The angiogenic pathway 'vascular endothelial growth factor/flk-I (KDR)-receptor' in rheumatoid arthritis and osteoarthritis

Journal of Pathology

Volumn 194, Issue 1, 2001, Pages 101-108

  Giatromanolaki, Alexandra ^a   Sivridis, Efthimios ^a   Athanassou, Nick ^b   Zois, Emmanuel ^c   Thorpe, Philip E ^d   Brekken, Rolf A ^d   Gatter, Kevin C ^b   Harris, Adrian L ^b   Koukourakis, Ioannis M ^c   Koukourakis, Michael I ^e,f  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c Venizelion General Hospital   (Greece)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e UNIVERSITY OF THESSALY   (Greece)

^f Tumour and Angiogenesis Research Group Iraklion   (Greece)

Author keywords

Angiogenesis; Flk 1 (KDR); Osteoarthritis; PD ECGF; Rheumatoid arthritis; VEGF

Indexed keywords

ANGIOGENIC FACTOR; CD31 ANTIGEN; CYTOPLASM PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 11B5; NUCLEAR PROTEIN; PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

ADULT; AGED; ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; DEGENERATIVE DISEASE; DENSITY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; OSTEOARTHRITIS; PATHOGENESIS; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIUM; VASCULARIZATION;

ADULT; AGED; ARTHRITIS, RHEUMATOID; ENDOTHELIAL GROWTH FACTORS; FEMALE; FIBROBLASTS; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHOKINES; MALE; MICROCIRCULATION; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; OSTEOARTHRITIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, MITOGEN; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SYNOVIAL MEMBRANE; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035041939     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.842     Document Type: Article

References (42)

1. Autoimmunity in rheumatoid arthritis. An approach via a study of B lymphocytes
2. Pathology of osteoarthritis
3. Angiogenic factor from synovial fluid resembling that from tumours
4. Rheumatoid- and osteo-arthritis: Quantitation of ultrastructural features of capillary endothelial cells
5. Rheumatoid arthritis and osteoarthritis synovial fluid effects on primary human endothelial cell cultures
6. The biology of vascular endothelial growth factor
7. Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis
8. Neovascularisation and its role in the osteoarthritic process
9. Angiogenesis and arthritis
10. Molecular and biological properties of the vascular endothelial growth factor family of proteins
11. Inhibitory effects of anti-rheumatic drugs on vascular endothelial growth factor in cultured rheumatoid synovial cells
12. The fms-like tyrosine kinase receptor for vascular endothelial growth factor
13. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor
14. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR is up-regulated by hypoxia
15. Regulation of vascular endothelial growth factor receptor KDR in vitro by a soluble factor in confluent endothelial cells
16. Expression of vascular endothelial growth factor in synovial fibrolasts is induced by hypoxia and interleukin 1beta
17. Hypoxia augments cytokine [transforming growth factor-beta (TGF-beta) and IL-1]-induced vascular endothelial growth factor secretion by human synovial fibroblasts
18. Thymidine phosphorylase is angiogenic and promotes tumor growth
19. Increased sensitivity to the pro-drug 5′-deoxy-5-fluorouridine and modulation of 5′-fluoro-2′-deoxyuridine sensitivity in MCF-7 cell transfected with thymidine phosphorylase
20. Patterns of expression of tumor necrosis factor alpha, tumor necrosis factor beta, and their receptors in synovia of patients with juvenile rheumatoid arthritis and juvenile spondylarthropathy
21. Increased expression of interferon (IFN) gamma together with IFN gamma receptor in the rheumatoid synovial membrane compared with synovium of patients with osteoarthritis
22. Expression of interferon-gamma (IFN-gamma), IL-10, IL-12 and transforming growth factor-beta (TGF-beta) mRNA in synov́ial fluid cells from patients in the early and late phases of rheumatoid arthritis (RA)
23. Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma
24. Vascular endothelial growth factor as a marker of tumor endothelium
25. Validation of anti-vascular endothelial growth factor (anti-VEGF) antibodies for immuno-histochemical localization of VEGF in tissue sections: Expression of VEGF in the human endometrium
26. Platelet derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: An immunohistochemical study
27. JC70: A new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections
28. The correspondence of angiogenesis and chronic inflammation
29. Angiogenesis: A critical process in the pathogenesis of RA - A role for VEGF?
30. Hepatocyte growth factor. A cytokine mediating endothelial migration in inflammatory arthritis
31. Expression and functional expansion of fibroblast growth factor receptor T cells in rheumatoid synovium and peripheral blood of patients with rheumatoid arthritis
32. Focally regulated endothelial proliferation and cell death in human synovium
33. Expression of receptor tyrosine kinase Axl and its ligand Gas6 in rheumatoid arthritis: Evidence for a novel endothelial cell survival pathway
34. Prognostic and pathologic comparison of VEGF/KDR activated microvessel density (aMVD) vs. CD31 standard MVD (sMVD) in non-small cell lung cancer
35. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol-3-kinase/Akt signal transduction pathway. Requirement for Flk-2/KDR activation
36. Assessment of vascular maturation in non-small cell lung cancer using a novel basement membrane component, LH39. Correlation with p53 and angiogenic factor expression
37. Antibodies to occupied VEGF receptors (VEGF/KDR complex) show neo-vascularization in the stroma of non-small cell lung cancer which correlates with VEGF expression by fibroblasts and CD31+ lymphocytic infiltration
38. ZD4190: An orally active inhibitor of vascular endothelial growth factor signalling with broad-spectrum antitumor efficacy
39. An antagonistic vascular endothelial growth factor (VEGF) variant inhibits VEGF-stimulated receptor autophosphorylation and proliferation of human endothelial cells
40. In vitro and in vivo activation of endothelial cells by colony-stimulating factors
41. Oral administration of recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) in the management of radiotherapy induced oesophagitis