Imaging brain inflammation with [11C]PK11195 by PET and induction of the peripheral-type benzodiazepine receptor after transient focal ischemia in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 27, Issue 12, 2007, Pages 1975-1986

  Rojas, Santiago ^a   Martín, Abraham ^a   Arranz, Maria J ^a   Pareto, Deborah ^b   Purroy, Jesús ^a   Verdaguer, Esther ^a   Llop, Jordi ^b   Gómez, Vanessa ^b   Gispert, Joan D ^b   Millán, Olga ^b   Chamorro, Ángel ^c   Planas, Anna M ^a,d  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b Barcelona Biomedical Research Park   (Spain)

^c HOSPITAL CLÍNIC   (Spain)

^d INST D INVESTIGACIONS B   (Spain)

Author keywords

Benzodiazepine receptor subtypes; Binding; Cerebral ischemia and or reperfusion; Focal ischemia; Inflammation; PET imaging

Indexed keywords

BENZODIAZEPINE RECEPTOR; MESSENGER RNA; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; TRACER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; ENCEPHALITIS; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MACROPHAGE; MALE; MICROGLIA; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

EID: 36249006825     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600500     Document Type: Article

References (40)

1. 11C] (R)-PK11195 PET-imaging of activated microglia in vivo in Rasmussen's encephalitis. Neurology 53:2199-203
2. 3H]PK11195 binding to activated microglia. J Neurocytol 26:77-82
3. Banati RB, Newcombe J, Gunn RN, Cagnin A, Turkheimer F, Heppner F, Price G, Wegner F, Giovannoni G, Miller DH, Perkin GD, Smith T, Hewson AK, Bydder G, Kreutzberg GW, Jones T, Cuzner ML, Myers R (2000) The peripheral benzodiazepine binding site in the brain in multiple sclerosis. Quantitative in vivo imaging of microglia as a measure of disease activity. Brain 123:2321-37
4. 3H-PK11195, an isoquinoline carboxamide derivative: kinetic studies and autoradiographic localization. J Neurochem 41:1744-50
5. Beschorner R, Schluesener HJ, Gözalan F, Meyermann R, Schwab JM (2002) Infiltrating CD14+ monocytes and expression of CD14 by activated parenchymal microglia/macrophages contributes to the pool of CD14+ cells in ischemic brain lesions. J Neuroimmunol 126:107-15
6. Cagnin A, Brooks DJ, Kennedy AM, Gunn RN, Myers R, Turkheimer FE, Jones T, Banati RB (2001) In-vivo measurement of activated microglia in dementia. Lancet 358:461-7
7. Camsonne R, Crouzel C, Comar D (1984) Synthesis of n-(C-11) methyl, n-(methyl-1 propyl), (chloro-2 phenyl)-1 isoquinoleine carboxamide-3 (PK-11195) - a new ligand for peripheral benzodiazepine receptors. J Labelled Compd Rad 21:985-91
8. Carayon P, Portier M, Dussossoy D, Bord A, Petitpretre G, Canat X, Le Fur G, Casellas P (1996) Involvement of peripheral benzodiazepine receptors in the protection of hematopoietic cells against oxygen radical damage. Blood 87:3170-8
9. Castedo M, Perfettini JL, Kroemer G (2002) Mitochondrial apoptosis and the peripheral benzodiazepine receptor: a novel target for viral and pharmacological manipulation. J Exp Med 196:1121-5
10. Chelli B, Falleni A, Salvetti F, Gremigni V, Lucacchini A, Martini C (2001) Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue. Biochem Pharmacol 61:695-705
11. Chen MK, Baidoo K, Verina T, Guilarte TR (2004) Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. Brain 127:1379-92
12. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction. Anal Biochem 162:156-9
13. 11C]PK11195 and positron emission tomography in patients after ischemic stroke. NeuroReport 11:2957-60
14. 11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis 21:404-12
15. 11C] (R)-PK11195 PET study. Neuro-Image 24:591-5
16. Jander S, Schroeter M, D'Urso D, Gillen C, Witte OW, Stoll G (1998) Focal ischemia of the rat brain elicits an unusual inflammatory response: early appearance of CD8+ macrophages/microglia. Eur J Neurosci 10:680-8
17. Jander S, Schroeter M, Stoll G (2002) Interleukin-18 expression after focal ischemia of the rat brain: association with late-stage inflammatory response. J Cereb Blood Flow Metab 22:62-70
