENESIS; NEOPLASM; ORGANOGENESIS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; STEM CELL NICHE; VERTEBRATE;

ANIMALS; BODY PATTERNING; BONE MORPHOGENETIC PROTEINS; CELL POLARITY; ENDODERM; ENTERIC NERVOUS SYSTEM; EPHRINS; GENE REGULATORY NETWORKS; HEPATOCYTE NUCLEAR FACTOR 4; HOMEODOMAIN PROTEINS; HOMEOSTASIS; HUMANS; INTESTINAL MUCOSA; INTESTINES; NEOPLASMS; ORGANOGENESIS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STEM CELL NICHE; TRANSCRIPTION FACTORS; VERTEBRATES; WNT PROTEINS;

EID: 77955327446     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0070-2153(10)90004-5     Document Type: Chapter

References (134)

1. Abud H.E., et al. Growth of intestinal epithelium in organ culture is dependent on EGF signalling. Exp. Cell Res. 2005, 303:252-262.
2. Abud H.E., Heath J.K. Detecting apoptosis during the formation of polarized intestinal epithelium in organ culture. Cell Death Differ. 2004, 11:788-789.
3. Ahn S.H., et al. Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. Inflamm. Bowel Dis. 2008, 14:908-920.
4. Alexander J., Stainier D.Y.R. A molecular pathway leading to endoderm formation in zebrafish. Curr. Biol. 1999, 9:1147-1157.
5. Anderson R.B., et al. Neural crest and the development of the enteric nervous system. Adv. Exp. Med. Biol. 2006, 589:181-196.
6. Aoki T.O., et al. Molecular integration of casanova in the nodal signalling pathway controlling endoderm formation. Development 2002, 129:275-286.
7. Aoki T.O., et al. Regulation of nodal signalling and mesendoderm formation by TARAM-A, a TGF[beta]-related type I receptor. Dev. Biol. 2002, 241:273-288.
8. Bagnat M., et al. Genetic control of single lumen formation in the zebrafish gut. Nat. Cell Biol. 2007, 9:954-960.
9. Barker N., et al. Identification of stem cells in small intestine and colon by marker gene lgr5. Nature 2007, 449:1003-1007.
10. Barker N., et al. The intestinal stem cell. Genes Dev. 2008, 22:1856-1864.
11. Barrett J.C., et al. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat. Genet. 2009, 41:1330-1334.
12. Batlle E., et al. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 2002, 111:251-263.
13. Battle M.A., et al. Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc. Natl. Acad. Sci. USA 2006, 103:8419-8424.
14. Batts E.B., et al. Bmp signaling is required for intestinal growth and morphogenesis. Dev. Dyn. 2006, 235:1563-1570.
15. Beck F., et al. Expression of cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes. Dev. Dyn. 1995, 204:219-227.
16. Beck F., et al. Reprogramming of intestinal differentiation and intercalary regeneration in cdx2 mutant mice. Proc. Natl. Acad. Sci. USA 1999, 96:7318-7323.
17. Bitgood M.J., McMahon A.P. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol. 1995, 172:126-138.
18. Bjerknes M., Cheng H. Gastrointestinal stem cells. II. Intestinal stem cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 289:G381-G387.
19. Bondurand N., et al. Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling. Development 2006, 133:2075-2086.
20. Burkitt H.G., et al. Wheater's Functional Histology 1993, Churchill Livingstone (Edinburgh and Melbourne).
21. Burns R.C., et al. Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse. Dev. Biol. 2004, 265:61-74.
22. Burzynski G., et al. Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease. Neurogastroenterol. Motil. 2009, 21:113-127.
23. Cervantes S., et al. Wnt5a is essential for intestinal elongation in mice. Dev. Biol. 2009, 326:285-294.
24. Chawengsaksophak K., et al. Homeosis and intestinal tumours in cdx2 mutant mice. Nature 1997, 386:84-87.
25. Chen W.S., et al. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 1994, 8:2466-2477.
26. Chen C., et al. Pdx1 inactivation restricted to the intestinal epithelium in mice alters duodenal gene expression in enterocytes and enteroendocrine cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 297:G1126-G1137.
27. Cheng H., Leblond C.P. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell. Am. J. Anat. 1974, 141:461-479.
28. Chrusch C., et al. Morphogenesis as a parallel of invasion: the epithelial-mesenchymal boundary and basal lamina in foetal rat colon. Clin. Exp. Metastasis 1990, 8:121-127.
