Spices, herbal xenobiotics and the stomach: Friends or foes?

World Journal of Gastroenterology

Volumn 16, Issue 22, 2010, Pages 2710-2719

  Al Mofleh, Ibrahim Abdulkarim ^a  

^a KING KHALID UNIVERSITY HOSPITAL   (Saudi Arabia)

Author keywords

Anti ulcer agents; Herbs; Spices; Stomach; Stomach ulcers

Indexed keywords

CISSUS QUADRANGULARIS EXTRACT; CISSUS SICYOIDES EXTRACT; GINGER EXTRACT; HERBACEOUS AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; MOMORDICA CHARANTIA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANTIOXIDANT ACTIVITY; CECROPIACEAE; CELL PROTECTION; CHRONIC GASTRITIS; CISSUS QUADRANGULARIS; DUODENUM ULCER; EDITORIAL; FOOD SAFETY; GASTROENTERITIS; HELICOBACTER PYLORI; HERB; HUMAN; NONHUMAN; PEPTIC ULCER; PHYTOTHERAPY; PHYTOTOXICITY; RUTACEAE; SPICE; STOMACH MUCOSA; STOMACH PROTECTION; STOMACH ULCER; STRESS ULCER; ULCER HEALING;

EID: 77954296046     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v16.i22.2710     Document Type: Editorial

References (129)

1. Cai L, Wu CD. Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens. J Nat Prod 1996; 59: 987-990
2. Nanji AA, Jokelainen K, Tipoe GL, Rahemtulla A, Thomas P, Dannenberg AJ. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes. Am J Physiol Gastrointest Liver Physiol 2003; 284: G321-G327
3. Bengmark S. Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases. JPEN J Parenter Enteral Nutr 2006; 30: 45-51
4. Nicoll R, Henein MY. Ginger (Zingiber officinale Roscoe): a hot remedy for cardiovascular disease? Int J Cardiol 2009; 131: 408-409
5. Weseler A, Saller R, Reichling J. Comparative investigation of the antimicrobial activity of PADMA 28 and selected European herbal drugs. Forsch Komplementarmed Klass Naturheilkd 2002; 9: 346-351
6. Liu CS, Cham TM, Yang CH, Chang HW, Chen CH, Chuang LY. Antibacterial properties of Chinese herbal medicines against nosocomial antibiotic resistant strains of Pseudomonas aeruginosa in Taiwan. Am J Chin Med 2007; 35: 1047-1060
7. Shan B, Cai YZ, Brooks JD, Corke H. Antibacterial properties and major bioactive components of cinnamon stick (Cinnamomum burmannii): activity against foodborne pathogenic bacteria. J Agric Food Chem 2007; 55: 5484-5490
8. Chen HC, Chang MD, Chang TJ. [Antibacterial properties of some spice plants before and after heat treatment] Zhonghua Minguo Weisheng Wujimian Yixue Zazhi 1985; 18: 190-195
9. Tayel AA, El-Tras WF. Possibility of fighting food borne bacteria by egyptian folk medicinal herbs and spices extracts. J Egypt Public Health Assoc 2009; 84: 21-32
10. Sekine T, Sugano M, Majid A, Fujii Y. Antifungal effects of volatile compounds from black zira (Bunium persicum) and other spices and herbs. J Chem Ecol 2007; 33: 2123-2132
11. Seneviratne CJ, Wong RW, Samaranayake LP. Potent antimicrobial activity of traditional Chinese medicine herbs against Candida species. Mycoses 2008; 51: 30-34
12. Hitokoto H, Morozumi S, Wauke T, Sakai S, Kurata H. Inhibitory effects of spices on growth and toxin production of toxigenic fungi. Appl Environ Microbiol 1980; 39: 818-822
13. Karapinar M. Inhibitory effects of anethole and eugenol on the growth and toxin production of Aspergillus parasiticus. Int J Food Microbiol 1990; 10: 193-199
14. El Garhy MF, Mahmoud LH. Anthelminthic efficacy of traditional herbs on Ascaris lumbricoides. J Egypt Soc Parasitol 2002; 32: 893-900