18. Jayakumar AR, Panickar KS, Norenberg MD (2002) Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells. J Neurochem 83:1226-34
19. Jorda EG, Jiménez A, Verdaguer E, Canudas AM, Folch J, Sureda FX, Camins A, Pallas M (2005) Evidence in favour of a role for peripheral-type benzodiazepine receptor ligand in amplification of neuronal apoptosis. Apoptosis 10:91-104
20. Justicia C, Martín A, Rojas S, Gironella M, Cervera A, Panés J, Chamorro A, Planas AM (2006) Anti-VCAM-1 antibodies did not protect against ischemic damage neither in rats nor in mice. J Cereb Blood Flow Metab 26:321-32
21. Kreutzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19:312-8
22. Kuhlmann AC, Guilarte TR (2000) Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity. J Neurochem 74:1694-704
23. Le Fur G, Perrier MI, Vaucher N, Imbault F, Flamier A, Benavides J, Uzan A, Renault C, Dubroeucq MC, Guremy C (1983) Peripheral benzodiazepine binding site: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methyl- propyl)-3-isoquinolinecarboxamide. Life Sci 32:1839-47
24. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25: 402-408
25. McEnery MW, Snowman AM, Trifiletti RR, Snyder SH (1992) Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci USA 89:3170-4
26. Moynagh PN, Schousboe A, Williams DC (1994) The peripheral-type benzodiazepine receptor is present in astrocytes but is not a primary site of action for convulsants/anticonvulsants. J Neurochem 62:673-9
27. 3H-PK 11195 binding in rat cerebral cortex following a local ischaemic lesion. J Cereb Blood Flow Metab 11:314-22
28. 3H-PK 11195 and the localisation of secondary thalamic lesions following focal ischaemia in rat motor cortex. Neurosci Lett 133:20-4
29. Olson JM, Ciliax BJ, Mancini WR, Young AB (1988) Presence of peripheral-type benzodiazepine binding sites on human erythrocyte membranes. Eur J Pharmacol 152:47-53
30. Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapere JJ, Lindemann P, Norenberg MD, Nutt D, Weizman A, Zhang MR, Gavish M (2006) Translocator protein (18kDa): new nomenclature for the peripheraltype benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci 27:402-409
31. 11C]PK11195. Neurology 55:1052-4
32. Price CJ, Wang D, Menon DK, Guadagno JV, Cleij M, Fryer T, Aigbirhio F, Baron JC, Warburton EA (2006) Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke. Stroke 37:1749-53
33. Pubill D, Canudas AM, Pallàs M, Camins A, Camarasa J, Escubedo E (2003) Different glial response against methamphetamine and methylenedioxymethamphetamine-induced neurotoxicity. Naunyn-Schmiedeberg's Arch Pharmacol 367:490-9
34. Ramsay SC, Weiller C, Myers R, Cremer JE, Luthra SK, Lammertsma AA, Frackowiak RS (1992) Monitoring by PET of macrophage accumulation in brain after ischaemic stroke. Lancet 339:1054-5
35. Reichmann G, Schroeter M, Jander S, Fisher H-G (2002) Dendritic cells and dendritic-like microglia in focal cortical ischemia of the mouse brain. J Neuroimmunol 129:125-32
36. Rey C, Mauduit C, Naureils O, Benahmed M, Louisot P, Gasnier F (2000) Up-regulation of mitochondrial peripheral benzodiazepine receptor expression by tumor necrosis factor alpha in testicular leydig cells. Possible involvement in cell survival. Biochem Pharmacol 60:1639-46
37. Rubins DJ, Melega WP, Lacan G, Way B, Plenevaux A, Luxen A, Cherry SR (2003) Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain. Neuroimage 20:2100-18
38. Schroeter M, Jander S, Witte OW, Stoll G (1999) Heterogeneity of the microglial response in photochemically induced focal ischemia of the rat cortex. Neuroscience 89:1367-77
39. Stephenson DT, Schober DA, Smalstig EB, Mincy RE, Gehlert DR, Clemens JA (1995) Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat. J Neurosci 15:5263-74
40. Veenman L, Gavish M (2006) The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development. Pharmacol & Therap 110:503-24