Engineering of substrate selectivity for tissue factor·factor VIIa complex signaling through protease-activated receptor 2

Journal of Biological Chemistry

Volumn 285, Issue 26, 2010, Pages 19959-19966

  Larsen, Katrine S ^a,b   Østergaard, Henrik ^a,b   Olsen, Ole H ^a   Bjelke, Jais R ^a   Ruf, Wolfram ^b   Petersen, Lars C ^a  

^a NOVO NORDISK A S   (Denmark)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; COFACTORS; EXOSITE INTERACTIONS; IN-VIVO; PROTEASE-ACTIVATED RECEPTOR 2; PROTEIN ENGINEERING; PROTEOLYTIC CLEAVAGE; SIDE CHAINS; SIGNALING COMPLEX; SUBSTRATE INTERACTION; SUBSTRATE SELECTIVITY; TISSUE FACTORS;

BIOCHEMICAL ENGINEERING; COAGULATION; COMPLEXATION; GENETIC ENGINEERING; MACROMOLECULES; SIGNALING; TISSUE ENGINEERING;

SUBSTRATES;

BLOOD CLOTTING FACTOR 7A; PROTEINASE ACTIVATED RECEPTOR 2;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ENGINEERING; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION;

AMINO ACID SUBSTITUTION; BINDING SITES; CELL LINE; CELL LINE, TUMOR; FACTOR VIIA; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, PAR-2; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; THROMBOPLASTIN; TRANSFECTION;

EID: 77953802931     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.101030     Document Type: Article

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