Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway

Genome Biology

Volumn 3, Issue 3, 2002, Pages

  Schell, Thomas ^a   Kulozik, Andreas E ^b   Hentze, Matthias W ^a,b  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

COMPLEX FORMATION; CONTROLLED STUDY; EXON; GENE EXPRESSION; GENE TRANSFER; HUMAN; NONHUMAN; RNA BINDING; RNA DEGRADATION; RNA SPLICING; RNA TRANSLATION; SHORT SURVEY; STOP CODON;

ANIMALS; CODON, NONSENSE; EXONS; HUMANS; MODELS, GENETIC; PROTEIN BIOSYNTHESIS; QUALITY CONTROL; RNA CAP-BINDING PROTEINS; RNA SPLICING; RNA, MESSENGER; RNA-BINDING PROTEINS;

EID: 0036204810     PISSN: 14656906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (35)

1. RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer
2. Nonsense codon mutations in the terminal exon of the beta-globin gene are not associated with a reduction in beta-mRNA accumulation: A mechanism for the phenotype of dominant beta-thalassemia
3. Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B
4. Nonsense surveillance in lymphocytes?
5. Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover
6. Cloning and characterization of HUPFI, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPFI protein
7. A mutated human homologue to yeast Upfl protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells
8. Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes
9. Human Upf proteins target an mRNA for nonsense-mediated decay when bound down-stream of a termination codon
10. Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)
11. Evidence that phosphorylation of human upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway
12. The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs
13. A perfect message: RNA surveillance and nonsense-mediated decay
14. Nonsense-mediated RNA decay in mammalian cells: A splicing-dependent means to down-regulate the levels of mRNAs that prematurely terminate translation
15. Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay
16. The human intronless melanocortin 4-receptor gene is NMD insensitive
17. Splicing and 3′ end formation in the definition of nonsense-mediated decay-competent human β-globin mRNPs
18. Binary specification of nonsense codons by splicing and cytoplasmic translation
19. A splicing-dependent regulatory mechanism that detects translation signals
20. A rule for termination-codon position within intron-containing genes: When nonsense affects RNA abundance
21. Mechanisms of mRNA surveillance in eukaryotes
22. Pre-mRNA splicing alters mRNP composition: Evidence for stable association of proteins at exon-exon junctions
23. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay
24. Nucleocytoplasmic transport enters the atomic age
25. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPSI
26. Role of the nonsense-mediated decay factor hUpf3 in the splicing- dependent exon-exon junction complex
27. Coupled transcription and translation within nuclei of mammalian cells
28. Protein synthesis. Believe it or not-translation in the nucleus
29. Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA
30. The role of the cap structure in RNA processing and nuclear export
31. Translocation of a specific premessenger ribonucleoprotein particle through the nuclear pore studied with electron microscope tomography
32. The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation
33. Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m(7) guanosine cap
34. Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20
35. The role of nuclear cap binding protein Cbclp of yeast in mRNA termination and degradation