-
1
-
-
0038811741
-
Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days
-
Abraham J, Agrawal M, Bakke S, et al. 2003. Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days. J Clin Oncol, 21:1866-73.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1866-1873
-
-
Abraham, J.1
Agrawal, M.2
Bakke, S.3
-
2
-
-
34047212584
-
Phase I study of the novel epothilone analog ixabepilone (BMS-247550) in patients with advanced solid tumors and lymphomas
-
Aghajanian C, Burris HA 3rd, Jones S, et al. 2007. Phase I study of the novel epothilone analog ixabepilone (BMS-247550) in patients with advanced solid tumors and lymphomas. J Clin Oncol, 25:1082-8.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1082-1088
-
-
Aghajanian, C.1
Burris III, H.A.2
Jones, S.3
-
3
-
-
33745052354
-
A multi-center phase II study of BMS-247550 (Ixabepilone) by two schedules in patients with metastatic gastric adenocarcinoma previously treated with a taxane
-
Ajani JA, Safran H, Bokemeyer C, et al. 2006. A multi-center phase II study of BMS-247550 (Ixabepilone) by two schedules in patients with metastatic gastric adenocarcinoma previously treated with a taxane. Invest New Drugs, 24:441-6.
-
(2006)
Invest New Drugs
, vol.24
, pp. 441-446
-
-
Ajani, J.A.1
Safran, H.2
Bokemeyer, C.3
-
5
-
-
18744390786
-
Recent developments in the chemical biology of epothilones
-
Altmann K-H. 2005. Recent developments in the chemical biology of epothilones. Current Pharm Design, 11:1595-613.
-
(2005)
Current Pharm Design
, vol.11
, pp. 1595-1613
-
-
Altmann, K.-H.1
-
6
-
-
42949142153
-
Epothilones as lead structures for new anticancer drugs-pharmacology, fermentation, and structure-activityrelationships
-
Altmann K-H, Memmert K. 2008. Epothilones as lead structures for new anticancer drugs-pharmacology, fermentation, and structure-activityrelationships. Prog Drug Res, 66:275-334.
-
(2008)
Prog Drug Res
, vol.66
, pp. 275-334
-
-
Altmann, K.-H.1
Memmert, K.2
-
7
-
-
28744456341
-
The natural products epothilones A and B as lead structures for anticancer drug discovery: Chemistry, biology, and SAR studies
-
Altmann KH, Florsheimer A, O'Reilly T, et al. 2004. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies. Prog Med Chem, 42:171-205.
-
(2004)
Prog Med Chem
, vol.42
, pp. 171-205
-
-
Altmann, K.H.1
Florsheimer, A.2
O'Reilly, T.3
-
8
-
-
0347967091
-
An open-label phase IIA trial evaluating the safety and efficacy of EPO906 as therapy in patients with metastatic carcinoid and other neuroendocrine tumors
-
Anthony L, Carlisle T, Pommier R, et al. 2003. An open-label phase IIA trial evaluating the safety and efficacy of EPO906 as therapy in patients with metastatic carcinoid and other neuroendocrine tumors. Proc Am Soc Clin Oncol, 22:1413a.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Anthony, L.1
Carlisle, T.2
Pommier, R.3
-
9
-
-
4243391690
-
Phase I clinical and pharmacology study of the epothilone analog BMS-247550 given weekly in patients (pts) with advanced solid tumors
-
Awada A, Bleiber H, de Valeriola D, et al. 2001. Phase I clinical and pharmacology study of the epothilone analog BMS-247550 given weekly in patients (pts) with advanced solid tumors. Proc Am Soc Clin Oncol, 20:427a.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Awada, A.1
Bleiber, H.2
de Valeriola, D.3
-
10
-
-
39549088960
-
Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel
-
Beer TM, Higano CS, Saleh M, et al. 2007. Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel. Invest New Drugs, 25:565-70.
-
(2007)
Invest New Drugs
, vol.25
, pp. 565-570
-
-
Beer, T.M.1
Higano, C.S.2
Saleh, M.3
-
11
-
-
1342287839
-
Do beta-tubulin mutations have a role in resistance to chemotherapy?
-
Berrieman HK, Lind MJ, Cawkwell L. 2004. Do beta-tubulin mutations have a role in resistance to chemotherapy? Lancet Oncol, 5:158-64.
-
(2004)
Lancet Oncol
, vol.5
, pp. 158-164
-
-
Berrieman, H.K.1
Lind, M.J.2
Cawkwell, L.3
-
12
-
-
34250614320
-
Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry
-
Beumer JH, Garner RC, Cohen MB, et al. 2007. Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry. Invest New Drugs, 25:327-34.
-
(2007)
Invest New Drugs
, vol.25
, pp. 327-334
-
-
Beumer, J.H.1
Garner, R.C.2
Cohen, M.B.3
-
13
-
-
34249794861
-
Microtubule-associated proteins as targets in cancer chemotherapy
-
Bhat KM and Setaluri V. 2007. Microtubule-associated proteins as targets in cancer chemotherapy. Clin Cancer Res, 13:2849-54.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2849-2854
-
-
Bhat, K.M.1
Setaluri, V.2
-
14
-
-
33749565180
-
Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of rac1 and cdc42 activity and changes in the endothelial cytoskeleton
-
Bijman M, Amerongen G, Laurens N, et al. 2006. Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of rac1 and cdc42 activity and changes in the endothelial cytoskeleton. Mol Cancer Ther, 5:2348-57.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2348-2357
-
-
Bijman, M.1
Amerongen, G.2
Laurens, N.3
-
15
-
-
0029049468
-
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
-
Bollag DM, McQueney PA, Zhu J, et al. 1995. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res, 55:2325-33.
-
(1995)
Cancer Res
, vol.55
, pp. 2325-2333
-
-
Bollag, D.M.1
McQueney, P.A.2
Zhu, J.3
-
16
-
-
24944549982
-
Therapeutic index, tubulin binders, and clinical medicine
-
Budman DR. 2005. Therapeutic index, tubulin binders, and clinical medicine. Cancer Invest, 23:479-80.
-
(2005)
Cancer Invest
, vol.23
, pp. 479-480
-
-
Budman, D.R.1
-
18
-
-
0003339023
-
Phase I study of the novel epothilone BMS-247550 administered weekly in patients (pts) with advanced malignancies
-
Burris III H, Awada A, Jones S, et al. 2002. Phase I study of the novel epothilone BMS-247550 administered weekly in patients (pts) with advanced malignancies. Proc Am Soc Clin Oncol, 21:412a.
