메뉴 건너뛰기




Volumn 24, Issue 2, 2010, Pages 395-403

Time-dependently expressed markers and the characterization for premature senescence induced by ionizing radiation in MCF7

Author keywords

Gene expression profile; Ionizing radiation; MCF7; Premature senescence

Indexed keywords

ACTIN; TUMOR MARKER;

EID: 77954365162     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000872     Document Type: Article
Times cited : (14)

References (49)
  • 1
    • 4644304152 scopus 로고    scopus 로고
    • Computerized video time lapse study of cell cycle delay and arrest, mitotic catastrophe, apoptosis and clonogenic survival in irradiated 14-3-3sigma and CDKN1A (p21) knockout cell lines
    • Chu K, Teele N, Dewey MW, Albright N and Dewey WC: Computerized video time lapse study of cell cycle delay and arrest, mitotic catastrophe, apoptosis and clonogenic survival in irradiated 14-3-3sigma and CDKN1A (p21) knockout cell lines. Radiat Res 162: 270-286, 2004.
    • (2004) Radiat Res , vol.162 , pp. 270-286
    • Chu, K.1    Teele, N.2    Dewey, M.W.3    Albright, N.4    Dewey, W.C.5
  • 2
    • 33751190516 scopus 로고    scopus 로고
    • Microarray analysis of radiation response genes in primary human fibroblasts
    • Kis E, Szatmari T, Keszei M, et al: Microarray analysis of radiation response genes in primary human fibroblasts. Int J Radiat Oncol Biol Phys 66: 1506-1514, 2006.
    • (2006) Int J Radiat Oncol Biol Phys , vol.66 , pp. 1506-1514
    • Kis, E.1    Szatmari, T.2    Keszei, M.3
  • 3
    • 34247581288 scopus 로고    scopus 로고
    • Short telomeres limit tumor progression in vivo by inducing senescence
    • Feldser DM and Greider CW: Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell 11: 461-469, 2007.
    • (2007) Cancer Cell , vol.11 , pp. 461-469
    • Feldser, D.M.1    Greider, C.W.2
  • 4
    • 52949152429 scopus 로고    scopus 로고
    • Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation
    • Gewirtz DA, Holt SE and Elmore LW: Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharmacol 76: 947-957, 2008.
    • (2008) Biochem Pharmacol , vol.76 , pp. 947-957
    • Gewirtz, D.A.1    Holt, S.E.2    Elmore, L.W.3
  • 5
    • 34247860915 scopus 로고    scopus 로고
    • Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence
    • Cosme-Blanco W, Shen MF, Lazar AJ, et al: Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep 8: 497-503, 2007.
    • (2007) EMBO Rep , vol.8 , pp. 497-503
    • Cosme-Blanco, W.1    Shen, M.F.2    Lazar, A.J.3
  • 6
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • Campisi J and d'Adda di Fagagna F: Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8: 729-740, 2007.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 729-740
    • Campisi, J.1    D'Adda Di Fagagna, F.2
  • 7
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • Collado M, Blasco MA and Serrano M: Cellular senescence in cancer and aging. Cell 130: 223-233, 2007.
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 8
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri GP, Lee X, Basile G, et al: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9363-9367
    • Dimri, G.P.1    Lee, X.2    Basile, G.3
  • 10
    • 23244452684 scopus 로고    scopus 로고
    • Suppressing cancer: The importance of being senescent
    • Campisi J: Suppressing cancer: the importance of being senescent. Science 309: 886-887, 2005.
    • (2005) Science , vol.309 , pp. 886-887
    • Campisi, J.1
  • 11
    • 33748422079 scopus 로고    scopus 로고
    • Oncogene-induced cell senescence-halting on the road to cancer
    • Mooi WJ and Peeper DS: Oncogene-induced cell senescence-halting on the road to cancer. N Engl J Med 355: 1037-1046, 2006.
    • (2006) N Engl J Med , vol.355 , pp. 1037-1046
    • Mooi, W.J.1    Peeper, D.S.2
  • 12
    • 24744454582 scopus 로고    scopus 로고
    • Senescence comes of age
    • Narita M and Lowe SW: Senescence comes of age. Nat Med 11: 920-922, 2005.
    • (2005) Nat Med , vol.11 , pp. 920-922
    • Narita, M.1    Lowe, S.W.2
  • 15
    • 0037452888 scopus 로고    scopus 로고
    • Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci
    • Zhang H, Pan KH and Cohen SN: Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci. Proc Natl Acad Sci USA 100: 3251-3256, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3251-3256
    • Zhang, H.1    Pan, K.H.2    Cohen, S.N.3
  • 16
    • 53649109801 scopus 로고    scopus 로고
    • Critical pathways in cellular senescence and immortalization revealed by gene expression profiling
    • Fridman AL and Tainsky MA: Critical pathways in cellular senescence and immortalization revealed by gene expression profiling. Oncogene 27: 5975-5987, 2008.
    • (2008) Oncogene , vol.27 , pp. 5975-5987
    • Fridman, A.L.1    Tainsky, M.A.2
  • 17
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-non-autonomous functions of oncogenic RAS and the p53 tumor suppressor
    • Coppe JP, Patil CK, Rodier F, et al: Senescence-associated secretory phenotypes reveal cell-non-autonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6: 2853-2868, 2008.
    • (2008) PLoS Biol , vol.6 , pp. 2853-2868
    • Coppe, J.P.1    Patil, C.K.2    Rodier, F.3
  • 18
    • 44649095065 scopus 로고    scopus 로고
    • Unexpected pieces to the senescence puzzle
    • Cichowski K and Hahn WC: Unexpected pieces to the senescence puzzle. Cell 133: 958-961, 2008.
    • (2008) Cell , vol.133 , pp. 958-961
    • Cichowski, K.1    Hahn, W.C.2
  • 19
    • 4444240175 scopus 로고    scopus 로고
    • Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects
    • Saras J, Wollberg P and Aspenstrom P: Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects. Exp Cell Res 299: 356-369, 2004.
    • (2004) Exp Cell Res , vol.299 , pp. 356-369
    • Saras, J.1    Wollberg, P.2    Aspenstrom, P.3
  • 20
    • 9244239247 scopus 로고    scopus 로고
    • Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase
    • Shutes A, Berzat AC, Cox AD and Der CJ: Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase. Curr Biol 14: 2052-2056, 2004.
    • (2004) Curr Biol , vol.14 , pp. 2052-2056
    • Shutes, A.1    Berzat, A.C.2    Cox, A.D.3    Der, C.J.4
  • 21
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • Van Aelst L and D'Souza-Schorey C: Rho GTPases and signaling networks. Genes Dev 11: 2295-2322, 1997.
    • (1997) Genes Dev , vol.11 , pp. 2295-2322
    • Van Aelst, L.1    D'Souza-Schorey, C.2
  • 22
    • 0032489841 scopus 로고    scopus 로고
    • A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion
    • Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A and Chardin P: A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J Cell Biol 141: 187-197, 1998.
    • (1998) J Cell Biol , vol.141 , pp. 187-197
    • Nobes, C.D.1    Lauritzen, I.2    Mattei, M.G.3    Paris, S.4    Hall, A.5    Chardin, P.6
  • 23
    • 41149122298 scopus 로고    scopus 로고
    • Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF (FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1
    • Hayakawa M, Matsushima M, Hagiwara H, et al: Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF (FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1. Genes Cells 13: 329-342, 2008.
    • (2008) Genes Cells , vol.13 , pp. 329-342
    • Hayakawa, M.1    Matsushima, M.2    Hagiwara, H.3
  • 24
    • 0141521654 scopus 로고    scopus 로고
    • Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin
    • Chunqiu Hou J and Pessin JE: Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin. Mol Biol Cell 14: 3578-3591, 2003.
    • (2003) Mol Biol Cell , vol.14 , pp. 3578-3591
    • Chunqiu Hou, J.1    Pessin, J.E.2
  • 25
    • 33748626907 scopus 로고    scopus 로고
    • Zyxin is upregulated in the nucleus by thymosin beta4 in SiHa cells
    • Moon HS, Even-Ram S, Kleinman HK and Cha HJ: Zyxin is upregulated in the nucleus by thymosin beta4 in SiHa cells. Exp Cell Res 312: 3425-3431, 2006.
    • (2006) Exp Cell Res , vol.312 , pp. 3425-3431
    • Moon, H.S.1    Even-Ram, S.2    Kleinman, H.K.3    Cha, H.J.4
  • 26
    • 0026514995 scopus 로고
    • BTG1, a member of a new family of antiproliferative genes
    • Rouault JP, Rimokh R, Tessa C, et al: BTG1, a member of a new family of antiproliferative genes. EMBO J 11: 1663-1670, 1992.
    • (1992) EMBO J , vol.11 , pp. 1663-1670
