Curcumin targeted signaling pathways: Basis for anti-photoaging and anti-carcinogenic therapy

International Journal of Dermatology

Volumn 49, Issue 6, 2010, Pages 608-622

  Heng, Madalene C Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; GROWTH FACTOR; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHORYLASE KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P53; SUNSCREEN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; ANTINEOPLASTIC AGENT;

ANTINEOPLASTIC ACTIVITY; CARCINOGENESIS; CELL CYCLE REGULATION; CELL PROLIFERATION; CUTANEOUS PARAMETERS; DNA DAMAGE; DRUG ABSORPTION; GENETIC TRANSCRIPTION; HUMAN; MALIGNANT TRANSFORMATION; PHOTOAGING; PSORIASIS; RADIATION INJURY; REVIEW; SIGNAL TRANSDUCTION; SKIN CANCER; SOLAR RADIATION; SUN EXPOSURE; TRANSCRIPTION INITIATION; TUMOR PROMOTION; ULTRAVIOLET A RADIATION; DRUG EFFECTS; METABOLISM; PATHOLOGY; SKIN NEOPLASMS;

ANTINEOPLASTIC AGENTS; CURCUMIN; HUMANS; SIGNAL TRANSDUCTION; SKIN AGING; SKIN NEOPLASMS;

EID: 77954188904     PISSN: 00119059     EISSN: 13654632     Source Type: Journal    
DOI: 10.1111/j.1365-4632.2010.04468.x     Document Type: Review

References (76)

