Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival

Journal of Biological Chemistry

Volumn 285, Issue 3, 2010, Pages 1743-1753

  Lim, Ssang Taek ^a   Miller, Nichol L G ^a   Nam, Ju Ock ^a   Chen, Xiao Lei ^a   Lim, Yangmi ^a,b   Schlaepfer, David D ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b Mogam Biotechnology Research Institute   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CELL LINES; CELL-CYCLE ARREST; CIS-PLATIN; CYTOPLASMIC TYROSINE KINASE; FOCAL ADHESION KINASE; HUMAN FIBROBLAST; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; INTRINSIC MECHANISMS; MOUSE EMBRYO FIBROBLASTS; NUCLEAR ACCUMULATION; NUCLEAR LOCALIZATION; OVARIAN CARCINOMA CELL; STAUROSPORINES; TUMOR SUPPRESSORS; UBIQUITINATION; UP-REGULATION;

AMINO ACIDS; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; FIBROBLASTS; GROWTH KINETICS; PHOSPHATASES; PLATINUM COMPOUNDS;

ENDOTHELIAL CELLS;

FOCAL ADHESION KINASE; FOCAL ADHESION KINASE 2; PROTEIN P53; STAUROSPORINE; BROXURIDINE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; PROTEIN MDM2;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL SURVIVAL; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; UBIQUITINATION; ACTIVE TRANSPORT; ADAPTATION; ANIMAL; CELL CYCLE; CHEMISTRY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; MUTATION; PHYSIOLOGICAL STRESS; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

MUS;

ACTIVE TRANSPORT, CELL NUCLEUS; ADAPTATION, PHYSIOLOGICAL; ANIMALS; BROMODEOXYURIDINE; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FOCAL ADHESION KINASE 2; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MDM2; STAUROSPORINE; STRESS, PHYSIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 76249097844     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.064212     Document Type: Article

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