Getting the adrenaline going: Crystal structure of the adrenaline-synthesizing enzyme PNMT

Structure

Volumn 9, Issue 10, 2001, Pages 977-985

  Martin, Jennifer L ^a   Begun, Jake ^a   McLeish, Michael J ^b   Caine, Joanne M ^b   Grunewald, Gary L ^c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

Adrenaline; Catecholamine synthesis; Epinephrine; Fold recruitment; Methyltransferases; Protein evolution

Indexed keywords

1,2,3,4 TETRAHYDRO 7 ISOQUINOLINESULFONAMIDE; 7,8 DICHLORO 1,2,3,4 TETRAHYDROISOQUINOLINE; ADRENALIN; AMINE; CATECHOLAMINE; METHYLTRANSFERASE; NORADRENALIN; PHENYLETHANOLAMINE N METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SOLVENT;

ARTICLE; BINDING SITE; CATALYSIS; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; EVOLUTION; HUMAN; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN FOLDING;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; EPINEPHRINE; EVOLUTION, MOLECULAR; HUMANS; LIGANDS; MODELS, MOLECULAR; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; SUBSTRATE SPECIFICITY;

EID: 0034798636     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00662-1     Document Type: Article

References (38)

1. Overview and concluding remarks
2. Neurons containing phenylethanolamine N-methyltransferase: A component of the baroreceptor reflex
3. Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain
4. Evidence for the involvement of central epinephrine systems in the regulation of luteinizing hormone, prolactin and growth hormone release in female rats
5. Antagonism of ethanol intoxication in rats by inhibitors of phenylethanolamine N-methyltransferase
6. Evidence for decreased transport of PNMT protein in advanced Alzheimer's disease
7. Inhibitors of phenylethanolamine-N-methyltransferase: Effects on brain catecholamine content and blood pressure in DOCA-salt hypertensive rats
8. Blood pressure response to central and/or peripheral inhibition of phenylethanolamine N-methyltransferase in normotensive and hypertensive rats
9. α2-Adrenoceptor affinity of some inhibitors of norepinephrine N-methyltransferase
10. Loops in globular proteins: A novel category of secondary structure
11. Analysis and prediction of the different β-turns in proteins
12. Crystal structure of catechol O-methyltransferase
13. Crystal structure of glycine N-methyltransferase from rat liver
14. Glycine N-methyltransferase is an example of functional diversity
15. Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: Crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes
16. On the evolution of biochemical syntheses
17. The evolution of α/β barrel enzymes
18. Recombinant human phenylethanolamine N-methyltransferase: Overproduction in Escherichia coli, purification and characterization
19. Identification of the essential cysteinyl residue located in the active site of human phenylethanolamine N-methyltransferase
20. Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1, 2, 3, 4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the α2-adrenoceptor
21. An active site model of phenylethanolamine N-methyltransferase using CoMFA
22. Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1, 2, 3, 4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the α2-adrenoceptor
23. Purification and properties of phenylethanolamine-N-methyltransferase
24. The remarkable substrate activity for phenylethanolamine N-methyltransferase of some conformationally defined phenylethylamines lacking a side-chain hydroxyl group. Conformationally defined adrenergic agents. 6
25. Processing of X-ray diffraction data collected in oscillation mode
26. SHELXL: High resolution refinement
27. PHASES-95: A program package for processing and analyzing diffraction data from macromolecules
28. Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods
29. Methods used in the structure determination of bovine mitochondrial F1 ATPase
30. Improved methods for building protein models in electron density maps and the location of errors in these models
31. Crystallography & NMR system: A new software suite for macromolecular structure determination
32. On the treatment of negative intensity observations
33. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
34. Raster3D version 2.0. A program for photorealistic molecular graphics
35. SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules
36. The protein data bank
37. Free R value: A novel statistical quantity for assessing the accuracy of crystal structures