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Volumn 2, Issue 2, 2010, Pages 221-232

Epigenetic targets in human neoplasms

Author keywords

DNA methyltransferases inhibitor; epigenetics; epigenome; histone acetylation; histone methylation; miRNA

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; DNA METHYLTRANSFERASE INHIBITOR; HISTONE; HISTONE DEACETYLASE INHIBITOR; MICRORNA; OLIGONUCLEOTIDE; VALPROIC ACID;

EID: 77954104642     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.10.1     Document Type: Review
Times cited : (5)

References (100)
  • 1
    • 35848951163 scopus 로고    scopus 로고
    • Covalent modifcations of histones during development and disease pathogenesis
    • Bhaumik SR, Smith E, Shilatifard A: Covalent modifcations of histones during development and disease pathogenesis. Nat. Struct. Mol. Biol. 14(11), 1008-1016 (2007).
    • (2007) Nat. Struct. Mol. Biol , vol.14 , Issue.11 , pp. 1008-1016
    • Bhaumik, S.R.1    Smith, E.2    Shilatifard, A.3
  • 2
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB: The epigenomics of cancer. Cell 128(4), 683-692 (2007).
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 3
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB: The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3(6), 415-428 (2002).
    • (2002) Nat. Rev. Genet , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 5
    • 37249012276 scopus 로고    scopus 로고
    • Nucleosome destabilization in the epigenetic regulation of gene expression
    • Henikoff S: Nucleosome destabilization in the epigenetic regulation of gene expression. Nat. Rev. Genet. 9(1), 15-26 (2008).
    • (2008) Nat. Rev. Genet , vol.9 , Issue.1 , pp. 15-26
    • Henikoff, S.1
  • 6
    • 58149345088 scopus 로고    scopus 로고
    • Lymphocytes from patients with Type 1 diabetes display a distinct profle of chromatin histone H3 lysine 9 dimethylation: An epigenetic study in diabetes
    • Miao F, Smith DD, Zhang L, Min A, Feng W, Natarajan R: Lymphocytes from patients with Type 1 diabetes display a distinct profle of chromatin histone H3 lysine 9 dimethylation: an epigenetic study in diabetes. Diabetes 57(12), 3189-3198 (2008).
    • (2008) Diabetes , vol.57 , Issue.12 , pp. 3189-3198
    • Miao, F.1    Smith, D.D.2    Zhang, L.3    Min, A.4    Feng, W.5    Natarajan, R.6
  • 7
    • 58049204426 scopus 로고    scopus 로고
    • Epigenetics in multiple sclerosis susceptibility: Difference in transgenerational risk localizes to the major histocompatibility complex
    • Chao MJ, Ramagopalan SV, Herrera BM et al.: Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex. Hum. Mol. Genet. 18(2), 261-266 (2009).
    • (2009) Hum. Mol. Genet , vol.18 , Issue.2 , pp. 261-266
    • Chao, M.J.1    Ramagopalan, S.V.2    Herrera, B.M.3
  • 8
    • 56249113842 scopus 로고    scopus 로고
    • Epigenetic connections between autoimmune disorders and haematological malignancies
    • Javierre BM, Esteller M, Ballestar E: Epigenetic connections between autoimmune disorders and haematological malignancies. Trends Immunol. 29(12), 616-623 (2008).
    • (2008) Trends Immunol , vol.29 , Issue.12 , pp. 616-623
    • Javierre, B.M.1    Esteller, M.2    Ballestar, E.3
  • 9
    • 35448960424 scopus 로고    scopus 로고
    • Helicobacter pylori and epigenetic mechanisms underlying gastric carcinogenesis
    • Nardone G, Compare D, De Colibus P, de Nucci G, Rocco A: Helicobacter pylori and epigenetic mechanisms underlying gastric carcinogenesis. Dig. Dis. 25(3), 225-229 (2007).
    • (2007) Dig. Dis , vol.25 , Issue.3 , pp. 225-229
    • Nardone, G.1    Compare, D.2    De Colibus, P.3    De Nucci, G.4    Rocco, A.5
  • 10
    • 0035895559 scopus 로고    scopus 로고
    • A high-resolution radiation hybrid map of the human genome draft sequence
    • Olivier M, Aggarwal A, Allen J et al.: A high-resolution radiation hybrid map of the human genome draft sequence. Science 291(5507), 1298-1302 (2001).
    • (2001) Science , vol.291 , Issue.5507 , pp. 1298-1302
    • Olivier, M.1    Aggarwal, A.2    Allen, J.3
  • 11
    • 49649122472 scopus 로고    scopus 로고
    • American Association for Cancer Research Human Epigenome Task Force, European Union Network of Excellence, Scientifc Advisory Board: Moving AHEAD with an international human epigenome project
    • American Association for Cancer Research Human Epigenome Task Force, European Union Network of Excellence, Scientifc Advisory Board: Moving AHEAD with an international human epigenome project. Nature 454(7205), 711-715 (2008).
    • (2008) Nature , vol.454 , Issue.7205 , pp. 711-715
  • 12
    • 53349098906 scopus 로고    scopus 로고
    • Epigenomics: A roadmap, but to where?
    • Madhani HD, Francis NJ, Kingston RE et al.: Epigenomics: a roadmap, but to where? Science 322(5898), 43-44 (2008).
