-
1
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years
-
Newman, D. J.; Cragg, G. M. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod., 2007, 70, 461-77.
-
(2007)
J. Nat. Prod.
, vol.70
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
2
-
-
0030221053
-
Understanding and controlling the cell cycle with natural products
-
Hung, D. T.; Jamison, T. F.; Schreiber, S. L. Understanding and controlling the cell cycle with natural products. Chem. Biol., 1996, 3, 623-39.
-
(1996)
Chem. Biol.
, vol.3
, pp. 623-639
-
-
Hung, D.T.1
Jamison, T.F.2
Schreiber, S.L.3
-
3
-
-
43749106622
-
Polymeric black tea polyphenols inhibit mouse skin chemical carcinogenesis by decreasing cell proliferation
-
Patel, R.; Krishnan, R.; Ramchandani, A.; Maru, G. Polymeric black tea polyphenols inhibit mouse skin chemical carcinogenesis by decreasing cell proliferation. Cell Prolif., 2008, 41, 532-53.
-
(2008)
Cell Prolif
, vol.41
, pp. 532-553
-
-
Patel, R.1
Krishnan, R.2
Ramchandani, A.3
Maru, G.4
-
4
-
-
65649137735
-
Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and cardiovascular diseases
-
Jagtap, S.; Meganathan, K.; Wagh, V.; Winkler, J.; Hescheler, J.; Sachinidis, A. Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and cardiovascular diseases. Curr. Med. Chem., 2009, 16, 1451-62.
-
(2009)
Curr. Med. Chem.
, vol.16
, pp. 1451-1462
-
-
Jagtap, S.1
Meganathan, K.2
Wagh, V.3
Winkler, J.4
Hescheler, J.5
Sachinidis, A.6
-
5
-
-
55349122598
-
Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis
-
Shi, Y.; Sahu, R. P.; Srivastava, S. K. Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis. BMC Cancer, 2008, 8, 294.
-
(2008)
BMC Cancer
, vol.8
, pp. 294
-
-
Shi, Y.1
Sahu, R.P.2
Srivastava, S.K.3
-
6
-
-
77149179813
-
Curcumin as an anticancer agent: Review of the gap between basic and clinical applications
-
Bar-Sela, G.; Epelbaum, R.; Schaffer, M. Curcumin as an anticancer agent: review of the gap between basic and clinical applications. Curr. Med. Chem., 2010, 17(3), 190-197.
-
(2010)
Curr. Med. Chem.
, vol.17
, Issue.3
, pp. 190-197
-
-
Bar-Sela, G.1
Epelbaum, R.2
Schaffer, M.3
-
7
-
-
73349094986
-
Curcumin and cancer cells: How many ways can curry kill tumor cells selectively?
-
Ravindran, J.; Prasad, S.; Aggarwal, B. B. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS. J., 2009, 11, 495-510.
-
(2009)
AAPS. J.
, vol.11
, pp. 495-510
-
-
Ravindran, J.1
Prasad, S.2
Aggarwal, B.B.3
-
8
-
-
0035433799
-
Natural products in anticancer therapy
-
da Rocha, A. B.; Lopes, R. M.; Schwartsmann, G. Natural products in anticancer therapy. Curr. Opin. Pharmacol., 2001, 1, 364-9.
-
(2001)
Curr. Opin. Pharmacol.
, vol.1
, pp. 364-369
-
-
da Rocha, A.B.1
Lopes, R.M.2
Schwartsmann, G.3
-
9
-
-
0033865492
-
Molecular mechanisms of anticancer activity of natural dietetic products
-
Colic, M.; Pavelic, K. Molecular mechanisms of anticancer activity of natural dietetic products. J. Mol. Med., 2000, 78, 333-336.
-
(2000)
J. Mol. Med.
, vol.78
, pp. 333-336
-
-
Colic, M.1
Pavelic, K.2
-
10
-
-
70350225860
-
Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics
-
Sarkar, F. H.; Li, Y. Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics. Cancer Treat. Rev., 2009, 35, 597-607.
-
(2009)
Cancer Treat. Rev.
, vol.35
, pp. 597-607
-
-
Sarkar, F.H.1
Li, Y.2
-
11
-
-
0037180432
-
The mechanism of topoisomerase I poisoning by a camptothecin analog
-
Staker, B. L.; Hjerrild, K.; Feese, M. D.; Behnke, C. A.; Burgin, A. B. Jr.; Stewart, L. The mechanism of topoisomerase I poisoning by a camptothecin analog. Proc. Natl. Acad. Sci. USA, 2002, 99, 15387-15392.
