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Volumn 47, Issue , 2010, Pages 139-165

Noninvasive brain imaging in small animal stroke models: MRI and PET

Author keywords

ADC; DTI; DWI; fMRI; MRI; PET; PWI; Rodents; Stroke.

Indexed keywords

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; FLUMAZENIL C 11; FLUORODEOXYGLUCOSE F 18; GADODIAMIDE; GADOLINIUM PENTETATE; GLUCOSE; OXYGEN; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE;

EID: 77954227072     PISSN: 08932336     EISSN: 19406045     Source Type: Book Series    
DOI: 10.1007/978-1-60761-750-1_11     Document Type: Review
Times cited : (3)

References (163)
  • 2
    • 33646366429 scopus 로고    scopus 로고
    • Present status of magnetic resonance imaging and spectroscopy in animal stroke models
    • Weber R, Ramos-Cabrer P, Hoehn M (2006) Present status of magnetic resonance imaging and spectroscopy in animal stroke models. J Cereb Blood Flow Metab 26:591-604
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 591-604
    • Weber, R.1    Ramos-Cabrer, P.2    Hoehn, M.3
  • 3
    • 0346881348 scopus 로고    scopus 로고
    • Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging
    • Shen Q, Meng X, Fisher M, Sotak CH, Duong TQ (2003) Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging. J Cereb Blood Flow Metab 23:1479-1488
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 1479-1488
    • Shen, Q.1    Meng, X.2    Fisher, M.3    Sotak, C.H.4    Duong, T.Q.5
  • 4
    • 0028284035 scopus 로고
    • Magnetic resonance imaging assessment of evolving focal cerebral ischemia. Comparison with histopathology in rats
    • Knight RA, Dereski MO, Helpern JA, Ordidge RJ, Chopp M (1994) Magnetic resonance imaging assessment of evolving focal cerebral ischemia. Comparison with histopathology in rats. Stroke 25(6):1252-1261
    • (1994) Stroke , vol.25 , Issue.6 , pp. 1252-1261
    • Knight, R.A.1    Dereski, M.O.2    Helpern, J.A.3    Ordidge, R.J.4    Chopp, M.5
  • 5
    • 0033862478 scopus 로고    scopus 로고
    • Serial MRI after transient focal cerebral ischemia in rats: Dynamics of tissue injury, blood-brain barrier damage, and edema formation
    • Neumann-Haefelin T, Kastrup A, de Crespigny A, Yenari MA, Ringer T, Sun GH, Moseley ME (2000) Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation. Stroke 31:1965-1972
    • (2000) Stroke , vol.31 , pp. 1965-1972
    • Neumann-Haefelin, T.1    Kastrup, A.2    De Crespigny, A.3    Yenari, M.A.4    Ringer, T.5    Sun, G.H.6    Moseley, M.E.7
  • 6
    • 0035074072 scopus 로고    scopus 로고
    • A model for multiparametric MRI tissue characterization in experimental cerebral ischemia with histological validation in rat: Part 1
    • Jacobs MA, Zhang ZG, Knight RA, Soltanian-Zadeh H, Goussev AV, Peck DJ, Chopp M (2001) A model for multiparametric MRI tissue characterization in experimental cerebral ischemia with histological validation in rat: part 1. Stroke 32:943-949
    • (2001) Stroke , vol.32 , pp. 943-949
    • Jacobs, M.A.1    Zhang, Z.G.2    Knight, R.A.3    Soltanian-Zadeh, H.4    Goussev, A.V.5    Peck, D.J.6    Chopp, M.7
  • 11
    • 33745124702 scopus 로고    scopus 로고
    • Modest MRI signal intensity changes precede delayed cortical necrosis after transient focal ischemia in the rat
    • Rojas S, Martin A, Justicia C, Falcon C, Bargallo N, Chamorro A, Planas AM (2006) Modest MRI signal intensity changes precede delayed cortical necrosis after transient focal ischemia in the rat. Stroke 37:1525-1532
    • (2006) Stroke , vol.37 , pp. 1525-1532
    • Rojas, S.1    Martin, A.2    Justicia, C.3    Falcon, C.4    Bargallo, N.5    Chamorro, A.6    Planas, A.M.7
  • 12
    • 34250167199 scopus 로고    scopus 로고
    • Rodent stroke induced by photochemical occlusion of proximal middle cerebral artery: Evolution monitored with MR imaging and histopathology
    • Chen F, Suzuki Y, Nagai N, Jin L, Yu J, Wang H, Marchal G, Ni Y (2007) Rodent stroke induced by photochemical occlusion of proximal middle cerebral artery: evolution monitored with MR imaging and histopathology. Eur J Radiol 63:68-75
    • (2007) Eur J Radiol , vol.63 , pp. 68-75
    • Chen, F.1    Suzuki, Y.2    Nagai, N.3    Jin, L.4    Yu, J.5    Wang, H.6    Marchal, G.7    Ni, Y.8
  • 13
    • 36849010241 scopus 로고    scopus 로고
    • Magnetic resonance angiography of carotid and cerebral arterial occlusion in rats using a clinical scanner
    • Yang YM, Feng X, Yao ZW, Tang WJ, Liu HQ, Zhang L (2008) Magnetic resonance angiography of carotid and cerebral arterial occlusion in rats using a clinical scanner. J Neurosci Methods 167:176-183
    • (2008) J Neurosci Methods , vol.167 , pp. 176-183
    • Yang, Y.M.1    Feng, X.2    Yao, Z.W.3    Tang, W.J.4    Liu, H.Q.5    Zhang, L.6
  • 14
    • 33846999907 scopus 로고    scopus 로고
    • Comparison of two neonatal ischemic injury models using magnetic resonance imaging
    • Ashwal S, Tone B, Tian HR, Chong S, Obenaus A (2007) Comparison of two neonatal ischemic injury models using magnetic resonance imaging. Pediatr Res 61:9-14
    • (2007) Pediatr Res , vol.61 , pp. 9-14
    • Ashwal, S.1    Tone, B.2    Tian, H.R.3    Chong, S.4    Obenaus, A.5
  • 15
    • 34548025323 scopus 로고    scopus 로고
    • Anaesthesia of small rodents during magnetic resonance imaging
    • Hanusch C, Hoeger S, Beck GC (2007) Anaesthesia of small rodents during magnetic resonance imaging. Methods 43:68-78
    • (2007) Methods , vol.43 , pp. 68-78
    • Hanusch, C.1    Hoeger, S.2    Beck, G.C.3
  • 16
    • 48549090047 scopus 로고    scopus 로고
    • Drug-anaesthetic interaction in phMRI: The case of the psychotomimetic agent phencyclidine
    • Gozzi A, Schwarz A, Crestan V, Bifone A (2008) Drug-anaesthetic interaction in phMRI: the case of the psychotomimetic agent phencyclidine. Magn Reson Imaging 26:999-1006
    • (2008) Magn Reson Imaging , vol.26 , pp. 999-1006
    • Gozzi, A.1    Schwarz, A.2    Crestan, V.3    Bifone, A.4
  • 17
    • 27844573813 scopus 로고    scopus 로고
    • Continuous noninvasive monitoring of transcutaneous blood gases for a stable and persistent BOLD contrast in fMRI studies in the rat
    • Ramos-Cabrer P, Weber R, Wiedermann D, Hoehn M (2005) Continuous noninvasive monitoring of transcutaneous blood gases for a stable and persistent BOLD contrast in fMRI studies in the rat. NMR Biomed 18:440-446
    • (2005) NMR Biomed , vol.18 , pp. 440-446
    • Ramos-Cabrer, P.1    Weber, R.2    Wiedermann, D.3    Hoehn, M.4
  • 18
    • 0030928151 scopus 로고    scopus 로고
    • Quantitative measurements of regional cerebral blood volume using MRI in rats: Effects of arterial carbon dioxide tension and mannitol
    • Lin W, Paczynski RP, Kuppusamy K, Hsu CY, Haacke EM (1997) Quantitative measurements of regional cerebral blood volume using MRI in rats: effects of arterial carbon dioxide tension and mannitol. Magn Reson Med 38:420-428