    • (2008) Science , vol.322 , Issue.5898 , pp. 43-44
    • Madhani, H.D.1    Francis, N.J.2    Kingston, R.E.3
  • 13
    • 40049091154 scopus 로고    scopus 로고
    • Research funding. are epigeneticists ready for big science?
    • Pennisi E: Research funding. are epigeneticists ready for big science? Science 319(5867), 1177 (2008).
    • (2008) Science , vol.319 , Issue.5867 , pp. 1177
    • Pennisi, E.1
  • 14
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A: Perceptions of epigenetics. Nature 447(7143), 396-3988 (2007).
    • (2007) Nature , vol.447 , Issue.7143 , pp. 396-3988
    • Bird, A.1
  • 15
    • 65549113750 scopus 로고    scopus 로고
    • CBP/p300-mediated acetylation of histone H3 on lysine 56
    • Das C, Lucia MS, Hansen KC, Tyler JK: CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature 459(7243), 113-117 (2009).
    • (2009) Nature , vol.459 , Issue.7243 , pp. 113-117
    • Das, C.1    Lucia, M.S.2    Hansen, K.C.3    Tyler, J.K.4
  • 16
    • 4444301185 scopus 로고    scopus 로고
    • SUMO and ubiquitin in the nucleus: Different functions, similar mechanisms?
    • Gill G: SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? Genes Dev. 18(17), 2046-2059 (2004).
    • (2004) Genes Dev , vol.18 , Issue.17 , pp. 2046-2059
    • Gill, G.1
  • 17
    • 44649139771 scopus 로고    scopus 로고
    • Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation
    • Shilatifard A: Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation. Curr. Opin. Cell Biol. 20(3), 341-348 (2008).
    • (2008) Curr. Opin. Cell Biol , vol.20 , Issue.3 , pp. 341-348
    • Shilatifard, A.1
  • 18
    • 40849106789 scopus 로고    scopus 로고
    • Histone ubiquitination: Triggering gene activity
    • Weake VM, Workman JL: Histone ubiquitination: triggering gene activity. Mol. Cell 29(6), 653-663 (2008).
    • (2008) Mol. Cell , vol.29 , Issue.6 , pp. 653-663
    • Weake, V.M.1    Workman, J.L.2
  • 19
    • 0029693220 scopus 로고    scopus 로고
    • The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation
    • Van Lint C, Emiliani S, Verdin E: The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation. Gene Expr. 5(4-5), 245-253 (1996).
    • (1996) Gene Expr , vol.5 , Issue.4-5 , pp. 245-253
    • Van Lint, C.1    Emiliani, S.2    Verdin, E.3
  • 20
    • 20744449274 scopus 로고    scopus 로고
    • Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-KB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-jun N-terminal kinase 1 activation
    • Dai Y, Rah man i M, Dent P, Grant S: Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-KB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-jun N-terminal kinase 1 activation. Mol. Cell. Biol. 25(13), 5429-5444 (2005).
    • (2005) Mol. Cell. Biol , vol.25 , Issue.13 , pp. 5429-5444
    • Dai, Y.1    Rah Man, I.M.2    Dent, P.3    Grant, S.4
  • 21
    • 21144444486 scopus 로고    scopus 로고
    • HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
    • Kovacs JJ, Murphy PJ, Gaillard S et al.: HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol. Cell 18(5), 601-607 (2005).
    • (2005) Mol. Cell , vol.18 , Issue.5 , pp. 601-607
    • Kovacs, J.J.1    Murphy, P.J.2    Gaillard, S.3
  • 22
    • 67650090545 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Potential in cancer therapy
    • Marks PA, Xu WS: Histone deacetylase inhibitors: potential in cancer therapy. J. Cell. Biochem. 107(4), 600-6088 (2009).
    • (2009) J. Cell. Biochem , vol.107 , Issue.4 , pp. 600-6088
    • Marks, P.A.1    Xu, W.S.2
  • 23
    • 0344304443 scopus 로고    scopus 로고
    • Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1
    • Nusinzon I, Horvath CM: Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc. Natl Acad. Sci. USA 100(25), 14742-147477 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.25 , pp. 14742-147477
    • Nusinzon, I.1    Horvath, C.M.2
  • 24
    • 3142721913 scopus 로고    scopus 로고
    • Requirement of histone deacetylase activity for signaling by STAT1
    • Klampfer L, Huang J, Swaby LA, Augenlicht L: Requirement of histone deacetylase activity for signaling by STAT1. J. Biol. Chem. 279(29), 30358-30368 (2004).
    • (2004) J. Biol. Chem , vol.279 , Issue.29 , pp. 30358-30368
    • Klampfer, L.1    Huang, J.2    Swaby, L.A.3    Augenlicht, L.4
  • 25
    • 34548789152 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce cell death selectively in cells that harbor activated kRasV12: The role of signal transducers and activators of transcription 1 and p21
    • Klampfer L, Huang J, Shirasawa S, Sasazuki T, Augenlicht L: Histone deacetylase inhibitors induce cell death selectively in cells that harbor activated kRasV12: the role of signal transducers and activators of transcription 1 and p21. Cancer Res. 67(18), 8477-8485 (2007).
