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Volumn 247, Issue 2, 2010, Pages 129-137

Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response

Author keywords

Chemoprevention; Glutathione (GSH); Microcystin LR (MC LR); NF E2 related factor 2 (Nrf2); Phase II enzymes; Sulforaphane (SFN)

Indexed keywords

GLUTATHIONE; HEME OXYGENASE 1; MICROCYSTIN LR; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2;

EID: 77955266905     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.06.005     Document Type: Article
Times cited : (46)

References (38)
  • 1
    • 0034854057 scopus 로고    scopus 로고
    • Potent induction of phase 2 enzymes in human prostate cells by Sulforaphane
    • Brook J.D., Paton V.G., Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by Sulforaphane. Cancer Epidemiol. Biomark. Prev. 2001, 10:949-954.
    • (2001) Cancer Epidemiol. Biomark. Prev. , vol.10 , pp. 949-954
    • Brook, J.D.1    Paton, V.G.2    Vidanes, G.3
  • 2
    • 0028127691 scopus 로고
    • The toxins of cyanobacteria
    • Carmichael W.W. The toxins of cyanobacteria. Sci. Am. 1994, 270:78-86.
    • (1994) Sci. Am. , vol.270 , pp. 78-86
    • Carmichael, W.W.1
  • 4
    • 34547795788 scopus 로고    scopus 로고
    • Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
    • Cornblatt B.S., Ye L.X., Dinkova-Kostova A.T., Erb M. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis 2007, 28:1485-1490.
    • (2007) Carcinogenesis , vol.28 , pp. 1485-1490
    • Cornblatt, B.S.1    Ye, L.X.2    Dinkova-Kostova, A.T.3    Erb, M.4
  • 5
    • 0037015035 scopus 로고    scopus 로고
    • Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    • Dinkova-Kostova A.T., Holtzclaw W.D., Cole R.N., Itoh K., Wakabayashi N., Katoh Y., et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:11908-11913.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 11908-11913
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Cole, R.N.3    Itoh, K.4    Wakabayashi, N.5    Katoh, Y.6
  • 6
    • 54149084936 scopus 로고    scopus 로고
    • Oridonin Confers Protection against Arsenic-Induced Toxicity through Activation of the Nrf2-Mediated Defensive Response
    • Du Y., Villeneuve N.F., Wang X.J., Sun Z.H., Chen W.M., Li J.X., et al. Oridonin Confers Protection against Arsenic-Induced Toxicity through Activation of the Nrf2-Mediated Defensive Response. Environ. Health Perspect. 2008, 116:1154-1161.
    • (2008) Environ. Health Perspect. , vol.116 , pp. 1154-1161
    • Du, Y.1    Villeneuve, N.F.2    Wang, X.J.3    Sun, Z.H.4    Chen, W.M.5    Li, J.X.6
  • 7
    • 0034874474 scopus 로고    scopus 로고
    • Toxic cyanobacterial bloom problems in Australian waters: risks and impacts on human health
    • Falconer I.R. Toxic cyanobacterial bloom problems in Australian waters: risks and impacts on human health. Phycologia 2001, 40:228-233.
    • (2001) Phycologia , vol.40 , pp. 228-233
    • Falconer, I.R.1
  • 8
    • 0042674326 scopus 로고    scopus 로고
    • Urinary isothiocyanate levels, brassica, and human breast cancer
    • Fowke J.H., Chung F.L., Jin F., Qi D., Cai Q., et al. Urinary isothiocyanate levels, brassica, and human breast cancer. Cancer Res. 2003, 63:3980-3986.
    • (2003) Cancer Res. , vol.63 , pp. 3980-3986
    • Fowke, J.H.1    Chung, F.L.2    Jin, F.3    Qi, D.4    Cai, Q.5
  • 9
    • 0035909947 scopus 로고    scopus 로고
    • Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane
    • Gao X., Dinkova-Kostova A.T., Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:15221-15226.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 15221-15226
    • Gao, X.1    Dinkova-Kostova, A.T.2    Talalay, P.3
