Clinical and molecular genetics of ADHD and Tourette syndrome: Two related polygenic disorders

Annals of the New York Academy of Sciences

Volumn 931, Issue , 2001, Pages 50-83

  Comings, D E ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

ADD; Attention deficit disorder; Dopamine; GABA; Receptors; Transporter

Indexed keywords

4 AMINOBUTYRIC ACID; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANDROGEN RECEPTOR; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE BETA MONOOXYGENASE; DOPAMINE TRANSPORTER; NEUROTRANSMITTER; NORADRENALIN; NORADRENALIN TRANSPORTER; SEROTONIN;

ANXIETY NEUROSIS; ATTENTION DEFICIT DISORDER; BRAIN BLOOD FLOW; BRAIN SCINTISCANNING; COMORBIDITY; DEPRESSION; GENETIC LINKAGE; GILLES DE LA TOURETTE SYNDROME; HUMAN; HYPERMETABOLISM; LEARNING DISORDER; NEUROTRANSMISSION; NONHUMAN; REVIEW; SUBSTANCE ABUSE; TIC;

ANIMALIA;

EID: 0034952023     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb05773.x     Document Type: Review

References (218)

1. A family study of the hyperactive child syndrome
2. Psychiatric illness in the families of hyperactive children
3. Familial subtypes of childhood hyperactivity
4. Demonstration of vertical transmission of attention deficit disorder
5. A controlled study of siblings of hyperactive children
6. A familial factor in minimal brain dysfunction
7. A family study of patients with attention deficit disorder and normal controls
8. A family-genetic study of girls with DSM-III attention deficit disorder
9. Attention deficit hyperactivity disorder - Family-genetic risk factors and comorbidity
10. Separation of DSM-III attention deficit disorder and conduct disorder - Evidence from a family-genetic study of American child psychiatric patients
11. Evidence of familial association between attention deficit disorder and major affective disorders
12. Family-genetic and psychosocial risk factors in DSM-III attention deficit disorder
13. Segregation analysis of attention deficit hyperactivity disorder
14. Patterns of psychiatric comorbidity, cognition, and psychosocial functioning in adults with attention deficit hyperactivity disorder
15. Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder
16. An exploratory study of ADHD among second-degree relatives of ADHD children
17. High rate of affective disorders in probands with attention deficit disorder and their relatives: A controlled family study
18. Psychiatric interviews suitable for use in research with children and adolescents
19. A case of Tourette's syndrome with symptoms of attention deficit disorder treated with desipramine
20. Evidence for the independent familial transmission of attention deficit hyperactivity disorder and learning disabilities: Results from a family genetic study
21. Psychiatric and developmental disorders in families of children with attention-defict hyperactivity disorder
22. The role of genetic factors in conduct disorder based on studies of Tourette syndrome and ADHD probands and their relatives
23. The role of genetic factors in human sexual behavior based on studies of Tourette syndrome and ADHD probands and their relatives
24. Genetic factors in depression based on studies of Tourette syndrome and attention deficit hyperactivity disorder probands and relatives
25. Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives. II. Alcohol abuse
26. Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives. I. Drug abuse
27. Psychopathology in adopted away offspring of biologic parents with antisocial behavior
28. Studies of adoptees from psychiatrically disturbed biological parents. II. Temperament, hyperactive, antisocial, and developmental variables
29. Studies of adoptees from psychiatrically disturbed biological parents. I. Psychiatric conditions in childhood and adolescence
30. Evidence for a genetic etiology in hyperactivity
31. Twin concordance for attention deficit hyperactivity disorder: A comparison of teachers and mothers' reports
32. Genetic and environmental influences on the convariation between hyperactivity and conduct disorder in juvenile twins
33. Childhood hyperactivity scores are highly heritable and show sibling competition effects: Twins study evidence
34. Genetic and neurobiological aspects of attention deficit hyperactivity disorder: A review
35. Attention deficit disorder in reading-disabled twins: Evidence for a genetic etiology
36. Multiple sclerosis and the workplace: Report of an industry based cluster
37. Attention-deficit hyperactivity disorder dimensions: A twin study of inattention and impulsivity-hyperactivity
38. A twin study of the etiology of comorbidity: Attention deficit hyperactivity disorder and dyslexia
39. Tourette's syndrome and attention deficit disorder with hyperactivity: Are they genetically related?
40. Tourette's syndrome and attention deficit disorder
41. Genetic factors in substance abuse based on studies of Tourette syndrome and ADHD probands and relatives. II. Alcohol abuse
42. Tourette syndrome: A hereditary neuropsychiatric spectrum disorder
43. Comorbid behavioral disorders
44. Neurobiology of attention deficit disorder with hyperactivity: Where have we come in 50 years?
45. Detection of major gene for Gilles de la Tourette syndrome