    • (1997) Magn Reson Med , vol.38 , pp. 420-428
    • Lin, W.1    Paczynski, R.P.2    Kuppusamy, K.3    Hsu, C.Y.4    Haacke, E.M.5
  • 20
    • 0028869998 scopus 로고
    • Relationship between diffusion-weighted MR images, cerebral blood flow, and energy state in experimental brain infarction
    • Kohno K, Hoehn-Berlage M, Mies G, Back T, Hossmann KA (1995) Relationship between diffusion-weighted MR images, cerebral blood flow, and energy state in experimental brain infarction. Magn Reson Imaging 13:73-80
    • (1995) Magn Reson Imaging , vol.13 , pp. 73-80
    • Kohno, K.1    Hoehn-Berlage, M.2    Mies, G.3    Back, T.4    Hossmann, K.A.5
  • 21
    • 0028811177 scopus 로고
    • Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: The relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances
    • Hoehn-Berlage M, Norris DG, Kohno K, Mies G, Leibfritz D, Hossmann KA (1995) Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances. J Cereb Blood Flow Metab 15:1002-1011
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 1002-1011
    • Hoehn-Berlage, M.1    Norris, D.G.2    Kohno, K.3    Mies, G.4    Leibfritz, D.5    Hossmann, K.A.6
  • 23
    • 2542494959 scopus 로고    scopus 로고
    • Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats
    • Kazemi M, Silva MD, Li F, Fisher M, Sotak CH (2004) Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats. Magn Reson Imaging 22:653-659
    • (2004) Magn Reson Imaging , vol.22 , pp. 653-659
    • Kazemi, M.1    Silva, M.D.2    Li, F.3    Fisher, M.4    Sotak, C.H.5
  • 25
    • 0842325866 scopus 로고    scopus 로고
    • Characterizing the diffusion/ perfusion mismatch in experimental focal cerebral ischemia
    • Meng X, Fisher M, Shen Q, Sotak CH, Duong TQ (2004) Characterizing the diffusion/ perfusion mismatch in experimental focal cerebral ischemia. Ann Neurol 55:207-212
    • (2004) Ann Neurol , vol.55 , pp. 207-212
    • Meng, X.1    Fisher, M.2    Shen, Q.3    Sotak, C.H.4    Duong, T.Q.5
  • 26
    • 34247880466 scopus 로고    scopus 로고
    • Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging
    • Bardutzky J, Shen Q, Henninger N, Schwab S, Duong TQ, Fisher M (2007) Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging. Stroke 38: 1336-1344
    • (2007) Stroke , vol.38 , pp. 1336-1344
    • Bardutzky, J.1    Shen, Q.2    Henninger, N.3    Schwab, S.4    Duong, T.Q.5    Fisher, M.6
  • 27
    • 0032765684 scopus 로고    scopus 로고
    • Magnetic resonance angiography of the rat cerebrovascular system without the use of contrast agents
    • Reese T, Bochelen D, Sauter A, Beckmann N, Rudin M (1999) Magnetic resonance angiography of the rat cerebrovascular system without the use of contrast agents. NMR Biomed 12:189-196
    • (1999) NMR Biomed , vol.12 , pp. 189-196
    • Reese, T.1    Bochelen, D.2    Sauter, A.3    Beckmann, N.4    Rudin, M.5
  • 29
    • 0346250982 scopus 로고    scopus 로고
    • Magnetic resonance imaging in experimental models of brain disorders
    • Dijkhuizen RM, Nicolay K (2003) Magnetic resonance imaging in experimental models of brain disorders. J Cereb Blood Flow Metab 23:1383-1402
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 1383-1402
    • Dijkhuizen, R.M.1    Nicolay, K.2
  • 30
    • 0034110797 scopus 로고    scopus 로고
    • Unsupervised segmentation of multiparameter MRI in experimental cerebral ischemia with comparison to T2, diffusion, and ADC MRI parameters and histopathological validation
    • Jacobs MA, Knight RA, Soltanian-Zadeh H, Zheng ZG, Goussev AV, Peck DJ, Windham JP, Chopp M (2000) Unsupervised segmentation of multiparameter MRI in experimental cerebral ischemia with comparison to T2, diffusion, and ADC MRI parameters and histopathological validation. J Magn Reson Imaging 11:425-437
    • (2000) J Magn Reson Imaging , vol.11 , pp. 425-437
    • Jacobs, M.A.1    Knight, R.A.2    Soltanian-Zadeh, H.3    Zheng, Z.G.4    Goussev, A.V.5    Peck, D.J.6    Windham, J.P.7    Chopp, M.8
  • 31
    • 0037307933 scopus 로고    scopus 로고
    • Plasticity of cortical projections after stroke
    • Carmichael ST (2003) Plasticity of cortical projections after stroke. Neuroscientist 9: 64-75
    • (2003) Neuroscientist , vol.9 , pp. 64-75
    • Carmichael, S.T.1
  • 32
    • 85056073444 scopus 로고    scopus 로고
    • Long-term monitoring of post-stroke plasticity after transient cerebral ischemia in mice using in vivo and ex vivo diffusion tensor MRI
    • Granziera C, D'Arceuil H, Zai L, Magistretti PJ, Sorensen AG, de Crespigny AJ (2007) Long-term monitoring of post-stroke plasticity after transient cerebral ischemia in mice using in vivo and ex vivo diffusion tensor MRI. Open Neuroimag J 1:10-17
    • (2007) Open Neuroimag J , vol.1 , pp. 10-17
    • Granziera, C.1    D'Arceuil, H.2    Zai, L.3    Magistretti, P.J.4    Sorensen, A.G.5    De Crespigny, A.J.6
  • 33
    • 0036868705 scopus 로고    scopus 로고
    • The role of diffusion tensor imaging in the evaluation of ischemic brain injury - A review
    • Sotak CH (2002) The role of diffusion tensor imaging in the evaluation of ischemic brain injury -a review. NMR Biomed 15:561-569
    • (2002) NMR Biomed , vol.15 , pp. 561-569
    • Sotak, C.H.1
  • 34
    • 46549085259 scopus 로고    scopus 로고
    • Longitudinal in vivo MRI of alterations in perilesional tissue after transient ischemic stroke in rats
    • van der Zijden JP, van der Toorn A, van der Marel K, Dijkhuizen RM (2008) Longitudinal in vivo MRI of alterations in perilesional tissue after transient ischemic stroke in rats. Exp Neurol 212:207-212
    • (2008) Exp Neurol , vol.212 , pp. 207-212
    • Van Der Zijden, J.P.1    Van Der Toorn, A.2    Van Der Marel, K.3    Dijkhuizen, R.M.4
  • 38
    • 46749137235 scopus 로고    scopus 로고
    • A geometric flow for segmenting vasculature in proton-density weighted MRI
    • Descoteaux M, Collins DL, Siddiqi K (2008) A geometric flow for segmenting vasculature in proton-density weighted MRI. Med Image Anal 12:497-513
    • (2008) Med Image Anal , vol.12 , pp. 497-513
    • Descoteaux, M.1    Collins, D.L.2    Siddiqi, K.3
  • 42
    • 0030958501 scopus 로고    scopus 로고
    • Enlargement of human cerebral ischemic lesion volumes measured by diffusion weighted magnetic resonance imaging
    • Baird AE, Benfield A, Schlaug G, Siewert B, Lövblad KO, Edelman RR, Warach S (1997) Enlargement of human cerebral ischemic lesion volumes measured by diffusion weighted magnetic resonance imaging. Ann Neurol 41:581-589
    • (1997) Ann Neurol , vol.41 , pp. 581-589
    • Baird, A.E.1    Benfield, A.2    Schlaug, G.3    Siewert, B.4    Lövblad, K.O.5    Edelman, R.R.6    Warach, S.7
  • 43
    • 0034839640 scopus 로고    scopus 로고
    • Usefulness of magnetic resonancederived quantitative measurements of cerebral blood flow and volume in prediction of infarct growth in hyperacute stroke