-
(2002)
Proc. Natl. Acad. Sci. USA.
, vol.99
, pp. 15387-15392
-
-
Staker, B.L.1
Hjerrild, K.2
Feese, M.D.3
Behnke, C.A.4
Burgin Jr., A.B.5
Stewart, L.6
-
12
-
-
64949178567
-
Cytotoxicity and cellular uptake of doxorubicin and its formamidine derivatives in HL60 sensitive and HL60/MX2 resistant cells
-
Kik, K.; Wasowska-Lukawska, M.; Oszczapowicz, I.; Szmigiero, L. Cytotoxicity and cellular uptake of doxorubicin and its formamidine derivatives in HL60 sensitive and HL60/MX2 resistant cells. Anticancer Res., 2009, 29, 1429-1433.
-
(2009)
Anticancer Res
, vol.29
, pp. 1429-1433
-
-
Kik, K.1
Wasowska-Lukawska, M.2
Oszczapowicz, I.3
Szmigiero, L.4
-
13
-
-
35748968504
-
DNA topoisomerase II structures and anthracycline activity: Insights into ternary complex formation
-
Dal Ben, D.; Palumbo, M.; Zagotto, G.; Capranico, G.; Moro, S. DNA topoisomerase II structures and anthracycline activity: insights into ternary complex formation. Curr. Pharm. Des., 2007, 13, 2766-2780.
-
(2007)
Curr. Pharm. Des.
, vol.13
, pp. 2766-2780
-
-
dal Ben, D.1
Palumbo, M.2
Zagotto, G.3
Capranico, G.4
Moro, S.5
-
14
-
-
4344623889
-
Imatinib as a paradigm of targeted therapies
-
Druker, B. J. Imatinib as a paradigm of targeted therapies. Adv. Cancer Res., 2004, 91, 1-30.
-
(2004)
Adv. Cancer Res.
, vol.91
, pp. 1-30
-
-
Druker, B.J.1
-
15
-
-
70350490045
-
Gefitinib: A review of its use in the treatment of locally advanced/metastatic non-small cell lung cancer
-
Sanford, M.; Scott, L. J. Gefitinib: a review of its use in the treatment of locally advanced/metastatic non-small cell lung cancer. Drugs, 2009, 69, 2303-2328.
-
(2009)
Drugs
, vol.69
, pp. 2303-2328
-
-
Sanford, M.1
Scott, L.J.2
-
16
-
-
65349097586
-
Tubulin-interactive natural products as anticancer agents (1)
-
Kingston, D. G. Tubulin-interactive natural products as anticancer agents (1). J. Nat. Prod., 2009, 72, 507-515.
-
(2009)
J. Nat. Prod.
, vol.72
, pp. 507-515
-
-
Kingston, D.G.1
-
17
-
-
39149137869
-
Plant-derived compounds in clinical trials
-
Saklani, A.; Kutty, S. K. Plant-derived compounds in clinical trials. Drug Discov. Today, 2008, 13, 161-171.
-
(2008)
Drug Discov. Today.
, vol.13
, pp. 161-171
-
-
Saklani, A.1
Kutty, S.K.2
-
18
-
-
33746622984
-
Strategies for optimizing combinations of molecularly targeted anticancer agents
-
Dancey, J. E.; Chen, H. X. Strategies for optimizing combinations of molecularly targeted anticancer agents. Nat. Rev. Drug Discov., 2006, 5, 649-659.
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 649-659
-
-
Dancey, J.E.1
Chen, H.X.2
-
19
-
-
42449147919
-
Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)
-
Kitada, S.; Kress, C. L.; Krajewska, M.; Jia, L.; Pellecchia, M.; Reed, J. C. Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). Blood, 2008, 111, 3211-3219.
-
(2008)
Blood
, vol.111
, pp. 3211-3219
-
-
Kitada, S.1
Kress, C.L.2
Krajewska, M.3
Jia, L.4
Pellecchia, M.5
Reed, J.C.6
-
20
-
-
33745305095
-
Antiangiogenic drugs: From bench to clinical trials
-
Quesada, A. R.; Munoz-Chapuli, R.; Medina, M. A. Antiangiogenic drugs: from bench to clinical trials. Med. Res. Rev., 2006, 26, 483-530.
-
(2006)
Med. Res. Rev.
