PG-mediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 285, Issue 5 48-5, 2003, Pages

  Gookin, Jody L ^a   Galanko, Joseph A ^b   Blikslager, Anthony T ^a   Argenzio, Robert A ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Deoxycholate; Permeability; Resistance; Tight junction

Indexed keywords

CHLORIDE ION; DEOXYCHOLIC ACID; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL PROTECTION; CLINICAL PATHWAY; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG CONTRAINDICATION; DRUG USE; ENTERITIS; ILEUM DISEASE; ILEUM MUCOSA; INTESTINE CRYPT; INTESTINE MUCOSA PERMEABILITY; INTESTINE VILLUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SWINE; TIGHT JUNCTION;

EID: 0142182040     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00532.2002     Document Type: Article

References (36)

1. Argenzio RA, Henderson CK, and Liacos JA. Restitution of barrier and transport function of porcine colon after acute mucosal injury. Am J Physiol Gastrointest Liver Physiol 255: G62-G71, 1988.
2. Argenzio RA, Henderson CK, and Liacos JA. Effect of prostaglandin inhibitors on bile salt-induced mucosal damage of porcine colon. Gastroenterology 96: 95-109, 1989.
3. Argenzio RA, Liacos JA, Levy ML, Meuten DJ, Lecce JG, and Powell DW. Villous atrophy, crypt hyperplasia, cellular infiltration, and impaired glucose-Na absorption in enteric cryptosporidiosis of pigs. Gastroenterology 98: 1129-1140, 1990.
4. Bjarnason I, Hayllar J, MacPherson AJ, and Russell AS. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 104: 1832-1847, 1993.
5. Bjarnason I, Williams P, Smethurst P, Peters TJ, and Levi AJ. The effect of NSAIDs and prostaglandins on the permeability of the human small intestine. Gut 27: 1292-1297, 1986.
6. Blikslager AT, Roberts MC, and Argenzio RA. Prostaglandin-induced recovery of barrier function in porcine ileum is triggered by chloride secretion. Am J Physiol Gastrointest Liver Physiol 276: G28-G36, 1999.
7. 2 have a synergistic role in rescuing epithelial barrier function in porcine ileum. J Clin Invest 100: 1928-1933, 1997.
8. Ciacci C, Lind SE, and Podolsky DK. Transforming growth factor β regulation of migration in wounded rat intestinal epithelial monolayers. Gastroenterology 105: 93-101, 1993.
9. Claude P. Morphological factors influencing transepithelial permeability:A model for the resistance of the Zonula Occludens. J Membr Biol 39: 219-232, 1978.
10. Collett A, Walker D, Sims E, He YL, Speers P, Ayrton J, Rowland M, and Warhurst G. Influence of morphometric factors on quantitation of paracellular permeability of intestinal epithelia in vitro. Pharmacol Res 14: 767-773, 1997.
11. Dykstra MJ. A Manual of Applied Techniques for Biological Electron Microscopy. New York: Plenum, 1993.
12. 2 and indomethacin on bile acid-induced intestinal injury and restitution in rats. J Lab Clin Med 112: 735-744, 1988.
13. 2 induces villus contraction in rats without affecting intestinal restitution. Gastroenterology 99: 708-716, 1990.
14. Freel RW, Hatch M, Earnest DL, and Goldner AM. Role of tight junctional pathways in bile salt-induced increases in colonic permeability. Am J Physiol Gastrointest Liver Physiol 245: G816-G823, 1983.
15. Frizzell RA and Schultz SG. Ion conductances of extracellular shunt pathway in rabbit ileum. J Gen Physiol 59: 318-346, 1972.
16. Gookin JG, Rhoads JM, and Argenzio RA. Inducible nitric oxide synthase mediates early epithelial repair of porcine ileum. Am J Physiol Gastrointest Liver Physiol 283: G157-G168, 2002.
17. Graumlich JF. Preventing gastrointestinal complications of NSAIDs: risk factors, recent advances, and latest strategies. Postgrad Med 109: 117-28, 2001.