  • 10
    • 0037832210 scopus 로고    scopus 로고
    • An investigation of the role of vitamin E in the protection of mice against microcystin toxicity
    • Gehringer M.M., Govender S., Shah M. An investigation of the role of vitamin E in the protection of mice against microcystin toxicity. Environ. Toxicol. 2003, 18:142-148.
    • (2003) Environ. Toxicol. , vol.18 , pp. 142-148
    • Gehringer, M.M.1    Govender, S.2    Shah, M.3
  • 12
    • 0033956744 scopus 로고    scopus 로고
    • The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin
    • Hayes J.D., Chanas S.A., Henderson C.J., McMahon M., Sun C., Moffat G.J., et al. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem. Soc. Trans. 2000, 28:33-41.
    • (2000) Biochem. Soc. Trans. , vol.28 , pp. 33-41
    • Hayes, J.D.1    Chanas, S.A.2    Henderson, C.J.3    McMahon, M.4    Sun, C.5    Moffat, G.J.6
  • 13
    • 33644649421 scopus 로고    scopus 로고
    • Nrf2: a potential molecular target for cancer chemoprevention by natural compounds
    • Jeong W.S., Jun M., Kong A.N. Nrf2: a potential molecular target for cancer chemoprevention by natural compounds. Antioxid. Redox Signal. 2006, 8:99-106.
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 99-106
    • Jeong, W.S.1    Jun, M.2    Kong, A.N.3
  • 14
    • 18144451569 scopus 로고    scopus 로고
    • Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil
    • Jochimsen E.M., Carmichael W.W., Jisi A. Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil. New Engl. J Med. 1998, 338:873-878.
    • (1998) New Engl. J Med. , vol.338 , pp. 873-878
    • Jochimsen, E.M.1    Carmichael, W.W.2    Jisi, A.3
  • 15
    • 12744278308 scopus 로고    scopus 로고
    • Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk
    • Joseph M.A., Moysich K.B., Freudenheim J.L., Shields P.G., Bowman E.D., et al. Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk. Nutr. Cancer 2004, 50:206-213.
    • (2004) Nutr. Cancer , vol.50 , pp. 206-213
    • Joseph, M.A.1    Moysich, K.B.2    Freudenheim, J.L.3    Shields, P.G.4    Bowman, E.D.5
  • 16
    • 33847050801 scopus 로고    scopus 로고
    • Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
    • Kensler T.W., Wakabayashi N., Biswal S. Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway. Annu. Rev. Pharmacol. Toxicol. 2007, 47:89-116.
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 17
    • 0242610791 scopus 로고    scopus 로고
    • Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane
    • Kim B.R., Hu R., Keum Y.S., Hebbar V., Shen G., Nair S.S., Kong A.N. Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane. Cancer Res. 2003, 63:7520-7525.
    • (2003) Cancer Res. , vol.63 , pp. 7520-7525
    • Kim, B.R.1    Hu, R.2    Keum, Y.S.3    Hebbar, V.4    Shen, G.5    Nair, S.S.6    Kong, A.N.7
  • 18
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • Kobayashi A., Kang M.I., Okawa H., Ohtsuji M., Zenke Y., Chiba T., et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol. Cell. Biol. 2004, 24:7130-7139.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.I.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5    Chiba, T.6
  • 19
    • 0001497590 scopus 로고    scopus 로고
    • Signal transduction events elicited by cancer prevention compounds
    • Kong A.N., Yu R., Hebbar V., Chen C., Owuor E., Hu R., et al. Signal transduction events elicited by cancer prevention compounds. Mutat. Res. 2001, 480-481:231-241.
    • (2001) Mutat. Res. , pp. 231-241
    • Kong, A.N.1    Yu, R.2    Hebbar, V.3    Chen, C.4    Owuor, E.5    Hu, R.6
  • 21
    • 33846214452 scopus 로고    scopus 로고
    • Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen
    • Moffit J.S., Aleksunes L.M., Kardas M.J., Slitt A.L., Klaassen C.D., Manautou J.E. Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. Toxicology 2007, 230:197-206.
    • (2007) Toxicology , vol.230 , pp. 197-206
    • Moffit, J.S.1    Aleksunes, L.M.2    Kardas, M.J.3    Slitt, A.L.4    Klaassen, C.D.5    Manautou, J.E.6
  • 22
    • 0031788805 scopus 로고    scopus 로고
    • Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin LR: the first step in detoxification
    • Pflugmacher S., Wiegand C., Oberemm A., Beattie K.A., Krause E., Codd G.A., et al. Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin LR: the first step in detoxification. Biochim. Biophys. Acta 1998, 1425:527-533.
    • (1998) Biochim. Biophys. Acta , vol.1425 , pp. 527-533
    • Pflugmacher, S.1    Wiegand, C.2    Oberemm, A.3    Beattie, K.A.4    Krause, E.5    Codd, G.A.6
  • 23
    • 0029027838 scopus 로고
    • Electrophile and antioxidant regulation of enzymes that detoxify carcinogens
    • Prestera T., Talalay P. Electrophile and antioxidant regulation of enzymes that detoxify carcinogens. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:8965-8969.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 8965-8969
    • Prestera, T.1    Talalay, P.2
  • 24
    • 15244356847 scopus 로고    scopus 로고
    • Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
    • Rangasamy T., Cho C.Y., Thimmulappa R.K., Zhen L., Srisuma S.S., Kensler T.W., et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J. Clin. Invest. 2004, 114:1248-1259.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1248-1259
    • Rangasamy, T.1    Cho, C.Y.2    Thimmulappa, R.K.3    Zhen, L.4    Srisuma, S.S.5    Kensler, T.W.6
  • 25
    • 61449208761 scopus 로고    scopus 로고
    • Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes
    • Reisman S.A., Aleksunes L.M., Klaassen C.D. Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochem. Pharmacol. 2009, 77:1273-1282.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 1273-1282
    • Reisman, S.A.1    Aleksunes, L.M.2    Klaassen, C.D.3
  • 26
    • 0026612119 scopus 로고
    • DT-diaphorase and cancer chemotherapy
    • Riley R.J., Workman P. DT-diaphorase and cancer chemotherapy. Biochem. Pharmacol. 1992, 43:1657-1669.
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 1657-1669
    • Riley, R.J.1    Workman, P.2
  • 27
    • 33644882749 scopus 로고    scopus 로고
    • Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes
    • Shinkai Y., Sumi D., Fukami I., Ishii T., Kumagai Y. Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. FEBS Lett. 2006, 580:1771-1774.
    • (2006) FEBS Lett. , vol.580 , pp. 1771-1774
    • Shinkai, Y.1    Sumi, D.2    Fukami, I.3    Ishii, T.4    Kumagai, Y.5
  • 28
    • 0033789926 scopus 로고    scopus 로고
    • Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk
    • Spitz M.R., Duphorne C.M., Detry M.A., Pillow P.C., Amos C.I., et al. Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk. Cancer Epidemiol. Biomark. Prev. 2000, 9:1017-1020.
    • (2000) Cancer Epidemiol. Biomark. Prev. , vol.9 , pp. 1017-1020
    • Spitz, M.R.1    Duphorne, C.M.2    Detry, M.A.3    Pillow, P.C.4    Amos, C.I.5
  • 30
    • 0035065923 scopus 로고    scopus 로고
    • Covalent glutathione conjugation to cyanobacterial hepatotoxin microcystin LR by F344 rat cytosolic and microsomal glutathione S-transferases
    • Takenaka S. Covalent glutathione conjugation to cyanobacterial hepatotoxin microcystin LR by F344 rat cytosolic and microsomal glutathione S-transferases. Environ. Toxicol. Pharmacol. 2001, 9:135-139.
