Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy

Journal of the American Chemical Society

Volumn 131, Issue 23, 2009, Pages 8252-8261

  Nanga, Ravi Prakash Reddy ^a   Brender, Jeffrey R ^a   Xu, Jiadi ^a   Hartman, Kevin ^a   Subramanian, Vivekanandan ^b   Ramamoorthy, Ayyalusamy ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPATHIC; AMYLOID DEPOSITS; AMYLOID FIBERS; AMYLOID FIBRIL; AMYLOIDOGENIC PEPTIDES; BOUND STRUCTURE; C-TERMINUS; GLUCOSE METABOLISM; HELICAL STRUCTURES; HIGH-RESOLUTION STRUCTURES; INTERMEDIATE STATE; N-TERMINAL; PEPTIDE HORMONES; RAT ISLETS; RECEPTOR BINDING; SELF-ASSOCIATION; SOLUTION NMR; THREE-DIMENSIONAL STRUCTURE; TRANSIENT MEMBRANE; TYPE II;

AMINES; ASSOCIATION REACTIONS; DETERGENTS; GLUCOSE; HORMONES; MICELLES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYPEPTIDES; QUENCHING; TOXICITY;

GLYCOPROTEINS;

AMYLIN; DODECYLPHOSPHORYLCHOLINE; AMYLOID; DRUG DERIVATIVE; PHOSPHORYLCHOLINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; MEMBRANE; MICELLE; MOLECULAR MIMICRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN ANALYSIS; PROTEIN STRUCTURE; RAT; RECEPTOR BINDING; THREE DIMENSIONAL IMAGING; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN SECONDARY STRUCTURE; SOLUTION AND SOLUBILITY;

AMINO ACID SEQUENCE; AMYLOID; ANIMALS; MEMBRANES; MICELLES; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORYLCHOLINE; PROTEIN STRUCTURE, SECONDARY; RATS; SOLUTIONS;

EID: 67650533782     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9010095     Document Type: Article

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