Homology modelling of the GABA transporter and analysis of tiagabine binding

ChemMedChem

Volumn 5, Issue 7, 2010, Pages 986-1000

  Skovstrup, Søren ^a   Taboureau, Olivier ^b   Bräuner Osborne, Hans ^a   Jørgensen, Flemming Steen ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Binding modes; GABA transporter; Homology modeling; Molecular dynamics; Tiagabine

Indexed keywords

4 AMINOBUTYRIC ACID CARRIER; LEUCINE; NIPECOTIC ACID; PHENYLALANINE; SERINE; TIAGABINE; TYROSINE; ANTICONVULSIVE AGENT; NIPECOTIC ACID DERIVATIVE; SLC6A1 PROTEIN, HUMAN;

AQUIFEX AEOLICUS; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; MOLECULAR DYNAMICS; MOLECULAR STABILITY; PRIORITY JOURNAL; SIMULATION; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; HUMAN; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY;

AMINO ACID SEQUENCE; ANTICONVULSANTS; BINDING SITES; DRUG DESIGN; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; NIPECOTIC ACIDS; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 77954125609     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000100     Document Type: Article

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