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Burris III, H.1
Awada, A.2
Jones, S.3
-
19
-
-
54349090852
-
A randomized phase II study of BMS-247550 (ixabepilone) given daily ss5 days every 3 weeks or weekly in patients with metastatic or recurrent squamous cell cancer of the head and neck
-
Burtness B, Goldwasser M, Axelrod R, et al. 2006. A randomized phase II study of BMS-247550 (ixabepilone) given daily ss5 days every 3 weeks or weekly in patients with metastatic or recurrent squamous cell cancer of the head and neck. Proc Am Soc Clin Oncol, 24:5532a.
-
(2006)
Proc Am Soc Clin Oncol
, vol.24
-
-
Burtness, B.1
Goldwasser, M.2
Axelrod, R.3
-
20
-
-
0000155381
-
A phase I clinical and pharmacokinetic study of EPO906 (epothilone B), given every three weeks, in patients with advanced solid tumors
-
Calvert P, O'Neill V, Twelves C, et al. 2001. A phase I clinical and pharmacokinetic study of EPO906 (epothilone B), given every three weeks, in patients with advanced solid tumors. Proc Am Soc Clin Oncol, 20:429a.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Calvert, P.1
O'Neill, V.2
Twelves, C.3
-
21
-
-
54349123095
-
Patupilone in chemotherapypretreated patients with advanced colorectal cancer receiving nutritional support and intensive diarrhea management. A phase I multicenter trial
-
Casado E, Tabernero J, Melicher B, et al. 2006. Patupilone in chemotherapypretreated patients with advanced colorectal cancer receiving nutritional support and intensive diarrhea management. A phase I multicenter trial. Proc Am Soc Clin Oncol, 24:3593a.
-
(2006)
Proc Am Soc Clin Oncol
, vol.24
-
-
Casado, E.1
Tabernero, J.2
Melicher, B.3
-
22
-
-
0036531790
-
Differential mitotic responses to microtubulestabilizing and-destabilizing drugs
-
Chen JG and Horwitz SB. 2002. Differential mitotic responses to microtubulestabilizing and-destabilizing drugs. Cancer Res, 62:1935-8.
-
(2002)
Cancer Res
, vol.62
, pp. 1935-1938
-
-
Chen, J.G.1
Horwitz, S.B.2
-
23
-
-
33745262198
-
Epothilone B analog (BMS-247550) at the recommended phase II dose (RPTD) in patients (pts) with gynecologic (gyn) and breast cancers
-
Chen T, Molina A, Moore S, et al. 2004. Epothilone B analog (BMS-247550) at the recommended phase II dose (RPTD) in patients (pts) with gynecologic (gyn) and breast cancers. Proc Am Soc Clin Oncol, 22:2115a.
-
(2004)
Proc Am Soc Clin Oncol
, vol.22
-
-
Chen, T.1
Molina, A.2
Moore, S.3
-
24
-
-
58749105016
-
A phase II study of patupilone in patients with metastatic hormone refractory prostate cancer (HRPC) who have progressed after docetaxel
-
Chi K, Beardsley E, Venner P, et al. 2008. A phase II study of patupilone in patients with metastatic hormone refractory prostate cancer (HRPC) who have progressed after docetaxel. Proc Am Soc Clin Oncol, 26:5166a.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Chi, K.1
Beardsley, E.2
Venner, P.3
-
25
-
-
0032416734
-
Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel
-
Chou TC, Zhang XG, Harris CR, et al. 1998. Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel. Proc Natl Acad Sci U S A, 95:15798-802.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 15798-15802
-
-
Chou, T.C.1
Zhang, X.G.2
Harris, C.R.3
-
26
-
-
38749111883
-
Phase I clinical trial of ixabepilone and pegylated liposomal doxorubicin in patients with advanced breast or ovarian cnacers: New York Consortium Trial P7229
-
Chuang E, Vahdat L, Caputo T, et al. 2007. Phase I clinical trial of ixabepilone and pegylated liposomal doxorubicin in patients with advanced breast or ovarian cnacers: New York Consortium Trial P7229. Proc Am Soc Clin Oncol, 25:2570a.
-
(2007)
Proc Am Soc Clin Oncol
, vol.25
-
-
Chuang, E.1
Vahdat, L.2
Caputo, T.3
-
27
-
-
58749100031
-
Phase II trial of patupilone in patients (pts) with breast cancer brain metastases (BCBM) progressing or recurring after whole brain radiation therapy (WBXRT)
-
Conlin A, D'Andrea G, Hudis C, et al. 2008. Phase II trial of patupilone in patients (pts) with breast cancer brain metastases (BCBM) progressing or recurring after whole brain radiation therapy (WBXRT). Proc Am Soc Clin Oncol, 26:1086a.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Conlin, A.1
D'Andrea, G.2
Hudis, C.3
-
28
-
-
34147112848
-
Targeting the microtubules in breast cancer beyond taxanes: The epothilones
-
Cortes J, Baselga J. 2007. Targeting the microtubules in breast cancer beyond taxanes:the epothilones. Oncologist, 12:271-80.
-
(2007)
Oncologist
, vol.12
, pp. 271-280
-
-
Cortes, J.1
Baselga, J.2
-
29
-
-
34548169630
-
Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes
-
Denduluri N, Low JA, Lee JJ, et al. 2007. Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes. J Clin Oncol, 25:3421-7.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3421-3427
-
-
Denduluri, N.1
Low, J.A.2
Lee, J.J.3
-
30
-
-
34547865354
-
Phase 2 trial of epothilone B analog BMS-247550 (ixabepilone) in advanced carcinoma of the urothelium (E3800): A trial of the Eastern Cooperative Oncology Group
-
Dreicer R, Li S, Manola J, et al. 2007. Phase 2 trial of epothilone B analog BMS-247550 (ixabepilone) in advanced carcinoma of the urothelium (E3800): a trial of the Eastern Cooperative Oncology Group. Cancer, 110:759-63.
-
(2007)
Cancer
, vol.110
, pp. 759-763
-
-
Dreicer, R.1
Li, S.2
Manola, J.3
-
31
-
-
3442898528
-
A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer
-
Eng C, Kindler HL, Nattam S, et al. 2004. A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer. Ann Oncol, 15:928-32.
-
(2004)
Ann Oncol
, vol.15
, pp. 928-932
-
-
Eng, C.1
Kindler, H.L.2
Nattam, S.3
-
32
-
-
25444465116
-
Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function
-
Escuin D, Kline ER, Giannakakou P. 2005. Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function. Cancer Res, 65:9021-8.
-
(2005)
Cancer Res
, vol.65
, pp. 9021-9028
-
-
Escuin, D.1
Kline, E.R.2
Giannakakou, P.3
-
34
-
-
40749128006
-
Safety of repeated administrations of ixabepilone given as a 3-hour infusion every other week in combination with irinotecan in patients with advanced malignancies
-
Faivre S, Delbaldo C, Boige V, et al. 2008. Safety of repeated administrations of ixabepilone given as a 3-hour infusion every other week in combination with irinotecan in patients with advanced malignancies. Eur J Cancer, 44:674-82.