    • Grandin CB, Duprez TP, Smith AM, Mataigne F, Peeters A, Oppenheim C, Cosnard G (2001) Usefulness of magnetic resonancederived quantitative measurements of cerebral blood flow and volume in prediction of infarct growth in hyperacute stroke. Stroke 32:1147-1153
    • (2001) Stroke , vol.32 , pp. 1147-1153
    • Grandin, C.B.1    Duprez, T.P.2    Smith, A.M.3    Mataigne, F.4    Peeters, A.5    Oppenheim, C.6    Cosnard, G.7
  • 44
    • 0019822988 scopus 로고
    • Thresholds in cerebral ischemia - The ischemic penumbra
    • Astrup J, Siesjö BK, Symon L (1981) Thresholds in cerebral ischemia - the ischemic penumbra. Stroke 12:723-725
    • (1981) Stroke , vol.12 , pp. 723-725
    • Astrup, J.1    Siesjö, B.K.2    Symon, L.3
  • 45
    • 0027982679 scopus 로고
    • Viability thresholds and the penumbra of focal ischemia
    • Hossmann KA (1994) Viability thresholds and the penumbra of focal ischemia. Ann Neurol 36:557-565
    • (1994) Ann Neurol , vol.36 , pp. 557-565
    • Hossmann, K.A.1
  • 47
    • 0037224703 scopus 로고    scopus 로고
    • Adventures in the pathophysiology of brain ischemia: Penumbra, gene expression, neuroprotection. The 2002 Thomas Willis Lecture
    • Ginsberg MD (2003) Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection. The 2002 Thomas Willis Lecture. Stroke 34:214-223
    • (2003) Stroke , vol.34 , pp. 214-223
    • Ginsberg, M.D.1
  • 48
    • 60049091968 scopus 로고    scopus 로고
    • Penumbral selection of patients for trials of acute stroke therapy
    • Donnan GA, Baron JC, Ma H, Davis SM (2009) Penumbral selection of patients for trials of acute stroke therapy. Lancet Neurol 8:261-269
    • (2009) Lancet Neurol , vol.8 , pp. 261-269
    • Donnan, G.A.1    Baron, J.C.2    Ma, H.3    Davis, S.M.4
  • 49
    • 18744434897 scopus 로고    scopus 로고
    • Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke: A brain proton magnetic resonance spectroscopic imaging study
    • Nicoli F, Lefur Y, Denis B, Ranjeva JP, Confort-Gouny S, Cozzone PJ (2003) Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke: a brain proton magnetic resonance spectroscopic imaging study. Stroke 34:e82-e87
    • (2003) Stroke , vol.34
    • Nicoli, F.1    Lefur, Y.2    Denis, B.3    Ranjeva, J.P.4    Confort-Gouny, S.5    Cozzone, P.J.6
  • 52
    • 18244367363 scopus 로고    scopus 로고
    • Does the mismatch match the penumbra? Magnetic resonance imaging and positron emission tomography in early ischemic stroke
    • Sobesky J, Weber OZ, Lehnhardt F-G, Hesselmann V, Neveling M, Jacobs A, Heiss WD (2005) Does the mismatch match the penumbra? Magnetic resonance imaging and positron emission tomography in early ischemic stroke. Stroke 36:80-85
    • (2005) Stroke , vol.36 , pp. 80-85
    • Sobesky, J.1    Weber, O.Z.2    Lehnhardt, F.-G.3    Hesselmann, V.4    Neveling, M.5    Jacobs, A.6    Heiss, W.D.7
  • 54
    • 0242694042 scopus 로고    scopus 로고
    • Beyond mismatch evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging
    • Kidwell CS, Alger JR, Saver JL (2003) Beyond mismatch evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging. Stroke 34:2729-2735
    • (2003) Stroke , vol.34 , pp. 2729-2735
    • Kidwell, C.S.1    Alger, J.R.2    Saver, J.L.3
  • 55
  • 56
    • 34548128827 scopus 로고    scopus 로고
    • Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats
    • Henninger N, Bouley J, Nelligan JM, Sicard KM, Fisher M (2007) Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 27:1632-1642
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 1632-1642
    • Henninger, N.1    Bouley, J.2    Nelligan, J.M.3    Sicard, K.M.4    Fisher, M.5
  • 57
    • 34848873498 scopus 로고    scopus 로고
    • Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke
    • Henninger N, Fisher M (2007) Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke. Stroke 38:2779-2786
    • (2007) Stroke , vol.38 , pp. 2779-2786
    • Henninger, N.1    Fisher, M.2
  • 59
    • 0034788225 scopus 로고    scopus 로고
    • Reversal of early diffusion-weighted magnetic resonance imaging abnormalities does not necessarily reflect tissue salvage in experimental cerebral ischemia
    • Ringer TM, Neumann-Haefelin T, Sobel RA, Moseley ME, Yenari MY (2001) Reversal of early diffusion-weighted magnetic resonance imaging abnormalities does not necessarily reflect tissue salvage in experimental cerebral ischemia. Stroke 32:2362-2369
    • (2001) Stroke , vol.32 , pp. 2362-2369
    • Ringer, T.M.1    Neumann-Haefelin, T.2    Sobel, R.A.3    Moseley, M.E.4    Yenari, M.Y.5
  • 60
    • 0036171779 scopus 로고    scopus 로고
    • Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats
    • Li F, Liu KF, Silva MD, Meng X, Gerriets T, Helmer KG, Fenstermacher JD, Sotak CH, Fisher M (2002) Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats. AJNR Am J Neuroradiol 23:180-188
    • (2002) AJNR Am J Neuroradiol , vol.23 , pp. 180-188
    • Li, F.1    Liu, K.F.2    Silva, M.D.3    Meng, X.4    Gerriets, T.5    Helmer, K.G.6    Fenstermacher, J.D.7    Sotak, C.H.8    Fisher, M.9
  • 61
    • 0032806959 scopus 로고    scopus 로고
    • Dynamics of cerebral injury, perfusion, and blood-brain barrier changes after temporary and permanent middle cerebral artery occlusion in the rat
    • Kastrup A, Engelhorn T, Beaulieu C, de Crespigny A, Moseley ME (1999) Dynamics of cerebral injury, perfusion, and blood-brain barrier changes after temporary and permanent middle cerebral artery occlusion in the rat. J Neurol Sci 166:91-99
    • (1999) J Neurol Sci , vol.166 , pp. 91-99
    • Kastrup, A.1    Engelhorn, T.2    Beaulieu, C.3    De Crespigny, A.4    Moseley, M.E.5
  • 62
    • 0028128974 scopus 로고
    • Reperfusioninduced injury to the blood-brain barrier after middle cerebral artery occlusion in rats
    • Yang GY, Betz AL (1994) Reperfusioninduced injury to the blood-brain barrier after middle cerebral artery occlusion in rats. Stroke 25:1658-1664
    • (1994) Stroke , vol.25 , pp. 1658-1664
    • Yang, G.Y.1    Betz, A.L.2
  • 63
    • 33846866507 scopus 로고    scopus 로고
    • Reperfusion injury following cerebral ischemia: Pathophysiology, MRimaging, and potencial therapies
    • Pan J, Constas A-A, Bateman B, Ortolano GA, Pile-Spellman J (2007) Reperfusion injury following cerebral ischemia: pathophysiology, MRimaging, and potencial therapies. Neuroradiology 49:93-102
    • (2007) Neuroradiology , vol.49 , pp. 93-102
    • Pan, J.1    Constas, A.-A.2    Bateman, B.3    Ortolano, G.A.4    Pile-Spellman, J.5
  • 66
    • 25144441310 scopus 로고    scopus 로고
    • Statistical prediction of tissue fate in acute ischemic brain injury
    • DOI 10.1038/sj.jcbfm.9600126, PII 9600126
    • Shen Q, Ren H, Fisher M, Duong TQ (2005) Statistical prediction of tissue fate in acute ischemic brain injury. J Cereb Blood Flow Metab 25:1336-1345 (Pubitemid 41348735)
    • (2005) Journal of Cerebral Blood Flow and Metabolism , vol.25 , Issue.10 , pp. 1336-1345