15. Kiuchi F, Goto Y, Sugimoto N, Akao N, Kondo K, Tsuda Y. Nematocidal activity of turmeric: synergistic action of curcuminoids. Chem Pharm Bull (Tokyo) 1993; 41: 1640-1643
16. Sharma JN, Srivastava KC, Gan EK. Suppressive effects of eugenol and ginger oil on arthritic rats. Pharmacology 1994; 49: 314-318
17. Setty AR, Sigal LH. Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects. Semin Arthritis Rheum 2005; 34: 773-784
18. Li EK, Tam LS, Wong CK, Li WC, Lam CW, Wachtel-Galor S, Benzie IF, Bao YX, Leung PC, Tomlinson B. Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial. Arthritis Rheum 2007; 57: 1143-1150
19. Spiller F, Alves MK, Vieira SM, Carvalho TA, Leite CE, Lunardelli A, Poloni JA, Cunha FQ, de Oliveira JR. Antiinflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation. J Pharm Pharmacol 2008; 60: 473-478
20. Al-Amin ZM, Thomson M, Al-Qattan KK, Peltonen-Shalaby R, Ali M. Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. Br J Nutr 2006; 96: 660-666
21. Ejaz A, Wu D, Kwan P, Meydani M. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J Nutr 2009; 139: 919-925
22. Kang Q, Chen A. Curcumin suppresses expression of lowdensity lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells. Br J Pharmacol 2009; 157: 1354-1367
23. Alwi I, Santoso T, Suyono S, Sutrisna B, Suyatna FD, Kresno SB, Ernie S. The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med Indones 2008; 40: 201-210
24. Alizadeh-Navaei R, Roozbeh F, Saravi M, Pouramir M, Jalali F, Moghadamnia AA. Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Med J 2008; 29: 1280-1284
25. Graham DY, Smith JL, Opekun AR. Spicy food and the stomach. Evaluation by videoendoscopy. JAMA 1988; 260: 3473-3475
26. al-Yahya MA, Rafatullah S, Mossa JS, Ageel AM, Parmar NS, Tariq M. Gastroprotective activity of ginger zingiber officinale rosc., in albino rats. Am J Chin Med 1989; 17: 51-56
27. Rafatullah S, Tariq M, Al-Yahya MA, Mossa JS, Ageel AM. Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats. J Ethnopharmacol 1990; 29: 25-34
28. Marotta RB, Floch MH. Diet and nutrition in ulcer disease. Med Clin North Am 1991; 75: 967-979
29. Al Mofleh IA, Alhaider AA, Mossa JS, Al-Sohaibani MO, Al-Yahya MA, Rafatullah S, Shaik SA. Gastroprotective effect of an aqueous suspension of black cumin Nigella sativa on necrotizing agents-induced gastric injury in experimental animals. Saudi J Gastroenterol 2008; 14: 128-134
30. Miller EC, Swanson AB, Phillips DH, Fletcher TL, Liem A, Miller JA. Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. Cancer Res 1983; 43: 1124-1134
31. Schiestl RH, Chan WS, Gietz RD, Mehta RD, Hastings PJ. Safrole, eugenol and methyleugenol induce intrachromosomal recombination in yeast. Mutat Res 1989; 224: 427-436
32. Myers BM, Smith JL, Graham DY. Effect of red pepper and black pepper on the stomach. Am J Gastroenterol 1987; 82: 211-214
33. Lichtenberger LM, Romero JJ, Carryl OR, Illich PA, Walters ET. Effect of pepper and bismuth subsalicylate on gastric pain and surface hydrophobicity in the rat. Aliment Pharmacol Ther 1998; 12: 483-490
34. Vasudevan K, Vembar S, Veeraraghavan K, Haranath PS. Influence of intragastric perfusion of aqueous spice extracts on acid secretion in anesthetized albino rats. Indian J Gastroenterol 2000; 19: 53-56
35. Tanida N, Kawaura A, Takahashi A, Sawada K, Shimoyama T. Suppressive effect of wasabi (pungent Japanese spice) on gastric carcinogenesis induced by MNNG in rats. Nutr Cancer 1991; 16: 53-58
36. Lo YC, Yang YC, Wu IC, Kuo FC, Liu CM, Wang HW, Kuo CH, Wu JY, Wu DC. Capsaicin-induced cell death in a human gastric adenocarcinoma cell line. World J Gastroenterol 2005; 11: 6254-6257
37. Mothana RA, Gruenert R, Bednarski PJ, Lindequist U. Evaluation of the in vitro anticancer, antimicrobial and antioxidant activities of some Yemeni plants used in folk medicine. Pharmazie 2009; 64: 260-268
38. Oya T, Osawa T, Kawakishi S. Spice constituents scavenging free radicals and inhibiting pentosidine formation in a model system. Biosci Biotechnol Biochem 1997; 61: 263-266
39. Shan B, Cai YZ, Sun M, Corke H. Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. J Agric Food Chem 2005; 53: 7749-7759
40. Srinivasan K. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr 2007; 47: 735-748
41. Adhikari S, Indira Priyadarsini K, Mukherjee T. Physicochemical studies on the evaluation of the antioxidant activity of herbal extracts and active principles of some Indian medicinal plants. J Clin Biochem Nutr 2007; 40: 174-183
42. Huang WY, Cai YZ, Xing J, Corke H, Sun M. Comparative analysis of bioactivities of four Polygonum species. Planta Med 2008; 74: 43-49
43. Schwarz K, Ternes W. Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. I. Determination of phenolic diterpenes with antioxidative activity amongst tocochromanols using HPLC. Z Lebensm Unters Forsch 1992; 195: 95-98
44. Cheel J, Schmeda-Hirschmann G, Jordan M, Theoduloz C, Rodríguez JA, Gerth A, Wilken D. Free radical scavenging activity and secondary metabolites from in vitro cultures of Sanicula graveolens. Z Naturforsch C 2007; 62: 555-562
45. Korkina LG. Phenylpropanoids as naturally occurring antioxidants: from plant defense to human health. Cell Mol Biol (Noisy-le-grand) 2007; 53: 15-25
46. Agbor GA, Vinson JA, Oben JE, Ngogang JY. In vitro antioxidant activity of three Piper species. J Herb Pharmacother 2007; 7: 49-64
47. Toma W, Hiruma-Lima CA, Guerrero RO, Brito AR. Preliminary studies of Mammea americana L. (Guttiferae) bark/ latex extract point to an effective antiulcer effect on gastric ulcer models in mice. Phytomedicine 2005; 12: 345-350
48. Gürbüz I, Ustün O, Yeşilada E, Sezik E, Akyürek N. In vivo gastroprotective effects of five Turkish folk remedies against ethanol-induced lesions. J Ethnopharmacol 2002; 83: 241-244
49. Xia J. Medicinal herbs used in pairs for treatment of 98 cases of chronic gastritis. J Tradit Chin Med 2004; 24: 208-209
50. Chernomorets NN, Seleznev AV, Revutskiǐ BI, Alifanova RE, Kravchenko ZV, Cherkasskaia EP. [The differentiated phytotherapy of patients with duodenal peptic ulcer] Lik Sprava 1992; 112-115
51. Chakǔrski I, Matev M, Stefanov G, Koǐchev A, Angelova I. [Treanntment of duodenal ulcers and gastroduodenitis with a herbal combination of Symphitum officinalis and Calendula officinalis with and without antacids] Vutr Boles 1981; 20: 44-47
52. Al-Howiriny T, Al-Sohaibani M, Al-Said M, Al-Yahya M, El-Tahir K, Rafatullah S. Effect of Commiphora opobalsamum (L.) Engl. (Balessan) on experimental gastric ulcers and secretion in rats. J Ethnopharmacol 2005; 98: 287-294
53. AI-Mofleh IA, Alhaider AA, Mossa IS, Al-Sohaibani MO, Rafatullah S, Qureshi S. Protection of gastric mucosal damage by Coriandrum sativum L. pretreatment in Wistar albino rats. Environmental Toxicol Pharmacol 2006; 22: 64-69.