-
(2008)
Eur J Cancer
, vol.44
, pp. 674-682
-
-
Faivre, S.1
Delbaldo, C.2
Boige, V.3
-
35
-
-
34547702867
-
Phase II trial of ixabepilone in patients with cisplatin-refractory germ cell tumors
-
Feldman DR, Kondagunta GV, Ginsberg MS, et al. 2007. Phase II trial of ixabepilone in patients with cisplatin-refractory germ cell tumors. Invest New Drugs, 25:487-90.
-
(2007)
Invest New Drugs
, vol.25
, pp. 487-490
-
-
Feldman, D.R.1
Kondagunta, G.V.2
Ginsberg, M.S.3
-
36
-
-
38949121627
-
Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization
-
Feyen F, Cachoux F, Gertsch J, et al. 2008. Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization. Acc Chem Res, 41:21-31.
-
(2008)
Acc Chem Res
, vol.41
, pp. 21-31
-
-
Feyen, F.1
Cachoux, F.2
Gertsch, J.3
-
37
-
-
33745273723
-
A translational study of ixabepilone (BMS-247550) in renal cell cancer (RCC): Assessment of its activity and demonstration of target engagement in tumor cells
-
Fojo A, Menefee M, Poruchynsky M, et al. 2005. A translational study of ixabepilone (BMS-247550) in renal cell cancer (RCC): Assessment of its activity and demonstration of target engagement in tumor cells. Proc Am Soc Clin Oncol, 23:4541a.
-
(2005)
Proc Am Soc Clin Oncol
, vol.23
-
-
Fojo, A.1
Menefee, M.2
Poruchynsky, M.3
-
38
-
-
34547128846
-
A phase Ib and pharmacokinetic trial of patupilone combined with carboplatin in patients with advanced cancer
-
Forster M, Kaye S, Oza A, et al. 2007. A phase Ib and pharmacokinetic trial of patupilone combined with carboplatin in patients with advanced cancer. Clin Cancer Res, 13:4178-84.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4178-4184
-
-
Forster, M.1
Kaye, S.2
Oza, A.3
-
39
-
-
38449120471
-
Novel tubulin-targeting agents: Anticancer activity and pharmacologic profile of epothilones and related analogues
-
Fumoleau P, Coudert B, Isambert N, et al. 2007. Novel tubulin-targeting agents:anticancer activity and pharmacologic profile of epothilones and related analogues. Ann Oncol, 18(Suppl 5):v9-15.
-
(2007)
Ann Oncol
, vol.18
, Issue.SUPPL. 5
-
-
Fumoleau, P.1
Coudert, B.2
Isambert, N.3
-
40
-
-
24344450233
-
Phase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 2B design
-
Gadgeel SM, Wozniak A, Boinpally RR, et al. 2005. Phase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 2B design. Clin Cancer Res, 11:6233-9.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6233-6239
-
-
Gadgeel, S.M.1
Wozniak, A.2
Boinpally, R.R.3
-
41
-
-
20144377696
-
Multi-institutional randomized phase II trial of the epothilone B analog ixabepilone (BMS-247550) with or without estramustine phosphate in patients with progressive castrate metastatic prostate cancer
-
Galsky MD, Small EJ, Oh WK, et al. 2005. Multi-institutional randomized phase II trial of the epothilone B analog ixabepilone (BMS-247550) with or without estramustine phosphate in patients with progressive castrate metastatic prostate cancer. J Clin Oncol, 23:1439-46.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1439-1446
-
-
Galsky, M.D.1
Small, E.J.2
Oh, W.K.3
-
42
-
-
42549103468
-
Phase II trial of the novel epothilone ZK-EPO as second-line therapy in patients with stage IIIB or stage IV non-small cell lung cancer
-
Gatzemeier U, von Pawel J, Eschbach C, et al. 2007. Phase II trial of the novel epothilone ZK-EPO as second-line therapy in patients with stage IIIB or stage IV non-small cell lung cancer. Eur J Cancer Suppl, 5:6548a.
-
(2007)
Eur J Cancer Suppl
, vol.5
-
-
Gatzemeier, U.1
von Pawel, J.2
Eschbach, C.3
-
43
-
-
83255179947
-
Phase I trial of the novel epothilone sagopilone (ZK-EPO) in combination with cisplatin as firstline therapy in patients with extensive-disease small-cell lung cancer (ED-SCLC)
-
Gauler T, Christoph D, Gamarra F, et al. 2008. Phase I trial of the novel epothilone sagopilone (ZK-EPO) in combination with cisplatin as firstline therapy in patients with extensive-disease small-cell lung cancer (ED-SCLC). Proc Am Soc Clin Oncol, 26:19081a.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Gauler, T.1
Christoph, D.2
Gamarra, F.3
-
44
-
-
0030018666
-
Epohtilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties
-
Gerth K, Bedorf N, Hofle G, et al. 1996. Epohtilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. J Antibiotics, 49:560-3.
-
(1996)
J Antibiotics
, vol.49
, pp. 560-563
-
-
Gerth, K.1
Bedorf, N.2
Hofle, G.3
-
45
-
-
12944277104
-
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
-
Giannakakou P, Gussio R, Nogales E, et al. 2000. A common pharmacophore for epothilone and taxanes:molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. Proc Natl Acad Sci U S A, 97:2904-9.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 2904-2909
-
-
Giannakakou, P.1
Gussio, R.2
Nogales, E.3
-
46
-
-
52049120147
-
The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: A first in class epothilone B analogue in late-phase clinical development
-
Goel S, Cohen M, Comezoglu SN, et al. 2008. The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development. Clin Cancer Res, 14:2701-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2701-2709
-
-
Goel, S.1
Cohen, M.2
Comezoglu, S.N.3
-
47
-
-
3042701597
-
Epothilones: Mechanism of action and biologic activity
-
Goodin S, Kane MP, Rubin EH. 2004. Epothilones:mechanism of action and biologic activity. J Clin Oncol, 22:2015-25.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2015-2025
-
-
Goodin, S.1
Kane, M.P.2
Rubin, E.H.3
-
48
-
-
58749099507
-
Phase II study of sagopilone (ZK-EPO) plus prednisone as first-line chemotherapy in patients with metastatic androgen-independent prostate cancer (AIPC)
-
Graff J, Smith D, Neerukonda L, et al. 2008. Phase II study of sagopilone (ZK-EPO) plus prednisone as first-line chemotherapy in patients with metastatic androgen-independent prostate cancer (AIPC). Proc Am Soc Clin Oncol, 26:5141a.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Graff, J.1
Smith, D.2
Neerukonda, L.3
-
49
-
-
23244452107
-
Continuous weekly administration of the epothilone-B derivative, BMS-247550 (NSC710428): A phase I and pharmacokinetic (PK) study
-
Hao D, Hammond L, deBono J, et al. 2002. Continuous weekly administration of the epothilone-B derivative, BMS-247550 (NSC710428): A phase I and pharmacokinetic (PK) study. Proc Am Soc Clin Oncol, 21:411a.