, vol.26
, pp. 483-530
-
-
Quesada, A.R.1
Munoz-Chapuli, R.2
Medina, M.A.3
-
21
-
-
35048895357
-
Targeting protein-protein interactions: Lessons from p53/MDM2
-
Murray, J. K.; Gellman, S. H. Targeting protein-protein interactions: lessons from p53/MDM2. Biopolymers, 2007, 88, 657-686.
-
(2007)
Biopolymers
, vol.88
, pp. 657-686
-
-
Murray, J.K.1
Gellman, S.H.2
-
22
-
-
2642551603
-
Development of the proteasome inhibitor Velcade (Bortezomib)
-
Adams, J.; Kauffman, M. Development of the proteasome inhibitor Velcade (Bortezomib). Cancer Invest., 2004, 22, 304-311.
-
(2004)
Cancer Invest
, vol.22
, pp. 304-311
-
-
Adams, J.1
Kauffman, M.2
-
23
-
-
77249121048
-
Geldanamycin and its anticancer activities
-
Fukuyo, Y.; Hunt, C. R.; Horikoshi, N. Geldanamycin and its anticancer activities. Cancer Lett., 2010, 290, 24-35.
-
(2010)
Cancer Lett
, vol.290
, pp. 24-35
-
-
Fukuyo, Y.1
Hunt, C.R.2
Horikoshi, N.3
-
24
-
-
63149118507
-
Ready for a comeback of natural products in oncology
-
Bailly, C. Ready for a comeback of natural products in oncology. Biochem. Pharmacol., 2009, 77, 1447-1457.
-
(2009)
Biochem. Pharmacol.
, vol.77
, pp. 1447-1457
-
-
Bailly, C.1
-
25
-
-
34748826129
-
HSP90 antagonist, geldanamycin, inhibits proliferation, induces apoptosis and blocks migration of rhabdomyosarcoma cells in vitro and seeding into bone marrow in vivo
-
Lesko, E.; Gozdzik, J.; Kijowski, J.; Jenner, B.; Wiecha, O.; Majka, M. HSP90 antagonist, geldanamycin, inhibits proliferation, induces apoptosis and blocks migration of rhabdomyosarcoma cells in vitro and seeding into bone marrow in vivo. Anticancer Drugs, 2007, 18, 1173-1181.
-
(2007)
Anticancer Drugs
, vol.18
, pp. 1173-1181
-
-
Lesko, E.1
Gozdzik, J.2
Kijowski, J.3
Jenner, B.4
Wiecha, O.5
Majka, M.6
-
26
-
-
43749123904
-
Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1
-
Sugimoto, K.; Sasaki, M.; Isobe, Y.; Tsutsui, M.; Suto, H.; Ando, J.; Tamayose, K.; Ando, M.; Oshimi, K. Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1. Oncogene, 2008, 27, 3091-3101.
-
(2008)
Oncogene
, vol.27
, pp. 3091-3101
-
-
Sugimoto, K.1
Sasaki, M.2
Isobe, Y.3
Tsutsui, M.4
Suto, H.5
Ando, J.6
Tamayose, K.7
Ando, M.8
Oshimi, K.9
-
27
-
-
0036236752
-
Antileukemia effect of resveratrol
-
Tsan, M. F.; White, J. E.; Maheshwari, J. G.; Chikkappa, G. Antileukemia effect of resveratrol. Leuk. Lymphoma, 2002, 43, 983-987.
-
(2002)
Leuk. Lymphoma.
, vol.43
, pp. 983-987
-
-
Tsan, M.F.1
White, J.E.2
Maheshwari, J.G.3
Chikkappa, G.4
-
28
-
-
15944387964
-
The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim
-
Nikrad, M.; Johnson, T.; Puthalalath, H.; Coultas, L.; Adams, J.; Kraft, A. S. The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. Mol. Cancer Ther., 2005, 4, 443-449.
-
(2005)
Mol. Cancer Ther.
, vol.4
, pp. 443-449
-
-
Nikrad, M.1
Johnson, T.2
Puthalalath, H.3
Coultas, L.4
Adams, J.5
Kraft, A.S.6
-
29
-
-
0012433771
-
Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts
-
Nawrocki, S. T.; Bruns, C. J.; Harbison, M. T.; Bold, R. J.; Gotsch, B. S.; Abbruzzese, J. L.; Elliott, P.; Adams, J.; McConkey, D. J. Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts. Mol. Cancer Ther., 2002, 1, 1243-1253.
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 1243-1253
-
-
Nawrocki, S.T.1
Bruns, C.J.2
Harbison, M.T.3
Bold, R.J.4
Gotsch, B.S.5
Abbruzzese, J.L.6
Elliott, P.7
Adams, J.8
McConkey, D.J.9
-
30
-
-
33847066706
-
Functions of the proteasome: From protein degradation and immune surveillance to cancer therapy
-
Goldberg, A. L. Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy. Biochem. Soc. Trans., 2007, 35, 12-17.