    • (2007) Cancer Res , vol.67 , Issue.18 , pp. 8477-8485
    • Klampfer, L.1    Huang, J.2    Shirasawa, S.3    Sasazuki, T.4    Augenlicht, L.5
  • 26
    • 2342599619 scopus 로고    scopus 로고
    • The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases
    • Yang XJ: The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res. 32(3), 959-976 (2004).
    • (2004) Nucleic Acids Res , vol.32 , Issue.3 , pp. 959-976
    • Yang, X.J.1
  • 27
    • 18844413266 scopus 로고    scopus 로고
    • Acetylation in histone H3 globular domain regulates gene expression in yeast
    • Xu F, Zhang K, Grunstein M: Acetylation in histone H3 globular domain regulates gene expression in yeast. Cell 121(3), 375-385 (2005).
    • (2005) Cell , vol.121 , Issue.3 , pp. 375-385
    • Xu, F.1    Zhang, K.2    Grunstein, M.3
  • 28
    • 48249148195 scopus 로고    scopus 로고
    • Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation
    • Williams SK, Truong D, Tyler JK: Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation. Proc. Natl Acad. Sci. USA 105(26), 9000-9005 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.26 , pp. 9000-9005
    • Williams, S.K.1    Truong, D.2    Tyler, J.K.3
  • 29
    • 67650215370 scopus 로고    scopus 로고
    • Phosphorylation of histone H3 thr-45 is linked to apoptosis
    • Hurd PJ, Bannister AJ, Halls K et al.: Phosphorylation of histone H3 thr-45 is linked to apoptosis. J. Biol. Chem. 284(24), 16575-16583 (2009).
    • (2009) J. Biol. Chem , vol.284 , Issue.24 , pp. 16575-16583
    • Hurd, P.J.1    Bannister, A.J.2    Halls, K.3
  • 30
    • 0343953594 scopus 로고    scopus 로고
    • Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia
    • Myohanen SK, Baylin SB, Herman JG: Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. Cancer Res. 58(4), 591-593 (1998).
    • (1998) Cancer Res , vol.58 , Issue.4 , pp. 591-593
    • Myohanen, S.K.1    Baylin, S.B.2    Herman, J.G.3
  • 31
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG, Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 349(21), 2042-2054 (2003).
    • (2003) N. Engl. J. Med , vol.349 , Issue.21 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 32
    • 34250661469 scopus 로고    scopus 로고
    • DNA demethylating agents and histone deacetylase inhibitors in hematologic malignancies
    • Fandy TE, Carraway H, Gore SD: DNA demethylating agents and histone deacetylase inhibitors in hematologic malignancies. Cancer J. 13(1), 40-48 (2007).
    • (2007) Cancer J , vol.13 , Issue.1 , pp. 40-48
    • Fandy, T.E.1    Carraway, H.2    Gore, S.D.3
  • 33
    • 0842289159 scopus 로고    scopus 로고
    • Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms
    • House MG, Herman JG, Guo MZ et al.: Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms. Ann. Surg. 238, 423-432 (2003).
    • (2003) Ann. Surg , vol.238 , pp. 423-432
    • House, M.G.1    Herman, J.G.2    Guo, M.Z.3
  • 34
    • 0041924707 scopus 로고    scopus 로고
    • Aberrant promoter methylation profles of tumor suppressor genes in hepatocellular carcinoma
    • Yang B, Guo M, Herman JG, Clark DP: Aberrant promoter methylation profles of tumor suppressor genes in hepatocellular carcinoma. Am. J. Pathol. 163, 1101-1107 (2003).
    • (2003) Am. J. Pathol , vol.163 , pp. 1101-1107
    • Yang, B.1    Guo, M.2    Herman, J.G.3    Clark, D.P.4
  • 35
    • 10744229661 scopus 로고    scopus 로고
    • Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behavior
    • House MG, Guo M, Efron DT et al.: Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behavior. J. Gastrointest. Surg. 7, 1004-1014 (2003).
    • (2003) J. Gastrointest. Surg , vol.7 , pp. 1004-1014
    • House, M.G.1    Guo, M.2    Efron, D.T.3
  • 36
    • 65649142216 scopus 로고    scopus 로고
    • Global levels of histone modifcations predict prognosis in different cancers
    • Seligson DB, Horvath S, McBrian MA et al.: Global levels of histone modifcations predict prognosis in different cancers. Am. J. Pathol. 174(5), 1619-1628 (2009).
    • (2009) Am. J. Pathol , vol.174 , Issue.5 , pp. 1619-1628
    • Seligson, D.B.1    Horvath, S.2    McBrian, M.A.3
  • 37
    • 33646095253 scopus 로고    scopus 로고
    • A novel method to detect functional microRNA targets
    • Vatolin S, Navaratne K, Weil RJ: A novel method to detect functional microRNA targets. J. Mol. Biol. 358(4), 983-996 (2006).
    • (2006) J. Mol. Biol , vol.358 , Issue.4 , pp. 983-996
    • Vatolin, S.1    Navaratne, K.2    Weil, R.J.3
  • 38
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V: The functions of animal microRNAs. Nature 431(7006), 350-355 (2004).