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Hao, D.1
Hammond, L.2
deBono, J.3
-
50
-
-
48549095021
-
Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone
-
Hoffmann J, Vitale I, Buchmann B, et al. 2008. Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone. Cancer Res, 68:5301-8.
-
(2008)
Cancer Res
, vol.68
, pp. 5301-5308
-
-
Hoffmann, J.1
Vitale, I.2
Buchmann, B.3
-
51
-
-
8344260820
-
Phase I study using continuous intravenous (CI) KOS-862 (Epothilone D) in patients with solid tumors
-
Holen K, Syed S, Hannah A, et al. 2004. Phase I study using continuous intravenous (CI) KOS-862 (Epothilone D) in patients with solid tumors. Proc Am Soc Clin Oncol, 22:2024a.
-
(2004)
Proc Am Soc Clin Oncol
, vol.22
-
-
Holen, K.1
Syed, S.2
Hannah, A.3
-
52
-
-
33750351161
-
Efficacy of patupilone in advanced local or metastatic gastric cancer: A phase IIa trial
-
Hsin K, Boyer M, Ducreux M, et al. 2006. Efficacy of patupilone in advanced local or metastatic gastric cancer: A phase IIa trial. Proc Am Soc Clin Oncol, 24:4069a.
-
(2006)
Proc Am Soc Clin Oncol
, vol.24
-
-
Hsin, K.1
Boyer, M.2
Ducreux, M.3
-
53
-
-
58749106861
-
Ixabepilone (BMS-247550) and metastatic renal cell carcinoma (mRCC)
-
Huang H, Menefee M, Edgerly M, et al. 2008. Ixabepilone (BMS-247550) and metastatic renal cell carcinoma (mRCC). Proc Am Soc Clin Oncol, 26:5053a.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Huang, H.1
Menefee, M.2
Edgerly, M.3
-
54
-
-
6344282151
-
A Phase IIa trial of weekly EPO906 in patients with hormone-refractory prostate cancer (HPRC)
-
Hussain A, Dipaola R, Baron A, et al. 2004. A Phase IIa trial of weekly EPO906 in patients with hormone-refractory prostate cancer (HPRC) Proc Am Soc Clin Oncol, 22:4563a.
-
(2004)
Proc Am Soc Clin Oncol
, vol.22
-
-
Hussain, A.1
Dipaola, R.2
Baron, A.3
-
55
-
-
33644843604
-
Ixabepilone (epothilone B analogue BMS-247550) is active in chemotherapy-naive patients with hormone-refractory prostate cancer: A Southwest Oncology Group trial S0111
-
Hussain M, Tangen CM, Lara PN Jr, et al. 2005. Ixabepilone (epothilone B analogue BMS-247550) is active in chemotherapy-naive patients with hormone-refractory prostate cancer: a Southwest Oncology Group trial S0111. J Clin Oncol, 23:8724-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8724-8729
-
-
Hussain, M.1
Tangen, C.M.2
Lara Jr., P.N.3
-
56
-
-
58749108722
-
Phase II trial of ixabepilone (BMS-247550) in children and young adults with refractory solid tumors: A report from the Children's Oncology Group
-
Jacobs S, Fox B, Krailo M, et al. 2008. Phase II trial of ixabepilone (BMS-247550) in children and young adults with refractory solid tumors: A report from the Children's Oncology Group. Proc Am Soc Clin Oncol, 26:10026a.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Jacobs, S.1
Fox, B.2
Krailo, M.3
-
57
-
-
16844365749
-
BetaIII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability
-
Kamath K, Wilson L, Cabral F, et al. 2005. BetaIII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability. J Biol Chem, 280:12902-7.
-
(2005)
J Biol Chem
, vol.280
, pp. 12902-12907
-
-
Kamath, K.1
Wilson, L.2
Cabral, F.3
-
58
-
-
52949107914
-
Patupilone-induced apoptosis is mediated by mitochondrial reactive oxygen species through Bim relocalization to mitochondria
-
in press
-
Khawaja NR, Carre M, Kovacic H, et al. 2008. Patupilone-induced apoptosis is mediated by mitochondrial reactive oxygen species through Bim relocalization to mitochondria. Mol Pharmacol, in press.
-
(2008)
Mol Pharmacol
-
-
Khawaja, N.R.1
Carre, M.2
Kovacic, H.3
-
59
-
-
33845486692
-
Total synthesis and antitumor activity of ZK-EPO: The first fully synthetic epothilone in clinical development
-
Klar U, Buchmann B, Schwede W, et al. 2006. Total synthesis and antitumor activity of ZK-EPO: The first fully synthetic epothilone in clinical development. Angew Chem Int, 45:7942-8.
-
(2006)
Angew Chem Int
, vol.45
, pp. 7942-7948
-
-
Klar, U.1
Buchmann, B.2
Schwede, W.3
-
60
-
-
0031027531
-
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)
-
Kowalski RJ, Giannakakou P and Hamel E. 1997. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R). J Biol Chem, 272:2534-41.
-
(1997)
J Biol Chem
, vol.272
, pp. 2534-2541
-
-
Kowalski, R.J.1
Giannakakou, P.2
Hamel, E.3
-
61
-
-
51649123237
-
Ixabepilone in combination with capecitabine and as monotherapy for treatment of advanced breast cancer refractory to previous treatments
-
Lechleider R, Kaminskas E, Jiang X, et al. 2008. Ixabepilone in combination with capecitabine and as monotherapy for treatment of advanced breast cancer refractory to previous treatments. Clin Cancer Res, 14:4378-84.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4378-4384
-
-
Lechleider, R.1
Kaminskas, E.2
Jiang, X.3
-
62
-
-
0034895987
-
BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
-
Lee FY, Borzilleri R, Fairchild CR, et al. 2001. BMS-247550:a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res, 7:1429-37.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1429-1437
-
-
Lee, F.Y.1
Borzilleri, R.2
Fairchild, C.R.3
-
63
-
-
53149127645
-
Preclinical discovery of ixabepilone, a highly active antineoplastic agent
-
In press
-
Lee FY, Borzilleri R, Fairchild CR, et al. 2008. Preclinical discovery of ixabepilone, a highly active antineoplastic agent. Cancer Chemother Pharmacol, In press.