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 12-17
-
-
Goldberg, A.L.1
-
31
-
-
33947596504
-
Why is cancer drug discovery so difficult?
-
Kamb, A.; Wee, S.; Lengauer, C. Why is cancer drug discovery so difficult? Nat. Rev. Drug Discov., 2007, 6, 115-120.
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 115-120
-
-
Kamb, A.1
Wee, S.2
Lengauer, C.3
-
32
-
-
65549152514
-
Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
-
Seeliger, M. A.; Ranjitkar, P.; Kasap, C.; Shan, Y.; Shaw, D. E.; Shah, N. P.; Kuriyan, J.; Maly, D. J. Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations. Cancer Res., 2009, 69, 2384-2392.
-
(2009)
Cancer Res
, vol.69
, pp. 2384-2392
-
-
Seeliger, M.A.1
Ranjitkar, P.2
Kasap, C.3
Shan, Y.4
Shaw, D.E.5
Shah, N.P.6
Kuriyan, J.7
Maly, D.J.8
-
33
-
-
33847659183
-
C-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty
-
Seeliger, M. A.; Nagar, B.; Frank, F.; Cao, X.; Henderson, M. N.; Kuriyan, J. c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. Structure, 2007, 15, 299-311.
-
(2007)
Structure
, vol.15
, pp. 299-311
-
-
Seeliger, M.A.1
Nagar, B.2
Frank, F.3
Cao, X.4
Henderson, M.N.5
Kuriyan, J.6
-
34
-
-
13844251975
-
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
-
Weisberg, E.; Manley, P. W.; Breitenstein, W.; Bruggen, J.; Cowan-Jacob, S. W.; Ray, A.; Huntly, B.; Fabbro, D.; Fendrich, G.; Hall-Meyers, E.; Kung, A. L.; Mestan, J.; Daley, G. Q.; Callahan, L.; Catley, L.; Cavazza, C.; Azam, M.; Neuberg, D.; Wright, R. D.; Gilliland, D. G.; Griffin, J. D. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell, 2005, 7, 129-141.
-
(2005)
Cancer Cell
, vol.7
, pp. 129-141
-
-
Weisberg, E.1
Manley, P.W.2
Breitenstein, W.3
Bruggen, J.4
Cowan-Jacob, S.W.5
Ray, A.6
Huntly, B.7
Fabbro, D.8
Fendrich, G.9
Hall-Meyers, E.10
Kung, A.L.11
Mestan, J.12
Daley, G.Q.13
Callahan, L.14
Catley, L.15
Cavazza, C.16
Azam, M.17
Neuberg, D.18
Wright, R.D.19
Gilliland, D.G.20
Griffin, J.D.21
more..
-
35
-
-
62449337409
-
The structure of the leukemia drug imatinib bound to human quinine reductase 2 (NQO2)
-
Winger, J. A.; Hantschel, O.; Superti-Furga, G.; Kuriyan, J. The structure of the leukemia drug imatinib bound to human quinine reductase 2 (NQO2). BMC Struct. Biol., 2009, 9, 7.
-
(2009)
BMC Struct. Biol.
, vol.9
, pp. 7
-
-
Winger, J.A.1
Hantschel, O.2
Superti-Furga, G.3
Kuriyan, J.4
-
36
-
-
28344433705
-
NRH:Quinine reductase 2: An enzyme of surprises and mysteries
-
Vella, F.; Ferry, G.; Delagrange, P.; Boutin, J. A. NRH:quinine reductase 2: an enzyme of surprises and mysteries. Biochem. Pharmacol., 2005, 71, 1-12.
-
(2005)
Biochem. Pharmacol.
, vol.71
, pp. 1-12
-
-
Vella, F.1
Ferry, G.2
Delagrange, P.3
Boutin, J.A.4
-
37
-
-
4444267291
-
Crystal structure of quinone reductase 2 in complex with resveratrol
-
Buryanovskyy, L.; Fu, Y.; Boyd, M.; Ma, Y.; Hsieh, T. C.; Wu, J. M.; Zhang, Z. Crystal structure of quinone reductase 2 in complex with resveratrol. Biochemistry, 2004, 43, 11417-11426.