    • (2004) Nature , vol.431 , Issue.7006 , pp. 350-355
    • Ambros, V.1
  • 39
    • 20044395613 scopus 로고    scopus 로고
    • RAS is regulated by the let-7 microRNA family
    • Johnson SM, Grosshans H, Shingara J et al.: RAS is regulated by the let-7 microRNA family. Cell 120(5), 635-647 (2005).
    • (2005) Cell , vol.120 , Issue.5 , pp. 635-647
    • Johnson, S.M.1    Grosshans, H.2    Shingara, J.3
  • 40
    • 36749026906 scopus 로고    scopus 로고
    • Switching from repression to activation: MicroRNAs can up-regulate translation
    • Vasudevan S, Tong Y, Steitz JA: Switching from repression to activation: microRNAs can up-regulate translation. Science 318(5858), 1931-1934 (2007).
    • (2007) Science , vol.318 , Issue.5858 , pp. 1931-1934
    • Vasudevan, S.1    Tong, Y.2    Steitz, J.A.3
  • 42
    • 2542626605 scopus 로고    scopus 로고
    • Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
    • Takamizawa J, Konishi H, Yanagisawa K et al.: Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 64(11), 3753-3756 (2004).
    • (2004) Cancer Res , vol.64 , Issue.11 , pp. 3753-3756
    • Takamizawa, J.1    Konishi, H.2    Yanagisawa, K.3
  • 43
    • 54249117763 scopus 로고    scopus 로고
    • A SNP in a let-7 microRNA complementary site in the KRAS 3́ untranslated region increases non-small cell lung cancer risk
    • Chin LJ, Ratner E, Leng S et al.: A SNP in a let-7 microRNA complementary site in the KRAS 3́ untranslated region increases non-small cell lung cancer risk. Cancer Res. 68(20), 8535-8540 (2008).
    • (2008) Cancer Res , vol.68 , Issue.20 , pp. 8535-8540
    • Chin, L.J.1    Ratner, E.2    Leng, S.3
  • 44
    • 38049152791 scopus 로고    scopus 로고
    • Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes
    • Meng F, Wehbe-Janek H, Henson R, Smith H, Patel T: Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes. Oncogene 27(3), 378-386 (2008).
    • (2008) Oncogene , vol.27 , Issue.3 , pp. 378-386
    • Meng, F.1    Wehbe-Janek, H.2    Henson, R.3    Smith, H.4    Patel, T.5
  • 45
    • 58349119585 scopus 로고    scopus 로고
    • MicroRNA silencing in primates: Towards development of novel therapeutics
    • Petri A, Lindow M, Kauppinen S: MicroRNA silencing in primates: towards development of novel therapeutics. Cancer Res. 69(2), 393-395 (2009).
    • (2009) Cancer Res , vol.69 , Issue.2 , pp. 393-395
    • Petri, A.1    Lindow, M.2    Kauppinen, S.3
  • 46
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with 'antagomirs'
    • Krützfeldt j, Rajewsky N, Braich R et al.: Silencing of microRNAs in vivo with 'antagomirs'. Nature 438, 685-689 (2005).
    • (2005) Nature , vol.438 , pp. 685-689
    • Krützfeldt J, R.1
  • 47
    • 48749122914 scopus 로고    scopus 로고
    • Circulating microRNAs as stable blood-based markers for cancer detection
    • Mitchell PS, Parkin RK, Kroh EM et al.: Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl Acad. Sci. USA 105(30), 10513-10518 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.30 , pp. 10513-10518
    • Mitchell, P.S.1    Parkin, R.K.2    Kroh, E.M.3
  • 48
    • 57649091633 scopus 로고    scopus 로고
    • The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform
    • Resnick KE, Alder H, Hagan JP, Richardson DL, Croce CM, Cohn DE: The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform. Gynecol. Oncol. 112(1), 55-59 (2009).
    • (2009) Gynecol. Oncol , vol.112 , Issue.1 , pp. 55-59
    • Resnick, K.E.1    Alder, H.2    Hagan, J.P.3    Richardson, D.L.4    Croce, C.M.5    Cohn, D.E.6
  • 49
    • 18044364832 scopus 로고    scopus 로고
    • Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: Structure-activity relationship and molecular-modeling studies
    • Chen D, Wang CY, Lambert JD, Ai N, Welsh WJ, Yang CS: Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies. Biochem. Pharmacol. 69(10), 1523-1531 (2005).
    • (2005) Biochem. Pharmacol , vol.69 , Issue.10 , pp. 1523-1531
    • Chen, D.1    Wang, C.Y.2    Lambert, J.D.3    Ai, N.4    Welsh, W.J.5    Yang, C.S.6
  • 50
    • 33845969839 scopus 로고    scopus 로고
    • Dietary polyphenols may affect DNA methylation
    • Fang M, Chen D, Yang CS: Dietary polyphenols may affect DNA methylation. J. Nutr. 137(1 Suppl.), S223-S228 (2007).
    • (2007) J. Nutr , vol.137 , Issue.1 SUPPL.
    • Fang, M.1    Chen, D.2    Yang, C.S.3
  • 51
    • 31544441371 scopus 로고    scopus 로고
    • Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols
    • Lee WJ, Zhu BT: Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols. Carcinogenesis 27(2), 269-277 (2006).
