Effect of 14-deoxyandrographolide on Calcium-mediated Rat Uterine Smooth Muscle Contractility

Phytotherapy Research

Volumn 17, Issue 9, 2003, Pages 1011-1015

  Burgos, Rafael A ^a   Loyola, Mario ^a   Hidalgo, María A ^a   Labranche, Timothy P ^b   Hancke, Juan L ^a  

^a UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

^b VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

Author keywords

14 deoxyandrographolide; Calcium channel; Rat uterus

Indexed keywords

14 DEOXYANDROGRAPHOLIDE; ANDROGRAPHIS PANICULATA EXTRACT; CALCIUM; CALCIUM CHANNEL; CALCIUM CHLORIDE; ISOPRENALINE; OXYTOCIN; PHENYLBUTAZONE; PROSTAGLANDIN F2 ALPHA; SPASMOLYTIC AGENT; UNCLASSIFIED DRUG; VANADIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; IC 50; MYOMETRIUM; NONHUMAN; RAT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE RELAXATION;

ANDROGRAPHIS; ANIMALS; CALCIUM CHLORIDE; DINOPROST; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INHIBITORY CONCENTRATION 50; ISOPROTERENOL; MUSCLE, SMOOTH; OXYTOCIN; PHENYLBUTAZONE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; UTERINE CONTRACTION; VANADATES;

EID: 0242268444     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1275     Document Type: Article

References (24)

1. Berkels R, Egink G, Marsen TA, Bartels H, Roesen R, Klaus W. 2001. Nifedipine increases endothelial nitric oxide bioavailability by antioxidative mechanisms. Hypertension 37: 240-245.
2. +2 influx. Phytother Res 15: 235-239.
3. Burgos RA, Imilan M, Sánchez NS, Hancke JL. 2000. Andrographis paniculata (Ness) Selectively blocks voltage operated calcium channels in rat vas deferens. J Ethnopharmacol 71: 115-121.
4. 2+ transport systems of the adipocyte plasma membrane and endoplasmic reticulum. Arch Biochem Biophys 241: 665-672.
5. Fernandez AI, Cantabrana B, Hidalgo A. 1992. Mediators involved in the rat uterus contraction in calcium-free solution. Gen Pharmacol 23: 291-296.
6. i following OX stimulation in cultured human myocytes and on myometrial OX receptor. Acta Obstet Gynaecol Jp 45: 636-642.
7. 2+. Eur J Pharmacol 220: 99-102.
8. Gimpl G, Fahrenholz F. 2001. The oxytocin receptor system: structure, function, and regulation. Physiol Rev 81: 629-683.
9. Hidalgo A, Cantabrana B, Perez-Vallina JR. 1998. Contribution of cAMP to the inhibitory effect of non-steroidal antiinflammatory drugs in rat uterine smooth muscle. J Auton Pharmacol 18: 31-37.
10. Ichida S, Moriyama M, Terao M. 1984. Characteristics of Ca influxes through voltage- and receptor-operated Ca channels in uterine smooth muscle. J Pharmacol Exp Ther 228: 439-445.
11. 2+ transport in myometrium. In Control of Uterine Contractility, Garfield RE, Tabb TN (eds). Boca Raton: Florida, USA; 129-154.
12. 2+-free medium. Br J Pharmacol 81: 317-326.
13. Marc S, Leiber D, Harbor S. 1986. Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium. FEBS Lett 201: 9-14.
14. Marshall JM, Fain JN. 1984. Effects of forskolin and isoproterenol on cyclic AMP and tension in the myometrium. Eur J Pharmacol 107: 25-34.
15. Matsuda T, Kuroyanagi M, Sugiyama S, Umeahra K, Ueno A, Nishi K. 1994. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chem Pharm Bull 42: 1216-1225.
16. 2+-free solution. Br J Pharmacol 82: 735-743.
17. Murad F. 1994. The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular communication. Recent Prog Horm Res 49: 239-248.
18. Perez Vallina JR, Cantabrana B, Hidalgo A. 1991. Mechanisms involved in the effects of phenidone, diclofenac and ethacrynic acid in rat uterus in vitro. Gen Pharmacol 22: 435-441.
19. Perez Vallina JR, Cantabrana B, Hidalgo A. 1995. Calcium-and G-protein-related spasmolytic effects of nonsteroidal antiinflammatory drugs on rat uterus contractions in vitro. Pharmacology 50: 324-332.
20. Sanborn BM, Dodge K, Monga M, Qian A, Wang W, Yue C. 1998. Molecular mechanisms regulating the effects of oxytocin on myometrial intracellular calcium. Adv Exp Med Biol 449: 277-286.
21. 2+)-ATPase activity in rat myometrial plasma membranes. J Biol Chem 257: 10687-10693.
22. Villar A, D'Ocon P, Anselmi E. 1986. Role of intracellular calcium stores in the contractile response of uterus to several agonists. J Pharmacol 17: 541-546.
23. Zhang CY, Tan BK. 1998. Vasorelaxation of rat thoracic aorta caused by 14-deoxyandrographolide. Clin Exp Pharmacol Physiol 25: 424-429.
24. Zhang CY, Tan BK. 1999. Effects of 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide on nitric oxide production in cultured human endothelial cells. Phytother Res 13: 157-159.