-
(2008)
Cancer Chemother Pharmacol
-
-
Lee, F.Y.1
Borzilleri, R.2
Fairchild, C.R.3
-
64
-
-
41549164459
-
The epothilones: Translating from the laboratory to the clinic
-
Lee JJ, Swain SM. 2008. The epothilones:translating from the laboratory to the clinic. Clin Cancer Res, 14:1618-24.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1618-1624
-
-
Lee, J.J.1
Swain, S.M.2
-
65
-
-
0034231606
-
P-glycoprotein as a drug target in the treatment of multidrug resistant cancer
-
Lehne G. 2000. P-glycoprotein as a drug target in the treatment of multidrug resistant cancer. Curr Drug Targets, 1:85-99.
-
(2000)
Curr Drug Targets
, vol.1
, pp. 85-99
-
-
Lehne, G.1
-
66
-
-
21044441003
-
Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer
-
Low JA, Wedam SB, Lee JJ, et al. 2005. Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer. J Clin Oncol, 23:2726-34.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2726-2734
-
-
Low, J.A.1
Wedam, S.B.2
Lee, J.J.3
-
67
-
-
33745593252
-
The betaI/betaIII-tubulin isoforms and their complexes with antimitotic agents. Docking and molecular dynamics studies
-
Magnani M, Ortuso F, Soro S, et al. 2006. The betaI/betaIII-tubulin isoforms and their complexes with antimitotic agents. Docking and molecular dynamics studies. Febs J, 273:3301-10.
-
(2006)
Febs J
, vol.273
, pp. 3301-3310
-
-
Magnani, M.1
Ortuso, F.2
Soro, S.3
-
68
-
-
24344454303
-
Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents
-
Mani S, Huang H, Sundarababu S, et al. 2005. Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents. Clin Cancer Res, 11:6359-69.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6359-6369
-
-
Mani, S.1
Huang, H.2
Sundarababu, S.3
-
69
-
-
12144285977
-
Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors
-
Mani S, McDaid H, Hamilton A, et al. 2004. Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors. Clin Cancer Res, 10:1289-98.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1289-1298
-
-
Mani, S.1
McDaid, H.2
Hamilton, A.3
-
70
-
-
33846478930
-
Peripheral blood mononuclear and tumor cell pharmacodynamics of the novel epothilone B analogue, ixabepilone
-
Mani S, McDaid HM, Grossman A, et al. 2007. Peripheral blood mononuclear and tumor cell pharmacodynamics of the novel epothilone B analogue, ixabepilone. Ann Oncol, 18:190-5.
-
(2007)
Ann Oncol
, vol.18
, pp. 190-195
-
-
Mani, S.1
McDaid, H.M.2
Grossman, A.3
-
71
-
-
0038206660
-
Managing taxane toxicities
-
Markman M. 2003. Managing taxane toxicities. Support Care Cancer, 11:144-7.
-
(2003)
Support Care Cancer
, vol.11
, pp. 144-147
-
-
Markman, M.1
-
72
-
-
0347325036
-
Phase I trial of novel epothilone B analog BMS-310705 IV q 21 days
-
Mekhail T, Chung C, Holden S, et al. 2003. Phase I trial of novel epothilone B analog BMS-310705 IV q 21 days. Proc Am Soc Clin Oncol, 22:515a.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Mekhail, T.1
Chung, C.2
Holden, S.3
-
73
-
-
34548091847
-
Effects of patupilone (epothilone B; EPO906), a novel chemotherapeutic agent, in hepatocellular carcinoma: An in vitro study
-
Mok TS, Choi E, Yau D, et al. 2006. Effects of patupilone (epothilone B; EPO906), a novel chemotherapeutic agent, in hepatocellular carcinoma: an in vitro study. Oncology, 71:292-6.
-
(2006)
Oncology
, vol.71
, pp. 292-296
-
-
Mok, T.S.1
Choi, E.2
Yau, D.3
-
74
-
-
0033063875
-
Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations
-
Monzo M, Rosell R, Sanchez JJ, et al. 1999. Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations. J Clin Oncol, 17:1786-93.
-
(1999)
J Clin Oncol
, vol.17
, pp. 1786-1793
-
-
Monzo, M.1
Rosell, R.2
Sanchez, J.J.3
-
75
-
-
45349093142
-
A phase II trial of trastuzumab, weekly ixabepilone and carboplatin (TIC) in patients with HER2/neu-positive (HER2H) metastatic breast cancer (MBC): A trial coordinated by the Eastern Cooperative Oncology Group (E2103)
-
Moulder S, Wang M, Gradishar W, et al. 2007. A phase II trial of trastuzumab, weekly ixabepilone and carboplatin (TIC) in patients with HER2/neu-positive (HER2H) metastatic breast cancer (MBC): A trial coordinated by the Eastern Cooperative Oncology Group (E2103). Proc Am Soc Clin Oncol, 25:152a.
-
(2007)
Proc Am Soc Clin Oncol
, vol.25
-
-
Moulder, S.1
Wang, M.2
Gradishar, W.3
-
76
-
-
83255168369
-
The binding mode of epothilone A on alpha, beta-tubulin by electron crystallography. Science, 305:866-9. Nicolaou KC, Winssinger N, Pastor J, et al. 1997) Synthesis of epothilones A and B in solid and solution phase
-
Nettles JH, Li H, Cornett B, et al. 2004. The binding mode of epothilone A on alpha, beta-tubulin by electron crystallography. Science, 305:866-9. Nicolaou KC, Winssinger N, Pastor J, et al. 1997) Synthesis of epothilones A and B in solid and solution phase. Nature, 387:268-72.
-
(2004)
Nature
, vol.387
, pp. 268-272
-
-
Nettles, J.H.1
Li, H.2
Cornett, B.3
-
77
-
-
33746604292
-
Predictive factors for response to docetaxel in human breast cancers
-
Noguchi S. 2006. Predictive factors for response to docetaxel in human breast cancers. Cancer Sci, 97:813-20.
-
(2006)
Cancer Sci
, vol.97
, pp. 813-820
-
-
Noguchi, S.1
-
78
-
-
48549095270
-
Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer
-
O'Brien C, Cavet G, Pandita A, et al. 2008. Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer. Cancer Res, 68:5380-9.
-
(2008)
Cancer Res
, vol.68
, pp. 5380-5389
-
-
O'Brien, C.1
Cavet, G.2
Pandita, A.3
-
79
-
-
34247214228
-
Targeting the microtubule apparatus in indolent and mantle cell lymphoma with the novel epothilone analog BMS247550 induces major and durable remissions in very drug resistant disease
-
O'Connor O, Straus D, Moskowitz C, et al. 2005. Targeting the microtubule apparatus in indolent and mantle cell lymphoma with the novel epothilone analog BMS247550 induces major and durable remissions in very drug resistant disease. Proc Am Soc Clin Oncol, 23:6569a.