    • (2006) Carcinogenesis , vol.27 , Issue.2 , pp. 269-277
    • Lee, W.J.1    Zhu, B.T.2
  • 52
    • 65349196261 scopus 로고    scopus 로고
    • Constrained (l-)-S-adenosyl-L-homocysteine (SAH) analogues as DNA methyltransferase inhibitors
    • Isakovic L, Saavedra OM, Llewellyn DB et al.: Constrained (l-)-S-adenosyl-L-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. Bioorg. Med. Chem. Lett. 19(10), 2742-2746 (2009).
    • (2009) Bioorg. Med. Chem. Lett , vol.19 , Issue.10 , pp. 2742-2746
    • Isakovic, L.1    Saavedra, O.M.2    Llewellyn, D.B.3
  • 53
    • 65349157819 scopus 로고    scopus 로고
    • SAR around (l)-S-adenosyl-L-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes
    • Saavedra OM, Isakovic L, Llewellyn DB et al.: SAR around (l)-S-adenosyl-L-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. Bioorg. Med. Chem. Lett. 19(10), 2747-2751 (2009).
    • (2009) Bioorg. Med. Chem. Lett , vol.19 , Issue.10 , pp. 2747-2751
    • Saavedra, O.M.1    Isakovic, L.2    Llewellyn, D.B.3
  • 54
    • 27644597195 scopus 로고    scopus 로고
    • Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2́-deoxycytidine
    • Chuang JC, Yoo CB, Kwan JM et al.: Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2́-deoxycytidine. Mol. Cancer Ther. 4(10), 1515-1520 (2005).
    • (2005) Mol. Cancer Ther , vol.4 , Issue.10 , pp. 1515-1520
    • Chuang, J.C.1    Yoo, C.B.2    Kwan, J.M.3
  • 55
    • 0038523843 scopus 로고    scopus 로고
    • Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: A case control study
    • Pufulete M, Al-Ghnaniem R, Leather AJ et al.: Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology 124(5), 1240-1248 (2003).
    • (2003) Gastroenterology , vol.124 , Issue.5 , pp. 1240-1248
    • Pufulete, M.1    Al-Ghnaniem, R.2    Leather, A.J.3
  • 56
    • 0034307291 scopus 로고    scopus 로고
    • Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse
    • Song J, Medline A, Mason JB, Gallinger S, Kim YI: Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse. Cancer Res. 60(19), 5434-5440 (2000).
    • (2000) Cancer Res , vol.60 , Issue.19 , pp. 5434-5440
    • Song, J.1    Medline, A.2    Mason, J.B.3    Gallinger, S.4    Kim, Y.I.5
  • 58
    • 0037263628 scopus 로고    scopus 로고
    • Impact of Dnmt1 defciency, with and without low folate diets, on tumor numbers and DNA methylation in min mice
    • Trasler J, Deng L, Melnyk S et al.: Impact of Dnmt1 defciency, with and without low folate diets, on tumor numbers and DNA methylation in min mice. Carcinogenesis 24(1), 39-45 (2003).
    • (2003) Carcinogenesis , vol.24 , Issue.1 , pp. 39-45
    • Trasler, J.1    Deng, L.2    Melnyk, S.3
  • 59
    • 66649109098 scopus 로고    scopus 로고
    • Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors
    • Figueiredo JC, Grau M V, Wallace K et al.: Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors. Cancer Epidemiol. Biomarkers Prev. 18(4), 1041-1049 (2009).
    • (2009) Cancer Epidemiol. Biomarkers Prev , vol.18 , Issue.4 , pp. 1041-1049
    • Figueiredo, J.C.1    Grau, M.V.2    Wallace, K.3
  • 60
    • 19844371353 scopus 로고    scopus 로고
    • Cell and stage of transformation-specifc effects of folate defciency on methionine cycle intermediates and DNA methylation in an in vitro model
    • Stempak JM, Sohn KJ, Chiang EP, Shane B, Kim YI: Cell and stage of transformation-specifc effects of folate defciency on methionine cycle intermediates and DNA methylation in an in vitro model. Carcinogenesis 26(5), 981-990 (2005).
    • (2005) Carcinogenesis , vol.26 , Issue.5 , pp. 981-990
    • Stempak, J.M.1    Sohn, K.J.2    Chiang, E.P.3    Shane, B.4    Kim, Y.I.5
  • 61
    • 27744523911 scopus 로고    scopus 로고
    • The vegetarian lifestyle and DNA methylation
    • Geisel J, Schorr H, Bodis M et al.: The vegetarian lifestyle and DNA methylation. Clin. Chem. Lab. Med. 43(10), 1164-1169 (2005).
    • (2005) Clin. Chem. Lab. Med , vol.43 , Issue.10 , pp. 1164-1169
    • Geisel, J.1    Schorr, H.2    Bodis, M.3
  • 62
    • 0026579875 scopus 로고
    • Methyl groups in carcinogenesis: Effects on DNA methylation and gene expression
    • Wainfan E, Poirier LA: Methyl groups in carcinogenesis: effects on DNA methylation and gene expression. Cancer Res. 52(7 Suppl.), S2071-S2077 (1992).
    • (1992) Cancer Res , vol.52 , Issue.7 SUPPL.
