Structure-based design and characterization of exocyclic peptidomimetics that inhibit TNFα binding to its receptor

Nature Biotechnology

Volumn 15, Issue 12, 1997, Pages 1266-1270

  Takasaki, Wataru ^a   Kajino, Yuri ^a   Kajino, Kiichi ^a   Murali, Ramachandran ^a   Greene, Mark I ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Inflammation; Rational drug design; TNF inhibitor

Indexed keywords

PEPTIDE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DRUG SYNTHESIS; IMMUNOTHERAPY; INFLAMMATORY DISEASE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BINDING SITES; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030687562     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1197-1266     Document Type: Article

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