Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells

Cancer Letters

Volumn 296, Issue 1, 2010, Pages 123-131

  Huang, Xiaoli ^a   Zhang, Zhihong ^a   Jia, Li ^a   Zhao, Yan ^a   Zhang, Xuguang ^a   Wu, Kun ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Endoplasmic reticulum stress; Gastric carcinoma; Vitamin E succinate

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA TOCOPHEROL SUCCINATE; CALCIUM; CASPASE 4; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; STRESS ACTIVATED PROTEIN KINASE; X BOX BINDING PROTEIN 1;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOLOGY; DOSE TIME EFFECT RELATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; STOMACH CANCER; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

ALPHA-TOCOPHEROL; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; CELL DIVISION; DNA PRIMERS; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE GLYCOPROTEINS; MICROSCOPY, ELECTRON; MOLECULAR CHAPERONES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; STOMACH NEOPLASMS; STRESS, MECHANICAL; TUMOR CELLS, CULTURED;

EID: 77954815467     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.04.002     Document Type: Article

References (52)

1. Sun S.Y., Hail N., Lotan R. Apoptosis as a novel target for cancer chemoprevention. J. Natl. Cancer Inst. 2004, 96:662-672.
2. Ghobrial I.M., Witzig T.E., Adjei A.A. Targeting apoptosis pathways in cancer therapy. CA Cancer J. Clin. 2005, 55:178-194.
3. Tomasetti M., Gellert N., Procopio A., Neuzil J. A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: a future drug against a fatal neoplastic disease?. Int. J. Cancer 2004, 109:641-642.
4. Neuzil J., Weber T., Gellert N., Weber C. Selective cancer cell killing by alpha-tocopheryl succinate. Brit. J. Cancer 2001, 84:87-89.
5. Pussinen P.J., Lindner H., Glatter O., Reicher H., Kostner G.M., Wintersperger A., Malle E., Sattler W. Lipoprotein-associated alpha-tocopheryl-succinate inhibits cell growth and induces apoptosis in human MCF-7 and HBL-100 breast cancer cells. Biochim. Biophys. Acta 2000, 1485:129-144.
6. Malafa M.P., Fokum F.D., Mowlavi A., Abusief M., King M. Vitamin E inhibits melanoma growth in mice. Surgery 2002, 131:85-91.
7. Yamamoto S., Tamai H., Ishisaka R., Kanno T., Arita K., Kobuchi H., Utsumi K. Mechanism of alpha-tocopheryl succinate-induced apoptosis of promyelocytic leukemia cells. Free Radical Res. 2000, 33:407-418.
8. Zhang Y., Ni J., Messing E.M., Chang E., Yang C.R., Yeh S. Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells. Proc. Natl. Acad. Sci. USA 2002, 99:7408-7413.
9. Kline K., Yu W., Sanders B.G. Vitamin E and breast cancer. J. Nutr. 2004, 134:3458S-3462S.
10. Wu K., Zhao Y., Liu B.H., Li Y., Liu F., Guo J., Yu W.P. RRR-alpha-tocopheryl succinate inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest. World J. Gastroenterol. 2002, 8:26-30.
11. Chun K.H., Benbrook D.M., Berlin K.D., Hong W.K., Lotan R. The synthetic heteroarotinoid SHetA2 induces apoptosis in squamous carcinoma cells through a receptor-independent and mitochondria-dependent pathway. Cancer Res. 2003, 63:3826-3832.
12. Rao R.V., Ellerby H.M., Bredesen D.E. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 2004, 11:372-380.
13. Sun W., Xu W., Liu H., Liu J., Wang Q., Zhou J., Dong F., Chen B. Gamma-tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. J. Nutr. Biochem. 2009, 20:276-284.
14. Schmitz A., Herzog V. Endoplasmic reticulum-associated degradation: exceptions to the rule. Eur. J. Cell Biol. 2004, 83:501-509.
15. Harding H.P., Calfon M., Urano F., Novoa I., Ron D. Transcriptional and translational control in the Mammalian unfolded protein response. Annu. Rev. Cell Dev. Biol. 2002, 18:575-599.
16. Schroder M., Kaufman R.J. The mammalian unfolded protein response. Annu. Rev. Biochem. 2005, 74:739-789.
17. Kaufman R.J. Orchestrating the unfolded protein response in health and disease. J. Clin. Invest. 2002, 110:1389-1398.
18. Harding H.P., Zhang Y., Bertolotti A., Zeng H., Ron D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol. Cell 2000, 5:897-904.
19. McCullough K.D., Martindale J.L., Klotz L.O., Aw T.Y., Holbrook N.J. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell Biol. 2001, 21:1249-1259.
20. Rutkowski D.T., Kaufman R.J. A trip to the ER: coping with stress. Trends Cell Biol. 2004, 14:20-28.
21. Mori K., Ma W., Gething M.J., Sambrook J. A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell 1993, 74:743-756.
22. Morishima N., Nakanishi K., Takenouchi H., Shibata T., Yasuhiko Y., Cytochrome c-independent activation of caspase-9 by caspase-12 An endoplasmic reticulum stress-specific caspase cascade in apoptosis. J. Biol. Chem. 2002, 277:34287-34294.
