Superoxide anion mediated mitochondrial dysfunction leads to hepatocyte apoptosis preferentially in the periportal region during copper toxicity in rats

Chemico-Biological Interactions

Volumn 182, Issue 2-3, 2009, Pages 136-147

  Roy, Dijendra Nath ^a   Mandal, Samir ^a   Sen, Gargi ^a   Biswas, Tuli ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Copper toxicity; Hepatocyte apoptosis; Mitochondrial dysfunction; Periportal region; Superoxide anion

Indexed keywords

ADENOSINE TRIPHOSPHATE; COPPER; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; THIOPHENE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENZYME ACTIVITY; IN VIVO STUDY; LIVER CELL; LIVER INJURY; LIVER TOXICITY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OXIDATION REDUCTION REACTION; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL NUCLEOLUS; COPPER; GLUTATHIONE; HEPATOCYTES; INTRACELLULAR MEMBRANES; LIVER; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; SUPEROXIDES;

RATTUS;

EID: 70350134241     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.08.014     Document Type: Article

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