1. Runger TM. Role of UVA in the pathogenesis of melanoma and non-melanoma skin cancer: a short review. Photodermatol Photoimmunol Photomed 1999, 15:212-216.
2. Bachelor MA, Bowden GT. UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. Semin Cancer Biol 2004, 14:131-138.
3. Jiang Y, Rabbi M, Kim M. UVA generates pyrimidine dimers in DNA directly. Biophys J 2009, 96:1151-1158.
4. Weinstock MA. Do sunscreens increase or decrease melanoma risk: an epidemiologic evaluation. J Invest Dermatol Symp Proc 1999, 4:97-100.
5. Green A, Williams G, Neale R. Daily sunscreen application and betacarotene supplementation in prevention of basal cell and squamous cell carcinomas of the skin: a randomized controlled trial. Lancet 1999, 354:723-729.
6. Haywood R. Sunscreens inadequately protect against ultraviolet A-induced free radicals in skin: implications for skin aging and melanoma. J Invest Dermatol 2003, 121:862-868.
7. Gailani MR, Leffell DJ, Ziegler A. Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. J Natl Cancer Institute 1996, 88:349-354.
8. de Castro IA, Schutz L, Capp E. p53 protein expression in skin with different levels of photoaging. Photodermatol Photoimmunol Photomed 2009, 25:106-108.
9. Baliga MS, Katiyar SK. Chemoprevention of photocarcinogenesis by selected dietary botanicals. Photochem Photobiol Sci 2006, 5:243-253.
10. Heng MCY. Signaling pathways targeted by curcumin: basis for anti-photoaging and anti-carcinogenic therapy. Anti-aging Therapeutics 2008, vol X, chapter 19
11. Drobetsky EA, Tyrcotte J, Chateauneuf A. A role for ultraviolet A in solar mutagenesis. Proc Natl Acad Sci USA 1995, 92:2350-2354.
12. Mouret S, Baudouin C, Charveron M. Cyclobutane pyrimidine dimers are predominant in DNA lesions in whole human skin exposed to UVA radiation. Proc Natl Acad Sci USA 2006, 103:13567-13568.
13. Rochette PJ, Therrien JP, Drouin R. UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells. Nucleic Acid Res 2003, 31:2786-2794.
14. Perdiz D, Grof P, Mezzina M. Distribution and repair of bipyrimidine photoproducts in solar UV-irradiated mammalian cells. Possible role of Dewar photoproducts in solar mutagenesis. J Biol Chem 2000, 275:26732-26742.
15. Douki T, Reynaud-Angelin A, Cadet J. Bipymidine photoproducts rather than oxidative lesions are the main type of DNA damage involved in the genotoxic effect of solar UVA radiation. Biochemistry 2003, 42:9221-9226.
16. Whiteside JR, McMillan TJ. A bystander effect is induced in human cells treated with UVA radiation but not UVB radiation. Radiat Res 2009, 171:204-211.
17. Siege H, Roza L, Vink A. Enzyme plus light therapy to repair immunosuppressive effects on human skin damaged by ultraviolet B radiation. Proc Natl Acad Sci USA 2000, 97:179-195.
18. Grether-Beck S, Oliazola-Horn S, Schmitt H. Activation of transcription factor AP-2 mediates ultraviolet A radiation and singlet oxygen induced expression of the human intercellular adhesion molecule-1 gene. Proc Natl Acad Sci USA 1996, 93:14586-14591.
19. Aggarwal BB. Nuclear factor-kappa B: the enemy within. Cancer Cell 2004, 6:203-208.
20. Verma IM, Stevenson JK, Schwarz EM. Rel/NF-kB/IkB family: intimate tales of association and disassociation. Gen Dev 1995, 9:2723-2735.
21. Singh S, Aggarwal BB. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloyl-methane). J Biol Chem 1995, 270:24995-25000.
22. Takada Y, Singh S, Aggarwal BB. Identification of p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem 2004, 279:15096-15104.
23. Lallena MJ, Diaz-Meco MT, Bren G. Activation of IγB beta by protein kinase C isoforms. Mol Cell Biol 1999, 19:2180-2188.
24. Huang WC, Chen JJ, Chen CC. c-src dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression. J Biol Chem 2003, 278:9944-9952.
25. Yang F, Yamashita J, Tang E. The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop. J Immunol 2004, 172:2446-2452.
26. Huang TT, Feinberg SL, Suryanarayanan S. The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors. Mol Cell Biol 2002, 22:5813-5825.
27. Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF- [kappa]B activity. Annu Rev Immunol 2000, 18:621-663.
28. Palkowitsch L, Leidner J, Ghosh S. Phosphorylation of serine 68 in the IkappaB Kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity. J Biol Chem 2008, 283:76-86.
29. Reddy S, Aggarwal BB. Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase. FEBS Lett 1994, 341:19-22.
30. Bharti AC, Aggarwal BB. Nuclear factor-γB and cancer: its role in prevention and therapy. Biochem Pharmacol 2002, 64:883-888.
31. Heng MC, Song MK, Harker J. Drug induced suppression of phosphorylase kinase activity correlates with resolution of psoriasis as assessed by clinical, histological and immunohistochemical parameters. Br J Dermatol 2000, 143:937-949.
32. Bohrmann D, Bos TJ, Admon A. Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 1987, 238:1386-1392.
33. Baldin V, Lukas J, Marcote MJ. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 1993, 7:812-821.
34. Tanos T, Marinissen MJ, Leskow FC. Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light. J Biol Chem 2005, 280:18842-18852.
35. Chen YR, Tan TH. Inhibition of the c-jun N-terminal kinase (JNK) signaling pathway by curcumin. Oncogene 1998, 17:173-178.
36. Takada Y, Ichikawa H, Pataer A. Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 and p38 MAPKactivation. Oncogene 2007, 26:1201-1212.
37. Cho JW, Park K, Kweon GR. Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets. Exp Mol Med 2005, 37:186-192.