54. Alqasoumi S, Al-Sohaibani M, Al-Howiriny T, Al-Yahya M, Rafatullah S. Rocket "Eruca sativa": a salad herb with potential gastric anti-ulcer activity. World J Gastroenterol 2009; 15: 1958-1965
55. Nanjundaiah SM, Annaiah HN, M Dharmesh S. Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract: Role of Gallic Acid and Cinnamic Acid in H+, K+- ATPase/H. pylori Inhibition and Anti-oxidative Mechanism. Evid Based Complement Alternat Med 2009; Epub ahead of print
56. Choi SM, Shin JH, Kang KK, Ahn BO, Yoo M. Gastroprotective effects of DA-6034, a new flavonoid derivative, in various gastric mucosal damage models. Dig Dis Sci 2007; 52: 3075-3080
57. Singh S, Khajuria A, Taneja SC, Khajuria RK, Singh J, Johri RK, Qazi GN. The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats. Phytomedicine 2008; 15: 408-415
58. Qian Y, Si JM, Wu JG, Chen SJ, Zhu YF, Sun KK, Deng YY, Chen K, Wang LJ, Liu WL. [Effect of mucosal protective on the quality of gastric ulcer healing] Zhejiang Daxue Xuebao Yixueban 2007; 36: 71-77
59. Kivilaakso E. Pathogenetic mechanisms in experimental gastric stress ulceration. Scand J Gastroenterol Suppl 1985; 110: 57-62
60. Nayeb-Hashemi H, Kaunitz JD. Gastroduodenal mucosal defense. Curr Opin Gastroenterol 2009; 25: 537-543
61. Konturek SJ, Konturek PC, Brzozowski T. Prostaglandins and ulcer healing. J Physiol Pharmacol 2005; 56 Suppl 5: 5-31
62. Brzozowski T, Konturek PC, Konturek SJ, Brzozowska I, Pawlik T. Role of prostaglandins in gastroprotection and gastric adaptation. J Physiol Pharmacol 2005; 56 Suppl 5: 33-55
63. Jainu M, Vijai Mohan K, Shyamala Devi CS. Gastroprotective effect of Cissus quadrangularis extract in rats with experimentally induced ulcer. Indian J Med Res 2006; 123: 799-806
64. Baggio CH, Freitas CS, Otofuji Gde M, Cipriani TR, Souza LM, Sassaki GL, Iacomini M, Marques MC, Mesia-Vela S. Flavonoid-rich fraction of Maytenus ilicifolia Mart. ex. Reiss protects the gastric mucosa of rodents through inhibition of both H+,K+ -ATPase activity and formation of nitric oxide. J Ethnopharmacol 2007; 113: 433-440
65. Baek SW, Kim NK, Jin HJ, Koh CW, Kim CK, Kwon OH, Kim JS, Cho MH, Park CK. Anti-ulcer actions of phytosphingosine hydrochloride in different experimental rat ulcer models. Arzneimittelforschung 2005; 55: 461-465
66. Alam S, Asad M, Asdaq SM, Prasad VS. Antiulcer activity of methanolic extract of Momordica charantia L. in rats. J Ethnopharmacol 2009; 123: 464-469
67. Souccar C, Cysneiros RM, Tanae MM, Torres LM, Lima- Landman MT, Lapa AJ. Inhibition of gastric acid secretion by a standardized aqueous extract of Cecropia glaziovii Sneth and underlying mechanism. Phytomedicine 2008; 15: 462-469
68. Zanatta F, Gandolfi RB, Lemos M, Ticona JC, Gimenez A, Clasen BK, Cechinel Filho V, de Andrade SF. Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae). Chem Biol Interact 2009; 180: 312-317
69. Olaleye SB, Owoyele VB, Odukanmi AO. Antiulcer and gastric antisecretory effects of Landolphia owariensis extracts in rats. Niger J Physiol Sci 2008; 23: 23-26
70. Brzozowski T, Konturek SJ, Sliwowski Z, Pytko-Polończyk J, Szlachcic A, Drozdowicz D. Role of capsaicin-sensitive sensory nerves in gastroprotection against acid-independent and acid-dependent ulcerogens. Digestion 1996; 57: 424-432
71. Silva MI, Moura BA, Neto MR, Tomé Ada R, Rocha NF, de Carvalho AM, Macêdo DS, Vasconcelos SM, de Sousa DP, Viana GS, de Sousa FC. Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action. Naunyn Schmiedebergs Arch Pharmacol 2009; 380: 233-245
72. Fan TY, Feng QQ, Jia CR, Fan Q, Li CA, Bai XL. Protective effect of Weikang decoction and partial ingredients on model rat with gastric mucosa ulcer. World J Gastroenterol 2005; 11: 1204-1209