18. Joyce NC, Haire MF, and Palade GE. Morphologic and biochemical evidence for a contractile cell network within the rat intestinal mucosa. Gastroenterology 92: 68-81, 1987.
19. Kaufmann HJ and Taubin HL. Nonsteroidal anti-inflammatory drugs activate quiescent inflammatory bowel disease. Ann Intern Med 107: 513-516, 1987.
20. Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, Mahler JF, Lee CA, Goulding EH, Kluckman KD, Kim HS, and Smithies O. Prostaglandin synthase 1 gene disruption in mice reduced arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 83: 483-492, 1995.
21. Little D, Dean RA, Young KM, McKane SA, Martin LA, Jones SL, and Blikslager AT. Phosphatidylinositol-3-kinase (PI3'K) signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum. Am J Physiol Gastrointest Liver Physiol 284: G46-G56, 2003.
22. Loud AV and Anversa P. Biology of disease. Morphometric analysis of biologic processes. Lab Invest 50: 250-261, 1984.
23. Madara JL. Loosening tight junctions: lessens from the intestine. J Clin Invest 83: 1089-1094, 1989.
24. Marcial MA, Carlson SL, and Madara JL. Partitioning of paracellular conductance along the ileal crypt-villus axis: a hypothesis based on structural analysis with detailed consideration of tight junction structure-function relationships. J Membr Biol 80: 59-70, 1984.
25. McCormack SA, Viar MJ, and Johnson LR. Migration of IEC-6 cells: a model for mucosal healing. Am J Physiol Gastrointest Liver Physiol 263: G426-G435, 1992.
26. Moore R, Carlson S, and Madara JL. Villus contraction aids repair of intestinal epithelium after injury. Am J Physiol Gastrointest Liver Physiol 257: G274-G283, 1989.
27. Moore R, Carlson S, and Madara JL. Rapid barrier restitution in an in vitro model of intestinal epithelial injury. Lab Invest 60: 237-244, 1989.
28. Noiri E, Peresleni T, Srivastava N, Weber P, Bahou WF, Peunova N, and Goligorsky MS. Nitric oxide is necessary for a switch from stationary to locomoting phenotype in epithelial cells. Am J Physiol Cell Physiol 270: C794-C802, 1996.
29. Okada Y, Irimajiri A, and Inouye A. Electrical properties and active solute transport in the rat small intestine. II. Conductive properties of transepithelial routes. J Membr Biol 31: 221-232, 1977.
30. Powell DW. Barrier function of epithelia. Am J Physiol Gastrointest Liver Physiol 241: G275-G288, 1981.
31. Riegler M, Sedivy R, Sogukoglu T, Cosentini E, Bischof G, Teleky B, Feil W, Schiessel R, Hamilton G, and Wenzl E. Epidermal growth factor promotes rapid response to epithelial injury in rabbit duodenum in vitro. Gastroenterology 111: 28-36, 1996.
32. Rose RC and Schultz SG. Studies on the electrical potential profile across rabbit ileum: effects of sugars and amino acids on transmural and transmucosal electrical potential differences. J General Biol 57: 639-663, 1971.
33. Sigthorsson G, Tibble J, Hayllar J, Menzies I, Macpherson A, Moots R, Scott D, Gumperl MJ, and Bjarnason I. Intestinal permeability and inflammation in patients on NSAIDs. Gut 43: 506-511, 1998.
34. Svanes K, Ito S, Takeuchi K, and Silen W. Restitution of the surface epithelium of the in vitro frog gastric mucosa after damage with hyperosmolar sodium chloride. Morphologic and physiologic characteristics. Gastroenterology 82: 1409-1426, 1982.
35. Takahashi M, Ota S, Hata Y, Mikami Y, Azuma N, Nakamura T, Terano A, and Omata M. Hepatocyte growth factor as a key to modulate anti-ulcer action of prostaglandins in stomach. J Clin Invest 98, 2604-2611, 1996.
36. Zushi S, Shinomura Y, Kiyohara T, Minami T, Sugimachi M, Higashimoto Y, Kanayama S, and Matsuzawa Y. Role of prostaglandins in intestinal epithelial restitution stimulated by growth factors. Am J Physiol Gastrointest Liver Physiol 270: G757-G762, 1996.