46. The inheritance of Gilles de la Tourette's syndrome and associated behaviors. Evidence for autosomal dominant transmission
47. Complex segregation analysis of Gilles de la Tourette syndrome: Further evidence for a major locus mode of transmission
48. Familial Tourette's syndrome in a large British pedigree associated with psychopathology, severity, and potential for linkage analysis
49. Untying the Gordian knot - The genetics of Tourette syndrome
50. Genetic study on Tourette syndrome in the Netherlands
51. Hypothesis: Homozygosity in Tourette syndrome
52. Alternative hypotheses on the inheritance of Tourette syndrome
53. Bilineal transmission in Tourette's syndrome families
54. A family study and segregaton analysis of Tourette's syndrome: Evidence for a mixed model of inheritance
55. Intermediate inheritance of Tourette syndrome, assuming assortative mating
56. Attention deficit-hyperactivity disorder in people with generalized resistance to thyroid hormone
57. Attention-deficit hyperactivity disorder and thyroid function
58. Thyroid function and attention-deficit hyperactivity disorder
59. Attention-deficit hyperactivity disorder (ADHD) and thyroid abnormalities
60. Low intelligence but not attention deficit hyperactivity disorder is associated with resistance to thyroid hormone caused by the mutation R314H in the thyroid hormone receptor β gene
61. Neurocognitive characteristics of individuals with resistance to thyroid hormone: Comparision with individuals with attention-deficit hyperactivity disorder
62. Progress in the search for genetic linkage with Tourette syndrome - An exclusion map covering more than 50-percent of the autosomal genome
63. Linkage and Tourette syndrome
64. Polygenic inheritance of Tourette syndrome, stuttering, ADHD, conduct and oppositional defiant disorder: The additive and subtractive effect of the three dopaminergic genes - DRD2, DbH and DAT1
65. Polygenetic inheritance of psychiatric disorders
66. Common genetic factors for drug and alcohol abuse: Tourette syndrome (Gts)/ADHD genes
67. Genetic factors in human sexual behavior
68. Complex segregation analysis of Gilles de la Tourette's disorder families
69. Bilateral inheritance as evidence for polygenicity in the hyperactive child syndrome
70. Radiofrequency lesions of the ventral mesencephalic tegmentum: Neurological and behavioral considerations
71. Mesocorticolimbic dopaminergic network: Functional and regulatory roles
72. Selective brain dopamine depletion in developing rats: An experimental model of minimal brain dysfunction
73. Paradoxical response to amphetamine in developing rats treated with 6-hydroxydopamine
74. Chronic multiple tics of Gilles de la Tourette's disease. CSF acid monoamine metabolites after probenecid administration
75. Central biogenic amine metabolism in children with the syndrome of chronic multiple tics of Gilles de la Tourette: Norepinephrine, serotonin, and dopamine
76. Biogenic amine metabolism in Tourette syndrome
77. CSF monamine metabolites in children with minimal brain dysfunction: Evidence for alteration of brain dopamine
78. Striatal dysfunction in attention deficit and hyperkinetic disorder
79. Quantitative morphology of the caudate nucleus in attention deficit hyperactivity disorder
80. Cerebral glucose metabolism in adults with hyperactivity of childhood onset
81. Functional neuroanatomy of TS
82. The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders
83. The DRD2 Taql polymorphism and symptoms of attention deficit hyperactivity disorder
84. Effects of stimulation of the mesocortical dopaminergic system by stress
85. The D2 dopamine receptor (DRD2) gene and family stress; interactive effects on cognitive functions in children
86. Effects of methylphenidate on regional brain glucose metabolism in humans: Relationship to dopamine D2 receptors
87. Cerebrospinal fluid homovanillic acid predicts behavioral response to stimulants in 45 boys with attention deficit/hyperactivity disorder
88. D2 dopamine receptor polymorphism and brain regional glucose metabolism
89. Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism
90. D2 dopamine receptors and personality traits
91. Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in human brain
92. Confirmation of association between attention deficit disorder and a dopamine transporter polymorphism
93. 123I]β-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder
94. A common demominator theory of alcohol and opiate dependence: Review of similarities and differences
95. The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children
96. The relation between childhood antisocial behavior and the dopamine transporter gene (DAT1): Mediation via hyperactivity-impulsivity
97. Association of the dopamine transporter gene (DAT1) with poor methylphenidate response
98. Multiple dopamine D4 receptor variants in human population
99. A hypervariable segment in the human dopamine receptor (DRD4) gene
100. Modulation of interacellular cyclic AMP levels by different human dopamine D4 receptor variants
101. Dopamine D4 receptor gene association with normal personality traits
102. D-4 receptor polymorphism associated with personality variation in normals
103. The association between the dopamine D4 receptor (DRD4) 16 amino acid repeat polymorphisms and novelty seeking
