How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET

Stroke

Volumn 39, Issue 3, 2008, Pages 870-877

  Takasawa, Masashi ^a   Jones, P Simon ^a   Guadagno, Joseph V ^a   Christensen, Soren ^b   Fryer, Tim D ^a   Harding, Sally ^a   Gillard, Jonathan H ^a   Williams, Guy B ^a   Aigbirhio, Franklin I ^a   Warburton, Elizabeth A ^a   Østergaard, Leif ^c   Baron, Jean Claude ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Acute stroke; Cerebral blood flow; Imaging; Magnetic resonance; Penumbra; Perfusion; Positron emission tomography

Indexed keywords

OXYGEN 15; OXYGEN;

AGED; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN MAPPING; BRAIN PERFUSION; COMPARATIVE STUDY; FEMALE; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RELIABILITY; STROKE; VALIDATION PROCESS; BLOOD; BLOOD VOLUME; BRAIN; BRAIN CIRCULATION; DIFFERENTIAL THRESHOLD; MAGNETIC RESONANCE ANGIOGRAPHY; METABOLISM; PATHOPHYSIOLOGY; STANDARD; TIME; VALIDATION STUDY;

AGED; BLOOD VOLUME; BRAIN; CEREBROVASCULAR CIRCULATION; DIFFERENTIAL THRESHOLD; FEMALE; HUMANS; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; OXYGEN; POSITRON-EMISSION TOMOGRAPHY; STROKE; TIME FACTORS;

EID: 41249088909     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.107.500090     Document Type: Article

References (30)

