-
1
-
-
0032212728
-
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway
-
Finco T.S., et al. LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity 1998, 9(5):617-626.
-
(1998)
Immunity
, vol.9
, Issue.5
, pp. 617-626
-
-
Finco, T.S.1
-
2
-
-
0032992072
-
Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line
-
Zhang W., et al. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. Int. Immunol. 1999, 11(6):943-950.
-
(1999)
Int. Immunol.
, vol.11
, Issue.6
, pp. 943-950
-
-
Zhang, W.1
-
3
-
-
0033103833
-
Essential role of LAT in T cell development
-
Zhang W., et al. Essential role of LAT in T cell development. Immunity 1999, 10(3):323-332.
-
(1999)
Immunity
, vol.10
, Issue.3
, pp. 323-332
-
-
Zhang, W.1
-
4
-
-
0037077094
-
Induction of T helper type 2 immunity by a point mutation in the LAT adaptor
-
Aguado E., et al. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 2002, 296(5575):2036-2040.
-
(2002)
Science
, vol.296
, Issue.5575
, pp. 2036-2040
-
-
Aguado, E.1
-
5
-
-
0037076975
-
A LAT mutation that inhibits T cell development yet induces lymphoproliferation
-
Sommers C.L., et al. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 2002, 296(5575):2040-2043.
-
(2002)
Science
, vol.296
, Issue.5575
, pp. 2040-2043
-
-
Sommers, C.L.1
-
6
-
-
33746872949
-
The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity
-
Genton C., et al. The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity. J. Immunol. 2006, 177(4):2285-2293.
-
(2006)
J. Immunol.
, vol.177
, Issue.4
, pp. 2285-2293
-
-
Genton, C.1
-
7
-
-
46249103136
-
Unravelling the association of partial T-cell immunodeficiency and immune dysregulation
-
Liston A., et al. Unravelling the association of partial T-cell immunodeficiency and immune dysregulation. Nat. Rev. Immunol. 2008, 8(7):545-558.
-
(2008)
Nat. Rev. Immunol.
, vol.8
, Issue.7
, pp. 545-558
-
-
Liston, A.1
-
8
-
-
21044455152
-
Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function
-
Wang Y., et al. Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function. Mol. Cell Biol. 2005, 25(11):4455-4465.
-
(2005)
Mol. Cell Biol.
, vol.25
, Issue.11
, pp. 4455-4465
-
-
Wang, Y.1
-
9
-
-
0029094319
-
Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene
-
Malissen M., et al. Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene. Embo. J. 1995, 14(19):4641-4653.
-
(1995)
Embo. J.
, vol.14
, Issue.19
, pp. 4641-4653
-
-
Malissen, M.1
-
10
-
-
40749113582
-
Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells
-
Wang Y., et al. Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells. J. Immunol. 2008, 180(3):1565-1575.
-
(2008)
J. Immunol.
, vol.180
, Issue.3
, pp. 1565-1575
-
-
Wang, Y.1
-
11
-
-
20244365648
-
Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection
-
Sommers C.L., et al. Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection. J. Exp. Med. 2005, 201(7):1125-1134.
-
(2005)
J. Exp. Med.
, vol.201
, Issue.7
, pp. 1125-1134
-
-
Sommers, C.L.1
-
12
-
-
68649087416
-
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor
-
Mingueneau M., et al. Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity 2009, 31(2):197-208.
-
(2009)
Immunity
, vol.31
, Issue.2
, pp. 197-208
-
-
Mingueneau, M.1
-
13
-
-
0031028629
-
The single positive T cells found in CD3-zeta/eta-/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex
-
Lin S.Y., et al. The single positive T cells found in CD3-zeta/eta-/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex. J. Exp. Med. 1997, 185(4):707-715.
-
(1997)
J. Exp. Med.
, vol.185
, Issue.4
, pp. 707-715
-
-
Lin, S.Y.1
-
14
-
-
57449097558
-
Homeostasis of naive and memory T cells
-
Surh C.D., Sprent J. Homeostasis of naive and memory T cells. Immunity 2008, 29(6):848-862.
-
(2008)
Immunity
, vol.29
, Issue.6
, pp. 848-862
-
-
Surh, C.D.1
Sprent, J.2
-
15
-
-
77951902637
-
The role of the LAT-PLC-γ1 interaction in T regulatory cell function
-
Chuck M.I., et al. The role of the LAT-PLC-γ1 interaction in T regulatory cell function. J. Immunol. 2010, 184(5):2476-2486.
-
(2010)
J. Immunol.
, vol.184
, Issue.5
, pp. 2476-2486
-
-
Chuck, M.I.1
-
16
-
-
31344480633
-
LAT-mediated signaling in CD4+CD25+ regulatory T cell development
-
Koonpaew S., et al. LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J. Exp. Med. 2006, 203(1):119-129.
