An investigation of the role of vitamin E in the protection of mice against microcystin toxicity

Environmental Toxicology

Volumn 18, Issue 2, 2003, Pages 142-148

  Gehringer, Michelle M ^a   Govender, Sharlene ^a   Shah, Mrinal ^a   Downing, Timothy G ^a  

^a NELSON MANDELA METROPOLITAN UNIVERSITY   (South Africa)

Author keywords

Alanine transaminase; Cyanobacteria; Glutathione S transferase; Lipid peroxidation; Microcystin; Vitamin E

Indexed keywords

ALGAE; ANTIOXIDANTS; ENZYME KINETICS; LIPIDS; TOXICITY; VITAMINS;

ALANINE TRANSAMINASE (ALT); CHEMOPROTECTANT STUDIES; CYANOBACTERIA; GLUTATHIONE S-TRANSFERASE (GST); INTRAPERITONEAL DOSES; MICROCYSTIN TOXICITY;

WATER POLLUTION;

ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; CYANOGINOSIN; GLUTATHIONE TRANSFERASE; BACTERIAL TOXIN; CYANOGINOSIN LR; CYCLOPEPTIDE; MARINE TOXIN;

ALGAL BLOOM; BIOASSAY; CYANOBACTERIUM; DRINKING WATER; ENZYME; HEALTH RISK; PUBLIC HEALTH; RODENT; TOXICITY; TOXIN; VITAMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; LIPID PEROXIDATION; LIVER PROTECTION; LIVER TOXICITY; MICROCYSTIS AERUGINOSA; MOUSE; NONHUMAN; PRIORITY JOURNAL; VITAMIN SUPPLEMENTATION; ANIMAL; BAGG ALBINO MOUSE; CYANOBACTERIUM; INFUSION; LIVER; MALE; PATHOGENICITY; PATHOLOGY; PUBLIC HEALTH; RECREATION; WATER SUPPLY;

CYANOBACTERIA; MICROCYSTIS AERUGINOSA;

ANIMALS; BACTERIAL TOXINS; CYANOBACTERIA; GLUTATHIONE TRANSFERASE; INFUSIONS, PARENTERAL; LIPID PEROXIDATION; LIVER; MALE; MARINE TOXINS; MICE; MICE, INBRED BALB C; MICROCYSTINS; PEPTIDES, CYCLIC; PUBLIC HEALTH; RECREATION; VITAMIN E; WATER SUPPLY;

EID: 0037832210     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.10110     Document Type: Article

References (28)

