Synthesis and in vitro biological evaluation of carbon-11-labeled quinoline derivatives as new candidate PET radioligands for cannabinoid CB2 receptor imaging

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 6, 2010, Pages 2099-2106

  Gao, Mingzhang ^a   Wang, Min ^a   Miller, Kathy D ^a   Hutchins, Gary D ^a   Zheng, Qi Huang ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer imaging; Cannabinoid receptor 2 (CB2); Carbon 11 labeled quinoline derivatives; Positron emission tomography (PET); Radioligands

Indexed keywords

2 CHLORO 7 METHOXY 8 PENTYLOXY 1 QUINOLINE 3 CARBOXYLIC ACID [2 (4 FLUOROPHENYL)ETHYL]AMIDE C 11; 2 CHLOROQUINOLINE DERIVATIVE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 7 METHOXY 2 OXO 8 PENTYLOXY 1,2 DIHYDROQUINOLINE 3 CARBOXYLIC ACID [2 (4 CHLOROPHENYL)ETHYL]AMIDE C 11; 7 METHOXY 2 OXO 8 PENTYLOXY 1,2 DIHYDROQUINOLINE 3 CARBOXYLIC ACID [2 (4 FLUOROPHENYL)ETHYL]AMIDE C 11; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CARBON 11; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ISOTOPE LABELING; LIGAND BINDING; LIPOPHILICITY; METHYLATION; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RECEPTOR AFFINITY;

BINDING SITES; CARBON RADIOISOTOPES; DRUG DESIGN; HUMANS; ISOTOPE LABELING; LIGANDS; MOLECULAR IMAGING; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; QUINOLINES; RADIOLIGAND ASSAY; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; SOLID PHASE EXTRACTION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77649235665     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.011     Document Type: Article

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