    • (2001) Environ. Toxicol. Pharmacol. , vol.9 , pp. 135-139
    • Takenaka, S.1
  • 31
    • 0030006616 scopus 로고    scopus 로고
    • Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sample in Haimen and Fusui, endemic areas of Primary Liver Cancer in China, by highly sensitive immunoassay
    • Ueno Y., Nagata S., Tsutsumi T., Yu S.Z. Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sample in Haimen and Fusui, endemic areas of Primary Liver Cancer in China, by highly sensitive immunoassay. Carcinogenesis 1996, 17:1317-1321.
    • (1996) Carcinogenesis , vol.17 , pp. 1317-1321
    • Ueno, Y.1    Nagata, S.2    Tsutsumi, T.3    Yu, S.Z.4
  • 32
    • 0038672387 scopus 로고    scopus 로고
    • Guidelines for drinking-water quality. Addendum to Volume 2
    • Word Health Organization, Genveva, Switzerland, WHO
    • WHO Guidelines for drinking-water quality. Addendum to Volume 2. Health Criteria and Other Supporting Information 1998, Word Health Organization, Genveva, Switzerland.
    • (1998) Health Criteria and Other Supporting Information
  • 33
    • 47849083585 scopus 로고    scopus 로고
    • Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults
    • William O.O., Thomas W.K. Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults. Mutat. Res./Rev. Mutat. Res. 2008, 659:31-39.
    • (2008) Mutat. Res./Rev. Mutat. Res. , vol.659 , pp. 31-39
    • William, O.O.1    Thomas, W.K.2
  • 34
    • 66749112860 scopus 로고    scopus 로고
    • Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
    • Yates M.S., Tran Q.T., Dolan P.M., Osburn W.O., Shin S., et al. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis 2009, 30:1024-1031.
    • (2009) Carcinogenesis , vol.30 , pp. 1024-1031
    • Yates, M.S.1    Tran, Q.T.2    Dolan, P.M.3    Osburn, W.O.4    Shin, S.5
  • 35
    • 43049117465 scopus 로고    scopus 로고
    • Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme
    • Yoon H.Y., Kang N.I., Lee H.K., Jang K.Y., Park J.W., Park B.H. Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme. Biochem. Pharmacol. 2008, 75:2214-2223.
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 2214-2223
    • Yoon, H.Y.1    Kang, N.I.2    Lee, H.K.3    Jang, K.Y.4    Park, J.W.5    Park, B.H.6
  • 36
    • 33751173224 scopus 로고    scopus 로고
    • Alteration of intracellular GSH levels and its role in microcystin- LR-induced DNA damage in human hepatoma HepG2 cells
    • Zegura B., Lah T.T., Filipic M. Alteration of intracellular GSH levels and its role in microcystin- LR-induced DNA damage in human hepatoma HepG2 cells. Mutat. Res. 2006, 611:25-33.
    • (2006) Mutat. Res. , vol.611 , pp. 25-33
    • Zegura, B.1    Lah, T.T.2    Filipic, M.3
  • 37
    • 24044466764 scopus 로고    scopus 로고
    • Ubiquitination of Keap1, a BTB-Kelch Substrate Adaptor Protein for Cul3, Targets Keap1 for Degradation by a Proteasome-independent Pathway
    • Zhang D.D., Lo S.C., Sun Z.H., Habib G.M., Lieberman M.W., Hannink M. Ubiquitination of Keap1, a BTB-Kelch Substrate Adaptor Protein for Cul3, Targets Keap1 for Degradation by a Proteasome-independent Pathway. J. Biol. Chem. 2005, 280:30091-30099.
    • (2005) J. Biol. Chem. , vol.280 , pp. 30091-30099
    • Zhang, D.D.1    Lo, S.C.2    Sun, Z.H.3    Habib, G.M.4    Lieberman, M.W.5    Hannink, M.6
  • 38
    • 33845442925 scopus 로고    scopus 로고
    • Mechanistic studies of the Nrf2-Keap1 signaling pathway
    • Zhang D.D. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab. Rev. 2006, 38:769-789.
    • (2006) Drug Metab. Rev. , vol.38 , pp. 769-789
    • Zhang, D.D.1


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