73. de O Leite G, da Penha AR, Fernandes CN, Souza HH, da Costa JG, Campos AR. Gastroprotective mechanism of Vanillosmopsis arborea bark essential oil. Fitoterapia 2009; 80: 77-80
74. Nguelefack TB, Feumebo CB, Ateufack G, Watcho P, Tatsimo S, Atsamo AD, Tane P, Kamanyi A. Anti-ulcerogenic properties of the aqueous and methanol extracts from the leaves of Solanum torvum Swartz (Solanaceae) in rats. J Ethnopharmacol 2008; 119: 135-140
75. Kamath BS, Srikanta BM, Dharmesh SM, Sarada R, Ravishankar GA. Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis. Eur J Pharmacol 2008; 590: 387-395
76. Naito Y, Yoshikawa T. Oxidative stress involvement and gene expression in indomethacin-induced gastropathy. Redox Rep 2006; 11: 243-253
77. Bogdarin IuA, Potekhin PP, Kozlov DV, Shirokova NIu. [Efficacy of the new collection of herbs at stressful experimental sharp ulcer defects of the gastroduodenal zone] Eksp Klin Gastroenterol 2005; 74-78, 102
78. de Paula Ferreira M, Nishijima CM, Seito LN, Dokkedal AL, Lopes-Ferreira M, Di Stasi LC, Vilegas W, Hiruma-Lima CA. Gastroprotective effect of Cissus sicyoides (Vitaceae): involvement of microcirculation, endogenous sulfhydryls and nitric oxide. J Ethnopharmacol 2008; 117: 170-174
79. Kanter M, Demir H, Karakaya C, Ozbek H. Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats. World J Gastroenterol 2005; 11: 6662-6666
80. Komoike Y, Nakashima M, Nakagiri A, Takeuchi K. Prostaglandin E receptor EP1 subtype but not prostacyclin IP receptor involved in mucosal blood flow response of mouse stomachs following barrier disruption. Digestion 2003; 67: 186-194
81. Satyanarayana MN. Capsaicin and gastric ulcers. Crit Rev Food Sci Nutr 2006; 46: 275-328
82. Nylander O, Andersson H, Wilander E, Sababi M. Pros- taglandins reduce hydrochloric acid-induced increase in duodenal mucosal permeability by a mechanism not related to stimulation of alkaline secretion. Acta Physiol Scand 1995; 153: 365-374
83. Gookin JL, Galanko JA, Blikslager AT, Argenzio RA. PGmediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum. Am J Physiol Gastrointest Liver Physiol 2003; 285: G967-G979
84. Hatazawa R, Ohno R, Tanigami M, Tanaka A, Takeuchi K. Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats. J Pharmacol Exp Ther 2006; 318: 691-699
85. Konturek PC, Brzozowski T, Konturek SJ, Taut A, Kwiecien S, Pajdo R, Sliwowski Z, Hahn EG. Bacterial lipopolysaccharide protects gastric mucosa against acute injury in rats by activation of genes for cyclooxygenases and endogenous prostaglandins. Digestion 1998; 59: 284-297
86. Mehrabani D, Rezaee A, Azarpira N, Fattahi MR, Amini M, Tanideh N, Panjehshahin MR, Saberi-Firouzi M. The healing effects of Teucrium polium in the repair of indomethacininduced gastric ulcer in rats. Saudi Med J 2009; 30: 494-499
87. Beales IL. Gastrin and interleukin-1beta stimulate growth factor secretion from cultured rabbit gastric parietal cells. Life Sci 2004; 75: 2983-2995
88. Luo JC, Shin VY, Yang YH, Wu WK, Ye YN, So WH, Chang FY, Cho CH. Tumor necrosis factor-alpha stimulates gastric epithelial cell proliferation. Am J Physiol Gastrointest Liver Physiol 2005; 288: G32-G38
89. Konturek PC, Brzozowski T, Konturek SJ, Ernst H, Drozdowicz D, Pajdo R, Hahn EG. Expression of epidermal growth factor and transforming growth factor alpha during ulcer healing. Time sequence study. Scand J Gastroenterol 1997; 32: 6-15
90. Sasaki E, Tominaga K, Watanabe T, Fujiwara Y, Oshitani N, Matsumoto T, Higuchi K, Tarnawski AS, Arakawa T. COX-2 is essential for EGF induction of cell proliferation in gastric RGM1 cells. Dig Dis Sci 2003; 48: 2257-2262