-
(2004)
Biochemistry
, vol.43
, pp. 11417-11426
-
-
Buryanovskyy, L.1
Fu, Y.2
Boyd, M.3
Ma, Y.4
Hsieh, T.C.5
Wu, J.M.6
Zhang, Z.7
-
38
-
-
0032536187
-
Resveratrol, a remarkable inhibitor of ribonucleotide reductase
-
Fontecave, M.; Lepoivre, M.; Elleingand, E.; Gerez, C.; Guittet, O. Resveratrol, a remarkable inhibitor of ribonucleotide reductase. FEBS Lett., 1998, 421, 277-279.
-
(1998)
FEBS Lett
, vol.421
, pp. 277-279
-
-
Fontecave, M.1
Lepoivre, M.2
Elleingand, E.3
Gerez, C.4
Guittet, O.5
-
39
-
-
4544327822
-
Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography
-
Wang, Z.; Hsieh, T. C.; Zhang, Z.; Ma, Y.; Wu, J. M. Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography. Biochem. Biophys. Res. Commun., 2004, 323, 743-749.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.323
, pp. 743-749
-
-
Wang, Z.1
Hsieh, T.C.2
Zhang, Z.3
Ma, Y.4
Wu, J.M.5
-
40
-
-
0034777238
-
Effect of estradiol, diethylstilbestrol, and resveratrol on F0F1-ATPase activity from mitochondrial preparations of rat heart, liver, and brain
-
Kipp, J. L.; Ramirez, V. D. Effect of estradiol, diethylstilbestrol, and resveratrol on F0F1-ATPase activity from mitochondrial preparations of rat heart, liver, and brain. Endocrine, 2001, 15, 165-175.
-
(2001)
Endocrine
, vol.15
, pp. 165-175
-
-
Kipp, J.L.1
Ramirez, V.D.2
-
41
-
-
0037378391
-
Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells
-
Liang, Y. C.; Tsai, S. H.; Chen, L.; Lin-Shiau, S. Y.; Lin, J. K. Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells. Biochem. Pharmacol., 2003, 65, 1053-1060.
-
(2003)
Biochem. Pharmacol.
, vol.65
, pp. 1053-1060
-
-
Liang, Y.C.1
Tsai, S.H.2
Chen, L.3
Lin-Shiau, S.Y.4
Lin, J.K.5
-
42
-
-
33745823841
-
Ribonucleotide reductase inhibitors and future drug design
-
Shao, J.; Zhou, B.; Chu, B.; Yen, Y. Ribonucleotide reductase inhibitors and future drug design. Curr. Cancer Drug Targets, 2006, 6, 409-4031.
-
(2006)
Curr. Cancer Drug Targets
, vol.6
, pp. 409-4031
-
-
Shao, J.1
Zhou, B.2
Chu, B.3
Yen, Y.4
-
43
-
-
19044394312
-
Overview of ribonucleotide reductase inhibitors: An appealing target in anti-tumour therapy
-
Cerqueira, N. M.; Pereira, S.; Fernandes, P. A.; Ramos, M. J. Overview of ribonucleotide reductase inhibitors: an appealing target in anti-tumour therapy. Curr. Med. Chem., 2005, 12, 1283-1294.
-
(2005)
Curr. Med. Chem.
, vol.12
, pp. 1283-1294
-
-
Cerqueira, N.M.1
Pereira, S.2
Fernandes, P.A.3
Ramos, M.J.4
-
44
-
-
37049014938
-
Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets
-
Rix, U.; Hantschel, O.; Durnberger, G.; Remsing Rix, L. L.; Planyavsky, M.; Fernbach, N. V.; Kaupe, I.; Bennett, K. L.; Valent, P.; Colinge, J.; Kocher, T.; Superti-Furga, G. Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets. Blood, 2007, 110, 4055-4063.
-
(2007)
Blood
, vol.110
, pp. 4055-4063
-
-
Rix, U.1
Hantschel, O.2
Durnberger, G.3
Remsing, R.L.L.4
Planyavsky, M.5
Fernbach, N.V.6
Kaupe, I.7
Bennett, K.L.8
Valent, P.9
Colinge, J.10
Kocher, T.11
Superti-Furga, G.12
-
45
-
-
0034886973
-
Structural basis for allosteric substrate specificity regulation in anaerobic ribonucleotide reductases
-
Larsson, K. M.; Andersson, J.; Sjoberg, B. M.; Nordlund, P.; Logan, D. T. Structural basis for allosteric substrate specificity regulation in anaerobic ribonucleotide reductases. Structure, 2001, 9, 739-750.
