Novel interactions identified between μ-conotoxin and the Na + channel domain I P-loop: Implications for toxin-pore binding geometry

Biophysical Journal

Volumn 85, Issue 4, 2003, Pages 2299-2310

  Xue, Tian ^a   Ennis, Irene L ^a   Sato, Kazuki ^b   French, Robert J ^c   Li, Ronald A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FUKUOKA WOMEN'S UNIVERSITY   (Japan)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CONOTOXIN; MU CONOTOXIN; SODIUM CHANNEL; TETRODOTOXIN; TOXIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHANNEL GATING; ELECTROPHYSIOLOGY; GEOMETRY; NONHUMAN; RAT; SODIUM TRANSPORT; TOXIN SYNTHESIS; BINDING SITE; BIOLOGICAL MODEL; CELL CULTURE; CELL LINE; CELL MEMBRANE POTENTIAL; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; DOSE RESPONSE; DRUG EFFECT; EVALUATION; HUMAN; KIDNEY; PHYSIOLOGY; POROSITY; PRENATAL DEVELOPMENT; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

BINDING SITES; CELL LINE; CELLS, CULTURED; COMPUTER SIMULATION; CONOTOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ION CHANNEL GATING; KIDNEY; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; POROSITY; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0141530983     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(03)74654-2     Document Type: Article

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