The Interaction of the γ-Aminobutyric Acid Transporter GAT-1 with the Neurotransmitter Is Selectively Impaired by Sulfhydryl Modification of a Conformationally Sensitive Cysteine Residue Engineered into Extracellular Loop IV

Journal of Biological Chemistry

Volumn 278, Issue 44, 2003, Pages 42950-42958

  Zomot, Elia ^a   Kanner, Baruch I ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOLOGICAL MEMBRANES; CARBOXYLIC ACIDS; CONFORMATIONS; ELECTROPHYSIOLOGY; MUTAGENESIS; PROTEINS; SODIUM;

NEUROTRANSMITTERS;

BIOCHEMISTRY;

1 (4,4 DIPHENYL 3 BUTENYL)GUVACINE; 4 AMINOBUTYRIC ACID; CARRIER PROTEIN; CHLORIDE; CYSTEINE; GAMMA AMINOBUTYRIC ACID TRANSPORTER 1; NEUROTRANSMITTER; SODIUM; THIOSULFATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXTRACELLULAR MATRIX; GABAERGIC TRANSMISSION; HUMAN; HUMAN CELL; MUTAGENESIS; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; BIOTINYLATION; CARRIER PROTEINS; CHLORINE; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; HELA CELLS; HUMANS; KINETICS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MESYLATES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OOCYTES; ORGANIC ANION TRANSPORTERS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA, COMPLEMENTARY; SODIUM; SULFHYDRYL REAGENTS; TRANSCRIPTION, GENETIC; TRANSFECTION; XENOPUS LAEVIS;

EID: 0242353345     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209307200     Document Type: Article

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