-
(2001)
Structure
, vol.9
, pp. 739-750
-
-
Larsson, K.M.1
Andersson, J.2
Sjoberg, B.M.3
Nordlund, P.4
Logan, D.T.5
-
46
-
-
7544227865
-
Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase
-
Larsson, K. M.; Jordan, A.; Eliasson, R.; Reichard, P.; Logan, D. T.; Nordlund, P. Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase. Nat. Struct. Mol. Biol., 2004, 11, 1142-1149.
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 1142-1149
-
-
Larsson, K.M.1
Jordan, A.2
Eliasson, R.3
Reichard, P.4
Logan, D.T.5
Nordlund, P.6
-
47
-
-
0029705324
-
Automated docking of flexible ligands: Applications of AutoDock
-
Goodsell, D. S.; Morris, G. M.; Olson, A. J. Automated docking of flexible ligands: applications of AutoDock. J. Mol. Recognit., 1996, 9, 1-5.
-
(1996)
J. Mol. Recognit.
, vol.9
, pp. 1-5
-
-
Goodsell, D.S.1
Morris, G.M.2
Olson, A.J.3
-
48
-
-
33645802169
-
Cyclin-dependent kinase pathways as targets for cancer treatment
-
Shapiro, G. I. Cyclin-dependent kinase pathways as targets for cancer treatment. J. Clin. Oncol., 2006, 24, 1770-1783.
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 1770-1783
-
-
Shapiro, G.I.1
-
49
-
-
46949093191
-
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
-
Baumli, S.; Lolli, G.; Lowe, E. D.; Troiani, S.; Rusconi, L.; Bullock, A. N.; Debreczeni, J. E.; Knapp, S.; Johnson, L. N. The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation. EMBO J., 2008, 27, 1907-1918.
-
(2008)
EMBO J
, vol.27
, pp. 1907-1918
-
-
Baumli, S.1
Lolli, G.2
Lowe, E.D.3
Troiani, S.4
Rusconi, L.5
Bullock, A.N.6
Debreczeni, J.E.7
Knapp, S.8
Johnson, L.N.9
-
50
-
-
33745259006
-
Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells
-
Sambol, E. B.; Ambrosini, G.; Geha, R. C.; Kennealey, P. T.; Decarolis, P.; O'Connor, R.; Wu, Y. V.; Motwani, M.; Chen, J. H.; Schwartz, G. K.; Singer, S. Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells. Cancer Res., 2006, 66, 5858-5866.
-
(2006)
Cancer Res
, vol.66
, pp. 5858-5866
-
-
Sambol, E.B.1
Ambrosini, G.2
Geha, R.C.3
Kennealey, P.T.4
Decarolis, P.5
O'Connor, R.6
Wu, Y.V.7
Motwani, M.8
Chen, J.H.9
Schwartz, G.K.10
Singer, S.11
-
51
-
-
0034602424
-
Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site
-
Oikonomakos, N. G.; Schnier, J. B.; Zographos, S. E.; Skamnaki, V. T.; Tsitsanou, K. E.; Johnson, L. N. Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site. J. Biol. Chem. 2000, 275, 34566-34573.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34566-34573
-
-
Oikonomakos, N.G.1
Schnier, J.B.2
Zographos, S.E.3
Skamnaki, V.T.4
Tsitsanou, K.E.5
Johnson, L.N.6
-
52
-
-
0035864375
-
The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase
-
Kaiser, A.; Nishi, K.; Gorin, F. A.; Walsh, D. A.; Bradbury, E. M.; Schnier, J. B. The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase. Arch. Biochem. Biophys., 2001, 386, 179-187.
-
(2001)
Arch. Biochem. Biophys.
, vol.386
, pp. 179-187
-
-
Kaiser, A.1
Nishi, K.2
Gorin, F.A.3
Walsh, D.A.4
Bradbury, E.M.5
Schnier, J.B.6
-
53
-
-
0029993339
-
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
-
De Azevedo, W. F. Jr.; Mueller-Dieckmann, H. J.; Schulze-Gahmen, U.; Worland, P. J.; Sausville, E.; Kim, S. H. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc. Natl. Acad. Sci. USA, 1996, 93, 2735-2740.
-
(1996)
Proc. Natl. Acad. Sci. USA.
, vol.93
, pp. 2735-2740
-
-
de Azevedo Jr., W.F.1
Mueller-Dieckmann, H.J.2
Schulze-Gahmen, U.3
Worland, P.J.4
Sausville, E.5
Kim, S.H.6
-
54
-
-
2342427030
-
Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: New avenues for cancer chemoprevention and chemotherapy
-
Pellecchia, M.; Reed, J. C. Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy. Curr. Pharm. Des., 2004, 10, 1387-1398.
