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Volumn 65, Issue 6, 2004, Pages 1452-1461

Transmembrane domains I and II of the γ-aminobutyric acid transporter GAT-4 contain molecular determinants of substrate specificity

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; AMINO ACID; BETA ALANINE; CARRIER PROTEIN; GLUTAMIC ACID DERIVATIVE; GLYCINE; NEUROTRANSMITTER; PROTEIN GAT 4; SERINE; TAURINE; UNCLASSIFIED DRUG;

EID: 2442640243     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.6.1452     Document Type: Article
Times cited : (28)

References (27)
  • 1
    • 0035122827 scopus 로고    scopus 로고
    • Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition
    • Adkins EM, Barker EL, and Blakely RD (2001) Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition. Mol Pharmacol 59:514-523.
    • (2001) Mol Pharmacol , vol.59 , pp. 514-523
    • Adkins, E.M.1    Barker, E.L.2    Blakely, R.D.3
  • 2
    • 0033564765 scopus 로고    scopus 로고
    • Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter
    • Barker EL, Moore KR, Rakhshan F, and Blakely RD (1999) Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter. J Neurosci 19:4705-4717.
    • (1999) J Neurosci , vol.19 , pp. 4705-4717
    • Barker, E.L.1    Moore, K.R.2    Rakhshan, F.3    Blakely, R.D.4
  • 3
    • 0032584587 scopus 로고    scopus 로고
    • High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis: An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol
    • Barker EL, Perlman MA, Adkins EM, Houlihan WJ, Pristupa ZB, Niznik HB, and Blakely RD (1998) High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis: an aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol. J Biol Chem 273:19459-19468.
    • (1998) J Biol Chem , vol.273 , pp. 19459-19468
    • Barker, E.L.1    Perlman, M.A.2    Adkins, E.M.3    Houlihan, W.J.4    Pristupa, Z.B.5    Niznik, H.B.6    Blakely, R.D.7
  • 4
    • 0034529012 scopus 로고    scopus 로고
    • Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter
    • Bendahan A, Armon A, Madani N, Kavanaugh MP, and Kanner BI (2000) Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter. J Biol Chem 275:37436-37442.
    • (2000) J Biol Chem , vol.275 , pp. 37436-37442
    • Bendahan, A.1    Armon, A.2    Madani, N.3    Kavanaugh, M.P.4    Kanner, B.I.5
  • 5
    • 0030921440 scopus 로고    scopus 로고
    • Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition
    • Bismuth Y, Kavanaugh MP, and Kanner BI (1997) Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition. J Biol Chem 272:16096-16102.
    • (1997) J Biol Chem , vol.272 , pp. 16096-16102
    • Bismuth, Y.1    Kavanaugh, M.P.2    Kanner, B.I.3
  • 6
    • 0026757209 scopus 로고
    • Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system: Cloning of two novel high affinity GABA transporters from rat brain
    • Borden LA, Smith KE, Hartig PR, Branchek TA, and Weinshank RL (1992) Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system: cloning of two novel high affinity GABA transporters from rat brain. J Biol Chem 267:21098-21104.
    • (1992) J Biol Chem , vol.267 , pp. 21098-21104
    • Borden, L.A.1    Smith, K.E.2    Hartig, P.R.3    Branchek, T.A.4    Weinshank, R.L.5
  • 7
    • 0032524637 scopus 로고    scopus 로고
    • Determination of external loop topology in the serotonin transporter by site-directed chemical labeling
    • Chen JG, Liu-Chen S, and Rudnick G (1998) Determination of external loop topology in the serotonin transporter by site-directed chemical labeling. J Biol Chem 273:12675-12681.
    • (1998) J Biol Chem , vol.273 , pp. 12675-12681
    • Chen, J.G.1    Liu-Chen, S.2    Rudnick, G.3
  • 8
    • 0030692041 scopus 로고    scopus 로고
    • The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding
    • Chen JG, Sachpatzidis A, and Rudnick G (1997) The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding. J Biol Chem 272:28321-28327.
    • (1997) J Biol Chem , vol.272 , pp. 28321-28327
    • Chen, J.G.1    Sachpatzidis, A.2    Rudnick, G.3
  • 9
    • 0026800952 scopus 로고
    • Functional expression and CNS distribution of a beta-alanine-sensitive neuronal GABA transporter
    • Clark JA, Deutch AY, Gallipoli PZ, and Amara SG (1992) Functional expression and CNS distribution of a beta-alanine-sensitive neuronal GABA transporter. Neuron 9:337-348.
    • (1992) Neuron , vol.9 , pp. 337-348
    • Clark, J.A.1    Deutch, A.Y.2    Gallipoli, P.Z.3    Amara, S.G.4
  • 10
    • 0000233999 scopus 로고
    • Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase
    • Fuerst TR, Niles EG, Studier FW, and Moss B (1986) Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc Natl Acad Sci USA 83:8122-8126.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 8122-8126
    • Fuerst, T.R.1    Niles, E.G.2    Studier, F.W.3    Moss, B.4
  • 11
    • 0030071106 scopus 로고    scopus 로고
    • Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
    • Giros B, Jaber M, Jones SR, Wightman RM, and Caron MG (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature (Lond) 379:606-612.
    • (1996) Nature (Lond) , vol.379 , pp. 606-612
    • Giros, B.1    Jaber, M.2    Jones, S.R.3    Wightman, R.M.4    Caron, M.G.5
  • 13