91. Jones MK, Tomikawa M, Mohajer B, Tarnawski AS. Gastrointestinal mucosal regeneration: role of growth factors. Front Biosci 1999; 4: D303-D309
92. Tétreault MP, Chailler P, Beaulieu JF, Rivard N, Ménard D. Specific signaling cascades involved in cell spreading during healing of micro-wounded gastric epithelial monolayers. J Cell Biochem 2008; 105: 1240-1249
93. Shimura T, Kataoka H, Ogasawara N, Kubota E, Sasaki M, Tanida S, Joh T. Suppression of proHB-EGF carboxy-terminal fragment nuclear translocation: a new molecular target therapy for gastric cancer. Clin Cancer Res 2008; 14: 3956-3965
94. Yoshida K, Kanaoka S, Takai T, Uezato T, Miura N, Kajimura M, Hishida A. EGF rapidly translocates tight junction proteins from the cytoplasm to the cell-cell contact via protein kinase C activation in TMK-1 gastric cancer cells. Exp Cell Res 2005; 309: 397-409
95. Baek MK, Kim MH, Jang HJ, Park JS, Chung IJ, Shin BA, Ahn BW, Jung YD. EGF stimulates uPAR expression and cell invasiveness through ERK, AP-1, and NF-kappaB signaling in human gastric carcinoma cells. Oncol Rep 2008; 20: 1569-1575
96. Berlanga-Acosta J, Gavilondo-Cowley J, López-Saura P, González-López T, Castro-Santana MD, López-Mola E, Guillén- Nieto G, Herrera-Martinez L. Epidermal growth factor in clinical practice - a review of its biological actions, clinical indications and safety implications. Int Wound J 2009; 6: 331-346
97. Ma L, Chow JY, Wong BC, Cho CH. Role of capsaicin sensory nerves and EGF in the healing of gastric ulcer in rats. Life Sci 2000; 66: PL213-PL220
98. Zheng XG, Zhang JJ, Huang YC. [Study on the effect of weitongning on epidermal growth factor and nitric oxide contents in tissue of stomach of rats with gastric ulcer] Zhongguo Zhongxiyi Jiehe Zazhi 2004; 24: 549-551
99. Cao MB, Dong L, Chang XM, Zou BC, Qin B. Effect of Mexican tea herb and pilular adina herb on concrescence of gastric mucosa in experimental gastric ulcer rats. Chin J Integr Med 2007; 13: 132-136
100. Wang B, Zhao HY, Zhou L, Wang YF, Cao J. Effect of Kuiyangping on expressions of EGF and EGFR mRNA in gastric mucosa in rats with experimental gastric ulcer. Beijing Zhongyiyao Daxue Xuebao 2008; 31: Abstract
101. Meng H, Guo J, Sun JY, Pei JM, Wang YM, Zhu MZ, Huang C. Angiogenic effects of the extracts from Chinese herbs: Angelica and Chuanxiong. Am J Chin Med 2008; 36: 541-554
102. Bode AM, Ma WY, Surh YJ, Dong Z. Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Cancer Res 2001; 61: 850-853
103. Cai XZ, Wang J, Li XD, Wang GL, Liu FN, Cheng MS, Li F. Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression. Cancer Biol Ther 2009; 8: 1360-1368
104. Marijon H, Faivre S, Raymond E. [Targeted therapies in hepatocellular carcinomas: recent results and future development] Bull Cancer 2009; 96: 553-561
105. Kelly K, Huang C. Biological agents in non-small cell lung cancer: a review of recent advances and clinical results with a focus on epidermal growth factor receptor and vascular endothelial growth factor. J Thorac Oncol 2008; 3: 664-673
106. Ji C, Cao C, Lu S, Kivlin R, Amaral A, Kouttab N, Yang H, Chu W, Bi Z, Di W, Wan Y. Curcumin attenuates EGFinduced AQP3 up-regulation and cell migration in human ovarian cancer cells. Cancer Chemother Pharmacol 2008; 62: 857-865
107. Tsai PJ, Tsai TH, Yu CH, Ho SC. Evaluation of NO-suppressing activity of several Mediterranean culinary spices. Food Chem Toxicol 2007; 45: 440-447
108. Reyes-Trejo B, Sánchez-Mendoza ME, Becerra-García AA, Cedillo-Portugal E, Castillo-Henkel C, Arrieta J. Bioassayguided isolation of an anti-ulcer diterpenoid from Croton reflexifolius: role of nitric oxide, prostaglandins and sulfhydryls. J Pharm Pharmacol 2008; 60: 931-936