    • Shen, Q.1    Ren, H.2    Fisher, M.3    Duong, T.Q.4
  • 67
    • 46049104170 scopus 로고    scopus 로고
    • Blood-brain barrier permeability to manganese and to Gd-DOTA in a rat model of transient cerebral ischaemia
    • Grillon E, Provent P, Montigon O, Segebarth C, Rémy C, Barbier EL (2008) Blood-brain barrier permeability to manganese and to Gd-DOTA in a rat model of transient cerebral ischaemia. NMR Biomed 21:427-436
    • (2008) NMR Biomed , vol.21 , pp. 427-436
    • Grillon, E.1    Provent, P.2    Montigon, O.3    Segebarth, C.4    Rémy, C.5    Barbier, E.L.6
  • 69
    • 58149333282 scopus 로고    scopus 로고
    • Reperfusion-associated hemorrhagic transformation in SHR rats: Evidence of symptomatic parenchymal hematoma
    • Henning EC, Latour LL, Hallenbeck JM, Warach S (2008) Reperfusion-associated hemorrhagic transformation in SHR rats: evidence of symptomatic parenchymal hematoma. Stroke 39:3405-3410
    • (2008) Stroke , vol.39 , pp. 3405-3410
    • Henning, E.C.1    Latour, L.L.2    Hallenbeck, J.M.3    Warach, S.4
  • 70
    • 33846596215 scopus 로고    scopus 로고
    • Imaging inflammation in acute brain ischemia
    • Jander S, Schroeter M, Saleh A (2007) Imaging inflammation in acute brain ischemia. Stroke 38(2 Suppl):642-645
    • (2007) Stroke , vol.38 , Issue.2 SUPPL. , pp. 642-645
    • Jander, S.1    Schroeter, M.2    Saleh, A.3
  • 71
    • 59349104380 scopus 로고    scopus 로고
    • Imaging of inflammation in the peripheral and central nervous system by magnetic resonance imaging
    • Stoll G, Bendszus M (2009) Imaging of inflammation in the peripheral and central nervous system by magnetic resonance imaging. Neuroscience 158:1151-1160
    • (2009) Neuroscience , vol.158 , pp. 1151-1160
    • Stoll, G.1    Bendszus, M.2
  • 72
    • 34848828298 scopus 로고    scopus 로고
    • Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke
    • Saleh A, Schroeter M, Ringelstein A, Hartung HP, Siebler M, Mödder U, Jander S (2007) Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke. Stroke 38:2733-2737
    • (2007) Stroke , vol.38 , pp. 2733-2737
    • Saleh, A.1    Schroeter, M.2    Ringelstein, A.3    Hartung, H.P.4    Siebler, M.5    Mödder, U.6    Jander, S.7
  • 74
    • 46149109247 scopus 로고    scopus 로고
    • Imaging of the inflammatory response in reperfusion injury after transient cerebral ischemia in rats: Correlation of superparamagnetic iron oxide-enhanced magnetic resonance imaging with histopathology
    • Kim J, Kim DI, Lee SK, Kim DJ, Lee JE, Ahn SK (2008) Imaging of the inflammatory response in reperfusion injury after transient cerebral ischemia in rats: correlation of superparamagnetic iron oxide-enhanced magnetic resonance imaging with histopathology. Acta Radiol 49:580-588
    • (2008) Acta Radiol , vol.49 , pp. 580-588
    • Kim, J.1    Kim, D.I.2    Lee, S.K.3    Kim, D.J.4    Lee, J.E.5    Ahn, S.K.6
  • 75
    • 65549152740 scopus 로고    scopus 로고
    • Early-stage investigations of ultrasmall superparamagnetic iron oxide-induced signal change after permanent middle cerebral artery occlusion in mice
    • Desestret V, Brisset JC, Moucharrafie S, Devillard E, Nataf S, Honnorat J, Nighoghossian N, Berthezène Y, Wiart M (2009) Early-stage investigations of ultrasmall superparamagnetic iron oxide-induced signal change after permanent middle cerebral artery occlusion in mice. Stroke 40:1834-1841
    • (2009) Stroke , vol.40 , pp. 1834-1841
    • Desestret, V.1    Brisset, J.C.2    Moucharrafie, S.3    Devillard, E.4    Nataf, S.5    Honnorat, J.6    Nighoghossian, N.7    Berthezène, Y.8    Wiart, M.9
  • 80
    • 34547474911 scopus 로고    scopus 로고
    • Future contrast agents for molecular imaging in stroke
    • Heckl S (2007) Future contrast agents for molecular imaging in stroke. Curr Med Chem 14:1713-1728
    • (2007) Curr Med Chem , vol.14 , pp. 1713-1728
    • Heckl, S.1
  • 81
    • 59349100522 scopus 로고    scopus 로고
    • Noninvasive visualization of CNS inflammation with nuclear and optical imaging
    • Wunder A, Klohs J, Dirnagl U (2009) Noninvasive visualization of CNS inflammation with nuclear and optical imaging. Neuroscience 158:1161-1173
    • (2009) Neuroscience , vol.158 , pp. 1161-1173
    • Wunder, A.1    Klohs, J.2    Dirnagl, U.3
  • 82
    • 20944433389 scopus 로고    scopus 로고
    • Micropet imaging: In vivo biochemistry in small animals
    • Sossi V, Ruth TJ (2005) Micropet imaging: in vivo biochemistry in small animals. J Neural Transm 112:319-330
    • (2005) J Neural Transm , vol.112 , pp. 319-330
    • Sossi, V.1    Ruth, T.J.2
  • 83
    • 0017368491 scopus 로고
    • The [14C] deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure and normal values in the conscious and anesthetized albino rat
    • Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M (1977) The [14C] deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897-916
    • (1977) J Neurochem , vol.28 , pp. 897-916
    • Sokoloff, L.1    Reivich, M.2    Kennedy, C.3    Des Rosiers, M.H.4    Patlak, C.S.5    Pettigrew, K.D.6    Sakurada, O.7    Shinohara, M.8
  • 84
    • 0030716198 scopus 로고    scopus 로고
    • Transient middle cerebral artery occlusion by intraluminal suture: I. Threedimensional autoradiographic image-analysis of local cerebral glucose metabolism-blood flow interrelationships during ischemia and early recirculation
    • Belayev L, Zhao W, Busto R, Ginsberg MD (1997) Transient middle cerebral artery occlusion by intraluminal suture: I. Threedimensional autoradiographic image-analysis of local cerebral glucose metabolism-blood flow interrelationships during ischemia and early recirculation. J Cereb Blood Flow Metab 17:1266-1280
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 1266-1280
    • Belayev, L.1    Zhao, W.2    Busto, R.3    Ginsberg, M.D.4
  • 85
    • 2642573312 scopus 로고    scopus 로고
    • 3-Nitropropionic acid-induced neurotoxicity - Assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy
    • Brownell AL, Chen YI, Yu M, Wang X, Dedeoglu A, Cicchetti F, Jenkins BG, Beal MF (2004) 3-Nitropropionic acid-induced neurotoxicity - assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy. J Neurochem 89:1206-1214
    • (2004) J Neurochem , vol.89 , pp. 1206-1214
    • Brownell, A.L.1    Chen, Y.I.2    Yu, M.3    Wang, X.4    Dedeoglu, A.5    Cicchetti, F.6    Jenkins, B.G.7    Beal, M.F.8
  • 86
    • 15944409947 scopus 로고    scopus 로고
    • Cerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's disease
    • Wang X, Sarkar A, Cicchetti F, Yu M, Zhu A, Jokivarsi K, Saint-Pierre M, Brownell AL (2005) Cerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's disease. J Neurol Sci 231:57-66
    • (2005) J Neurol Sci , vol.231 , pp. 57-66
    • Wang, X.1    Sarkar, A.2    Cicchetti, F.3    Yu, M.4    Zhu, A.5    Jokivarsi, K.6    Saint-Pierre, M.7    Brownell, A.L.8
  • 87
    • 0033778913 scopus 로고    scopus 로고