104. Lack of evidence for alleleic association between personality traits and the dopmaine D4 receptor gene polymorphisms
105. No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore longitudinal study of aging participants
106. Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: A twin and genetic association study
107. D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects
108. Dopamine D4 receptor exon III alleles and variation of novelty seeking in alcoholics
109. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder
110. Why different rules are required for polygenic inheritance: Lessons from studies of the DRD2 gene
111. Urinary MHPG and HVA excretion in boys with attention deficit hyperactivity disorder and hyperactivity treated with d-amphetamine
112. Enzyme activity and behavior in hyperactive children grown up
113. Biochemical differences in children with conduct disorder socialized and undersocialized
114. Plasma dopamine-β-hydroxylase and preschool behavior in children with conduct disorder
115. Two Taq I dimorphic sites at the human β-hydroxylase locus
116. PCR amplification of the Taq I B1/B2 polymorphism at intron 5 of the dopamine β-hydroxylase gene
117. Mapping susceptability loci in attention deficit hyperactivity disorder: Preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children
118. Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors
119. Screening the dopamine D1 receptor gene in 131 schizophrenics and eight alcoholics: Identification of polymorphisms but lack of functionally significant sequence changes
120. A new look at dopamine D3 receptors
121. Association between schizophrenia and homozygosity at the dopamine D3 receptor gene
122. Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders
123. Association between Tourette's syndrome and homozygosity at the dopamine-D3 receptor gene
124. Tourette's syndrome and homozygosity for the dopamine D3 receptor gene - Reply
125. A study of the dopamine D2 receptor gene in pathological gambling
126. Comparison of the role of dopamine, serotonin, and noradrenergic genes in ADHD, ODD and conduct disorder. Multivariate regression analysis of 20 genes
127. Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P
128. DOPA decarboxylase activity in attention deficit hyperactivity disorder adults. A [fluorine-18] fluorodopa position emission tomographic study
129. Comparision of the effects of clonidine on pre-and postsynaptic adrenoceptors in the rabbit pulmonary artery
130. Clonidine benefits children with attention deficit disorder and hyperactivity: Report of a double-blind placebo-crossover therapeutic trial
131. The clonidine patch and behavioral problems
132. Attention deficit disorder with hyperactivity (ADHD): The contribution of catecholaminergic activity
133. Urinary MHPG excretion in minimal brain dsyfunction and its modification by d-amphetamine
134. Urinary 3-methoxy-4 hydroxyphenylglycol sulfate excretion in seventy-three schoolchildren with minimal brain dysfunction syndrome
135. Urinary epinephrine excretion during intelligence testing in attention-deficit hyperactivity disorder and normal boys
136. Aggressiveness and hyperactive behavior as related to adrenaline excretion. Special Issue: Personality and aggression
137. Urinary catecholamines in attention-deficit hyperactivity disorder with and without comorbid anxiety
138. Blunted catecholamine responses after glucose ingestion in children with attention deficit disorder
139. Arousal and physiological toughness: Implication for mental and physical health
140. Effect of lesions to ascending noradrenergic neurons on performance of 5-choice serial reaction task in rats: Implication for theories of dorsal noradrenergic bundle function based on selective attention and arousal
141. The dorsal tegmental noradrenergic projection: An analysis of its role in maze learning
142. Differential effects of selective dopamine, norepinephrine or catecholamine depletion on activity and learning in the developing rat
143. Suction lesions of the frontal cerebral cortex in the rat induce asymmetrical behavioral and catecholaminergic responses
144. Noradrenaline and selective attention: A review of the model and the evidence
145. Plasma catecholamine metabolites in ADHD boys with and without reading disabilities
146. Noradrenergic mechanisms in ADHD children with and without reading disabilities: A replication and extension
147. The attention system of the human brain
148. 2-noradrenergic mechanism to prefrontal cortical cognitive function. Potential significance for Attention-Deficit Hyperactivity Disorder
149. Additive effect of three noradrenergic genes (ADRA2A, ADRA2C, DBH) on attention deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects
150. Msp I identifies a biallelic polymorphism in the promoter region of the alpha 2A-adrenergic receptor gene
151. (CA)n-dinucleotide repeat polymorphism at the locus for the alpha2C adrenergic receptor (ADRA2C) on 4q16
152. Human monamine oxidase gene (MAOA): Chromosome positon (Xp21-p11) and DNA polymorphism
153. Assignment of genes for human monamine oxidase A and B to the X chromosome
154. Platelet MAO in children with attention deficit disorder and hyperactivity: A pilot study