109. Zayachkivska OS, Konturek SJ, Drozdowicz D, Brzozowski T, Gzhegotsky MR. Influence of plant-originated gastroproteciive and antiulcer substances on gastric mucosal repair. Fiziol Zh 2004; 50: 118-127
110. Chen SH, Liang YC, Chao JC, Tsai LH, Chang CC, Wang CC, Pan S. Protective effects of Ginkgo biloba extract on the ethanol-induced gastric ulcer in rats. World J Gastroenterol 2005; 11: 3746-3750
111. Al Mofleh IA, Alhaider AA, Mossa JS, Al-Soohaibani MO, Rafatullah S. Aqueous suspension of anise "Pimpinella anisum" protects rats against chemically induced gastric ulcers. World J Gastroenterol 2007; 13: 1112-1118
112. Tabak M, Armon R, Neeman I. Cinnamon extracts' inhibitory effect on Helicobacter pylori. J Ethnopharmacol 1999; 67: 269-277
113. Mahady GB, Pendland SL, Yun G, Lu ZZ. Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. Anticancer Res 2002; 22: 4179-4181
114. Mahady GB, Pendland SL, Stoia A, Hamill FA, Fabricant D, Dietz BM, Chadwick LR. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother Res 2005; 19: 988-991
115. Ali SM, Khan AA, Ahmed I, Musaddiq M, Ahmed KS, Polasa H, Rao LV, Habibullah CM, Sechi LA, Ahmed N. Antimicrobial activities of Eugenol and Cinnamaldehyde against the human gastric pathogen Helicobacter pylori. Ann Clin Microbiol Antimicrob 2005; 4: 20
116. O'Mahony R, Al-Khtheeri H, Weerasekera D, Fernando N, Vaira D, Holton J, Basset C. Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helico- bacter pylori. World J Gastroenterol 2005; 11: 7499-7507
117. Zaidi SF, Yamada K, Kadowaki M, Usmanghani K, Sugiyama T. Bactericidal activity of medicinal plants, employed for the treatment of gastrointestinal ailments, against Helicobacter pylori. J Ethnopharmacol 2009; 121: 286-291
118. Asiri Y, Al-Dhawailie A, AlQasoumi S, Al-Yahya M, Rafatullah S. Pharmacovigilance in Herbal Medicine: A Paradigm to Drug Toxicity Monitoring In Conventional Health Care. Hung Med J 2008; 2: 351-363
119. Balaji S, Chempakam B. Pharmacokinetics prediction and drugability assessment of diphenylheptanoids from turmeric (Curcuma longa L). Med Chem 2009; 5: 130-138
120. Kandarkar SV, Sawant SS, Ingle AD, Deshpande SS, Maru GB. Subchronic oral hepatotoxicity of turmeric in mice--histopathological and ultrastructural studies. Indian J Exp Biol 1998; 36: 675-679
121. Deshpande SS, Lalitha VS, Ingle AD, Raste AS, Gadre SG, Maru GB. Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats. Toxicol Lett 1998; 95: 183-193
122. Shah AH, Qureshi S, Ageel AM. Toxicity studies in mice of ethanol extracts of Foeniculum vulgare fruit and Ruta chalepensis aerial parts. J Ethnopharmacol 1991; 34: 167-172
123. Shah AH, Al-Shareef AH, Ageel AM, Qureshi S. Toxicity studies in mice of common spices, Cinnamomum zeylanicum bark and Piper longum fruits. Plant Foods Hum Nutr 1998; 52: 231-239
124. Daware MB, Mujumdar AM, Ghaskadbi S. Reproductive toxicity of piperine in Swiss albino mice. Planta Med 2000; 66: 231-236
125. Cao J, Jia L, Zhou HM, Liu Y, Zhong LF. Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells. Toxicol Sci 2006; 91: 476-483
126. Mendonça LM, Dos Santos GC, Antonucci GA, Dos Santos AC, Bianchi Mde L, Antunes LM. Evaluation of the cytotoxicity and genotoxicity of curcumin in PC12 cells. Mutat Res 2009; 675: 29-34
127. Bentzen PJ, Lang E, Lang F. Curcumin induced suicidal erythrocyte death. Cell Physiol Biochem 2007; 19: 153-164
128. Khader M, Bresgen N, Eckl PM. In vitro toxicological properties of thymoquinone. Food Chem Toxicol 2009; 47: 129-133
129. Qadri SM, Mahmud H, Föller M, Lang F. Thymoquinoneinduced suicidal erythrocyte death. Food Chem Toxicol 2009; 47: 1545-1549