    • Quantitative assessment of longitudinal metabolic changes in vivo after traumatic brain injury in the adult rat using FDG-microPET
    • Moore AH, Osteen CL, Chatziioannou AF, Hovda DA, Cherry SR (2000) Quantitative assessment of longitudinal metabolic changes in vivo after traumatic brain injury in the adult rat using FDG-microPET. J Cereb Blood Flow Metab 20:1492-1501
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 1492-1501
    • Moore, A.H.1    Osteen, C.L.2    Chatziioannou, A.F.3    Hovda, D.A.4    Cherry, S.R.5
  • 88
    • 2542469900 scopus 로고    scopus 로고
    • Measurement of cerebral glucose metabolic rates in the anesthetized rat by dynamic scanning with 18F-FDG, the ATLAS small animal PET scanner, and arterial blood sampling
    • Shimoji K, Ravasi L, Schmidt K, Soto- Montenegro ML, Esaki T, Seidel J, Jagoda E, Sokoloff L, Green MV, Eckelman WC (2004) Measurement of cerebral glucose metabolic rates in the anesthetized rat by dynamic scanning with 18F-FDG, the ATLAS small animal PET scanner, and arterial blood sampling. J Nucl Med 45:665-672
    • (2004) J Nucl Med , vol.45 , pp. 665-672
    • Shimoji, K.1    Ravasi, L.2    Schmidt, K.3    Soto-Montenegro, M.L.4    Esaki, T.5    Seidel, J.6    Jagoda, E.7    Sokoloff, L.8    Green, M.V.9    Eckelman, W.C.10
  • 92
  • 94
    • 65749100363 scopus 로고    scopus 로고
    • Depressed glucose consumption at reperfusion following brain ischemia does not correlate with mitochondrial dysfunction and development of infarction: An in vivo positron emission tomography study
    • Martin A, Rojas S, Pareto D, Santalucia T, Millan O, Abasolo I, Gomez V, Llop J, Gispert JD, Falcon C, Bargallo N, Planas AM (2009) Depressed glucose consumption at reperfusion following brain ischemia does not correlate with mitochondrial dysfunction and development of infarction: an in vivo positron emission tomography study. Curr Neurovasc Res 6:82-88
    • (2009) Curr Neurovasc Res , vol.6 , pp. 82-88
    • Martin, A.1    Rojas, S.2    Pareto, D.3    Santalucia, T.4    Millan, O.5    Abasolo, I.6    Gomez, V.7    Llop, J.8    Gispert, J.D.9    Falcon, C.10    Bargallo, N.11    Planas, A.M.12
  • 96
    • 0029034729 scopus 로고
    • Noninvasive measurement of cerebral blood flow and glucose metabolic rate in the rat with high-resolution animal positron emission tomography (PET): A novel in vivo approach for assessing drug action in the brains of small animals
    • Magata Y, Saji H, Choi SR, Tajima K, Takagaki T, Sasayama S, Yonekura Y, Kitano H, Watanabe M, Okada H, Yoshikawa E, Yamashita T, Yokoyama A, Konishi J (1995) Noninvasive measurement of cerebral blood flow and glucose metabolic rate in the rat with high-resolution animal positron emission tomography (PET): a novel in vivo approach for assessing drug action in the brains of small animals. Biol Pharm Bull 18:753-756
    • (1995) Biol Pharm Bull , vol.18 , pp. 753-756
    • Magata, Y.1    Saji, H.2    Choi, S.R.3    Tajima, K.4    Takagaki, T.5    Sasayama, S.6    Yonekura, Y.7    Kitano, H.8    Watanabe, M.9    Okada, H.10    Yoshikawa, E.11    Yamashita, T.12    Yokoyama, A.13    Konishi, J.14
  • 98
    • 0032741128 scopus 로고    scopus 로고
    • Disturbance of cerebral blood flow autoregulation in hypertension is attributable to ischaemia following subarachnoid haemorrhage in rats: A PET study
    • Yamamoto S, Teng W, Kakiuchi T, Tsukada H (1999) Disturbance of cerebral blood flow autoregulation in hypertension is attributable to ischaemia following subarachnoid haemorrhage in rats: a PET study. Acta Neurochir (Wien) 141:1213-1219
    • (1999) Acta Neurochir (Wien) , vol.141 , pp. 1213-1219
    • Yamamoto, S.1    Teng, W.2    Kakiuchi, T.3    Tsukada, H.4
  • 99
    • 26444526921 scopus 로고    scopus 로고
    • Noninvasive quantification of cerebral blood flow for rats by microPET imaging of 15O labelled water: The application of a cardiac time-activity curve for the tracer arterial input function
    • Yee SH, Jerabek PA, Fox PT (2005) Noninvasive quantification of cerebral blood flow for rats by microPET imaging of 15O labelled water: the application of a cardiac time-activity curve for the tracer arterial input function. Nucl Med Commun 26:903-911
    • (2005) Nucl Med Commun , vol.26 , pp. 903-911
    • Yee, S.H.1    Jerabek, P.A.2    Fox, P.T.3
  • 100
    • 67349283094 scopus 로고    scopus 로고
    • Neuroinflammation extends brain tissue at risk to vital peri-infarct tissue: A double tracer [11) C]PK11195- and [(18)F]FDGPET study
    • Schroeter M, Dennin MA, Walberer M, Backes H, Neumaier B, Fink GR, Graf R (2009) Neuroinflammation extends brain tissue at risk to vital peri-infarct tissue: a double tracer [(11)C]PK11195- and [(18)F]FDGPET study. J Cereb Blood Flow Metab 29:1216-1225
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1216-1225
    • Schroeter, M.1    Dennin, M.A.2    Walberer, M.3    Backes, H.4    Neumaier, B.5    Fink, G.R.6    Graf, R.7
  • 101
    • 0030671284 scopus 로고    scopus 로고
    • Early detection of irreversibly damaged ischemic tissue by flumazenil positron emission tomography in cats
    • Heiss WD, Graf R, Fujita T, Ohta K, Bauer B, Lottgen J, Wienhard K (1997) Early detection of irreversibly damaged ischemic tissue by flumazenil positron emission tomography in cats. Stroke 28:2045-2051
    • (1997) Stroke , vol.28 , pp. 2045-2051
    • Heiss, W.D.1    Graf, R.2    Fujita, T.3    Ohta, K.4    Bauer, B.5    Lottgen, J.6    Wienhard, K.7
  • 102
    • 0033621655 scopus 로고    scopus 로고
    • [11C] Flumazenil/H2O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy
    • Heiss WD, Kracht L, Grond M, Rudolf J, Bauer B, Wienhard K, Pawlik G (2000) [11C] Flumazenil/H2O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy. Stroke 31:366-369
    • (2000) Stroke , vol.31 , pp. 366-369
    • Heiss, W.D.1    Kracht, L.2    Grond, M.3    Rudolf, J.4    Bauer, B.5    Wienhard, K.6    Pawlik, G.7
  • 103
    • 0035186833 scopus 로고    scopus 로고
    • Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia
    • Heiss WD, Kracht LW, Thiel A, Grond M, Pawlik G (2001) Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia. Brain 124:20-29
    • (2001) Brain , vol.124 , pp. 20-29
    • Heiss, W.D.1    Kracht, L.W.2    Thiel, A.3    Grond, M.4    Pawlik, G.5
  • 104
    • 3242781057 scopus 로고    scopus 로고
    • Probability of cortical infarction predicted by flumazenil binding and diffusionweighted imaging signal intensity: A comparative positron emission tomography/ magnetic resonance imaging study in early ischemic stroke
    • Heiss WD, Sobesky J, Smekal U, Kracht LW, Lehnhardt FG, Thiel A, Jacobs AH, Lackner K (2004) Probability of cortical infarction predicted by flumazenil binding and diffusionweighted imaging signal intensity: a comparative positron emission tomography/ magnetic resonance imaging study in early ischemic stroke. Stroke 35:1892-1898
