Tiny dancers: The integrin-growth factor nexus in angiogenic signaling

Journal of Cell Biology

Volumn 158, Issue 1, 2002, Pages 17-21

  Smyth, Susan S ^a   Patterson, Cam ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Angiogenesis; Growth factor receptors; Growth factors; Integrins; Signal transduction pathways

Indexed keywords

GROWTH FACTOR; INTEGRIN;

ANGIOGENESIS; CELL INTERACTION; ENZYME INHIBITION; EXTRACELLULAR MATRIX; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SHORT SURVEY; SIGNAL TRANSDUCTION; TIGHT JUNCTION;

ANIMALS; GROWTH SUBSTANCES; HUMANS; INTEGRINS; MODELS, BIOLOGICAL; NEOVASCULARIZATION, PHYSIOLOGIC; SIGNAL TRANSDUCTION;

NEXUS;

EID: 0037043328     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200202100     Document Type: Short Survey

References (41)

1. Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins
2. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins
3. Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the β3 integrin through its extracellular domain
4. Thrombospondins as matricellular modulators of cell function
5. Requirement of vascular integrin αvβ3 for angiogenesis
6. Integrin αVβ3 antagonists promote tumor regression by inducing apoprosis of angiogenic blood vessels
7. A mechanism for modulation of cellular responses to VEGF: Activation of the integrins
8. ANGPTL3 stimulares endothelial cell adhesion and migration via integrin αVβ3 and induces blood vessel formation in vivo
9. Direct cell adhesion to the angiopoietins mediated by integrins
10. FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition
11. NSAIDs inhibit αVβ3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis
12. Integrin αVβ3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis
13. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
14. Src-mediated coupling of Fak to integrin αvβ5 in VEGF signaling
15. Basic FGF and TGF-β differentially modulate integrin expression of human microvascular endothelial cells
16. Definition of two angiogenic pathways by distinct αv integrins
17. CYR61 stimulates human skin fibroblast migration through integrin αvβ5 and enhances mitogenesis through integrin αvβ3, independent of its carboxyl-terminal domain
18. Cloning and characterization of developmental endothelial locus-1: An embryonic endothelial cell protein that binds the αvβ3 integrin receptor
19. β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
20. Normal development, wound healing, and adenovirus susceptibility in β5-deficient mice
21. Regulation of integrin αVβ3-mediated endothelial cell migration and angiogenesis by integrin α5β1 and protein kinase A
22. Rac recruit high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration Nat
23. Two RGD-independent αVβ3 integrin binding sites on tumstatin regulate distinct anti-tumor properties
24. Extracellular matrix-derived peptide binds to αvβ3 integrin and inhibits angiogenesis
25. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis
26. Cleavage of the cytoplasmic domain of the integrin β3 subunit during endothelial cell apoptosis
27. Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke
28. Del1 induces integrin signaling and angiogenesis by ligation of αvβ5
29. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex
30. Interaction of endostatin with integrins implicated in angiogenesis
31. Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins
32. NF-kappaB mediates αvβ3 integrin-induced endothelial cell survival
33. Basic fibroblast growth factor increases expression of the αVβ3 integrin complex on human microvascular endothelial cells
34. Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the αvβ3 integrin, osteopontin, and thrombin
35. The αVβ3 integrin regulates α5β1-mediated cell migration toward fibronectin
36. Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor-2
37. Suppression of p53 activity and p21WAFI/CIP1 expression by vascular cell integrin αVβ3 during angiogenesis
38. Loss of p53 compensates for αV-integrin function in retinal neovascularization
39. Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins
40. Specific interaction of angiostatin with integrin αVβ3 in endothelial cells
41. VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain