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Volumn 13, Issue 8, 1996, Pages 753-757

Effect of metformin on intact proinsulin and des 31,32 proinsulin concentrations in subjects with non-insulin-dependent (Type 2) diabetes mellitus

Author keywords

des 31,32 proinsulin; Insulin; Metformin; Proinsulin

Indexed keywords

GLUCOSE; INSULIN; METFORMIN; PLACEBO; PROINSULIN;

EID: 8944248809     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9136(199608)13:8<753::AID-DIA163>3.0.CO;2-Z     Document Type: Article
Times cited : (38)

References (31)
  • 2
    • 0027399661 scopus 로고
    • The effects of metformin on insulin resistance, risk factors for cardiovascular disease and plasminogen activator inhibitor in NIDDM subjects - A study of two ethnic groups
    • Nagi DK, Yudkin JS. The effects of metformin on insulin resistance, risk factors for cardiovascular disease and plasminogen activator inhibitor in NIDDM subjects - a study of two ethnic groups. Diabetes Care 1993; 16: 621-629.
    • (1993) Diabetes Care , vol.16 , pp. 621-629
    • Nagi, D.K.1    Yudkin, J.S.2
  • 3
    • 0022881373 scopus 로고
    • Effects of metformin on peripheral insulin sensitivity in non-insulin dependent diabetes mellitus
    • Prager R, Schernthaner C, Graf H. Effects of metformin on peripheral insulin sensitivity in non-insulin dependent diabetes mellitus. Diabete et Metabolisme 1986; 12: 346-350.
    • (1986) Diabete et Metabolisme , vol.12 , pp. 346-350
    • Prager, R.1    Schernthaner, C.2    Graf, H.3
  • 4
    • 0023275154 scopus 로고
    • Effect of metformin on insulin-stimulated glucose turnover and insulin binding to receptors in type II diabetes
    • Nosadini R, Avogaro A, Trevisan R, Valerio A, Tessari P, Duner E, et al. Effect of metformin on insulin-stimulated glucose turnover and insulin binding to receptors in type II diabetes. Diabetes Care 1987; 10: 62-67.
    • (1987) Diabetes Care , vol.10 , pp. 62-67
    • Nosadini, R.1    Avogaro, A.2    Trevisan, R.3    Valerio, A.4    Tessari, P.5    Duner, E.6
  • 5
    • 0025837055 scopus 로고
    • Mechanism of metformin action in obese and lean non-insulin-dependent diabetic subjects
    • DeFronzo RA, Barzilay N, Simonson DC. Mechanism of metformin action in obese and lean non-insulin-dependent diabetic subjects. J Clin Endocrinol Metab 1991; 73: 1294-1301.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1294-1301
    • DeFronzo, R.A.1    Barzilay, N.2    Simonson, D.C.3
  • 6
    • 0017754243 scopus 로고
    • Comparison of metformin and chlorpropamide in non-obese maturity onset diabetics uncontrolled by diet
    • Clarke BF, Campbell IW. Comparison of metformin and chlorpropamide in non-obese maturity onset diabetics uncontrolled by diet. Br Med J 1977; 2: 1576-1578.
    • (1977) Br Med J , vol.2 , pp. 1576-1578
    • Clarke, B.F.1    Campbell, I.W.2
  • 7
    • 0014423575 scopus 로고
    • Comparison of chlorpropamide and metformin treatment on weight and blood glucose response of uncontrolled obese diabetics
    • Clarke BF, Duncan LJP. Comparison of chlorpropamide and metformin treatment on weight and blood glucose response of uncontrolled obese diabetics. Lancet 1968; i: 123-126.
    • (1968) Lancet , vol.1 , pp. 123-126
    • Clarke, B.F.1    Duncan, L.J.P.2
  • 8
    • 0001157421 scopus 로고
    • Biguanides: Basic aspects and clinical uses
    • Alberti KGMM, Defronzo RA, Keen HA, Zimmer PA, Eds. Chichester: Wiley
    • Hermann LS, Melander A. Biguanides: basic aspects and clinical uses. In: Alberti KGMM, Defronzo RA, Keen HA, Zimmer PA, Eds. International Textbook of Diabetes Mellitus. Chichester: Wiley 1992: 773-795.
    • (1992) International Textbook of Diabetes Mellitus , pp. 773-795
    • Hermann, L.S.1    Melander, A.2
  • 9
    • 0024493106 scopus 로고
    • Effects of dietary treatment on serum insulin and proinsulin response in newly diagnosed NIDDM
    • Yoshioka N, Kazuya T, Matsuda A, Iwamoto Y. Effects of dietary treatment on serum insulin and proinsulin response in newly diagnosed NIDDM. Diabetes 1989; 38: 262-267.
    • (1989) Diabetes , vol.38 , pp. 262-267
    • Yoshioka, N.1    Kazuya, T.2    Matsuda, A.3    Iwamoto, Y.4
  • 10
    • 0023634652 scopus 로고
    • Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin dependent) diabetes mellitus and in experimental insulin resistance
    • Ward WK, LaCava EC, Paquette TL, Beard JC, Wallum BJ, Porte D. Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin dependent) diabetes mellitus and in experimental insulin resistance. Diabetologia 1987; 30: 698-702.
    • (1987) Diabetologia , vol.30 , pp. 698-702
    • Ward, W.K.1    LaCava, E.C.2    Paquette, T.L.3    Beard, J.C.4    Wallum, B.J.5    Porte, D.6
  • 11
    • 0025036044 scopus 로고
    • The relationship between concentrations of insulin, intact proinsulin, and 32-33 split proinsulin and cardiovascular risk factors in type 2 (non-insulin-dependent) diabetic subjects
    • Nagi DK, Hendra TJ, Ryle AJ, Cooper TM, Temple RC, Clark PMS, et al. The relationship between concentrations of insulin, intact proinsulin, and 32-33 split proinsulin and cardiovascular risk factors in type 2 (non-insulin-dependent) diabetic subjects. Diabetologia 1990; 33: 532-537.
    • (1990) Diabetologia , vol.33 , pp. 532-537
    • Nagi, D.K.1    Hendra, T.J.2    Ryle, A.J.3    Cooper, T.M.4    Temple, R.C.5    Clark, P.M.S.6
  • 12
    • 0027389774 scopus 로고
    • Increased proinsulin/insulin ratio in pancreas extracts of hyperglycemic rats
    • Leahy JL. Increased proinsulin/insulin ratio in pancreas extracts of hyperglycemic rats. Diabetes 1993; 42: 22-27.
    • (1993) Diabetes , vol.42 , pp. 22-27
    • Leahy, J.L.1
  • 13
    • 0025736943 scopus 로고
    • Relative hypersecretion of proinsulin in rat model of NIDDM
    • Leahy JL, Halban PA, Weir GC. Relative hypersecretion of proinsulin in rat model of NIDDM. Diabetes 1991; 40: 985-989.
    • (1991) Diabetes , vol.40 , pp. 985-989
    • Leahy, J.L.1    Halban, P.A.2    Weir, G.C.3
  • 14
    • 0027251601 scopus 로고
    • Insulin deficiency rather than hyperinsulinaemia in newly diagnosed type 2 diabetes mellitus
    • Davies MJ, Metcalf J, Gray IP, Day JL, Hales CN. Insulin deficiency rather than hyperinsulinaemia in newly diagnosed type 2 diabetes mellitus. Diabetic Med 1993; 10: 305-312.
    • (1993) Diabetic Med , vol.10 , pp. 305-312
    • Davies, M.J.1    Metcalf, J.2    Gray, I.P.3    Day, J.L.4    Hales, C.N.5
  • 15
    • 8944253336 scopus 로고
    • The relationship between insulin, intact proinsulin, des 31,32 proinsulin and other cardiovascular risk factors in non-diabetic subjects