    • 0141844649 scopus 로고    scopus 로고
    • Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I
    • Henry LK, Adkins EM, Han Q, and Blakely RD (2003) Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I. J Biol Chem 278:37052-37063.
    • (2003) J Biol Chem , vol.278 , pp. 37052-37063
    • Henry, L.K.1    Adkins, E.M.2    Han, Q.3    Blakely, R.D.4
  • 14
    • 0028535115 scopus 로고
    • Sodium-coupled neurotransmitter transport: Structure, function and regulation
    • Kanner BI (1994) Sodium-coupled neurotransmitter transport: structure, function and regulation. J Exp Biol 196:237-249.
    • (1994) J Exp Biol , vol.196 , pp. 237-249
    • Kanner, B.I.1
  • 15
    • 0037423375 scopus 로고    scopus 로고
    • Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes
    • Kanner BI (2003) Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes. J Biol Chem 278:3705-3712.
    • (2003) J Biol Chem , vol.278 , pp. 3705-3712
    • Kanner, B.I.1
  • 16
    • 0026691409 scopus 로고
    • Expression of a cloned gamma-aminobutyric acid transporter in mammalian cells
    • Keynan S, Suh YJ, Kanner BI, and Rudnick G (1992) Expression of a cloned gamma-aminobutyric acid transporter in mammalian cells. Biochemistry 31:1974-1979.
    • (1992) Biochemistry , vol.31 , pp. 1974-1979
    • Keynan, S.1    Suh, Y.J.2    Kanner, B.I.3    Rudnick, G.4
  • 17
    • 0028145307 scopus 로고
    • Identification of tryptophan residues critical for the function and targeting of the gamma-aminobutyric acid transporter (subtype A)
    • Kleinberger-Doron N and Kanner BI (1994) Identification of tryptophan residues critical for the function and targeting of the gamma-aminobutyric acid transporter (subtype A). J Biol Chem 269:3063-3067.
    • (1994) J Biol Chem , vol.269 , pp. 3063-3067
    • Kleinberger-Doron, N.1    Kanner, B.I.2
  • 18
    • 0023613953 scopus 로고
    • Rapid and efficient site-specific mutagenesis without phenotypic selection
    • Kunkel TA, Roberts JD, and Zakour RA (1987) Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol 154:367-382.
    • (1987) Methods Enzymol , vol.154 , pp. 367-382
    • Kunkel, T.A.1    Roberts, J.D.2    Zakour, R.A.3
  • 19
    • 0027391644 scopus 로고
    • Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain
    • Liu QR, Lopez-Corcuera B, Mandiyan S, Nelson H, and Nelson N (1993) Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [published erratum appears in J Biol Chem 1993;268:9156]. J Biol Chem 268:2106-2112.
    • (1993) J Biol Chem , vol.268 , pp. 2106-2112
    • Liu, Q.R.1    Lopez-Corcuera, B.2    Mandiyan, S.3    Nelson, H.4    Nelson, N.5
  • 20
    • 0027513951 scopus 로고
    • published erratum appears
    • Liu QR, Lopez-Corcuera B, Mandiyan S, Nelson H, and Nelson N (1993) Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [published erratum appears in J Biol Chem 1993;268:9156]. J Biol Chem 268:2106-2112.
    • (1993) J Biol Chem , vol.268 , pp. 9156
  • 21
    • 0027102017 scopus 로고
    • Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain
    • Liu QR, Lopez-Corcuera B, Nelson H, Mandiyan S, and Nelson N (1992) Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain. Proc Natl Acad Sci USA 89:12145-12149.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 12145-12149
    • Liu, Q.R.1    Lopez-Corcuera, B.2    Nelson, H.3    Mandiyan, S.4    Nelson, N.5
  • 23
    • 0031753789 scopus 로고    scopus 로고
    • - neurotransmitter transporters
    • - neurotransmitter transporters. J Neurochem 71:1785-1803.
    • (1998) J Neurochem , vol.71 , pp. 1785-1803
    • Nelson, N.1
  • 24
    • 0027532379 scopus 로고
    • Only one of the charged amino acids located in the transmembrane alpha-helices of the gamma-aminobutyric acid transporter (subtype A) is essential for its activity
    • Pantanowitz S, Bendahan A, and Kanner BI (1993) Only one of the charged amino acids located in the transmembrane alpha-helices of the gamma-aminobutyric acid transporter (subtype A) is essential for its activity. J Biol Chem 268:3222-3225.
    • (1993) J Biol Chem , vol.268 , pp. 3222-3225
    • Pantanowitz, S.1    Bendahan, A.2    Kanner, B.I.3
  • 25
    • 0037113887 scopus 로고    scopus 로고
    • Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1
    • Scholze P, Freissmuth M, and Sitte HH (2002) Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1. J Biol Chem 277:43682-43690.
    • (2002) J Biol Chem , vol.277 , pp. 43682-43690
    • Scholze, P.1    Freissmuth, M.2    Sitte, H.H.3
  • 26
    • 0037334617 scopus 로고    scopus 로고
    • Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter
    • Wu X and Gu HH (2003) Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter. Mol Pharmacol 63:653-658.
    • (2003) Mol Pharmacol , vol.63 , pp. 653-658
    • Wu, X.1    Gu, H.H.2
  • 27
    • 1842791407 scopus 로고    scopus 로고
    • The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 is modulated by its ligands
    • in press
    • Zhou Y, Bennett ER, and Kanner BI (2004) The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 is modulated by its ligands. J Biol Chem, in press.
    • (2004) J Biol Chem
    • Zhou, Y.1    Bennett, E.R.2    Kanner, B.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.