14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway

British Journal of Pharmacology

Volumn 160, Issue 7, 2010, Pages 1823-1843

  Roy, D N ^a   Mandal, S ^a   Sen, G ^a   Mukhopadhyay, S ^a   Biswas, T ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

14 deoxyandrographolide; andrographolide; apoptosis; Ca ATPase; calcium; cGMP; hepatocytes; nitric oxide; TNF ; TNFR1; TNFRSF1A

Indexed keywords

14 DEOXYANDROGRAPHOLIDE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ARTS 1 PROTEIN; CALCIUM; CYCLIC GMP; LIGAND; NITRIC OXIDE; NUCLEOBINDIN 2; PROTEIN; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; TRANSFERASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 1A; UNCLASSIFIED DRUG;

ANDROGRAPHIS PANICULATA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASSAY; CALCIUM TRANSPORT; CELL NUCLEUS; CELL SURFACE; CELL VACUOLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; DRUG EFFICACY; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; FLUOROMETRY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER CELL CULTURE; LIVER DYSFUNCTION; LIVER PROTECTION; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SECRETION; RAT;

ANDROGRAPHIS; ANIMALS; APOPTOSIS; CALCIUM; CALCIUM-TRANSPORTING ATPASES; CELLS, CULTURED; CYCLIC GMP; DITERPENES; ENDOPLASMIC RETICULUM; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATOCYTES; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NITRIC OXIDE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77954331797     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00836.x     Document Type: Article

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