-
(2004)
Curr. Pharm. Des.
, vol.10
, pp. 1387-1398
-
-
Pellecchia, M.1
Reed, J.C.2
-
55
-
-
0031815389
-
Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols
-
Yang, G. Y.; Liao, J.; Kim, K.; Yurkow, E. J.; Yang, C. S. Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis, 1998, 19, 611-616.
-
(1998)
Carcinogenesis
, vol.19
, pp. 611-616
-
-
Yang, G.Y.1
Liao, J.2
Kim, K.3
Yurkow, E.J.4
Yang, C.S.5
-
56
-
-
0347626109
-
Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins
-
Leone, M.; Zhai, D.; Sareth, S.; Kitada, S.; Reed, J. C.; Pellecchia, M. Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. Cancer Res., 2003, 63, 8118-8121.
-
(2003)
Cancer Res
, vol.63
, pp. 8118-8121
-
-
Leone, M.1
Zhai, D.2
Sareth, S.3
Kitada, S.4
Reed, J.C.5
Pellecchia, M.6
-
57
-
-
34047217206
-
Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia
-
O'Brien, S.; Moore, J. O.; Boyd, T. E.; Larratt, L. M.; Skotnicki, A.; Koziner, B.; Chanan-Khan, A. A.; Seymour, J. F.; Bociek, R. G.; Pavletic, S.; Rai, K. R. Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia. J. Clin. Oncol. 2007, 25, 1114-1120.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1114-1120
-
-
O'Brien, S.1
Moore, J.O.2
Boyd, T.E.3
Larratt, L.M.4
Skotnicki, A.5
Koziner, B.6
Chanan-Khan, A.A.7
Seymour, J.F.8
Bociek, R.G.9
Pavletic, S.10
Rai, K.R.11
-
58
-
-
33947541773
-
Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997
-
Flinn, I. W.; Neuberg, D. S.; Grever, M. R.; Dewald, G. W.; Bennett, J. M.; Paietta, E. M.; Hussein, M. A.; Appelbaum, F. R.; Larson, R. A.; Moore, D. F. Jr.; Tallman, M. S. Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997. J. Clin. Oncol., 2007, 25, 793-798.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 793-798
-
-
Flinn, I.W.1
Neuberg, D.S.2
Grever, M.R.3
Dewald, G.W.4
Bennett, J.M.5
Paietta, E.M.6
Hussein, M.A.7
Appelbaum, F.R.8
Larson, R.A.9
Moore Jr., D.F.10
Tallman, M.S.11
-
59
-
-
77950224306
-
Preclinical Studies of Apogossypolone, a Novel Pan Inhibitor of Bcl-2 and Mcl-1, Synergistically Potentiates Cytotoxic Effect of Gemcitabine in Pancreatic Cancer Cells
-
Banerjee, S.; Choi, M.; Aboukameel, A.; Wang, Z.; Mohammad, M.; Chen, J.; Yang, D.; Sarkar, F. H.; Mohammad, R. M. Preclinical Studies of Apogossypolone, a Novel Pan Inhibitor of Bcl-2 and Mcl-1, Synergistically Potentiates Cytotoxic Effect of Gemcitabine in Pancreatic Cancer Cells. Pancreas., 2010, 39, 323-331.
-
(2010)
Pancreas
, vol.39
, pp. 323-331
-
-
Banerjee, S.1
Choi, M.2
Aboukameel, A.3
Wang, Z.4
Mohammad, M.5
Chen, J.6
Yang, D.7
Sarkar, F.H.8
Mohammad, R.M.9
-
60
-
-
1842525199
-
A receptor for green tea polyphenol EGCG
-
Tachibana, H.; Koga, K.; Fujimura, Y.; Yamada, K. A receptor for green tea polyphenol EGCG. Nat. Struct. Mol. Biol., 2004, 11, 380-381.
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 380-381
-
-
Tachibana, H.1
Koga, K.2
Fujimura, Y.3
Yamada, K.4
-
61
-
-
0035918278
-
Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo
-
Nam, S.; Smith, D. M.; Dou, Q. P. Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. J. Biol. Chem., 2001, 276, 13322-13330.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 13322-13330
-
-
Nam, S.1
Smith, D.M.2
Dou, Q.P.3
-
62
-
-
67650249228
-
Molecular basis for cancer chemoprevention by green tea polyphenol EGCG
-
Tachibana, H. Molecular basis for cancer chemoprevention by green tea polyphenol EGCG. Forum Nutr., 2009, 61, 156-169.