    • Rouault, J.P.1    Rimokh, R.2    Tessa, C.3
  • 27
    • 16244408025 scopus 로고    scopus 로고
    • Coupling of human circadian and cell cycles by the timeless protein
    • Unsal-Kacmaz K, Mullen TE, Kaufmann WK and Sancar A: Coupling of human circadian and cell cycles by the timeless protein. Mol Cell Biol 25: 3109-3116, 2005.
    • (2005) Mol Cell Biol , vol.25 , pp. 3109-3116
    • Unsal-Kacmaz, K.1    Mullen, T.E.2    Kaufmann, W.K.3    Sancar, A.4
  • 29
    • 33847083441 scopus 로고    scopus 로고
    • Silencing of stathmin induces tumor-suppressor function in breast cancer cell lines harboring mutant p53
    • Alli E, Yang JM and Hait WN: Silencing of stathmin induces tumor-suppressor function in breast cancer cell lines harboring mutant p53. Oncogene 26: 1003-1012, 2007.
    • (2007) Oncogene , vol.26 , pp. 1003-1012
    • Alli, E.1    Yang, J.M.2    Hait, W.N.3
  • 31
    • 43749115174 scopus 로고    scopus 로고
    • Cofactor D functions as a centrosomal protein and is required for the recruitment of the gamma-tubulin ring complex at centrosomes and organization of the mitotic spindle
    • Cunningham LA and Kahn RA: Cofactor D functions as a centrosomal protein and is required for the recruitment of the gamma-tubulin ring complex at centrosomes and organization of the mitotic spindle. J Biol Chem 283: 7155-7165, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 7155-7165
    • Cunningham, L.A.1    Kahn, R.A.2
  • 32
    • 0035937180 scopus 로고    scopus 로고
    • MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody
    • Hirose K, Kawashima T, Iwamoto I, Nosaka T and Kitamura T: MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. J Biol Chem 276: 5821-5828, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 5821-5828
    • Hirose, K.1    Kawashima, T.2    Iwamoto, I.3    Nosaka, T.4    Kitamura, T.5
  • 33
    • 33751569886 scopus 로고    scopus 로고
    • Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2
    • Hanisch A, Sillje HH and Nigg EA: Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. EMBO J 25: 5504-5515, 2006.
    • (2006) EMBO J , vol.25 , pp. 5504-5515
    • Hanisch, A.1    Sillje, H.H.2    Nigg, E.A.3
  • 34
    • 0040142238 scopus 로고    scopus 로고
    • Biochemical and kinetic characterization of the RNA helicase activity of eukaryotic initiation factor 4A
    • Rogers GW Jr, Richter NJ and Merrick WC: Biochemical and kinetic characterization of the RNA helicase activity of eukaryotic initiation factor 4A. J Biol Chem 274: 12236-12244, 1999. (Pubitemid 129517981)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.18 , pp. 12236-12244
    • Rogers Jr., G.W.1    Richter, N.J.2    Merrick, W.C.3
  • 35
    • 0037311233 scopus 로고    scopus 로고
    • Eukaryotic translation initiation factors and regulators
    • Sonenberg N and Dever TE: Eukaryotic translation initiation factors and regulators. Curr Opin Struct Biol 13: 56-63, 2003.
    • (2003) Curr Opin Struct Biol , vol.13 , pp. 56-63
    • Sonenberg, N.1    Dever, T.E.2
  • 36
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L and Moorhead PS: The serial cultivation of human diploid cell strains. Exp Cell Res 25: 585-621, 1961.
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 37
    • 36549027541 scopus 로고    scopus 로고
    • Scientists study 'senescence' in cancer: Therapies aim to hold cells in a non-dividing state
    • Hampton T: Scientists study 'senescence' in cancer: therapies aim to hold cells in a non-dividing state. JAMA 298: 2357-2358, 2007.
    • (2007) JAMA , vol.298 , pp. 2357-2358
    • Hampton, T.1
  • 38
    • 0035736138 scopus 로고    scopus 로고
    • If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
    • Roninson IB, Broude EV and Chang BD: If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat 4: 303-313, 2001.
    • (2001) Drug Resist Updat , vol.4 , pp. 303-313
    • Roninson, I.B.1    Broude, E.V.2    Chang, B.D.3
  • 39
    • 66349101884 scopus 로고    scopus 로고
    • Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence
    • Byun HO, Han NK, Lee HJ, et al: Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence. Cancer Res 69: 4638-4647, 2009.