29. Cottrell S., et al. Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas. Lancet 1992, 340:626-630.
30. Coulthard M.G., et al. The role of the Eph-ephrin signalling system in the regulation of developmental patterning. Int. J. Dev. Biol. 2002, 46:375-384.
31. Crosnier Cc, et al. Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. Development 2005, 132:1093-1104.
32. Crosnier Cc, et al. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat. Rev. Genet. 2006, 7:349-359.
33. Danesh S.M., et al. BMP and BMP receptor expression during murine organogenesis. Gene Expr. Patterns 2009, 9:255-265.
34. Duboule D., Morata G. Colinearity and functional hierarchy among genes of the homeotic complexes. Trends Genet. 1994, 10:358-364.
35. Dufort D., et al. The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development 1998, 125:3015-3025.
36. Durbec P.L., et al. Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts. Development 1996, 122:349-358.
37. Flentjar N., et al. TGF-betaRII rescues development of small intestinal epithelial cells in Elf3-deficient mice. Gastroenterology 2007, 132:1410-1419.
38. Flores C.F., et al. Intestinal differentiation in zebrafish requires Cdx1b, a functional equivalent of mammalian Cdx2. Gastroenterology 2008, 135:1665-1675.
39. Franklin V., et al. Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo. Mech. Dev. 2008, 125:587-600.
40. Fre S., et al. Notch signals control the fate of immature progenitor cells in the intestine. Nature 2005, 435:964-968.
41. Fre S., et al. Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc. Natl. Acad. Sci. USA 2009, 106:6309-6314.
42. Gao N., et al. Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev. Cell 2009, 16:588-599.
43. Garrison W.D., et al. Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology 2006, 130:1207-1220.
44. Genander M., et al. Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell 2009, 139:679-692.
45. Grainger S., et al. Cdx2 regulates patterning of the intestinal epithelium. Dev. Biol. 2010, 339:155-165.
46. Grapin-Botton A., Melton D.A. Endoderm development: from patterning to organogenesis. Trends Genet. 2000, 16:124-130.
47. Groppe J., et al. Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature 2002, 420:636-642.
48. Haramis A.-P.G., et al. De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science 2004, 303:1684-1686.
49. He X.C., et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-[beta]-catenin signaling. Nat. Genet. 2004, 36:1117-1121.
50. He X.C., et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat. Genet. 2004, 36:1117-1121.
51. Ireland H., et al. Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology 2004, 126:1236-1246.
52. Ishizuya-Oka A., et al. Shh/BMP-4 signaling pathway is essential for intestinal epithelial development during Xenopus larval-to-adult remodeling. Dev. Dyn. 2006, 235:3240-3249.
53. Ishizuya-Oka A., Hasebe T. Sonic hedgehog and bone morphogenetic protein-4 signaling pathway involved in epithelial cell renewal along the radial axis of the intestine. Digestion 2008, 77(Suppl 1):42-47.
54. Jensen J., et al. Control of endodermal endocrine development by Hes-1. Nat. Genet. 2000, 24:36-44.
55. Jonsson J., et al. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994, 371:606-609.
56. Kanai-Azuma M., et al. Depletion of definitive gut endoderm in Sox17-null mutant mice. Development 2002, 129:2367-2379.
57. Karlsson L., et al. Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development 2000, 127:3457-3466.
58. Katsnelson A. Gut Churning. Scientist 2009, 23:51.
59. Keller P.J., et al. Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy. Science 2008, 322:1065-1069.
60. Kikuchi Y., et al. Casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish. Genes Dev. 2001, 15:1493-1505.
61. Kim J., et al. Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival. J. Clin. Oncol. 2005, 23:2744-2753.
62. Kim B.-M., et al. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology 2007, 133:529-538.
63. Kollmar O., et al. CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1. Int. J. Cancer 2010, 126:1302-1315.
64. Kolterud Å, et al. Paracrine hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology 2009, 137:618-628.
65. Kondo T., et al. Function of posterior HoxD genes in the morphogenesis of the anal sphincter. Development 1996, 122:2651-2659.
66. Korinek V., et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 1998, 19:379-383.
67. Landman K.A., et al. Mathematical and experimental insights into the development of the enteric nervous system and Hirschsprung's disease. Dev. Growth Differ. 2007, 49:277-286.
