Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation

Journal of Biological Chemistry

Volumn 285, Issue 28, 2010, Pages 21526-21536

  Lim, Ssang Taek ^a   Chen, Xiao Lei ^a   Tomar, Alok ^a   Miller, Nichol L G ^a   Yoo, Jiyeon ^a   Schlaepfer, David D ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC DOMAINS; CELL MOTILITY; DEVELOPMENT RESULTS; EX-VIVO; FOCAL ADHESION KINASE; FOCAL ADHESIONS; GROWTH FACTOR; HOMOLOGOUS RECOMBINATION; IN-CELL; INTEGRINS; MOUSE EMBRYO FIBROBLASTS; NEOVASCULARIZATION; POINT MUTATIONS; PRIMARY CAPILLARY PLEXUS; RHOA GTPASE; SIGNALING PROTEINS; TYROSINE PHOSPHORYLATION; WORK SUPPORT; YOLK SAC;

ADHESION; AMINO ACIDS; BLOOD; CELL CULTURE; CELL PROLIFERATION; DEFECTS; ENDOTHELIAL CELLS; FOCUSING; GROWTH KINETICS; PHOSPHATASES; PHOSPHORYLATION;

BLOOD VESSELS;

ARGININE; FIBRONECTIN; FOCAL ADHESION KINASE; LYSINE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TYROSINE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CELL MIGRATION; CELL MOTILITY; CELL POLARITY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOLYSIS; DEVELOPMENT; EMBRYO; ENDOTHELIUM CELL; ENZYME ACTIVITY; EX VIVO STUDY; FIBROBLAST; HOMOLOGOUS RECOMBINATION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; YOLK SAC;

ANIMALS; ANTIGENS, CD31; BLOOD VESSELS; CELL MOVEMENT; CELL PROLIFERATION; FIBRONECTINS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GOLGI APPARATUS; GTPASE-ACTIVATING PROTEINS; HOMOZYGOTE; MICE; MUTATION; RECOMBINATION, GENETIC; REPRESSOR PROTEINS;

EID: 77954351473     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.129999     Document Type: Article

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