    • (2004) Stroke , vol.35 , pp. 1892-1898
    • Heiss, W.D.1    Sobesky, J.2    Smekal, U.3    Kracht, L.W.4    Lehnhardt, F.G.5    Thiel, A.6    Jacobs, A.H.7    Lackner, K.8
  • 105
    • 33644875404 scopus 로고    scopus 로고
    • Selective neuronal damage and borderzone infarction in carotid artery occlusive disease: A 11C-flumazenil PET study
    • Yamauchi H, Kudoh T, Kishibe Y, Iwasaki J, Kagawa S (2005) Selective neuronal damage and borderzone infarction in carotid artery occlusive disease: a 11C-flumazenil PET study. J Nucl Med 46:1973-1979
    • (2005) J Nucl Med , vol.46 , pp. 1973-1979
    • Yamauchi, H.1    Kudoh, T.2    Kishibe, Y.3    Iwasaki, J.4    Kagawa, S.5
  • 106
    • 0029093550 scopus 로고
    • Dual-tracer autoradiography using 125I-iomazenil and 99Tcm-HMPAO in experimental brain ischaemia
    • Matsuda H, Tsuji S, Kuji I, Shiba K, Hisada K, Mori H (1995) Dual-tracer autoradiography using 125I-iomazenil and 99Tcm-HMPAO in experimental brain ischaemia. Nucl Med Commun 16:581-590
    • (1995) Nucl Med Commun , vol.16 , pp. 581-590
    • Matsuda, H.1    Tsuji, S.2    Kuji, I.3    Shiba, K.4    Hisada, K.5    Mori, H.6
  • 107
    • 3843059189 scopus 로고    scopus 로고
    • Discrepancy between cell injury and benzodiazepine receptor binding alter transient middle cerebral artery occlusion in rats
    • Abe K, Kashiwagi Y, Tokumura M, Hosoi R, Hatazawa J, Inoue O (2004) Discrepancy between cell injury and benzodiazepine receptor binding alter transient middle cerebral artery occlusion in rats. Synapse 53:234-239
    • (2004) Synapse , vol.53 , pp. 234-239
    • Abe, K.1    Kashiwagi, Y.2    Tokumura, M.3    Hosoi, R.4    Hatazawa, J.5    Inoue, O.6
  • 109
    • 0020972758 scopus 로고
    • Labelling of "peripheral-type" benzodiazepine binding sites in the rat brain by using 3H-PK11195, an isoquinoline carboxamide derivative: Kinetic studies and autoradiographic localization
    • Benavides J, Quarteronet D, Imbault F, Malgouris C, Uzan A, Renault C, Dubroeucq MC, Gueremy C, Le Fur G (1983) Labelling of "peripheral- type" benzodiazepine binding sites in the rat brain by using 3H-PK11195, an isoquinoline carboxamide derivative: kinetic studies and autoradiographic localization. J Neurochem 41:1744-1750
    • (1983) J Neurochem , vol.41 , pp. 1744-1750
    • Benavides, J.1    Quarteronet, D.2    Imbault, F.3    Malgouris, C.4    Uzan, A.5    Renault, C.6    Dubroeucq, M.C.7    Gueremy, C.8    Le Fur, G.9
  • 111
    • 0025975408 scopus 로고
    • Macrophage and astrocyte populations in relation to 3HPK 11195 binding in rat cerebral cortex following a local ischaemic lesion
    • Myers R, Manjil LG, Cullen BM, Price GW, Frackowiak RSJ, Cremer JE (1991) Macrophage and astrocyte populations in relation to 3HPK 11195 binding in rat cerebral cortex following a local ischaemic lesion. J Cereb Blood Flow Metab 11:314-322
    • (1991) J Cereb Blood Flow Metab , vol.11 , pp. 314-322
    • Myers, R.1    Manjil, L.G.2    Cullen, B.M.3    Price, G.W.4    Rsj, F.5    Cremer, J.E.6
  • 112
    • 0025918563 scopus 로고
    • 3HPK 11195 and the localisation of secondary thalamic lesions following focal ischaemia in rat motor cortex
    • Myers R, Manjil LG, Frackowiak RSJ, Cremer JE (1991) 3HPK 11195 and the localisation of secondary thalamic lesions following focal ischaemia in rat motor cortex. Neurosci Lett 133:20-24
    • (1991) Neurosci Lett , vol.133 , pp. 20-24
    • Myers, R.1    Manjil, L.G.2    Rsj, F.3    Cremer, J.E.4
  • 113
    • 0029047144 scopus 로고
    • Peripheral benzodiacepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat
    • Stephenson DT, Schober DA, Smalstig EB, Mincy RE, Gehlert DR, Clemens JA (1995) Peripheral benzodiacepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat. J Neurosci 15:5263-5274
    • (1995) J Neurosci , vol.15 , pp. 5263-5274
    • Stephenson, D.T.1    Schober, D.A.2    Smalstig, E.B.3    Mincy, R.E.4    Gehlert, D.R.5    Clemens, J.A.6
  • 114
    • 0030916343 scopus 로고    scopus 로고
    • PK ('peripheral benzodiazepine') - Binding sites in the CNS indicate early and discrete brain lesions: Microautoradiographic detection of [3H]PK11195 binding to activated microglia
    • Banati RB, Myers R, Kreutzberg GW (1997) PK ('peripheral benzodiazepine') - binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia. J Neurocytol 26:77-82
    • (1997) J Neurocytol , vol.26 , pp. 77-82
    • Banati, R.B.1    Myers, R.2    Kreutzberg, G.W.3
  • 115
    • 0028123413 scopus 로고
    • The peripheral-type benzodiazepine receptor is present in astrocytes but is not a primary site of action for convulsants/anticonvulsants
    • Moynagh PN, Schousboe A, Williams DC (1994) The peripheral-type benzodiazepine receptor is present in astrocytes but is not a primary site of action for convulsants/anticonvulsants. J Neurochem 62:673-679
    • (1994) J Neurochem , vol.62 , pp. 673-679
    • Moynagh, P.N.1    Schousboe, A.2    Williams, D.C.3
  • 117
    • 0034637843 scopus 로고    scopus 로고
    • In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke
    • Gerhard A, Neumaier B, Elitok E, Glatting G, Ries V, Tomczak R, Ludolph AC, Reske SN (2000) In vivo imaging of activated microglia using [11C]PK11195 and positron emission tomography in patients after ischemic stroke. NeuroReport 11:2957-2960
    • (2000) NeuroReport , vol.11 , pp. 2957-2960
    • Gerhard, A.1    Neumaier, B.2    Elitok, E.3    Glatting, G.4    Ries, V.5    Tomczak, R.6    Ludolph, A.C.7    Reske, S.N.8
  • 118
    • 16244422002 scopus 로고    scopus 로고
    • Evolution of microglial activation in patients after ischemic stroke: A [11C](R)-PK11195 PET study
    • Gerhard A, Schwarz J, Myers R, Wise R, Banati RB (2005) Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study. Neuroimage 24:591-595
    • (2005) Neuroimage , vol.24 , pp. 591-595
    • Gerhard, A.1    Schwarz, J.2    Myers, R.3    Wise, R.4    Banati, R.B.5
  • 121
    • 62449175342 scopus 로고    scopus 로고
    • Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation
    • Chauveau F, Van Camp N, Dollé F, Kuhnast B, Hinnen F, Damont A, Boutin H, James M, Kassiou M, Tavitian B (2009) Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation. J Nucl Med 50:468-476
    • (2009) J Nucl Med , vol.50 , pp. 468-476
    • Chauveau, F.1    Van Camp, N.2    Dollé, F.3    Kuhnast, B.4    Hinnen, F.5    Damont, A.6    Boutin, H.7    James, M.8    Kassiou, M.9    Tavitian, B.10
  • 125
    • 1642451807 scopus 로고    scopus 로고
    • Comparative studies of potential cancer biomarkers carbon-11 labeled MMP inhibitors (S)-2-(4¢-[11C]methoxybiphenyl-4- sulfonylamino)-3-methylbutyric acid and N-hydroxy-(R)-2-[[(4¢-[11C]methoxyphenyl) sulfonyl]benzylamino]- 3-methylbutanamide