    • Wainfan, E.1    Poirier, L.A.2
  • 63
    • 27144535374 scopus 로고    scopus 로고
    • Trapped in action: Direct visualization of DNA methyltransferase activity in living cells
    • Schermelleh L, Spada F, Easwaran HP et al.: Trapped in action: direct visualization of DNA methyltransferase activity in living cells. Nat. Methods 2(10), 751-756 (2005).
    • (2005) Nat. Methods , vol.2 , Issue.10 , pp. 751-756
    • Schermelleh, L.1    Spada, F.2    Easwaran, H.P.3
  • 64
    • 12444297637 scopus 로고    scopus 로고
    • Phase i and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks
    • Davis AJ, Gelmon KA, Siu LL et al.: Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks. Invest. New Drugs 21(1), 85-97 (2003).
    • (2003) Invest. New Drugs , vol.21 , Issue.1 , pp. 85-97
    • Davis, A.J.1    Gelmon, K.A.2    Siu, L.L.3
  • 65
    • 0038443956 scopus 로고    scopus 로고
    • A Phase i pharmacokinetic and pharmacodynamic study of the DNA methyltransferase 1 inhibitor MG98 administered twice weekly
    • Stewart DJ, Donehower RC, Eisenhauer EA et al.: A Phase I pharmacokinetic and pharmacodynamic study of the DNA methyltransferase 1 inhibitor MG98 administered twice weekly. Ann. Oncol. 14(5), 766-774 (2003).
    • (2003) Ann. Oncol , vol.14 , Issue.5 , pp. 766-774
    • Stewart, D.J.1    Donehower, R.C.2    Eisenhauer, E.A.3
  • 66
    • 33646595937 scopus 로고    scopus 로고
    • Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: A National Cancer Institute of Canada clinical trials group investigational new drug study
    • Winquist E, Knox J, Ayoub JP et al.: Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada clinical trials group investigational new drug study. Invest. New Drugs 24(2), 159-167 (2006).
    • (2006) Invest. New Drugs , vol.24 , Issue.2 , pp. 159-167
    • Winquist, E.1    Knox, J.2    Ayoub, J.P.3
  • 67
    • 42249104213 scopus 로고    scopus 로고
    • A Phase i biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia
    • Klisovic RB, Stock W, Cataland S et al.: A Phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia. Clin. Cancer Res. 14(8), 2444-2449 (2008).
    • (2008) Clin. Cancer Res , vol.14 , Issue.8 , pp. 2444-2449
    • Klisovic, R.B.1    Stock, W.2    Cataland, S.3
  • 68
    • 0037224722 scopus 로고    scopus 로고
    • DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells
    • Robert MF, Morin S, Beaulieu N et al.: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat. Genet. 33(1), 61-65 (2003).
    • (2003) Nat. Genet , vol.33 , Issue.1 , pp. 61-65
    • Robert, M.F.1    Morin, S.2    Beaulieu, N.3
  • 69
    • 22244435605 scopus 로고    scopus 로고
    • Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    • Brueckner B, Garcia Boy R, Siedlecki P et al.: Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res. 65(14), 6305-6311 (2005).
    • (2005) Cancer Res , vol.65 , Issue.14 , pp. 6305-6311
    • Brueckner, B.1    Garcia Boy, R.2    Siedlecki, P.3
  • 70
    • 43249103972 scopus 로고    scopus 로고
    • AML1 mutations induced MDS and MDS/AML in a mouse BMT model
    • Watanabe-Okochi N, Kitaura J, Ono R et al.: AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Blood 111(8), 4297-4308 (2008).
    • (2008) Blood , vol.111 , Issue.8 , pp. 4297-4308
    • Watanabe-Okochi, N.1    Kitaura, J.2    Ono, R.3
  • 71
    • 52649146276 scopus 로고    scopus 로고
    • Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras
    • Slape C, Liu LY, Beachy S, Aplan PD: Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl. Blood 112(5), 2017-2019 (2008).
    • (2008) Kras, and Cbl. Blood , vol.112 , Issue.5 , pp. 2017-2019
    • Slape, C.1    Liu, L.Y.2    Beachy, S.3    Aplan, P.D.4
  • 72
    • 50849126819 scopus 로고    scopus 로고
    • Impaired differentiation and apoptosis of hematopoietic precursors in a mouse model of myelodysplastic syndrome
    • Choi C W, Chung YJ, Slape C, Aplan PD: Impaired differentiation and apoptosis of hematopoietic precursors in a mouse model of myelodysplastic syndrome. Haematologica 93(9), 1394-1397 (2008).
    • (2008) Haematologica , vol.93 , Issue.9 , pp. 1394-1397
    • Choi, C.W.1    Chung, Y.J.2    Slape, C.3    Aplan, P.D.4
  • 74
    • 52949153952 scopus 로고    scopus 로고
    • Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell
    • Chung YJ, Choi CW, Slape C, Fry T, Aplan PD: Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell. Proc. Natl Acad. Sci. USA 105(37), 14088-14093 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.37 , pp. 14088-14093
    • Chung, Y.J.1    Choi, C.W.2    Slape, C.3    Fry, T.4    Aplan, P.D.5
  • 75
    • 0037420191 scopus 로고    scopus 로고
    • Inhibition of DNA methylation and reactivation of silenced genes by zebularine
    • Cheng JC, Matsen CB, Gonzales FA et al.: Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J. Natl Cancer Inst. 95(5), 399-409 (2003).