-
(2006)
J. Exp. Med.
, vol.203
, Issue.1
, pp. 119-129
-
-
Koonpaew, S.1
-
17
-
-
1542619331
-
Suppression of CD4+ T lymphocyte effector functions by CD4+CD25+ cells in vivo
-
Martin B., et al. Suppression of CD4+ T lymphocyte effector functions by CD4+CD25+ cells in vivo. J. Immunol. 2004, 172(6):3391-3398.
-
(2004)
J. Immunol.
, vol.172
, Issue.6
, pp. 3391-3398
-
-
Martin, B.1
-
18
-
-
0142124330
-
LAT regulates γδ T cell homeostasis and differentiation
-
Nunez-Cruz S., et al. LAT regulates γδ T cell homeostasis and differentiation. Nat. Immunol. 2003, 4(10):999-1008.
-
(2003)
Nat. Immunol.
, vol.4
, Issue.10
, pp. 999-1008
-
-
Nunez-Cruz, S.1
-
19
-
-
64849091388
-
STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells
-
Archambaud C., et al. STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells. J. Immunol. 2009, 182(5):2680-2689.
-
(2009)
J. Immunol.
, vol.182
, Issue.5
, pp. 2680-2689
-
-
Archambaud, C.1
-
20
-
-
23444457121
-
Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways
-
Houtman J.C., et al. Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways. J. Immunol. 2005, 175(4):2449-2458.
-
(2005)
J. Immunol.
, vol.175
, Issue.4
, pp. 2449-2458
-
-
Houtman, J.C.1
-
21
-
-
3142676432
-
Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice
-
Chiang Y.J., et al. Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice. J. Exp. Med. 2004, 200(1):25-34.
-
(2004)
J. Exp. Med.
, vol.200
, Issue.1
, pp. 25-34
-
-
Chiang, Y.J.1
-
22
-
-
0037379218
-
Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells
-
Yamasaki S., et al. Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells. Mol. Cell Biol. 2003, 23(7):2515-2529.
-
(2003)
Mol. Cell Biol.
, vol.23
, Issue.7
, pp. 2515-2529
-
-
Yamasaki, S.1
-
23
-
-
33750530393
-
T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2
-
Dong S., et al. T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2. J. Exp. Med. 2006, 203(11):2509-2518.
-
(2006)
J. Exp. Med.
, vol.203
, Issue.11
, pp. 2509-2518
-
-
Dong, S.1
-
24
-
-
34047149396
-
Dok-1 and Dok-2 are negative regulators of T cell receptor signaling
-
Yasuda T., et al. Dok-1 and Dok-2 are negative regulators of T cell receptor signaling. Int. Immunol. 2007, 19(4):487-495.
-
(2007)
Int. Immunol.
, vol.19
, Issue.4
, pp. 487-495
-
-
Yasuda, T.1
-
25
-
-
33749171235
-
Persistence of cooperatively stabilized signaling clusters drives T-cell activation
-
Bunnell S.C., et al. Persistence of cooperatively stabilized signaling clusters drives T-cell activation. Mol. Cell Biol. 2006, 26(19):7155-7166.
-
(2006)
Mol. Cell Biol.
, vol.26
, Issue.19
, pp. 7155-7166
-
-
Bunnell, S.C.1
-
26
-
-
0038487052
-
Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells
-
Seddon B., et al. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat. Immunol. 2003, 4(7):680-686.
-
(2003)
Nat. Immunol.
, vol.4
, Issue.7
, pp. 680-686
-
-
Seddon, B.1
-
27
-
-
66949162691
-
The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage
-
Shen S., et al. The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. J. Immunol. 2009, 182(9):5596-5604.
-
(2009)
J. Immunol.
, vol.182
, Issue.9
, pp. 5596-5604
-
-
Shen, S.1
-
28
-
-
0031448209
-
Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation
-
D'Oro U., et al. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation. Immunity 1997, 7(5):619-628.
-
(1997)
Immunity
, vol.7
, Issue.5
, pp. 619-628
-
-
D'Oro, U.1
-
29
-
-
0038363406
-
Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells
-
Kabouridis P.S. Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells. Biochem. J. 2003, 371(Pt 3):907-915.
-
(2003)
Biochem. J.
, vol.371
, Issue.PART 3
, pp. 907-915
-
-
Kabouridis, P.S.1
-
30
-
-
27844541328
-
Modeling T cell antigen discrimination based on feedback control of digital ERK responses
-
Altan-Bonnet G., Germain R.N. Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol. 2005, 3(11):e356.
-
(2005)
PLoS Biol.
, vol.3
, Issue.11
-
-
Altan-Bonnet, G.1
Germain, R.N.2
-
31
-
-
44049096285
-
Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity
-
Holst J., et al. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nat. Immunol. 2008, 9(6):658-666.