    • (2009) Cancer Res , vol.69 , pp. 4638-4647
    • Byun, H.O.1    Han, N.K.2    Lee, H.J.3
  • 40
    • 0033730616 scopus 로고    scopus 로고
    • Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
    • Kurz DJ, Decary S, Hong Y and Erusalimsky JD: Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J Cell Sci 113 ( Pt 20): 3613-3622, 2000.
    • (2000) J Cell Sci , vol.113 , Issue.PART 20 , pp. 3613-3622
    • Kurz, D.J.1    Decary, S.2    Hong, Y.3    Erusalimsky, J.D.4
  • 41
    • 0034639933 scopus 로고    scopus 로고
    • Characterization of the sialidase molecular defects in sialidosis patients suggests the structural organization of the lysosomal multienzyme complex
    • Lukong KE, Elsliger MA, Chang Y, et al: Characterization of the sialidase molecular defects in sialidosis patients suggests the structural organization of the lysosomal multienzyme complex. Hum Mol Genet 9: 1075-1085, 2000.
    • (2000) Hum Mol Genet , vol.9 , pp. 1075-1085
    • Lukong, K.E.1    Elsliger, M.A.2    Chang, Y.3
  • 42
    • 53149103203 scopus 로고    scopus 로고
    • Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2
    • Hinek A, Bodnaruk TD, Bunda S, Wang Y and Liu K: Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2. Am J Pathol 173: 1042-1056, 2008.
    • (2008) Am J Pathol , vol.173 , pp. 1042-1056
    • Hinek, A.1    Bodnaruk, T.D.2    Bunda, S.3    Wang, Y.4    Liu, K.5
  • 43
    • 33746770369 scopus 로고    scopus 로고
    • Structure meets function, centrosomes, genome maintenance and the DNA damage response
    • Loffler H, Lukas J, Bartek J and Kramer A: Structure meets function, centrosomes, genome maintenance and the DNA damage response. Exp Cell Res 312: 2633-2640, 2006.
    • (2006) Exp Cell Res , vol.312 , pp. 2633-2640
    • Loffler, H.1    Lukas, J.2    Bartek, J.3    Kramer, A.4
  • 44
    • 3042781117 scopus 로고    scopus 로고
    • Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts
    • Hutter E, Renner K, Pfister G, Stockl P, Jansen-Durr P and Gnaiger E: Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 380: 919-928, 2004.
    • (2004) Biochem J , vol.380 , pp. 919-928
    • Hutter, E.1    Renner, K.2    Pfister, G.3    Stockl, P.4    Jansen-Durr, P.5    Gnaiger, E.6
  • 45
    • 0346256784 scopus 로고    scopus 로고
    • Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
    • Zwerschke W, Mazurek S, Stockl P, Hutter E, Eigenbrodt E and Jansen-Durr P: Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. Biochem J 376: 403-411, 2003.
    • (2003) Biochem J , vol.376 , pp. 403-411
    • Zwerschke, W.1    Mazurek, S.2    Stockl, P.3    Hutter, E.4    Eigenbrodt, E.5    Jansen-Durr, P.6
  • 46
    • 0036498754 scopus 로고    scopus 로고
    • Microarray analysis of E-box binding-related gene expression in young and replicatively senescent human fibroblasts
    • DOI 10.1006/abio.2001.5515
    • Semov A, Marcotte R, Semova N, Ye X and Wang E: Microarray analysis of E-box binding-related gene expression in young and replicatively senescent human fibroblasts. Anal Biochem 302: 38-51, 2002. (Pubitemid 34174607)
    • (2002) Analytical Biochemistry , vol.302 , Issue.1 , pp. 38-51
    • Semov, A.1    Marcotte, R.2    Semova, N.3    Ye, X.4    Wang, E.5
  • 48
    • 20144388990 scopus 로고    scopus 로고
    • Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells
    • Akerman GS, Rosenzweig BA, Domon OE, et al: Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells. Environ Mol Mutagen 45: 188-205, 2005.
    • (2005) Environ Mol Mutagen , vol.45 , pp. 188-205
    • Akerman, G.S.1    Rosenzweig, B.A.2    Domon, O.E.3
  • 49
    • 15244350408 scopus 로고    scopus 로고
    • Radiation induces different changes in expression profiles of normal rectal tissue compared with rectal carcinoma
    • Nagtegaal ID, Gaspar CG, Peltenburg LT, et al: Radiation induces different changes in expression profiles of normal rectal tissue compared with rectal carcinoma. Virchows Arch 446: 127-135, 2005.
    • (2005) Virchows Arch , vol.446 , pp. 127-135
    • Nagtegaal, I.D.1    Gaspar, C.G.2    Peltenburg, L.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.