    • (2003) J. Natl Cancer Inst , vol.95 , Issue.5 , pp. 399-409
    • Cheng, J.C.1    Matsen, C.B.2    Gonzales, F.A.3
  • 76
    • 1642499364 scopus 로고    scopus 로고
    • Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells
    • Cheng JC, Weisenberger DJ, Gonzales FA et al.: Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol. Cell. Biol. 24(3), 1270-1278 (2004).
    • (2004) Mol. Cell. Biol , vol.24 , Issue.3 , pp. 1270-1278
    • Cheng, J.C.1    Weisenberger, D.J.2    Gonzales, F.A.3
  • 77
    • 5144228492 scopus 로고    scopus 로고
    • Preferential response of cancer cells to zebularine
    • Cheng JC, Yoo CB, Weisenberger DJ et al.: Preferential response of cancer cells to zebularine. Cancer Cell 6(2), 151-158 (2004).
    • (2004) Cancer Cell , vol.6 , Issue.2 , pp. 151-158
    • Cheng, J.C.1    Yoo, C.B.2    Weisenberger, D.J.3
  • 78
    • 0030786410 scopus 로고    scopus 로고
    • Conversion of 2́, 3́-dideoxyadenosine (ddA) and 2́, 3́-didehydro-2́, 3́-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodefciency virus and hepatitis B virus
    • Balzarini J, Kruining J, Wedgwood O et al.: Conversion of 2́, 3́-dideoxyadenosine (ddA) and 2́, 3́-didehydro-2́, 3́-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodefciency virus and hepatitis B virus. FEBS Lett. 410(2-3), 324-328 (1997).
    • (1997) FEBS Lett , vol.410 , Issue.2-3 , pp. 324-328
    • Balzarini, J.1    Kruining, J.2    Wedgwood, O.3
  • 79
    • 57349169241 scopus 로고    scopus 로고
    • Activation of p16 gene silenced by DNA methylation in cancer cells by phosphoramidate derivatives of 2́-deoxyzebularine
    • Yoo CB, Valente R, Congiatu C et al.: Activation of p16 gene silenced by DNA methylation in cancer cells by phosphoramidate derivatives of 2́-deoxyzebularine. J. Med. Chem. 51(23), 7593-7601 (2008).
    • (2008) J. Med. Chem , vol.51 , Issue.23 , pp. 7593-7601
    • Yoo, C.B.1    Valente, R.2    Congiatu, C.3
  • 80
    • 0037151042 scopus 로고    scopus 로고
    • Methyl-CpG binding domain protein 2 represses transcription from hypermethylated p-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells
    • Bakker J, Lin X, Nelson WG: Methyl-CpG binding domain protein 2 represses transcription from hypermethylated p-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells. J. Biol. Chem. 277(25), 22573-22580 (2002).
    • (2002) J. Biol. Chem , vol.277 , Issue.25 , pp. 22573-22580
    • Bakker, J.1    Lin, X.2    Nelson, W.G.3
  • 81
    • 33847111684 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor a (ER) gene expression without loss of DNA hypermethylation
    • Zhou Q, Atadja P, Davidson NE: Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor a (ER) gene expression without loss of DNA hypermethylation. Cancer Biol. Ther. 6(1), 64-69 (2007).
    • (2007) Cancer Biol. Ther , vol.6 , Issue.1 , pp. 64-69
    • Zhou, Q.1    Atadja, P.2    Davidson, N.E.3
  • 82
    • 54749110669 scopus 로고    scopus 로고
    • Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines
    • Lopes EC, Valls E, Figueroa ME et al.: Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines. Cancer Res. 68(18), 7258-7263 (2008).
    • (2008) Cancer Res , vol.68 , Issue.18 , pp. 7258-7263
    • Lopes, E.C.1    Valls, E.2    Figueroa, M.E.3
  • 83
    • 33646138230 scopus 로고    scopus 로고
    • JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor
    • Yamane K, Toumazou C, Tsukada Y et al.: JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 125(3), 483-495 (2006).
    • (2006) Cell , vol.125 , Issue.3 , pp. 483-495
    • Yamane, K.1    Toumazou, C.2    Tsukada, Y.3
  • 84
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • Shi Y, Lan F, Matson C et al.: Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119(7), 941-953 (2004).
    • (2004) Cell , vol.119 , Issue.7 , pp. 941-953
    • Shi, Y.1    Lan, F.2    Matson, C.3
  • 85
    • 32844454603 scopus 로고    scopus 로고
    • Histone demethylation by a family of JmjC domain-containing proteins
    • Tsukada Y, Fang J, Erdjument-Bromage H et al.: Histone demethylation by a family of JmjC domain-containing proteins. Nature 439(7078), 811-816 (2006).
    • (2006) Nature , vol.439 , Issue.7078 , pp. 811-816
    • Tsukada, Y.1    Fang, J.2    Erdjument-Bromage, H.3
  • 86
    • 1942503942 scopus 로고    scopus 로고
    • The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3
    • Cao R, Zhang Y: The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr. Opin. Genet. Dev. 14(2), 155-164 (2004).