23. Wu K., Li Y., Zhao Y., Shan Y.J., Xia W., Yu W.P., Zhao L. Roles of Fas signaling pathway in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells. World J. Gastroenterol. 2002, 8:982-986.
24. Wu K., Zhao Y., Li G.C., Yu W.P. c-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells. World J. Gastroenterol. 2004, 10:1110-1114.
25. Zhao Y., Li R., Xia W., Neuzil J., Lu Y., Zhang H., Zhao X., Zhang X., Sun C., Wu K. Bid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells. Cancer Lett. 2010, 288:42-49.
26. Zhao Y., Zhao X., Yang B., Neuzil J., Wu K. Alpha-tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner. Cancer Lett. 2007, 247:345-352.
27. Carew J.S., Nawrocki S.T., Xu R.H., Dunner K., McConkey D.J., Wierda W.G., Keating M.J., Huang P. Increased mitochondrial biogenesis in primary leukemia cells: the role of endogenous nitric oxide and impact on sensitivity to fludarabine. Leukemia 2004, 18:1934-1940.
28. Ferri K.F., Kroemer G. Organelle-specific initiation of cell death pathways. Nat. Cell Biol. 2001, 3:E255-E263.
29. Patil C., Walter P. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr. Opin. Cell Biol. 2001, 13:349-355.
30. Calfon M., Zeng H., Urano F., Till J.H., Hubbard S.R., Harding H.P., Clark S.G., Ron D. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002, 415:92-96.
31. Kim H.J., Cho H.K., Kwon Y.H. Synergistic induction of ER stress by homocysteine and beta-amyloid in SH-SY5Y cells. J. Nutr. Biochem. 2008, 19:754-761.
32. Vaux D.L., Korsmeyer S.J. Cell death in development. Cell 1999, 96:245-254.
33. Weber T., Lu M., Andera L., Lahm H., Gellert N., Fariss M.W., Korinek V., Sattler W., Ucker D.S., Terman A., Schroder A., Erl W., Brunk U.T., Coffey R.J., Weber C., Neuzil J. Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Clin. Cancer Res. 2002, 8:863-869.
34. Stapelberg M., Gellert N., Swettenham E., Tomasetti M., Witting P.K., Procopio A., Neuzil J. Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. J. Biol. Chem. 2005, 280:25369-25376.
35. Kim R., Emi M., Tanabe K., Murakami S. Role of the unfolded protein response in cell death. Apoptosis 2006, 11:5-13.
36. Xu C., Bailly-Maitre B., Reed J.C. Endoplasmic reticulum stress: cell life and death decisions. J. Clin. Invest. 2005, 115:2656-2664.
37. Yokouchi M., Hiramatsu N., Hayakawa K., Kasai A., Takano Y., Yao J., Kitamura M. Atypical bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response. Cell Death Differ. 2007, 14:1467-1474.
38. Dickhout J.G., Hossain G.S., Pozza L.M., Zhou J., Lhotak S., Austin R.C. Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis. Arterioscler. Thromb. Vasc. Biol. 2005, 25:2623-2629.
39. Lee A.S. The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem. Sci. 2001, 26:504-510.
40. Little E., Ramakrishnan M., Roy B., Gazit G., Lee A.S. The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications. Crit. Rev. Eukaryot. Gene Expr. 1994, 4:1-18.
41. Sheu M.L., Liu S.H., Lan K.H. Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. PLoS One 2007, 2:e1096.
42. 2+ entry in endothelial cells. Eur. J. Pharmacol. 1999, 373:111-120.
43. Boyce M., Yuan J. Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ. 2006, 13:363-373.
44. Hitomi J., Katayama T., Eguchi Y., Kudo T., Taniguchi M., Koyama Y., Manabe T., Yamagishi S., Bando Y., Imaizumi K., Tsujimoto Y., Tohyama M. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J. Cell Biol. 2004, 165:347-356.
45. Harding H.P., Novoa I., Zhang Y., Zeng H., Wek R., Schapira M., Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 2000, 6:1099-1108.
46. Zinszner H., Kuroda M., Wang X., Batchvarova N., Lightfoot R.T., Remotti H., Stevens J.L., Ron D. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 1998, 12:982-995.
47. Haze K., Okada T., Yoshida H., Yanagi H., Yura T., Negishi M., Mori K. Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein responsem. Biochem. J. 2001, 355:19-28.
48. Oyadomari S., Koizumi A., Takeda K., Gotoh T., Akira S., Araki E., Mori M. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J. Clin. Invest. 2002, 109:525-532.
49. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000, 403:98-103.
50. Urano F., Wang X., Bertolotti A., Zhang Y., Chung P., Harding H.P., Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000, 287:664-666.
51. Urano F., Bertolotti A., Ron D. IRE1 and efferent signaling from the endoplasmic reticulum. J. Cell Sci. 2000, 113 Pt 21:3697-3702.
52. Wu K., Liu B.H., Zhao D.Y., Zhao Y., TGF-beta1 Effect of vitamin E succinate on expression of c-Jun and JNK1 in human gastric cancer SGC-7901 cells. World J. Gastroenterol. 2001, 7:83-87.