Discovery of novel human phenylethanolamine N-methyltransferase (hPNMT) inhibitors using 3D pharmacophore-Based in silico, biophysical screening and enzymatic activity assays

Molecules and Cells

Volumn 29, Issue 6, 2010, Pages 595-602

  Kang, Dong Il ^a   Lee, Jee Young ^a   Kim, Woonghee ^a   Jeong, Ki Woong ^a   Shin, Soyoung ^a   Yang, Jiyoung ^a   Park, Eujin ^a   Chae, Young Kee ^b   Kim, Yangmee ^a  

^a Konkuk University   (South Korea)

^b Sejong University   (South Korea)

Author keywords

adrenaline; in silico screening; pharmacophore; PNMT; STD NMR

Indexed keywords

1,4 DIAMINONAPHTHALENE 2,6 DISULFONIC ACID; 4 (BENZO[D][1,3]DIOXOL 5 YLAMINO) 4 OXOBUTANOIC ACID; 4 OXO 1,4 DIHYDRODIHYDROQUINOLINE 3,7 DICARBOXYLIC ACID; ASPARAGINE; PHENYLALANINE; PHENYLETHANOLAMINE N METHYLTRANSFERASE; PHENYLETHANOLAMINE N METHYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; DRUG BINDING; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; NUCLEAR MAGNETIC RESONANCE; PHARMACOPHORE;

BIOPHYSICAL PHENOMENA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ENZYME ASSAYS; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; PROTEIN BINDING;

EID: 77955054977     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10059-010-0074-3     Document Type: Article

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