38. Bode AM, Dong Z. Signal transduction pathways: targets for chemoprevention of skin cancer. Lancet Oncol 2000, 1:181-188.
39. Bode AM, Dong Z. Mitogen-activated protein kinase activation in UV-induced signal transduction. Sci STKE 2003, 167:RE2.
40. Minden A, Lin A, McMahon M. Differential activation of ERK and JNK mitogen-activated protein kinases by raf-1 and MEKK. Science 1994, 266:1719-1723.
41. Crowley S, Paterson H, Kemp P. Activation of MAP kinase kinase is necessary for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 1994, 77:841-852.
42. Kallunki T, Su B, Tsigelny I. JNK 2 contains a specificity determining region responsible for efficient c-jun binding and phosphorylation. Genes Dev 1994, 8:2996-3007.
43. Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006, 71:1397-1421.
44. Skiba B, Neill B, Piva TJ. Gene expression profiles of TNF-alpha, TACE, furin, IL-1beta and matrilysin in UVA and UVB-irradiated HaCat cells. Photodermatol Photoimmunol Photomed 2005, 21:173-182.
45. Chen A, Zheng S. Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signaling. Br J Pharmacol 2008, 153:557-567.
46. Hong RL, Spohn WH, Hung MC. Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu. Clin Cancer Res 1999, 5:1884-1891.
47. Cardone MH, Roy N, Stennicke HR. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998, 282:1318-1321.
48. Bharti AC, Donato N, Singh S. Curcumin (diferuloylmethane) down-regulates the constitutive regulation of nuclear factor-kappa Band IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 2003, 101:1053-1062.
49. Jee SH, shen SC, Tseng CR. Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells. J Invest Dermatol 1998, 111:656-661.
50. Choudhuri T, Pal S, Das T. Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at the G2 phase of the cell cycle in a p53 dependent manner. J Biol Chem 2005, 280:11680-11685.
51. Anto RJ, Mukhopadhyay A, Denning K. Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 2002, 23:143-150.
52. Wang JB, Qi LL, Zheng SD. Curcumin induces apoptosis through the mitochondrial-mediated apoptotic pathway in HT-29 cells. J Zhejiang Univ Sci 2009, 19:93-102.
53. Alessi DR, Andjelkovic M, Caudwell B. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996, 15:6541-6551.
54. Ozes ON, Mayo LD, Gustin JA. NF-kappaB activation by tumour necrosis factor requires the AKT serine-threonine kinase. Nature 1999, 401:82-85.
55. Romashkova JA, Makarov SS. NF-kappB is a target of AKT in anti-apoptotic PDGF signaling. Nature 1999, 40:86-90.
56. Shinojima N, Yokoyama T, Kondo Y. Roles of Akt/mTOR/p70S6K and ERK signaling pathways in curcumin-induced autophagy. Autophagy 2007, 3:635-637.
57. Diehl JA. Cycling to cancer with cyclin D1. Cancer Biol Ther 2002, 1:226-231.
58. Nishida N, Fukuda Y, Komeda T. Amplification and overexpression of cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res 1994, 54:3107-3110.
59. Mukhopadhyay A, Banerjee S, Stafford LJ. Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1-expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene 2002, 21:8852-8861.
60. Aggarwal B, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 2003, 23:363-398.
61. el-Deiry WS, Tokino T, Velculescu VE. WAF1, a potential mediator of p53 tumor suppression. Cell 1993, 75:817-825.
62. Vogelstein B, Kinzler KW. p53 function and dysfunction. Cell 1992, 70:523-526.
63. Brash DE, Ziegler A, Jonason AS. Sunlight and sunburn in human cancer: p53, apoptosis, and tumor promotion. J Invest Dermatol 1996, 1:136-142.
64. Park MJ, Kim EH, Park IC. Curcumin inhibits cell cycle progression of immortalized human unbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53. Int J Oncol 2002, 21:379-383.
65. Jana NR, Dikshit P, Goswani A. Inhibition of proteosomal function by curcumin induces apoptosis through mitochondrial pathway. J Biol Chem 2004, 279:11680-11685.
66. Aggarwal S, Ichikawa H, Takada Y. Curcumin (diferuloylmethane) downregulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol Pharmacol 2006, 69:195-206.
67. Thaloor D, Singh AK, Sidhu GS. Inhibition of angiogenic differentiation of human unbilical vein endothelial cells by curcumin. Cell Growth Differ 1998, 9:305-312.
68. Okashi Y, Tsuchiya Y, Koizumi K. Prevention of intrahepatic metastases by curcumin in an orthopedic transplant model. Oncology 2003, 65:250-258.
69. Fundyler O, Khanna M, Smoller BR. Metalloproteinase-2 expression correlates with aggressiveness of cutaneous squamous cell carcinomas. Mod Pathol 2004, 17:496-502.
70. Johnson LN, Lowe ED, Noble ME. The Eleventh Datta Lecture. The structural basis for substrate recognition and control by protein kinases. FEBS Lett 1998, 430:1-11.
71. Graves D, Bartleson C, Bjorn A. Substrate and inhibitor recognition of protein kinases: what is known about the catalytic subunit of phosphorylase kinase? Pharmacol Ther 1999, 82:143-155.
72. Yuan CJ, Huang CY, Graves DJ. Phosphorylase kinase: a metal ion-dependent dual specificity kinase. J Biol Chem 1993, 268:17683-17686.
73. Li L, Braiteh FS, Kurzrock R. Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling and angiogenesis. Cancer 2005, 104:1322-1331.
74. Li L, Ahmed B, Mehta K. Liposomal curcumin with and without oxaliplatin: effects on cell growth, apoptosis, and angiogenesis in colorectal Cancer. Mol cancer Ther 2007, 6:1276-1282.
75. Dhillon N, Aggarwal BB, Newman RA. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 2008, 14:4491-4499.
76. Siwak DR, Shishodia S, Aggarwal BB. Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer 2005, 104:879-890.