155. Dinucleotide repeat polymorphism at the MAOA locus
156. Monoamine oxidase gene variants in Tourette syndrome and drug abuse
157. Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups
158. Trinucleotide (GGN) repeat polymorphism in the human androgen receptor (AR) gene
159. Trinucleotide repeat polymorphism in the androgen receptor gene (AR)
160. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Prenatal diagnosis for dystrophia myotonica using the polymerase chain reaction
161. Serotonin concentrations in whole blood of hyperactive children
162. Possible role of 5-hydroxytryptamine in minimal brain dysfunction
163. The dopamine D2 receptor gene is a modifier of the expression of the Tourette syndrome (Gts) and ADHD gene
164. Attention deficit hyperactivity disorder and whole-blood serotonin levels: Effects of comorbidity
165. Aggression, suicide and serotonin relationships to CSF amine metabolism
166. 5-Hydroxyindole acetic acid levels in attempted suicides who have killed their children
167. Impulsivity, aggression, and neuroendocrine responses to serotonergic stimulation in substance abusers
168. Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder
169. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity
170. Purification and properties of rat liver tryptophan oxygenase
171. The interaction between GABA and dopamine: Implications for schizophrenia
172. B receptor agonists and antagonists
173. Oxotremorine attenuates retrograde anmesia induced by post-training administration of the GABAergic agonists muscimol and baclofen
174. Involvement of the amygdala GABAergic system in the modulation of memory storage
175. Dinucleotide repeat polymorphism in human X-linked GABA-A receptor alpha3-subunit gene
176. A receptor β3 (GABRB3) locus in the Angelman/Prader-Willi region (AS/PWS) of chromosome 15
177. Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders
178. Normal personality assessment in clinical practice: The NEO personality inventory
179. A psychobiological model of temperament and character
180. Differential diagnosis of personality disorders by the seven-factor model of temperament and character
181. Symptom dimensions of the SCL-90R: A test of the tripartate model of anxiety and depression
182. Variations in locus of control and repression-sensitization in acute schizophrenics, schizophrenic criminals, and criminal psychopathic offenders
183. The relationship of locus of control dimensions to reported hostility and aggression
184. 3H-imipramine binding in the frontal cortex of suicides
185. An inventory for assessing different kinds of hostility
186. The determination of defense style by questionnaire
187. The defense style questionnaire
188. A two-part model of stimulant action on attention-deficit hyperactivity disorder in children
189. A neuroanatomical and biochemical basis for attention deficit disorder with hyperactivity in children: A defect in tonic adrenaline medicated inhibition of locus coeruleus stimulation
190. Neurochemistry and child and adolescent psychiatry
191. The mechanism of action of drugs used to treat attention deficit hyperactivity disorder: Focus on catecholamine receptor pharmacology
192. SNPs and polygenic disorders: A less gloomy view
193. Polygenes associated with intravenous drug use
194. Dopamine D1 receptor gene and addictive behaviors
195. Genetic variants of the human obesity gene: Association with psychiatric symptoms and body mass index in young women, and interaction with the dopamine D2 receptor gene
196. Human restriction fragment length polymorphisms and cancer risk assessment
197. An association between the risk of cancer and mutations in the Hras1 minisatellite locus
198. Allelic association of human dopamine D2 receptor gene in alcoholism
199. The D2 dopamine receptor gene: A review of association studies in alcoholism
200. Dopamine D2 receptor gene variants: Association and linkage studies in impulsive, addictive and compulsive disorders
201. Linkage, association and mutational analysis of the dopamine D3 receptor gene in schizophrenia
202. Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): A family based approach
203. Dopamine DRD4 receptor polymorphism and attention deficit hyperactivity disorder
204. Evidence that the dopamine D4 receptor is a susceptability gene in attention deficit hyperactivity disorder
205. Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit hyperactivity disorder: Genetic and brain morphometric analyses
206. The dopamine D4 gene 7-repeat allel is associated with ADHD in families ascertained through ADHD adults
207. A molecular genetic study of hyperkinetic disorder/attention deficit hyperactivity disorder
208. Attention deficit hyperactivity disorder association with the dopamine transporter (DAT1) but not with the dopamine D4 receptor (DRD4)
209. Studies of the 48 bp repeat of the DRD4 gene in impulsive-addictive behaviors: Tourette syndrome, ADHD, pathological gambling, and substance abuse
210. Association of DSM-IV attention deficit hyperactivity disorder (ADHD) and monoamine pathway genes
211. Is Tourette syndrome a cause of sudden infant death syndrome and childhood obstructive sleep apnea?
212. SIDS and Tourette syndrome: Is there an etiologic relationship?