-
(2005)
Proc Am Soc Clin Oncol
, vol.23
-
-
O'Connor, O.1
Straus, D.2
Moskowitz, C.3
-
80
-
-
21144441199
-
Evaluation of epothilone B analog in advanced soft tissue sarcoma: A phase II study of the phase II consortium
-
Okuno S, Maples WJ, Mahoney MR, et al. 2005. Evaluation of epothilone B analog in advanced soft tissue sarcoma:a phase II study of the phase II consortium. J Clin Oncol, 23:3069-73.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3069-3073
-
-
Okuno, S.1
Maples, W.J.2
Mahoney, M.R.3
-
81
-
-
33644975420
-
A phase II study of epothilone B analog (EpoB)-BMS 247550 (NSC#710428) in stage IV malignant melanoma (MM)
-
Pavlick A, Millward M, Farrell K, et al. 2004. A phase II study of epothilone B analog (EpoB)-BMS 247550 (NSC#710428) in stage IV malignant melanoma (MM). Proc Am Soc Clin Oncol, 22:7542a.
-
(2004)
Proc Am Soc Clin Oncol
, vol.22
-
-
Pavlick, A.1
Millward, M.2
Farrell, K.3
-
82
-
-
20044379059
-
Review: Tubulin function, action of antitubulin drugs, and new drug development
-
Pellegrini F and Budman DR. 2005. Review:tubulin function, action of antitubulin drugs, and new drug development. Cancer Invest, 23:264-73.
-
(2005)
Cancer Invest
, vol.23
, pp. 264-273
-
-
Pellegrini, F.1
Budman, D.R.2
-
83
-
-
34548157209
-
Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine
-
Perez EA, Lerzo G, Pivot X, et al. 2007. Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine. J Clin Oncol, 25:3407-14.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3407-3414
-
-
Perez, E.A.1
Lerzo, G.2
Pivot, X.3
-
84
-
-
26444507974
-
In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models
-
Peterson JK, Tucker C, Favours E, et al. 2005. In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models. Clin Cancer Res, 11:6950-8.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6950-6958
-
-
Peterson, J.K.1
Tucker, C.2
Favours, E.3
-
85
-
-
2442505920
-
KOS-862 (epothilone D): A comparison of two schedules in patients with advanced malignancies
-
Piro L, Rosen L, Parson M, et al. 2003. KOS-862 (epothilone D): A comparison of two schedules in patients with advanced malignancies. Proc Am Soc Clin Oncol, 22:539a.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Piro, L.1
Rosen, L.2
Parson, M.3
-
86
-
-
0347325038
-
Safety and efficacy of EPO906 in patients with advanced colorectal cancer: A review of 2 phase II trials
-
Poplin E, Moore M, O'Dwyer P, et al. 2003. Safety and efficacy of EPO906 in patients with advanced colorectal cancer: A review of 2 phase II trials. Proc Am Soc Clin Oncol, 22:1135a.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Poplin, E.1
Moore, M.2
O'Dwyer, P.3
-
87
-
-
34548265657
-
A phase II study of ixabepilone (BMS-247550) in metastatic renal-cell carcinoma
-
Posadas EM, Undevia S, Manchen E, et al. 2007. A phase II study of ixabepilone (BMS-247550) in metastatic renal-cell carcinoma. Cancer Biol Ther, 6:490-3.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 490-493
-
-
Posadas, E.M.1
Undevia, S.2
Manchen, E.3
-
88
-
-
38749089490
-
Markers predicting clinical benefit in breast cancer from microtubule-targeting agents
-
Pusztai L. 2007. Markers predicting clinical benefit in breast cancer from microtubule-targeting agents. Ann Oncol, 18(Suppl 12):xii15-20.
-
(2007)
Ann Oncol
, vol.18
, Issue.SUPPL. 12
-
-
Pusztai, L.1
-
90
-
-
78650278944
-
Evaluation of safety, tolerability and pharmacokinetics (PK) of patupilone in patients with advanced solid tumors and varying degrees of hepatic function: An open-label phase I study
-
Reid T, Takimoto C, Verschraegen C, et al. 2008. Evaluation of safety, tolerability and pharmacokinetics (PK) of patupilone in patients with advanced solid tumors and varying degrees of hepatic function: An open-label phase I study. Proc Am Soc Clin Oncol, 26:2557a.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Reid, T.1
Takimoto, C.2
Verschraegen, C.3
-
91
-
-
34548179878
-
Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy
-
Roche H, Yelle L, Cognetti F, et al. 2007. Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy. J Clin Oncol, 25:3415-20.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3415-3420
-
-
Roche, H.1
Yelle, L.2
Cognetti, F.3
-
92
-
-
34547119271
-
Activity of secondline chemotherapy in docetaxel-refractory hormone-refractory prostate cancer patients: Randomized phase 2 study of ixabepilone or mitoxantrone and prednisone
-
Rosenberg JE, Weinberg VK, Kelly WK, et al. 2007. Activity of secondline chemotherapy in docetaxel-refractory hormone-refractory prostate cancer patients: randomized phase 2 study of ixabepilone or mitoxantrone and prednisone. Cancer, 110:556-63.
-
(2007)
Cancer
, vol.110
, pp. 556-563
-
-
Rosenberg, J.E.1
Weinberg, V.K.2
Kelly, W.K.3
-
93
-
-
33644831567
-
Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors
-
Rubin EH, Rothermel J, Tesfaye F, et al. 2005. Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors. J Clin Oncol, 23:9120-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 9120-9129
-
-
Rubin, E.H.1
Rothermel, J.2
Tesfaye, F.3
-
94
-
-
40549084015
-
Differential response of mitotic spindle pole formation to microtubule-stabilizing agents epothilone A and B at low concentrations
-
Sakaushi S, Nishida K, Fukada T, et al. 2008. Differential response of mitotic spindle pole formation to microtubule-stabilizing agents epothilone A and B at low concentrations. Cell Cycle, 7:477-83.
-
(2008)
Cell Cycle
, vol.7
, pp. 477-483
-
-
Sakaushi, S.1
Nishida, K.2
Fukada, T.3
-
95
-
-
33646547391
-
A phase I study of the novel, third generation epothilone ZK-EPO in patients with advanced solid tumors
-
Schmid P, Kiewe P, Kuehnhardt D, et al. 2005. A phase I study of the novel, third generation epothilone ZK-EPO in patients with advanced solid tumors. Proc Am Soc Clin Oncol, 23:2051a.