    • Zheng QH, Fei X, Liu X, Wang JQ, Stone KL, Martinez TD, Gay DJ, Baity WL, Miller KD, Sledge GW, Hutchins GD (2004) Comparative studies of potential cancer biomarkers carbon-11 labeled MMP inhibitors (S)-2-(4¢-[11C] methoxybiphenyl-4- sulfonylamino)-3-methylbutyric acid and N-hydroxy-(R)-2- [[(4¢-[11C]methoxyphenyl) sulfonyl]benzylamino]-3-methylbutanamide. Nucl Med Biol 31:77-85
    • (2004) Nucl Med Biol , vol.31 , pp. 77-85
    • Zheng, Q.H.1    Fei, X.2    Liu, X.3    Wang, J.Q.4    Stone, K.L.5    Martinez, T.D.6    Gay, D.J.7    Baity, W.L.8    Miller, K.D.9    Sledge, G.W.10    Hutchins, G.D.11
  • 127
    • 60149095901 scopus 로고    scopus 로고
    • A new 18F-labelled derivative of the MMP inhibitor CGS 27023A for PET: Radiosynthesis and initial small-animal PET studies
    • Wagner S, Breyholz HJ, Höltke C, Faust A, Schober O, Schäfers M, Kopka K (2009) A new 18F-labelled derivative of the MMP inhibitor CGS 27023A for PET: radiosynthesis and initial small-animal PET studies. Appl Radiat Isot 67:606-610
    • (2009) Appl Radiat Isot , vol.67 , pp. 606-610
    • Wagner, S.1    Breyholz, H.J.2    Höltke, C.3    Faust, A.4    Schober, O.5    Schäfers, M.6    Kopka, K.7
  • 128
    • 36148960822 scopus 로고    scopus 로고
    • Novel fluorinated derivatives of the broadspectrum MMP inhibitors N-hydroxy-2(R)- [[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3- methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET
    • Wagner S, Breyholz HJ, Law MP, Faust A, Höltke C, Schröer S, Haufe G, Levkau B, Schober O, Schäfers M, Kopka K (2007) Novel fluorinated derivatives of the broadspectrum MMP inhibitors N-hydroxy-2(R)- [[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem 50:5752-5764
    • (2007) J Med Chem , vol.50 , pp. 5752-5764
    • Wagner, S.1    Breyholz, H.J.2    Law, M.P.3    Faust, A.4    Höltke, C.5    Schröer, S.6    Haufe, G.7    Levkau, B.8    Schober, O.9    Schäfers, M.10    Kopka, K.11
  • 130
    • 29744458180 scopus 로고    scopus 로고
    • Mapping brain activity following administration of a nicotinic acetylcholine receptor agonist, ABT-594, using functional magnetic resonance imaging in awake rats
    • Skoubis PD, Hradil V, Chin CL, Luo Y, Fox GB, McGaraughty S (2006) Mapping brain activity following administration of a nicotinic acetylcholine receptor agonist, ABT-594, using functional magnetic resonance imaging in awake rats. Neuroscience 137:583-591
    • (2006) Neuroscience , vol.137 , pp. 583-591
    • Skoubis, P.D.1    Hradil, V.2    Chin, C.L.3    Luo, Y.4    Fox, G.B.5    McGaraughty, S.6
  • 131
    • 33750683361 scopus 로고    scopus 로고
    • Pharmacological MRI in awake rats reveals neural activity in area postrema and nucleus tractus solitarius: Relevance as a potential biomarker for detecting druginduced emesis
    • Chin CL, Fox GB, Hradil VP, Osinski MA, McGaraughty SP, Skoubis PD, Cox BF, Luo Y (2006) Pharmacological MRI in awake rats reveals neural activity in area postrema and nucleus tractus solitarius: relevance as a potential biomarker for detecting druginduced emesis. Neuroimage 33:1152-1160
    • (2006) Neuroimage , vol.33 , pp. 1152-1160
    • Chin, C.L.1    Fox, G.B.2    Hradil, V.P.3    Osinski, M.A.4    McGaraughty, S.P.5    Skoubis, P.D.6    Cox, B.F.7    Luo, Y.8
  • 133
    • 35248848863 scopus 로고    scopus 로고
    • Confounding effects of volatile anesthesia on CBV assessment in rodent forebrain following ethanol challenge
    • Luo F, Li Z, Treistman SN, Kim YR, King JA, Fox GB, Ferris CF (2007) Confounding effects of volatile anesthesia on CBV assessment in rodent forebrain following ethanol challenge. J Magn Reson Imaging 26:557-563
    • (2007) J Magn Reson Imaging , vol.26 , pp. 557-563
    • Luo, F.1    Li, Z.2    Treistman, S.N.3    Kim, Y.R.4    King, J.A.5    Fox, G.B.6    Ferris, C.F.7
  • 134
    • 8844264509 scopus 로고    scopus 로고
    • Rat-PET study without anesthesia: Anesthetics modify the dopamine D1 receptor binding in rat brain
    • Momosaki S, Hatano K, Kawasumi Y, Kato T, Hosoi R, Kobayashi K, Inoue O, Ito K (2004) Rat-PET study without anesthesia: anesthetics modify the dopamine D1 receptor binding in rat brain. Synapse 54:207-213
    • (2004) Synapse , vol.54 , pp. 207-213
    • Momosaki, S.1    Hatano, K.2    Kawasumi, Y.3    Kato, T.4    Hosoi, R.5    Kobayashi, K.6    Inoue, O.7    Ito, K.8
  • 135
    • 38049003590 scopus 로고    scopus 로고
    • Anesthesia and other considerations for in vivo imaging of small animals
    • Hildebrandt IJ, Su H, Weber WA (2008) Anesthesia and other considerations for in vivo imaging of small animals. ILAR J 49:17-26
    • (2008) ILAR J , vol.49 , pp. 17-26
    • Hildebrandt, I.J.1    Su, H.2    Weber, W.A.3
  • 136
    • 0347286870 scopus 로고    scopus 로고
    • Animal anaesthesia for in vivo magnetic resonance
    • Lukasik VM, Gillies RJ (2003) Animal anaesthesia for in vivo magnetic resonance. NMR Biomed 16:459-467
    • (2003) NMR Biomed , vol.16 , pp. 459-467
    • Lukasik, V.M.1    Gillies, R.J.2
  • 137
    • 41649120317 scopus 로고    scopus 로고
    • Spatio-temporal characteristics of low-frequency BOLD signal fluctuations in isoflurane-anesthetized rat brain
    • Kannurpatti SS, Biswal BB, Kim YR, Rosen BR (2008) Spatio-temporal characteristics of low-frequency BOLD signal fluctuations in isoflurane-anesthetized rat brain. NeuroImage 40:1738-1747
    • (2008) NeuroImage , vol.40 , pp. 1738-1747
    • Kannurpatti, S.S.1    Biswal, B.B.2    Kim, Y.R.3    Rosen, B.R.4
  • 139
    • 33646203590 scopus 로고    scopus 로고
    • Light stimulus frequency dependence of activity in the rat visual system as studied with high-resolution BOLD fMRI
    • Van Camp N, Verhoye M, De Zeeuw CI, Van der Linden A (2006) Light stimulus frequency dependence of activity in the rat visual system as studied with high-resolution BOLD fMRI. J Neurophysiol 95:3164-3170
    • (2006) J Neurophysiol , vol.95 , pp. 3164-3170
    • Van Camp, N.1    Verhoye, M.2    De Zeeuw, C.I.3    Van Der Linden, A.4
  • 140
    • 31844451520 scopus 로고    scopus 로고
    • A fully noninvasive and robust experimental protocol for longitudinal fMRI studies in the rat
    • Weber R, Ramos-Cabrer P, Wiedermann D, van Camp N, Hoehn M (2006) A fully noninvasive and robust experimental protocol for longitudinal fMRI studies in the rat. NeuroImage 29:1303-1310
    • (2006) NeuroImage , vol.29 , pp. 1303-1310
    • Weber, R.1    Ramos-Cabrer, P.2    Wiedermann, D.3    Van Camp, N.4    Hoehn, M.5
  • 142
    • 36048946349 scopus 로고    scopus 로고
    • BOLD study of stimulation-induced neural activity and resting-state connectivity in medetomidine-sedated rat
    • Zhao F, Zhao T, Zhou L, Wu Q, Hu X (2008) BOLD study of stimulation-induced neural activity and resting-state connectivity in medetomidine-sedated rat. Neuroimage 39:248-260
    • (2008) Neuroimage , vol.39 , pp. 248-260
    • Zhao, F.1    Zhao, T.2    Zhou, L.3    Wu, Q.4    Hu, X.5
  • 143
    • 44449103553 scopus 로고    scopus 로고
    • Reproducible imaging of rat corticothalamic pathway by longitudinal manganese-enhanced MRI (L-MEMRI)