68. Le Douarin N.M., Tellet M.A. The migration of neural crest cells to the wall of the digestive tract in avian embryo. J. Embryol. Exp. Morphol. 1973, 30(1):31-48.
69. Lee C.S., et al. The initiation of liver development is dependent on Foxa transcription factors. Nature 2005, 435:944-947.
70. Leibl M.A., et al. Expression of endothelin 3 by mesenchymal cells of embryonic mouse caecum. Gut 1999, 44:246-252.
71. Madison B.B., et al. Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development 2005, 132:279-289.
72. Mizoguchi T., et al. Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation. Development 2008, 135:2521-2529.
73. Nair S., Schilling T.F. Chemokine signaling controls endodermal migration during zebrafish gastrulation. Science 2008, 322:89-92.
74. Ng A.Y., et al. Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium. Gastroenterology 2002, 122:1455-1466.
75. Ng A.N.Y., et al. Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis. Dev. Biol. 2005, 286:114-135.
76. Ng S.S., et al. Phosphatidylinositol 3-kinase signaling does not activate the Wnt cascade. J. Biol. Chem. 2009, 284:35308-35313.
77. Offield M.F., et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 1996, 122:983-995.
78. Orford K., et al. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J. Biol. Chem. 1997, 272:24735-24738.
79. Ottaiano A., et al. Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients. Clin. Cancer Res. 2006, 12:2795-2803.
80. Pasquale E.B. Eph receptor signalling casts a wide net on cell behaviour. Nat. Rev. Mol. Cell Biol. 2005, 6:462-475.
81. Persad S., et al. Tumor suppressor Pten inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J. Cell Biol. 2001, 153:1161-1174.
82. Pinto D., et al. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 2003, 17:1709-1713.
83. Polakis P. Wnt signaling and cancer. Genes Dev. 2000, 14:1837-1851.
84. Pollock R.A., et al. Altering the boundaries of Hox3.1 expression: evidence for antipodal gene regulation. Cell 1992, 71:911-923.
85. Poulain M., Lepage T. Mezzo, a paired-like homeobox protein is an immediate target of Nodal signalling and regulates endoderm specification in zebrafish. Development 2002, 129:4901-4914.
86. Powell S.M., et al. APC mutations occur early during colorectal tumorigenesis. Nature 1992, 359:235-237.
87. Powell D.W., et al. Myofibroblasts. II. Intestinal subepithelial myofibroblasts. Am. J. Physiol. Cell Physiol. 1999, 277:C183-C201.
88. Ramalho-Santos M., et al. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 2000, 127:2763-2772.
89. Roberts J.R. Molecular mechanisms of development of the gastrointestinal tract. Dev. Dyn. 2000, 219:109-120.
90. Rodilla V., et al. Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc. Natl. Acad. Sci. USA 2009, 106:6315-6320.
91. Sancho E., et al. Live and let die in the intestinal epithelium. Curr. Opin. Cell Biol. 2003, 15:763-770.
92. Sansom O.J., et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 2004, 18:1385-1390.
93. Sato T., et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009, 459:262-265.
94. Savory J.G.A., et al. Cdx1 and Cdx2 are functionally equivalent in vertebral patterning. Dev. Biol. 2009, 330:114-122.
95. Schier A.F. Nodal signaling in vertebrate development. Annu. Rev. Cell Dev. Biol. 2003, 19:589-621.
96. Segditsas S., Tomlinson I. Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene 2006, 25:7531-7537.
97. Sepich S.S., et al. Initiation of convergence and extension movements of lateral mesoderm during zebrafish gastrulation. Dev. Dyn. 2005, 234:279-292.
98. Silberg D.G., et al. Cdx1 and Cdx2 expression during intestinal development. Gastroenterology 2000, 119:961-971.
99. Simpson M.J., et al. Cell proliferation drives neural crest cell invasion of the intestine. Dev. Biol. 2007, 302:553-568.
100. Smith D.M., et al. Roles of BMP signaling and Nkx2.5 in patterning at the chick midgut-foregut boundary. Development 2000, 127:3671-3681.
101. Smith D.M., Tabin C.J. Developmental biology: BMP signalling specifies the pyloric sphincter. Nature 1999, 402:748-749.
