Interaction between double helix DNA fragments and a new topopyrone acting as human topoisomerase I poison

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 2, 2009, Pages 484-491

  Scaglioni, Leonardo ^a   Mazzini, Stefania ^a   Mondelli, Rosanna ^a   Dallavalle, Sabrina ^a   Gattinoni, Sonia ^a   Tinelli, Stella ^b   Beretta, Giovanni L ^b   Zunino, Franco ^b   Ragg, Enzio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Drug DNA interactions; NMR spectroscopy; Topoisomerase I inhibitors; Topopyrones

Indexed keywords

DNA FRAGMENT; DNA TOPOISOMERASE; LIGAND; PYRONE DERIVATIVE; RIBOSE PHOSPHATE; TOPOPYRONE A; TOPOPYRONE B; TOPOPYRONE C; TOPOPYRONE D; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CONFORMATIONAL TRANSITION; DNA HELIX; DRUG DNA BINDING; DRUG SYNTHESIS; INTERCALATION COMPLEX; MOLECULAR INTERACTION; MOLECULAR MODEL; NUCLEAR OVERHAUSER EFFECT; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; SURFACE PROPERTY;

ANTHRAQUINONES; BASE SEQUENCE; BINDING SITES; DNA; DNA TOPOISOMERASES, TYPE I; HUMANS; INTERCALATING AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACID CONFORMATION; PYRONES; SOLUBILITY;

EID: 58549095229     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.005     Document Type: Article

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