Role of zinc in human islet amyloid polypeptide aggregation

Journal of the American Chemical Society

Volumn 132, Issue 26, 2010, Pages 8973-8983

  Brender, Jeffrey R ^a   Hartman, Kevin ^a   Nanga, Ravi Prakash Reddy ^a   Popovych, Nataliya ^a   De La Salud Bea, Roberto ^a   Vivekanandan, Subramanian ^a   Marsh, E Neil G ^a,b   Ramamoorthy, Ayyalusamy ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCENTRATION (PROCESS); GLYCOPROTEINS; GRANULATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES; PH EFFECTS; TOXIC MATERIALS;

ACIDIC PH; DUAL EFFECT; ELECTROSTATIC EFFECT; EXTRACELLULAR ENVIRONMENTS; FIBER FORMATION; FIBRILLOGENESIS; HIGH CONCENTRATION; HIGH-RESOLUTION STRUCTURES; HUMAN ISLETS; INSULIN SECRETION; LAG-TIME; MILLIMOLAR CONCENTRATIONS; SECONDARY STRUCTURES; SECRETORY GRANULES; TYPE II; ZINC BINDING; ZINC TRANSPORTERS;

ZINC;

AMYLIN; HISTIDINE; ZINC; AMYLOID; LIGAND;

ACIDITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRICITY; EXTRACELLULAR SPACE; FIBER; HORMONE STRUCTURE; HUMAN; METAL BINDING; NUCLEAR MAGNETIC RESONANCE; PANCREAS ISLET BETA CELL; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE; SECRETORY GRANULE; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; KINETICS; METABOLISM; MOLECULAR GENETICS; PH; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE;

AMINO ACID SEQUENCE; AMYLOID; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; ISLET AMYLOID POLYPEPTIDE; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; ZINC;

EID: 77954269081     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja1007867     Document Type: Article

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