    • Mohamed-Ali V, Gould M, Goubet S, Yudkin JS. The relationship between insulin, intact proinsulin, des 31,32 proinsulin and other cardiovascular risk factors in non-diabetic subjects. Diabetic Med 1993; 10 (suppl 2): P54.
    • (1993) Diabetic Med , vol.10 , Issue.2 SUPPL.
    • Mohamed-Ali, V.1    Gould, M.2    Goubet, S.3    Yudkin, J.S.4
  • 16
    • 0027282072 scopus 로고
    • The relationship of proinsulin and insulin to cardiovascular risk factors in non-diabetic subjects
    • Haffner SM, Mykkanen L, Stern MP, Valdez RA, Heisserman JA, Bowsher RR. The relationship of proinsulin and insulin to cardiovascular risk factors in non-diabetic subjects. Diabetes 1993; 42: 1297-1302.
    • (1993) Diabetes , vol.42 , pp. 1297-1302
    • Haffner, S.M.1    Mykkanen, L.2    Stern, M.P.3    Valdez, R.A.4    Heisserman, J.A.5    Bowsher, R.R.6
  • 17
    • 0024340494 scopus 로고
    • Sensitive and specific two-site immunoradiometric assays to human insulin, proinsulin, 65-66 split and 32-33 split proinsulin
    • Sobey WJ, Beer SF, Carrington CA, Clark PMS, Frank BH, Gray P, et al. Sensitive and specific two-site immunoradiometric assays to human insulin, proinsulin, 65-66 split and 32-33 split proinsulin. Biochem J 1989: 260; 535-541.
    • (1989) Biochem J , vol.260 , pp. 535-541
    • Sobey, W.J.1    Beer, S.F.2    Carrington, C.A.3    Clark, P.M.S.4    Frank, B.H.5    Gray, P.6
  • 18
    • 0344568445 scopus 로고
    • An end-point amplified enzymoimmunoassay (IEMA) specific for human insulin
    • Mohamed-Ali V, Yudkin JS. An end-point amplified enzymoimmunoassay (IEMA) specific for human insulin. Clin Sci 1992; 82 (suppl 27) P4.
    • (1992) Clin Sci , vol.82 , Issue.27 SUPPL.
    • Mohamed-Ali, V.1    Yudkin, J.S.2
  • 19
    • 7844239519 scopus 로고
    • Simple and highly sensitive microplate assays (IRMAs) for intact proinsulin and des 31,32 proinsulin
    • Mohamed-Ali V, Yudkin JS. Simple and highly sensitive microplate assays (IRMAs) for intact proinsulin and des 31,32 proinsulin. Diabetic Med 1993; 10 (suppl 1) P67.
    • (1993) Diabetic Med , vol.10 , Issue.1 SUPPL.
    • Mohamed-Ali, V.1    Yudkin, J.S.2
  • 20
    • 0021053614 scopus 로고
    • Evidence of a rapid inhibitor to tissue plasminogen activators in plasma
    • Chmieiewska J, Ranby M, Wiman B. Evidence of a rapid inhibitor to tissue plasminogen activators in plasma. Thromb Res 1983; 31: 427-436.
    • (1983) Thromb Res , vol.31 , pp. 427-436
    • Chmieiewska, J.1    Ranby, M.2    Wiman, B.3
  • 23
    • 0028137716 scopus 로고
    • Improved Beta cell function, with reduction in secretion of intact and 32,33 split proninsulin, after dietary intervention in subjects with Type 2 diabetes mellitus
    • Davies MJ, Metcalf J, Day JL, Grenfell A, Hales CN, Gray IP. Improved Beta cell function, with reduction in secretion of intact and 32,33 split proninsulin, after dietary intervention in subjects with Type 2 diabetes mellitus. Diabetic Med 1994; 11: 71-78.
    • (1994) Diabetic Med , vol.11 , pp. 71-78
    • Davies, M.J.1    Metcalf, J.2    Day, J.L.3    Grenfell, A.4    Hales, C.N.5    Gray, I.P.6
  • 24
    • 0019995911 scopus 로고
    • The long-term effects of chlorpropamide on insulin, C-peptide, and proinsulin secretion