-
(2008)
Nat. Immunol.
, vol.9
, Issue.6
, pp. 658-666
-
-
Holst, J.1
-
32
-
-
33846456970
-
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
-
Hirota K., et al. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J. Exp. Med. 2007, 204(1):41-47.
-
(2007)
J. Exp. Med.
, vol.204
, Issue.1
, pp. 41-47
-
-
Hirota, K.1
-
33
-
-
37049019860
-
Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions
-
Siggs O.M., et al. Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity 2007, 27(6):912-926.
-
(2007)
Immunity
, vol.27
, Issue.6
, pp. 912-926
-
-
Siggs, O.M.1
-
34
-
-
70449721003
-
A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity
-
Hsu L.Y., et al. A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J. Exp. Med. 2009, 206(11):2527-2541.
-
(2009)
J. Exp. Med.
, vol.206
, Issue.11
, pp. 2527-2541
-
-
Hsu, L.Y.1
-
35
-
-
28444469783
-
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
-
Vang T., et al. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat. Genet. 2005, 37(12):1317-1319.
-
(2005)
Nat. Genet.
, vol.37
, Issue.12
, pp. 1317-1319
-
-
Vang, T.1
-
36
-
-
40949123088
-
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance
-
Oh-Hora M., et al. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat. Immunol. 2008, 9(4):432-443.
-
(2008)
Nat. Immunol.
, vol.9
, Issue.4
, pp. 432-443
-
-
Oh-Hora, M.1
-
37
-
-
0032212631
-
Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development
-
Ranger A.M., et al. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity 1998, 9(5):627-635.
-
(1998)
Immunity
, vol.9
, Issue.5
, pp. 627-635
-
-
Ranger, A.M.1
-
38
-
-
64249119896
-
PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background
-
Zikherman J., et al. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J. Immunol. 2009, 182(7):4093-4106.
-
(2009)
J. Immunol.
, vol.182
, Issue.7
, pp. 4093-4106
-
-
Zikherman, J.1
-
39
-
-
70349107991
-
Hypereosinophilic syndrome variants: diagnostic and therapeutic considerations
-
Roufosse F. Hypereosinophilic syndrome variants: diagnostic and therapeutic considerations. Haematologica 2009, 94(9):1188-1193.
-
(2009)
Haematologica
, vol.94
, Issue.9
, pp. 1188-1193
-
-
Roufosse, F.1
-
40
-
-
0033178502
-
T-cell receptor-independent activation of clonal Th2 cells associated with chronic hypereosinophilia
-
Roufosse F., et al. T-cell receptor-independent activation of clonal Th2 cells associated with chronic hypereosinophilia. Blood 1999, 94(3):994-1002.
-
(1999)
Blood
, vol.94
, Issue.3
, pp. 994-1002
-
-
Roufosse, F.1
-
41
-
-
34249732055
-
Angioimmunoblastic T cell lymphoma: pathobiological insights and clinical implications
-
Dunleavy K., et al. Angioimmunoblastic T cell lymphoma: pathobiological insights and clinical implications. Curr. Opin. Hematol. 2007, 14(4):348-353.
-
(2007)
Curr. Opin. Hematol.
, vol.14
, Issue.4
, pp. 348-353
-
-
Dunleavy, K.1
-
42
-
-
0034651923
-
Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis
-
Gringhuis S.I., et al. Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis. J. Immunol. 2000, 164(4):2170-2179.
-
(2000)
J. Immunol.
, vol.164
, Issue.4
, pp. 2170-2179
-
-
Gringhuis, S.I.1
-
43
-
-
0036136404
-
Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathways
-
Gringhuis S.I., et al. Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathways. Mol. Cell Biol. 2002, 22(2):400-411.
-
(2002)
Mol. Cell Biol.
, vol.22
, Issue.2
, pp. 400-411
-
-
Gringhuis, S.I.1
-
44
-
-
23244454965
-
The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells
-
Prinz I., et al. The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells. J. Immunol. 2005, 175(2):713-719.
-
(2005)
J. Immunol.
, vol.175
, Issue.2
, pp. 713-719
-
-
Prinz, I.1
-
45
-
-
2942755979
-
T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
-
Chtanova T., et al. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J. Immunol. 2004, 173(1):68-78.
-
(2004)
J. Immunol.
, vol.173
, Issue.1
, pp. 68-78
-
-
Chtanova, T.1
-
46
-
-
50249105938
-
Tailoring T-cell receptor signals by proximal negative feedback mechanisms
-
Acuto O., et al. Tailoring T-cell receptor signals by proximal negative feedback mechanisms. Nat. Rev. Immunol. 2008, 8(9):699-712.
-
(2008)
Nat. Rev. Immunol.
, vol.8
, Issue.9
, pp. 699-712
-
-
Acuto, O.1
|