Flavonoids can be potent inhibitors of human phenylethanolamine N-methyltransferase (hPNMT)

Bulletin of the Korean Chemical Society

Volumn 30, Issue 8, 2009, Pages 1835-1838

  Lee, Jee Young ^a   Jeong, Ki Woong ^a   Kim, Yangmee ^a  

^a Konkuk University   (South Korea)

Author keywords

Docking study; Flavonoid; In silico screening; Mental disease; PNMT

Indexed keywords

AUTOMATED DOCKING; BACKBONE CARBONYL; BINDING FREE ENERGY; CHEMICAL FEATURES; FLAVONOIDS; HYDROGEN BOND INTERACTION; HYDROPHOBIC INTERACTIONS; HYDROPHOBIC SITES; IN-SILICO SCREENING; MENTAL DISEASE; MENTAL PROCESS; METHYLTRANSFERASES; POTENT INHIBITOR; SIDE CHAINS; STRUCTURAL FEATURE;

BINDING ENERGY; DOCKING; HYDROGEN BONDS; OXYGEN;

HYDROPHOBICITY;

EID: 75649119625     PISSN: 02532964     EISSN: 12295949     Source Type: Journal    
DOI: 10.5012/bkcs.2009.30.8.1835     Document Type: Article

References (21)

1. Matsubara, K.; Aoyama, K.; Suno, M.; Awaya, T. Neurotoxicol. Teratol. 2002, 24, 593.
2. Berecek, K.H.; Brody, M.J. Am. J. Physiol. 1982, 242, H593.
3. Martin, J.L.; Begun, J.; McLeish, M.J.; Caine, J.M.; Grunewald, G.L. Structure 2001, 9, 977.
4. Mefford, I.N.; Lister, R.G.; Ota, M.; Linnoila, M. Alcohol. Clin. Exp. Res. 1990, 14, 53.
5. Kennedy, B.P.; Bottiglieri, T.; Arning, E.; Ziegler, M.G.; Hansen, L.A.; Masliah, E.J. Neural. Transm. 2004, 111, 547.
6. Krizanova, O.; Myslivecek, J.; Tillinger, A.; Jurkovicova, D.; Kubovcakova, L. Stress 2007, 10, 173.
7. Comings, D.E. Ann. N Y Acad. Sci. 2001, 931, 50.
8. Cazarolli, L.H.; Zanatta, L.; Alberton, E.H.; Figueiredo, M.S.; Folador, P.; Damazio, R.G.; Pizzolatti, M.G.; Silva, F.R. Mini Rev. Med. Chem. 2008, 8, 1429.
9. Rajnaryana, K.; Sripalreddy, M.; Chalavadi, M.R.; Krishna, D.R. Indian J. Pharmacol. 2001, 33, 2.
10. Saraf, S.; Ashawat, M.S.; Saraf, S. Phcog. Rev. 2007, 1, 30.
11. Morris, G.M.; Goodsell, D.S.; Halliday, R.S.; Huey, R.; Hart, W.E.; Belew, R.K.; Olson, A.J.J. Computational Chemistry 1998, 19, 1639.
12. Lee, J.Y.; Jung, K.W.; Kim, Y. Bull. Korean Chem. Soc. 2008, 29, 1717.
13. Healy, E.F.; Sanders, J.; King, P.J.; Robinson, W.E., Jr. J. Mol. Graph. Model. 2009, 27, 584.
14. Krammer, A.; Kirchhoff, P.D.; Venkatachalam, X.J.C. M.; Waldman, M.J. Mol. Graph. Model. 2005, 23, 395.
15. Lee, J.Y.; Jung, K.W.; Woo, E.R.; Kim, Y. Bull. Korean Chem. Soc. 2008, 29, 1479.
16. Gee, C.L.; Tyndall, J.D.; Grunewald, G.L.; Wu, Q.; McLeish, M.J.; Martin, J.L. Biochemistry 2005, 44, 16875.
17. Gee, C.L.; Drinkwater, N.; Tyndall, J.D.; Grunewald, G.L.; Wu, Q.; McLeish, M.J.; Martin, J.L. J. Med. Chem. 2007, 50, 4845.
18. Raha, K.; Merz, K.M., Jr. Calculating Binding Free Energy in Protein-ligand Interaction, in Annual Reports in Computational Chemistry; Spellmeyer, D., Ed.; Elsevier: Amsterdam, 2005; Vol. 1, p 115.
19. Grunewald, G.L.; Romero, F.A.; Criscione, K.R. J. Med. Chem. 2005, 48, 134.
20. Wu, Q.; Criscione, K.R.; Grunewald, G.L.; McLeish, M.J. Bioorg. Med. Chem. Lett. 2004, 14, 4217.
21. Coen, C.W.; Gallo, R.V.J. Endocrinol. 1986, 111, 51.