    • (2004) Curr. Opin. Genet. Dev , vol.14 , Issue.2 , pp. 155-164
    • Cao, R.1    Zhang, Y.2
  • 87
    • 0142105414 scopus 로고    scopus 로고
    • EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplifed in cancer
    • Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K: EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplifed in cancer. EMBO J. 22(20), 5323-5335 (2003).
    • (2003) EMBO J , vol.22 , Issue.20 , pp. 5323-5335
    • Bracken, A.P.1    Pasini, D.2    Capra, M.3    Prosperini, E.4    Colli, E.5    Helin, K.6
  • 88
    • 0035050744 scopus 로고    scopus 로고
    • The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma
    • Visser HP, Gunster MJ, Kluin-Nelemans HC et al.: The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma. Br. J. Haematol. 112(4), 950-958 (2001).
    • (2001) Br. J. Haematol , vol.112 , Issue.4 , pp. 950-958
    • Visser, H.P.1    Gunster, M.J.2    Kluin-Nelemans, H.C.3
  • 89
    • 18644382388 scopus 로고    scopus 로고
    • The Polycomb group protein EZH2 is involved in progression of prostate cancer
    • Varambally S, Dhanasekaran SM, Zhou M et al.: The Polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419(6907), 624-629 (2002).
    • (2002) Nature , vol.419 , Issue.6907 , pp. 624-629
    • Varambally, S.1    Dhanasekaran, S.M.2    Zhou, M.3
  • 90
    • 67649371461 scopus 로고    scopus 로고
    • DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
    • Miranda TB, Cortez CC, Yoo CB et al.: DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol. Cancer Ther. 8(6), 1579-1588 (2009).
    • (2009) Mol. Cancer Ther , vol.8 , Issue.6 , pp. 1579-1588
    • Miranda, T.B.1    Cortez, C.C.2    Yoo, C.B.3
  • 91
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan J, Yang X, Zhuang L et al.: Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 21(9), 1050-1063 (2007).
    • (2007) Genes Dev , vol.21 , Issue.9 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3
  • 92
    • 34249934238 scopus 로고    scopus 로고
    • Inhibition of lysine-specifc demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes
    • Huang Y, Greene E, Murray Stewart T et al.: Inhibition of lysine-specifc demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc. Natl Acad. Sci. USA 104(19), 8023-8028 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.19 , pp. 8023-8028
    • Huang, Y.1    Greene, E.2    Murray Stewart, T.3
  • 93
    • 62849104641 scopus 로고    scopus 로고
    • Effcacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, Phase III study
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E et al.: Effcacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, Phase III study. Lancet Oncol. 10(3), 223-232 (2009).
    • (2009) Lancet Oncol , vol.10 , Issue.3 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 94
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group Br
    • Silverman LR, Demakos EP, Peterson BL et al.: Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group Br. J. Clin. Oncol. 20(10), 2429-2440 (2002).
    • (2002) J. Clin. Oncol , vol.20 , Issue.10 , pp. 2429-2440
    • Silverman, L.R.1    Demakos, E.P.2    Peterson, B.L.3
  • 95
    • 33646071894 scopus 로고    scopus 로고
    • Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a Phase III randomized study
    • Kantarjian H, Issa J P, Rosenfeld CS et al.: Decitabine improves patient outcomes in myelodysplastic syndromes: results of a Phase III randomized study. Cancer 106(8), 1794-1803 (2006).
    • (2006) Cancer , vol.106 , Issue.8 , pp. 1794-1803
    • Kantarjian, H.1    Issa, J.P.2    Rosenfeld, C.S.3
  • 96
    • 34548131144 scopus 로고    scopus 로고
    • CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine
    • Raj K, John A, Ho A et al.: CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine. Leukemia 21(9), 1937-1944 (2007).
    • (2007) Leukemia , vol.21 , Issue.9 , pp. 1937-1944
    • Raj, K.1    John, A.2    Ho, A.3
  • 97
    • 70350506791 scopus 로고    scopus 로고
    • Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
    • Fandy TE, Herman JG, Kerns P et al.: Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. Blood 114(13), 2764-2773 (2009).
    • (2009) Blood , vol.114 , Issue.13 , pp. 2764-2773
    • Fandy, T.E.1    Herman, J.G.2    Kerns, P.3
  • 98
    • 33750530675 scopus 로고    scopus 로고
    • Phase 1/2 study of the combination of 5-aza-2́-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B et al.: Phase 1/2 study of the combination of 5-aza-2́-deoxycytidine with valproic acid in patients with leukemia. Blood 108(10), 3271-3279 (2006).
    • (2006) Blood , vol.108 , Issue.10 , pp. 3271-3279
    • Garcia-Manero, G.1    Kantarjian, H.M.2    Sanchez-Gonzalez, B.3
  • 99
    • 60249094793 scopus 로고    scopus 로고
    • Mechanisms of resistance to 5-aza-2́-deoxycytidine in human cancer cell lines
    • Qin T, Jelinek J, Si J, Shu J, Issa JP: Mechanisms of resistance to 5-aza-2́-deoxycytidine in human cancer cell lines. Blood 113(3), 659-667 (2009).
    • (2009) Blood , vol.113 , Issue.3 , pp. 659-667
    • Qin, T.1    Jelinek, J.2    Si, J.3    Shu, J.4    Issa, J.P.5
  • 100


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