Combination of RNA interference and U1 inhibition leads to increased inhibition of gene expression

Nucleic Acids Research

Volumn 38, Issue 13, 2010, Pages

  Abad, X ^a,b   Razquin, N ^a   Abad, A ^a,b   Fortes, P ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; MESSENGER RNA; NOTCH1 RECEPTOR; RNA DERIVATIVE; SMALL INTERFERING RNA; SMALL NUCLEAR RNA; SMALL NUCLEAR RNA U1 INHIBITOR; SMALL NUCLEAR RNA U1I; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENTIATION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; POLYADENYLATION; PRIORITY JOURNAL; RNA INTERFERENCE; RNA RECOMBINATION;

CELL LINE; DOWN-REGULATION; GENES, REPORTER; HELA CELLS; HUMANS; LUCIFERASES; RECEPTOR, NOTCH1; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA, SMALL NUCLEAR;

EID: 77955236073     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq299     Document Type: Article

References (32)

1. Rivas, F.V., Tolia, N.H., Song, J.J., Aragon, J.P., Liu, J., Hannon, G.J. and Joshua-Tor, L. (2005) Purified Argonaute2 and an siRNA form recombinant human RISC. Nat. Struct. Mol. Biol., 12, 340-349.
2. Lee, Y., Jeon, K., Lee, J.T., Kim, S. and Kim, V.N. (2002) MicroRNA maturation: stepwise processing and subcellular localization. Embo. J., 21, 4663-4670.
3. Chendrimada, T.P., Gregory, R.I., Kumaraswamy, E., Norman, J., Cooch, N., Nishikura, K. and Shiekhattar, R. (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature, 436, 740-744.
4. Gregory, R.I., Chendrimada, T.P., Cooch, N. and Shiekhattar, R. (2005) Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell, 123, 631-640.
5. Lewis, B.P., Burge, C.B. and Bartel, D.P. (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell, 120, 15-20.
6. Eulalio, A., Huntzinger, E. and Izaurralde, E. (2008) Getting to the root of miRNA-mediated gene silencing. Cell, 132, 9-14.
7. Brummelkamp, T.R., Bernards, R. and Agami, R. (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science, 296, 550-553.
8. Bridge, A.J., Pebernard, S., Ducraux, A., Nicoulaz, A.L. and Iggo, R. (2003) Induction of an interferon response by RNAi vectors in mammalian cells. Nat. Genet., 34, 263-264.
9. Sledz, C.A., Holko, M., de Veer, M.J., Silverman, R.H. and Williams, B.R. (2003) Activation of the interferon system by short-interfering RNAs. Nat. Cell Biol., 5, 834-839.
10. Grimm, D., Streetz, K.L., Jopling, C.L., Storm, T.A., Pandey, K., Davis, C.R., Marion, P., Salazar, F. and Kay, M.A. (2006) Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature, 441, 537-541.
11. Jackson, A.L., Bartz, S.R., Schelter, J., Kobayashi, S.V., Burchard, J., Mao, M., Li, B., Cavet, G. and Linsley, P.S. (2003) Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol., 21, 635-637.
12. Persengiev, S.P., Zhu, X. and Green, M.R. (2004) Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA, 10, 12-18.
13. Beckley, S.A., Liu, P., Stover, M.L., Gunderson, S.I., Lichtler, A.C. and Rowe, D.W. (2001) Reduction of target gene expression by a modified U1 snRNA. Mol. Cell Biol., 21, 2815-2825.
14. Fortes, P., Cuevas, Y., Guan, F., Liu, P., Pentlicky, S., Jung, S.P., Martinez-Chantar, M.L., Prieto, J., Rowe, D. and Gunderson, S.I. (2003) Inhibiting expression of specific genes in mammalian cells with 5' end-mutated U1 small nuclear RNAs targeted to terminal exons of pre-mRNA. Proc. Natl Acad. Sci. USA, 100, 8264-8269.
15. Will, C.L. and Luhrmann, R. (2001) Spliceosomal UsnRNP biogenesis, structure and function. Curr. Opin. Cell Biol., 13, 290-301.