1. Cheng W-H, Valentine BA, Gen Lei X. 1999. High levels of dietary vitamin E do not replace cellular glutathione peroxidase in protecting mice from acute oxidative stress. FASEB J 13:1951-1956.
2. Codd GA, Bell SG, Brooks WP. 1989. Cyanobacterial toxins in water. Water Sci Technol 21:1-13.
3. Ding W-X, Shen H-M, Zhu H-G, Ong C-O. 1998. Studies on the oxidative damage induced by cyanobacterial extract in primary cultured rat hepatocytes. Environ Res 78:12-18.
4. Ding W-X, Shen H-M, Ong C-O. 2000a. Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes. Hepatology 32:547-555.
5. Ding W-X, Shen H-M, Ong C-O. 2000b. Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes. Environ Health Perspec 108:605-609.
6. Falconer IR, Smith JV, Jackson AR, Jones AJ, Runnegar MT. 1988. Oral toxicity of a bloom of the cyanobacterium Microcystis aeruginosa administered to mice over periods up to 1 year. J Toxicol Environ Health 24:291-305.
7. Habig WH, Pabst MJ, Jokoby WB. 1974. Glutathione S-transferases: The first step in mercapturic acid formation. J Biol Chem 249:7130-7139.
8. Harris CM, Stone WL. 1987. The effects of in vitro lipid peroxidation on the activity of liver microsomal glutathione S-transferase from rats supplemented or deficient in antioxidants. Life Sci 42:415-420.
9. Hermansky SJ, Stohs SJ, Markin RS, Murray WJ. 1990. Hepatic lipid peroxidation, sulfhydryl status, and toxicity of the blue-green algal toxin Microcystin-LR in mice. J Toxicol Environ Health 31:71-91.
10. Hermansky SJ, Stohs SJ, Eldeen ZM, Roche VF, Mereish KA. 1991. Evaluation of potential cheomoprotectants against microcystin LR hepatotoxicity in mice. J Appl Toxicol 11:65-73.
11. Honkanen RE, Zwillers J, Moore RA, Daily SL, Khatra BS, Dukelow M, Boynton AL. 1990. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases. J Biol Chem 265:19401-19404.
12. Hooser SB, Beasley VR, Lovell RA, Carmichael WW, Haschek WM. 1989. Toxicity of microcystin-LR, a cyclic heptapeptide hepatotoxin from Microcystis aeruginosa to rats and mice. Vet Pathol 26:246-252.
13. Hooser SB, Beasley VR, Waite LL, Kuhlenschmidt MS, Carmichael WW, Haschek WM. 1991. Actin filament alterations in rat hepatocytes induced in vivo and in vitro by microcystin-LR, a hepatotoxin from the blue-green alga Microcystis aeruginosa. Vet Pathol 28:259-266.
14. Hunter PR. 1998. Cyanobacterial toxins and human health. J Appl Micro Sympos Suppl 84:35S-40S.
15. Kondo F, Matsumoto H, Yamada S, Ishikawa N, Ito E, Nagata S, Ueno Y, Suzuki M, Harada K. 1996. Detection and identification of metabolites of microcystins formed in vivo in mouse and rat livers. Chem Res Toxicol 9:1355-1359.
16. Mackintosh C, Beattie KA, Klumpp S, Cohen P, Codd GA. 1990. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Letters 264:187-192.
17. Miura GA, Robinson NA, Lawrence WB, Pace JG. 1991 Hepatotoxicity of microcystin-LR in fed and fasted rats. Toxicon 29:337-346.
18. Nordberg J, Arner ESJ. 2001. Reactive oxygen species, antioxidants and the mammalian thiroedoxin system. Free Radic Biol Med 31:1287-1312.
19. Ohta T, Nishiwake R, Yatsunami J, Komori A, Suganuma M, Fujiki H. 1992. Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumour promoter, in primary cultured rat hepatocytes. Carcinogenesis 13:2443-2447.
20. Pflugmacher S, Wiegand C, Oberemm A, Beattie KA, Krause E, Codd GA, Steinberg CEW. 1998. Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin LR: The first step in detoxification. Biochim Biophys Acta 1425:527-533.
21. Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123:1939-1951.
22. Runnegar M, Berndt N, Kaplowitz N. 1995. Microcystin uptake and inhibition of protein phosphatases: Effects of chemoprotectants and self-inhibition in relation to known hepatic transporters. Toxicol Appl Pharmacol 134:264-272
23. Rippka R. 1988. Isolation and purification of cyanobacteria. Meth Enzymology 167:3-27.
24. Sivonen K, Jones G. 1999. Cyanobacterial toxins. In: Chorus I, Bartram J, editors. Toxic cyanobacteria in water. A guide to public health consequences, monitoring and management. London: E & FN Spon. p 41-111.
25. Takenaka S. 2001. Covalent glutathione conjugation to cyanobacterial hepatotoxin microcystin LR by F344 rat cytosolic and microsomal glutathione S-transferases. Environ Toxicol Pharmacol 9:135-139
26. Uchiyama M, Mihara M. 1978. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86:271-278.
27. Ward CJ, Bettie KA, Lee EYC, Codd GA. 1997. Colourimetric protein phosphatase inhibition assay of laboratory strains and natural blooms of Cyanobacteria-Comparisons of high performance liquid chromatographic analysis for Microcystis. FEMS Microbiol Lett 153:465-473.
28. Yoshida T, Makita Y, Nagata S, Tsutsumi T, Yoshida F, Sekijima M, Tamura S, Ueno Y. 1997. Acute oral toxicity of microcystin-LR, a cyanobacterial hepatotoxin. Nat Toxins 5:91-95.