    • Elkeles RS, Heding LG, Paisey RB. The long-term effects of chlorpropamide on insulin, C-peptide, and proinsulin secretion. Diabetes Care 1982; 5: 427-429.
    • (1982) Diabetes Care , vol.5 , pp. 427-429
    • Elkeles, R.S.1    Heding, L.G.2    Paisey, R.B.3
  • 25
    • 0015413087 scopus 로고
    • Effect of chronic sulphonylurea therapy on plasma insulin and proinsulin levels
    • Duckworth WC, Solomon S, Kitabchi AE. Effect of chronic sulphonylurea therapy on plasma insulin and proinsulin levels. J Clin Endocrinol Metab 1974; 35: 585-591.
    • (1974) J Clin Endocrinol Metab , vol.35 , pp. 585-591
    • Duckworth, W.C.1    Solomon, S.2    Kitabchi, A.E.3
  • 26
    • 0028314832 scopus 로고
    • Effect of sulphonylurea therapy on plasma insulin, intact proinsulin, and 32,33 split proinsulin in subjects with Type 2 diabetes mellitus
    • Davies MJ, Metcalf J, Day JL, Grenfell A, Gray IP, Hales CN. Effect of sulphonylurea therapy on plasma insulin, intact proinsulin, and 32,33 split proinsulin in subjects with Type 2 diabetes mellitus. Diabetic Med 1994; 11: 293-298.
    • (1994) Diabetic Med , vol.11 , pp. 293-298
    • Davies, M.J.1    Metcalf, J.2    Day, J.L.3    Grenfell, A.4    Gray, I.P.5    Hales, C.N.6
  • 27
    • 0028204065 scopus 로고
    • Understanding oral glucose tolerance: Comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion
    • Phillips DIW, Clark PM, Hales CN, Osmond C. Understanding oral glucose tolerance: Comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabetic Med 1994; 11: 286-292.
    • (1994) Diabetic Med , vol.11 , pp. 286-292
    • Phillips, D.I.W.1    Clark, P.M.2    Hales, C.N.3    Osmond, C.4
  • 28
    • 8944244562 scopus 로고
    • Proinsulin-like molecules relate to insulin resistance in non-insulin-dependent diabetes
    • Panahloo A, Mohamed-Ali V, Denver E, Andres C, Yudkin JS. Proinsulin-like molecules relate to insulin resistance in non-insulin-dependent diabetes. Diabetic Med 1994; 11 (suppl 2): A24.
    • (1994) Diabetic Med , vol.11 , Issue.2 SUPPL.
    • Panahloo, A.1    Mohamed-Ali, V.2    Denver, E.3    Andres, C.4    Yudkin, J.S.5
  • 29
    • 0026239966 scopus 로고
    • The enzymology of proinsulin conversion
    • Hutton JC, Rhodes CJ. The enzymology of proinsulin conversion. Cell Biophysics 1991; 19: 57-62.
    • (1991) Cell Biophysics , vol.19 , pp. 57-62
    • Hutton, J.C.1    Rhodes, C.J.2
  • 30
    • 0023217851 scopus 로고
    • Daily insulin dose as a predictor of macrovascular disease in insulin treated non-insulin-dependent diabetics
    • Janka HU, Ziegler AG, Standl E, Mehnert H. Daily insulin dose as a predictor of macrovascular disease in insulin treated non-insulin-dependent diabetics. Diabete & Metabolisme 1987; 13: 359-364.
    • (1987) Diabete & Metabolisme , vol.13 , pp. 359-364
    • Janka, H.U.1    Ziegler, A.G.2    Standl, E.3    Mehnert, H.4
  • 31
    • 0022331714 scopus 로고
    • High serum insulin concentrations in relation to other cardiovascular risk factors in macrovas-cular disease of Type 2 diabetes
    • Standl E, Janka HU. High serum insulin concentrations in relation to other cardiovascular risk factors in macrovas-cular disease of Type 2 diabetes. Horm Metab Res 1985; 15: 46-51.
    • (1985) Horm Metab Res , vol.15 , pp. 46-51
    • Standl, E.1    Janka, H.U.2


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