16. Furth, P.A., Choe, W.T., Rex, J.H., Byrne, J.C. and Baker, C.C. (1994) Sequences homologous to 5' splice sites are required for the inhibitory activity of papillomavirus late 3' untranslated regions. Mol. Cell Biol., 14, 5278-5289.
17. Abad, X., Vera, M., Jung, S.P., Oswald, E., Romero, I., Amin, V., Fortes, P. and Gunderson, S.I. (2008) Requirements for gene silencing mediated by U1 snRNA binding to a target sequence. Nucleic Acids Res., 36, 2338-2352.
18. Gunderson, S.I., Polycarpou-Schwarz, M. and Mattaj, I.W. (1998) [1U] snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase. Mol. Cell, 1, 255-264.
19. Sajic, R., Lee, K., Asai, K., Sakac, D., Branch, D.R., Upton, C. and Cochrane, A. (2007) Use of modified U1 snRNAs to inhibit HIV-1 replication. Nucleic Acids Res., 35, 247-255.
20. Narvaiza, I., Aparicio, O., Vera, M., Razquin, N., Bortolanza, S., Prieto, J. and Fortes, P. (2006) Effect of adenovirus-mediated RNA interference on endogenous microRNAs in a mouse model of multidrug resistance protein 2 gene silencing. J. Virol., 80, 12236-12247.
21. Vera, M., Sobrevals, L., Zaratiegui, M., Martinez, L., Palencia, B., Rodriguez, C.M., Prieto, J. and Fortes, P. (2007) Liver transduction with a simian virus 40 vector encoding insulin-like growth factor I reduces hepatic damage and the development of liver cirrhosis. Gene Ther., 14, 203-210.
22. Aparicio, O., Razquin, N., Zaratiegui, M., Narvaiza, I. and Fortes, P. (2006) Adenovirus virus-associated RNA is processed to functional interfering RNAs involved in virus production. J. Virol., 80, 1376-1384.
23. Palomero, T. and Ferrando, A. (2008) Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas. Clin. Cancer Res., 14, 5314-5317.
24. Efstratiadis, A., Szabolcs, M. and Klinakis, A. (2007) Notch, Myc and breast cancer. Cell Cycle, 6, 418-429.
25. Kunnimalaiyaan, M. and Chen, H. (2007) Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors. Oncologist, 12, 535-542.
26. Talora, C., Campese, A.F., Bellavia, D., Felli, M.P., Vacca, A., Gulino, A. and Screpanti, I. (2008) Notch signaling and diseases: an evolutionary journey from a simple beginning to complex outcomes. Biochim. Biophys. Acta, 1782, 489-497.
27. Reynolds, A., Leake, D., Boese, Q., Scaringe, S., Marshall, W.S. and Khvorova, A. (2004) Rational siRNA design for RNA interference. Nat. Biotechnol., 22, 326-330.
28. Matveeva, O., Nechipurenko, Y., Rossi, L., Moore, B., Saetrom, P., Ogurtsov, A.Y., Atkins, J.F. and Shabalina, S.A. (2007) Comparison of approaches for rational siRNA design leading to a new efficient and transparent method. Nucleic Acids Res., 35, e63.
29. Purow, B.W., Haque, R.M., Noel, M.W., Su, Q., Burdick, M.J., Lee, J., Sundaresan, T., Pastorino, S., Park, J.K., Mikolaenko, I. et al. (2005) Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res., 65, 2353-2363.
30. Shin, H.M., Minter, L.M., Cho, O.H., Gottipati, S., Fauq, A.H., Golde, T.E., Sonenshein, G.E. and Osborne, B.A. (2006) Notch1 augments NF-kappaB activity by facilitating its nuclear retention. Embo. J., 25, 129-138.
31. Boese, Q., Leake, D., Reynolds, A., Read, S., Scaringe, S.A., Marshall, W.S. and Khvorova, A. (2005) Mechanistic insights aid computational short interfering RNA design. Methods Enzymol., 392, 73-96.
32. Hutvagner, G. and Zamore, P.D. (2002) A microRNA in a multiple-turnover RNAi enzyme complex. Science, 297, 2056-2060.