3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N- methyltransferase versus the α2-adrenoceptor(1a)

Journal of Medicinal Chemistry

Volumn 42, Issue 11, 1999, Pages 1982-1990

  Grunewald, Gary L ^a   Dahanukar, Vilas H ^a   Teoh, Bee ^a   Criscione, Kevin R ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDRO 7 ISOQUINOLINESULFONAMIDE; 3 HYDROXYMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 7 AMINOSULFONYL 3 HYDROXYMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 7,8 DICHLORO 1,2,3,4 TETRAHYDROISOQUINOLINE; ALPHA 2 ADRENERGIC RECEPTOR; PHENYLETHANOLAMINE N METHYLTRANSFERASE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHILICITY; LIPOPHILICITY; MALE; METHYLATION; NONHUMAN; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADRENAL GLANDS; ANIMALS; BINDING, COMPETITIVE; CATTLE; CEREBRAL CORTEX; ENZYME INHIBITORS; ISOQUINOLINES; LIGANDS; MALE; MODELS, MOLECULAR; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TETRAHYDROISOQUINOLINES;

EID: 0033519730     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9807252     Document Type: Article

References (39)

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