-
(2005)
Proc Am Soc Clin Oncol
, vol.23
-
-
Schmid, P.1
Kiewe, P.2
Kuehnhardt, D.3
-
96
-
-
34548385800
-
Phase I clinical study of the novel epothilone B analogue BMS-310705 given on a weekly schedule
-
Sessa C, Perotti A, Llado A, et al. 2007. Phase I clinical study of the novel epothilone B analogue BMS-310705 given on a weekly schedule. Ann Oncol, 18:1548-53.
-
(2007)
Ann Oncol
, vol.18
, pp. 1548-1553
-
-
Sessa, C.1
Perotti, A.2
Llado, A.3
-
97
-
-
21244499905
-
Phase I and pharmacokinetic (PK) study of the novel epothilone BMS-310705 in patients (pts) with advanced solid cancer
-
Sessa C, Perotti A, Malossi A, et al. 2003. Phase I and pharmacokinetic (PK) study of the novel epothilone BMS-310705 in patients (pts) with advanced solid cancer. Proc Am Soc Clin Oncol, 22:519a.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Sessa, C.1
Perotti, A.2
Malossi, A.3
-
98
-
-
30344437279
-
Class III beta-tubulin expression in tumor cells predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel
-
Seve P, Mackey J, Isaac S, et al. 2005. Class III beta-tubulin expression in tumor cells predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel. Mol Cancer Ther, 4:2001-7.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 2001-2007
-
-
Seve, P.1
McKey, J.2
Isaac, S.3
-
99
-
-
42549102569
-
Protein abundance of class III betatubulin but not Delta2-alpha-tubulin or tau is related to paclitaxel response in carcinomas of unknown primary site
-
Seve P, Reiman T, Isaac S, et al. 2008. Protein abundance of class III betatubulin but not Delta2-alpha-tubulin or tau is related to paclitaxel response in carcinomas of unknown primary site. Anticancer Res, 28:1161-7.
-
(2008)
Anticancer Res
, vol.28
, pp. 1161-1167
-
-
Seve, P.1
Reiman, T.2
Isaac, S.3
-
100
-
-
83255179946
-
-
In:, Budman, DR, Calvert A, Rowinsky E (eds). Baltimore: Lippincott, Williams and Wilkins
-
Shah R, Kaye S. 2003. In: Handbook of Anticancer Drug Development. Budman, DR, Calvert A, Rowinsky E (eds). Baltimore: Lippincott, Williams and Wilkins. pp. 13-24.
-
(2003)
Handbook of Anticancer Drug Development
, pp. 13-24
-
-
Shah, R.1
Kaye, S.2
-
101
-
-
39749126801
-
Phase I clinical and pharmacokinetic study of 3-weekly, 3-h infusion of ixabepilone (BMS-247550), an epothilone B analog, in Japanese patients with refractory solid tumors
-
Shimizu T, Yamamoto N, Yamada Y, et al. 2008. Phase I clinical and pharmacokinetic study of 3-weekly, 3-h infusion of ixabepilone (BMS-247550), an epothilone B analog, in Japanese patients with refractory solid tumors. Cancer Chemother Pharmacol, 61:751-8.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, pp. 751-758
-
-
Shimizu, T.1
Yamamoto, N.2
Yamada, Y.3
-
102
-
-
58749107039
-
A phase II study evaluating systemic sagopilone (ZK-EPO) treatment in patients with recurrent malignant gliomas
-
Silvani A, Fiumani A, Scaioli V, et al. 2008. A phase II study evaluating systemic sagopilone (ZK-EPO) treatment in patients with recurrent malignant gliomas. Proc Am Soc Clin Oncol, 26:2083a.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Silvani, A.1
Fiumani, A.2
Scaioli, V.3
-
103
-
-
66349093701
-
A phase II trial of the epothilone B analog BMS-247550 in patients (pts) with hepatobiliary cancer (HBC): An updated analysis
-
Singh D, Taber D, Ansari R, et al. 2006. A phase II trial of the epothilone B analog BMS-247550 in patients (pts) with hepatobiliary cancer (HBC): An updated analysis. Proc Am Soc Clin Oncol, 24:14050a.
-
(2006)
Proc Am Soc Clin Oncol
, vol.24
-
-
Singh, D.1
Taber, D.2
Ansari, R.3
-
104
-
-
33745245860
-
Phase I/II dose-escalation trial of patupilone every 3 weeks in patients with relapsed/refractory ovarian cancer
-
Smit W, Sufliarsky J, Spanik S, et al. 2005. Phase I/II dose-escalation trial of patupilone every 3 weeks in patients with relapsed/refractory ovarian cancer. Proc Am Soc Clin Oncol, 23:5056a.
-
(2005)
Proc Am Soc Clin Oncol
, vol.23
-
-
Smit, W.1
Sufliarsky, J.2
Spanik, S.3
-
105
-
-
33745245860
-
A phase II study of epothilone B analog BMS-247550 (NSC 710428) in patients with relapsed aggressive non-Hodgkin's lymphomas
-
Smith S, Pro B, van Besien K, et al. 2005. A phase II study of epothilone B analog BMS-247550 (NSC 710428) in patients with relapsed aggressive non-Hodgkin's lymphomas. Proc Am Soc Clin Oncol, 23:6625a.
-
(2005)
Proc Am Soc Clin Oncol
, vol.23
-
-
Smith, S.1
Pro, B.2
van Besien, K.3
-
106
-
-
3142755834
-
KOS-862 (epothilone D): Phase I dose escalating and pharmacokinetic (PK) study in patients with advanced malignancies
-
Spriggs D, Dupont J, Pezzulli S, et al. 2003. KOS-862 (epothilone D): Phase I dose escalating and pharmacokinetic (PK) study in patients with advanced malignancies. Proc Am Soc Clin Oncol, 22:894a.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Spriggs, D.1
Dupont, J.2
Pezzulli, S.3
-
107
-
-
0001252689
-
Phase 1 first-in-man study of epothilone B analog BMS-247550 in patients with advanced cancer
-
Spriggs D, Soignet S, Bienvenu B, et al. 2001. Phase 1 first-in-man study of epothilone B analog BMS-247550 in patients with advanced cancer. Proc Am Soc Clin Oncol, 20:428a.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Spriggs, D.1
Soignet, S.2
Bienvenu, B.3
-
108
-
-
55349115251
-
Phase I trial of KOS-1584 (a novel epothilone) using two weekly schedules
-
Stopeck A, Moulder S, Jones S, et al. 2007. Phase I trial of KOS-1584 (a novel epothilone) using two weekly schedules. Proc Am Soc Clin Oncol, 25:2571a.