1. Muir KW, Buchan A, von Kummer R, Rother J, Baron JC. Imaging of acute stroke. Lancet Neurol. 2006;5:755-768.
2. Wintermark M, Sesay M, Barbier E, Borbely K, Dillon WP, Eastwood JD, Glenn TC, Grandin CB, Pedraza S, Soustiel JF, Nariai T, Zaharchuk G, Caille JM, Dousset V, Yonas H. Comparative overview of brain perfusion imaging techniques. Stroke. 2005;36:e83-e99.
3. Calamante F, Gadian DG, Connelly A. Quantification of perfusion using bolus tracking magnetic resonance imaging in stroke: assumptions, limitations, and potential implications for clinical use. Stroke. 2002;33:1146-1151.
4. Grandin CB, Bol A, Smith AM, Michel C, Cosnard G. Absolute CBF and CBV measurements by MRI bolus tracking before and after acetazolamide challenge: repeatability and comparison with PET in humans. Neuroimage. 2005;26:525-535.
5. 2O positron emission tomography in humans. J Cereb Blood Flow Metab. 1998;18:935-940.
6. Lin W, Celik A, Derdeyn C, An H, Lee Y, Videen T, Ostergaard L, Powers WJ. Quantitative measurements of cerebral blood flow in patients with unilateral carotid artery occlusion: a PET and MR study. J Magn Reson Imaging. 2001;14:659-667.
7. Tanaka Y, Nariai T, Nagaoka T, Akimoto H, Ishiwata K, Ishii K, Matsushima Y, Ohno K. Quantitative evaluation of cerebral hemodynamics in patients with moyamoya disease by dynamic susceptibility contrast magnetic resonance imaging - comparison with positron emission tomography. J Cereb Blood Flow Metab. 2006;26:291-300.
8. Ibaraki M, Ito H, Shimosegawa E, Toyoshima H, Ishigame K, Takahashi K, Kanno I, Miura S. Cerebral vascular mean transit time in healthy humans: a comparative study with PET and dynamic susceptibility contrast-enhanced MRI. J Cereb Blood Flow Metab. 2007;27:404-413.
9. Sobesky J, Zaro Weber O, Lehnhardt FG, Hesselmann V, Thiel A, Dohmen C, Jacobs A, Neveling M, Heiss WD. Which time-to-peak threshold best identifies penumbral flow? a comparison of perfusion-weighted magnetic resonance imaging and positron emission tomography in acute ischemic stroke. Stroke. 2004;35:2843-2847.
10. Sobesky J, Zaro Weber O, Lehnhardt FG, Hesselmann V, Neveling M, Jacobs A, Heiss WD. Does the mismatch match the penumbra? magnetic resonance imaging and positron emission tomography in early ischemic stroke. Stroke. 2005;36:980-985.
11. Guadagno JV, Warburton EA, Jones PS, Day DJ, Aigbirhio FI, Fryer TD, Harding S, Price CJ, Green HA, Barret O, Gillard JH, Baron JC. How affected is oxygen metabolism in DWI lesions? a combined acute stroke PET-MR study. Neurology. 2006;67:824-829.
12. Guadagno JV, Jones PS, Fryer TD, Barret O, Aigbirhio FI, Carpenter TA, Price CJ, Gillard JH, Warburton EA, Baron JC. Local relationships between restricted water diffusion and oxygen consumption in the ischemic human brain. Stroke. 2006;37:1741-1748.
13. Guadagno JV, Warburton EA, Aigbirhio FI, Smielewski P, Fryer TD, Harding S, Price CJ, Gillard JH, Carpenter TA, Baron JC. Does the acute diffusion-weighted imaging lesion represent penumbra as well as core? a combined quantitative PET/MRI voxel-based study. J Cereb Blood Flow Metab. 2004;24:1249-1254.
14. Ostergaard L, Sorensen AG, Kwong KK, Weisskoff RM, Gyldensted C, Rosen BR. High resolution measurement of cerebral blood flow using intravascular tracer bolus passages, part II: experimental comparison and preliminary results. Magn Reson Med. 1996;36:726-736.
15. Wu O, Ostergaard L, Sorensen AG. Technical aspects of perfusion-weighted imaging. Neuroimaging Clin North Am. 2005;15:623-637; xi.
16. Shih LC, Saver JL, Alger JR, Starkman S, Leary MC, Vinuela F, Duckwiler G, Gobin YP, Jahan R, Villablanca JP, Vespa PM, Kidwell CS. Perfusion-weighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissue. Stroke. 2003;34:1425-1430.
17. Falcao AL, Reutens DC, Markus R, Koga M, Read SJ, Tochon-Danguy H, Sachinidis J, Howells DW, Donnan GA. The resistance to ischemia of white and gray matter after stroke. Ann Neurol. 2004;56:695-701.
18. Bristow MS, Simon JE, Brown RA, Eliasziw M, Hill MD, Coutts SB, Frayne R, Demchuk AM, Mitchell JR. MR perfusion and diffusion in acute ischemic stroke: human gray and white matter have different thresholds for infarction. J Cereb Blood Flow Metab. 2005;25:1280-1287.
19. Rose SE, Janke AL, Griffin M, Finnigan S, Chalk JB. Improved prediction of final infarct volume using bolus delay-corrected perfusion-weighted MRI: implications for the ischemic penumbra. Stroke. 2004;35:2466-2471.
20. Ibaraki M, Shimosegawa E, Toyoshima H, Takahashi K, Miura S, Kanno I. Tracer delay correction of cerebral blood flow with dynamic susceptibility contrast-enhanced MRI. J Cereb Blood Flow Metab. 2005;25:378-390.
21. Ostergaard L, Smith DF, Vestergaard-Poulsen P, Hansen SB, Gee AD, Gjedde A, Gyldensted C. Absolute cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking: comparison with positron emission tomography values. J Cereb Blood Flow Metab. 1998;18:425-432.
22. Kajimoto K, Moriwaki H, Yamada N, Hayashida K, Kobayashi J, Miyashita K, Naritomi H. Cerebral hemodynamic evaluation using perfusion-weighted magnetic resonance imaging: comparison with positron emission tomography values in chronic occlusive carotid disease. Stroke. 2003;34:1662-1666.
23. Sette G, Baron JC, Mazoyer B, Levasseur M, Pappata S, Crouzel C. Local brain haemodynamics and oxygen metabolism in cerebrovascular disease: positron emission tomography. Brain. 1989;112(pt 4):931-951.
24. Furlan M, Marchal G, Viader F, Derlon JM, Baron JC. Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol. 1996;40:216-226.
25. Neumann-Haefelin T, Wittsack HJ, Wenserski F, Siebler M, Seitz RJ, Modder U, Freund HJ. Diffusion- and perfusion-weighted MRI: the DWI/PWI mismatch region in acute stroke. Stroke. 1999;30:1591-1597.
26. Shimosegawa E, Hatazawa J, Ibaraki M, Toyoshima H, Suzuki A. Metabolic penumbra of acute brain infarction: a correlation with infarct growth. Ann Neurol. 2005;57:495-504.
27. Grandin CB, Duprez TP, Smith AM, Mataigne F, Peeters A, Oppenheim C, Cosnard G. Usefulness of magnetic resonance-derived quantitative measurements of cerebral blood flow and volume in prediction of infarct growth in hyperacute stroke. Stroke. 2001;32:1147-1153.
28. Grandin CB. Assessment of brain perfusion with MRI: methodology and application to acute stroke. Neuroradiology. 2003;45:755-766.
29. Parsons MW, Barber PA, Chalk J, Darby DG, Rose S, Desmond PM, Gerraty RP, Tress BM, Wright PM, Donnan GA, Davis SM. Diffusion- and perfusion-weighted MRI response to thrombolysis in stroke. Ann Neurol. 2002;51:28-37.
30. Thijs VN, Adami A, Neumann-Haefelin T, Moseley ME, Marks MP, Albers GW. Relationship between severity of MR perfusion deficit and DWI lesion evolution. Neurology. 2001;57:1205-1211.