102. Sukegawa A., et al. The concentric structure of the developing gut is regulated by sonic hedgehog derived from endodermal epithelium. Development 2000, 127:1971-1980.
103. Tai C.C., et al. Wnt5a knock-out mouse as a new model of anorectal malformation. J. Surg. Res. 2009, 156:278-282.
104. Tam P.P.L., et al. Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Curr. Opin. Genet. Dev. 2003, 13:393-400.
105. Tam P.P.L., et al. Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation. Development 2007, 134:251-260.
106. Tamai Y., et al. Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice. Cancer Res. 1999, 59:2965-2970.
107. Tamura A., et al. Megaintestine in claudin-15-deficient mice. Gastroenterology 2008, 134:523-534.
108. Taraviras S., et al. Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system. Development 1999, 126:2785-2797.
109. Tennyson M.T., et al. Fetal development of the enteric nervous system of transgenic mice that overexpress the Hoxa-4 gene. Dev. Dyn. 1998, 211:269-291.
110. Tian Q., et al. Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt. Proc. Natl. Acad. Sci. USA 2004, 101:15370-15375.
111. Tian Q., et al. Bridging the BMP and Wnt pathways by PI3 kinase/Akt and 14-3-3zeta. Cell Cycle 2005, 4:215-216.
112. Torihashi S., et al. Gut-like structures from mouse embryonic stem cells as an in vitro model for gut organogenesis preserving developmental potential after transplantation. Stem Cells 2006, 24:2618-2626.
113. Torihashi S., et al. The expression and crucial roles of BMP signaling in development of smooth muscle progenitor cells in the mouse embryonic gut. Differentiation 2009, 77:277-289.
114. van de Wetering M., et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002, 111:241-250.
115. van der Flier L.G., Clevers H. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu. Rev. Physiol. 2009, 71:241-260.
116. van der Flier L.G., et al. The intestinal Wnt/TCF signature. Gastroenterology 2007, 132:628-632.
117. van der Flier L.G., et al. Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell 2009, 136:903-912.
118. van Es J.H., et al. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 2005, 435:959-963.
119. Vandercappellen J., et al. The role of CXC chemokines and their receptors in cancer. Cancer Lett. 2008, 267:226-244.
120. Vearing C.J., Lackmann M. Eph receptor signalling; dimerisation just isn't enough. Growth Factors 2005, 23:67-76.
121. Verzi M.P., Shivdasani R.A. Wnt signaling in gut organogenesis. Organogenesis 2008, 4:87-91.
122. Weinstein D.C., et al. The winged-helix transcription factor HNF-3[beta] is required for notochord development in the mouse embryo. Cell 1994, 78:575-588.
123. Wimmer-Kleikamp S.H., et al. Recruitment of Eph receptors into signaling clusters does not require ephrin contact. J. Cell Biol. 2004, 164:661-666.
124. Wolgemuth B.R., Mostoller M.P., Brinster R.L., Palmiter R.D. Transgenic mice overexpressing the mouse homeobox-containing gene Hox-1.4 exhibit abnormal gut development. Nature 1989, 337:464-467.
125. Xanthos J.B., et al. Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis. Development 2001, 128:167-180.
126. Yang Q., et al. Requirement of math1 for secretory cell lineage commitment in the mouse intestine. Science 2001, 294:2155-2158.
127. Young H.M., et al. GDNF is a chemoattractant for enteric neural cells. Dev. Biol. 2001, 229:503-516.
128. Young H.M., et al. Dynamics of neural crest-derived cell migration in the embryonic mouse gut. Dev. Biol. 2004, 270:455-473.
129. Young T., Deschamps J. Chapter 8 Hox, Cdx, and anteroposterior patterning in the mouse embryo. Curr. Top. Dev. Biol. 2009, 88:235-255.
130. Zacchetti G., et al. Hox gene function in vertebrate gut morphogenesis: the case of the caecum. Development 2007, 134:3967-3973.
131. Zakany J., Duboule D. Hox genes and the making of sphincters. Nature 1999, 401:761-762.
132. Zeissig S., et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 2007, 56:61-72.
133. Zheng H., et al. KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 296:G490-G498.
134. Zorn A.M., Wells J.M. Vertebrate endoderm development and organ formation. Annu. Rev. Cell Dev. Biol. 2009, 25:221-251.