-
(2007)
Proc Am Soc Clin Oncol
, vol.25
-
-
Stopeck, A.1
Moulder, S.2
Jones, S.3
-
109
-
-
33750325012
-
Phase I trial of a novel epothilone, KOS-1584, using a weekly dosing schedule
-
Stopeck A, Thomas E, Jones S, et al. 2006. Phase I trial of a novel epothilone, KOS-1584, using a weekly dosing schedule. Proc Am Soc Clin Oncol, 24:2041a.
-
(2006)
Proc Am Soc Clin Oncol
, vol.24
-
-
Stopeck, A.1
Thomas, E.2
Jones, S.3
-
110
-
-
58749102659
-
Phase II trial of the epothilone analog sagopilone (ZK219477; ZK EPO) in patients with recurrent glioblastoma:Initial report of the EORTC study 26061
-
Stupp R, Tosoni A, Taal W, et al. 2008. Phase II trial of the epothilone analog sagopilone (ZK219477; ZK EPO) in patients with recurrent glioblastoma:Initial report of the EORTC study 26061. Proc Am Soc Clin Oncol, 26:2015a.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Stupp, R.1
Tosoni, A.2
Taal, W.3
-
111
-
-
78650265222
-
Evaluation of pharmacokinetics (PK) and pharmacodynamics (PD) of patupilone and warfarin in patients (pts) with advanced solid tumors:An open-label, phase I study
-
Takimoto C, Fu S, Dhillon N, et al. 2008. Evaluation of pharmacokinetics (PK) and pharmacodynamics (PD) of patupilone and warfarin in patients (pts) with advanced solid tumors:An open-label, phase I study. Proc Am Soc Clin Oncol, 26:2548a.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Takimoto, C.1
Fu, S.2
Dhillon, N.3
-
112
-
-
43749090834
-
Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment
-
Thomas E. 2008. Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. J Clin Oncol, 26:2223.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2223
-
-
Thomas, E.1
-
113
-
-
34548187738
-
Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer
-
Thomas E, Tabernero J, Fornier M, et al. 2007a. Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer. J Clin Oncol, 25:3399-406.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3399-3406
-
-
Thomas, E.1
Tabernero, J.2
Fornier, M.3
-
114
-
-
36849071808
-
Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment
-
Thomas ES, Gomez HL, Li RK, et al. 2007b. Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. J Clin Oncol, 25:5210-7.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5210-5217
-
-
Thomas, E.S.1
Gomez, H.L.2
Li, R.K.3
-
115
-
-
0347336851
-
Phase II trial evaluating the safety and efficacy of EPO906 in patients with advanced renal cancer
-
Thompson J, Swerdloff J, Escudier B, et al. 2003. Phase II trial evaluating the safety and efficacy of EPO906 in patients with advanced renal cancer. Proc Am Soc Clin Oncol, 22:1628a.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Thompson, J.1
Swerdloff, J.2
Escudier, B.3
-
116
-
-
34548158974
-
Phase II clinical trial of the epothilone B analog, ixabepilone, in patients with non smallcell lung cancer whose tumors have failed first-line platinum-based chemotherapy
-
Vansteenkiste J, Lara PN, Jr. Le Chevalier T, et al. 2007. Phase II clinical trial of the epothilone B analog, ixabepilone, in patients with non smallcell lung cancer whose tumors have failed first-line platinum-based chemotherapy. J Clin Oncol, 25:3448-55.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3448-3455
-
-
Vansteenkiste, J.1
Lara Jr., P.N.2
le Chevalier, T.3
-
117
-
-
43549097915
-
First-in-human phase I trial of a novel epothilone, KOS-1584
-
Villalona-Calero M, Goel S, Schaaf L, et al. 2006. First-in-human phase I trial of a novel epothilone, KOS-1584. Proc Am Soc Clin Oncol, 24:2003a.
-
(2006)
Proc Am Soc Clin Oncol
, vol.24
-
-
Villalona-Calero, M.1
Goel, S.2
Schaaf, L.3
-
118
-
-
67651090980
-
Phase II trial of sagopilone (ZKEPO), a novel epothilone, in patients with metastatic melanoma
-
Wenk D, Deconti R, Urbas P, et al. 2008. Phase II trial of sagopilone (ZKEPO), a novel epothilone, in patients with metastatic melanoma. Proc Am Soc Clin Oncol, 26:9046a.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Wenk, D.1
Deconti, R.2
Urbas, P.3
-
119
-
-
33747689092
-
A phase II trial of epothilone B analogue BMS-247550 (NSC #710428) ixabepilone, in patients with advanced pancreas cancer: A Southwest Oncology Group study
-
Whitehead RP, McCoy S, Rivkin SE, et al. 2006. A phase II trial of epothilone B analogue BMS-247550 (NSC #710428) ixabepilone, in patients with advanced pancreas cancer:a Southwest Oncology Group study. Invest New Drugs, 24:515-20.
-
(2006)
Invest New Drugs
, vol.24
, pp. 515-520
-
-
Whitehead, R.P.1
McCoy, S.2
Rivkin, S.E.3
-
120
-
-
59349121227
-
E3803:Updated results on phase II study of a weekly schedule of BMS-247550 for patients with castrate refractory prostate cancer (CRPC)
-
Wilding G, Chen Y, DiPaola R, et al. 2008. E3803:Updated results on phase II study of a weekly schedule of BMS-247550 for patients with castrate refractory prostate cancer (CRPC). Proc Am Soc Clin Oncol, 26:5070a.
-
(2008)
Proc Am Soc Clin Oncol
, vol.26
-
-
Wilding, G.1
Chen, Y.2
DiPaola, R.3
-
121
-
-
31344455354
-
A phase II study of KOS-862 (Epothilone D) as second-line therapy in non-small cell lung cancer
-
Yee L, Lynch T, Villalona-Calero M, et al. 2005. A phase II study of KOS-862 (Epothilone D) as second-line therapy in non-small cell lung cancer Proc Am Soc Clin Oncol, 2005:7127a.
-
(2005)
Proc Am Soc Clin Oncol
, vol.2005
-
-
Yee, L.1
Lynch, T.2
Villalona-Calero, M.3
-
122
-
-
20244376916
-
A Phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days
-
Zhuang SH, Agrawal M, Edgerly M, et al. 2005. A Phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days. Cancer, 103:1932-8.
-
(2005)
Cancer
, vol.103
, pp. 1932-1938
-
-
Zhuang, S.H.1
Agrawal, M.2
Edgerly, M.3
-
123
-
-
37549047609
-
Evidence for microtubule target engagement in tumors of patients receiving ixabepilone
-
Zhuang SH, Hung YE, Hung L, et al. 2007. Evidence for microtubule target engagement in tumors of patients receiving ixabepilone. Clin Cancer Res, 13:7480-6.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7480-7486
-
-
Zhuang, S.H.1
Hung, Y.E.2
Hung, L.3
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