    • Soria G, Wiedermann D, Justicia C, Ramos- Cabrer P, Hoehn M (2008) Reproducible imaging of rat corticothalamic pathway by longitudinal manganese-enhanced MRI (L-MEMRI). Neuroimage 41:668-674
    • (2008) Neuroimage , vol.41 , pp. 668-674
    • Soria, G.1    Wiedermann, D.2    Justicia, C.3    Ramos- Cabrer, P.4    Hoehn, M.5
  • 144
    • 44449097256 scopus 로고    scopus 로고
    • MRI detection of secondary damage after stroke: Chronic iron accumulation in the thalamus of the rat brain
    • Justicia C, Ramos-Cabrer P, Hoehn M (2008) MRI detection of secondary damage after stroke: chronic iron accumulation in the thalamus of the rat brain. Stroke 39:1541-1547
    • (2008) Stroke , vol.39 , pp. 1541-1547
    • Justicia, C.1    Ramos-Cabrer, P.2    Hoehn, M.3
  • 146
  • 148
    • 28444486874 scopus 로고    scopus 로고
    • Arterial spin labeling in small animals: Methods and applications to experimental cerebral ischemia
    • Thomas DL (2005) Arterial spin labeling in small animals: methods and applications to experimental cerebral ischemia. J Magn Reson Imaging 22:741-744
    • (2005) J Magn Reson Imaging , vol.22 , pp. 741-744
    • Thomas, D.L.1
  • 149
    • 0345731290 scopus 로고    scopus 로고
    • Development of acute edema following cerebral hypoxia-ischemia in neonatal compared with juvenile rats using magnetic resonance imaging
    • Qiao M, Latta P, Meng S, Tomanek B, Tuor UI (2004) Development of acute edema following cerebral hypoxia-ischemia in neonatal compared with juvenile rats using magnetic resonance imaging. Pediatric Res 55:101-106
    • (2004) Pediatric Res , vol.55 , pp. 101-106
    • Qiao, M.1    Latta, P.2    Meng, S.3    Tomanek, B.4    Tuor, U.I.5
  • 151
    • 33744742957 scopus 로고    scopus 로고
    • Principles of magnetic resonance assessment of brain function
    • Norris DG (2006) Principles of magnetic resonance assessment of brain function. J Magn Reson Imaging 23:794-807
    • (2006) J Magn Reson Imaging , vol.23 , pp. 794-807
    • Norris, D.G.1
  • 153
    • 19344362525 scopus 로고    scopus 로고
    • Temporal evolution of the CBVfMRI signal to rat whisker stimulation of variable duration and intensity: A linearity analysis
    • Lu H, Soltysik DA, Ward BD, Hyde JS (2005) Temporal evolution of the CBVfMRI signal to rat whisker stimulation of variable duration and intensity: a linearity analysis. NeuroImage 26:432-440
    • (2005) NeuroImage , vol.26 , pp. 432-440
    • Lu, H.1    Soltysik, D.A.2    Ward, B.D.3    Hyde, J.S.4
  • 154
    • 1542358814 scopus 로고    scopus 로고
    • Functional magnetic resonance imaging of macaque monkeys performing visually guided saccade tasks: Comparison of cortical eye fields with humans
    • Koyama M, Hasegawa I, Osada T, Adachi Y, Nakahara K, Miyashita Y (2004) Functional magnetic resonance imaging of macaque monkeys performing visually guided saccade tasks: comparison of cortical eye fields with humans. Neuron 41:795-807
    • (2004) Neuron , vol.41 , pp. 795-807
    • Koyama, M.1    Hasegawa, I.2    Osada, T.3    Adachi, Y.4    Nakahara, K.5    Miyashita, Y.6
  • 155
    • 10944227770 scopus 로고    scopus 로고
    • Functional magnetic resonance imaging and somatosensory evoked potentials in rats with a neonatally induced freeze lesion of the somatosensory cortex
    • Schwindt W, Burke M, Pillekamp F, Luhmann HJ, Hoehn M (2004) Functional magnetic resonance imaging and somatosensory evoked potentials in rats with a neonatally induced freeze lesion of the somatosensory cortex. J Cereb Blood Flow Metab 24:1409-1418
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 1409-1418
    • Schwindt, W.1    Burke, M.2    Pillekamp, F.3    Luhmann, H.J.4    Hoehn, M.5
  • 156
    • 33748167874 scopus 로고    scopus 로고
    • Differential effects of NMDA and AMPA glutamate receptors on functional magnetic resonance imaging signals and evoked neuronal activity during forepaw stimulation of the rat
    • Gsell W, Burke M, Wiedermann D, Bonvento G, Silva AC, Dauphin F, Bührle C, Hoehn M, Schwindt W (2006) Differential effects of NMDA and AMPA glutamate receptors on functional magnetic resonance imaging signals and evoked neuronal activity during forepaw stimulation of the rat. J Neurosci 26:8409-8416
    • (2006) J Neurosci , vol.26 , pp. 8409-8416
    • Gsell, W.1    Burke, M.2    Wiedermann, D.3    Bonvento, G.4    Silva, A.C.5    Dauphin, F.6    Bührle, C.7    Hoehn, M.8    Schwindt, W.9
  • 157
    • 24944536716 scopus 로고    scopus 로고
    • Methodological considerations in rat brain BOLD contrast pharmacological MRI
    • Steward CA, Marsden CA, Prior MJW, Morris PG, Shah YB (2005) Methodological considerations in rat brain BOLD contrast pharmacological MRI. Psychopharmacology 180:687-704
    • (2005) Psychopharmacology , vol.180 , pp. 687-704
    • Steward, C.A.1    Marsden, C.A.2    Mjw, P.3    Morris, P.G.4    Shah, Y.B.5
  • 159
    • 0028800537 scopus 로고
    • A modified rat model of middle cerebral artery thread occlusion under electrophysiological control for magnetic resonance investigations
    • Kohno K, Back T, Hoehn-Berlage M, Hossmann KA (1995) A modified rat model of middle cerebral artery thread occlusion under electrophysiological control for magnetic resonance investigations. Magn Reson Imaging 13:65-71
    • (1995) Magn Reson Imaging , vol.13 , pp. 65-71
    • Kohno, K.1    Back, T.2    Hoehn-Berlage, M.3    Hossmann, K.A.4
  • 160
    • 1542269064 scopus 로고    scopus 로고
    • Middle cerebral artery occlusion during MR-imaging: Investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats
    • Gerriets T, Stolz E, Walberer M, Müller C, Kluge A, Kaps M, Fisher M, Bachmann G (2004) Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats. Brain Res Brain Res Protoc 12:137-143
    • (2004) Brain Res Brain Res Protoc , vol.12 , pp. 137-143
    • Gerriets, T.1    Stolz, E.2    Walberer, M.3    Müller, C.4    Kluge, A.5    Kaps, M.6    Fisher, M.7    Bachmann, G.8
  • 162
    • 42049110989 scopus 로고    scopus 로고
    • Spillover and partial-volume correction for image-derived input functions for small-animal 18F-FDG PET studies
    • Fang YH, Muzic RF Jr (2008) Spillover and partial-volume correction for image-derived input functions for small-animal 18F-FDG PET studies. J Nucl Med 49:606-614
    • (2008) J Nucl Med , vol.49 , pp. 606-614
    • Fang, Y.H.1    Muzic Jr., R.F.2
  • 163
    • 34548713439 scopus 로고    scopus 로고
    • A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator
    • Mirrione MM, Schiffer WK, Fowler JS, Alexoff DL, Dewey SL, Tsirka SE (2007) A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator. Neuroimage 38:34-42
    • (2007) Neuroimage , vol.38 , pp. 34-42
    • Mirrione, M.M.1    Schiffer, W.K.2    Fowler, J.S.3    Alexoff, D.L.4    Dewey, S.L.5    Tsirka, S.E.6


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