Polycationic dendrimers interact with RNA molecules: Polyamine dendrimers inhibit the catalytic activity of Candida ribozymes

Chemical Communications

Volumn , Issue 3, 2005, Pages 313-315

  Wu, Jiangyu ^a   Zhou, Jiehua ^a   Qu, Fanqi ^a   Bao, Penghui ^a   Zhang, Yi ^a   Peng, Ling ^a,b  

^a WUHAN UNIVERSITY   (China)

^b Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DENDRIMER; POLYAMINE; POLYCATION; RIBOZYME; RNA; TRIETHANOLAMINE;

ARTICLE; BINDING AFFINITY; CANDIDA; COMPLEX FORMATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; GEL MOBILITY SHIFT ASSAY; MOLECULAR INTERACTION; NONHUMAN; PROTEIN RNA BINDING; RNA STRUCTURE; SYNTHESIS;

EID: 13244283074     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b414241a     Document Type: Article

References (16)

1. (a) D. A. Tomalia, A. M. Naylor and W. A. Goddard, III, Angew. Chem., Int. Ed. Engl., 1990, 29, 138;
2. (b) J. M. J. Fréchet, J. Polym. Sci., Part A: Polym. Chem., 2003, 41, 3713.
3. S.-E. Stiriba, H. Frey and R. Haag, Angew. Chem., Int. Ed., 2002, 41, 1329.
4. M. J. Cloninger, Curr. Opin. Chem. Biol., 2002, 6, 742.
5. J. Haensler and F. C. Szoka, Jr., Bioconjugate Chem., 1993, 4, 372.
6. O. Boussif, F. Lezoualc'h, M. A. Zanta, M. D. Mergny, D. Scherman, B. Demeneix and J. P. Behr, Proc. Natl. Acad. Sci. USA, 1995, 92, 7297.
7. J. F. Kukowska-Latallo, A. U. Bielinska, J. Johnson, R. Spindler, D. A. Tomalia and J. R. Baker, Jr., Proc. Natl. Acad. Sci. USA, 1996, 93, 4897.
8. J. Dennig and E. Duncan, Rev. Mol. Biotechnol., 2002, 90, 339.
9. U. von Ahsen, J. Davies and R. Schroeder, Nature, 1991, 353, 368.
10. J. A. Doudna and T. R. Cech, Nature, 2002, 418, 222.
11. Y. Zhang and M. J. Leibowitz, Nucleic Acids Res., 2001, 29, 2644.
12. M. X. Tang, C. T. Redemann and F. C. Szoka, Jr., Bioconjugate Chem., 1996, 7, 703.
13. D. A. Tomalia, H. Baker, J. Dewald, M. Hall, G. Kallos, S. Martin, J. Roeck, J. Ryder and P. Smith, Polym. J., 1985, 17, 117.
14. 2, respectively, although we are aware that these amines are protonated in the assays.
15. M. Xiao, M. J. Leibowitz and Y. Zhang, Nucleic Acids Res., 2003, 31, 3901.
16. Y. Zhang, Z. Li, D. S. Pilch and M. J. Leibowitz, Nucleic Acids Res., 2002, 30, 2961.