-
(2009)
Forum Nutr
, vol.61
, pp. 156-169
-
-
Tachibana, H.1
-
63
-
-
70350271965
-
Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism
-
Cook, K. M.; Hilton, S. T.; Mecinovic, J.; Motherwell, W. B.; Figg, W. D.; Schofield, C. J. Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism. J. Biol. Chem., 2009, 284, 26831-26838.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 26831-26838
-
-
Cook, K.M.1
Hilton, S.T.2
Mecinovic, J.3
Motherwell, W.B.4
Figg, W.D.5
Schofield, C.J.6
-
64
-
-
0842303313
-
Back to the future with ubiquitin
-
Pickart, C. M. Back to the future with ubiquitin. Cell, 2004, 116, 181-190.
-
(2004)
Cell
, vol.116
, pp. 181-190
-
-
Pickart, C.M.1
-
65
-
-
37249026703
-
Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004
-
Ciechanover, A. Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004. Ann. N. Y. Acad. Sci., 2007, 1116, 1-28.
-
(2007)
Ann. N. Y. Acad. Sci.
, vol.1116
, pp. 1-28
-
-
Ciechanover, A.1
-
66
-
-
10944267182
-
Ubiquitin: A Nobel protein
-
Wilkinson, K. D. Ubiquitin: a Nobel protein. Cell, 2004, 119, 741-745.
-
(2004)
Cell
, vol.119
, pp. 741-745
-
-
Wilkinson, K.D.1
-
67
-
-
0036083396
-
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
-
Glickman, M. H.; Ciechanover, A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev., 2002, 82, 373-428.
-
(2002)
Physiol. Rev.
, vol.82
, pp. 373-428
-
-
Glickman, M.H.1
Ciechanover, A.2
-
68
-
-
33745674468
-
Drug discovery in the ubiquitin-proteasome system
-
Nalepa, G.; Rolfe, M.; Harper, J. W. Drug discovery in the ubiquitin-proteasome system. Nat. Rev. Drug Discov. 2006, 5, 596-613.
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 596-613
-
-
Nalepa, G.1
Rolfe, M.2
Harper, J.W.3
-
69
-
-
35948933091
-
Molecular basis for the inhibition of p53 by Mdmx
-
Popowicz, G. M.; Czarna, A.; Rothweiler, U.; Szwagierczak, A.; Krajewski, M.; Weber, L.; Holak, T. A. Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle, 2007, 6, 2386-2392.
-
(2007)
Cell Cycle
, vol.6
, pp. 2386-2392
-
-
Popowicz, G.M.1
Czarna, A.2
Rothweiler, U.3
Szwagierczak, A.4
Krajewski, M.5
Weber, L.6
Holak, T.A.7
-
70
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev, L. T.; Vu, B. T.; Graves, B.; Carvajal, D.; Podlaski, F.; Filipovic, Z.; Kong, N.; Kammlott, U.; Lukacs, C.; Klein, C.; Fotouhi, N.; Liu, E. A. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science, 2004, 303, 844-848.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
Fotouhi, N.11
Liu, E.A.12
-
71
-
-
33745597909
-
Predicting protein interaction sites: Binding hot-spots in protein-protein and protein-ligand interfaces
-
Burgoyne, N. J.; Jackson, R. M. Predicting protein interaction sites: binding hot-spots in protein-protein and protein-ligand interfaces. Bioinformatics, 2006, 22, 1335-1342.
-
(2006)
Bioinformatics
, vol.22
, pp. 1335-1342
-
-
Burgoyne, N.J.1
Jackson, R.M.2
-
72
-
-
0142009674
-
Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions
-
Fuertes, G.; Martin De Llano, J. J.; Villarroya, A.; Rivett, A. J.; Knecht, E. Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions. Biochem. J., 2003, 375, 75-86.
-
(2003)
Biochem. J.
, vol.375
, pp. 75-86
-
-
Fuertes, G.1
de Martin, L.J.J.2
Villarroya, A.3
Rivett, A.J.4
Knecht, E.5
-
73
-
-
27644562277
-
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
-
Chauhan, D.; Catley, L.; Li, G.; Podar, K.; Hideshima, T.; Velankar, M.; Mitsiades, C.; Mitsiades, N.; Yasui, H.; Letai, A.; Ovaa, H.; Berkers, C.; Nicholson, B.; Chao, T. H.; Neuteboom, S. T.; Richardson, P.; Palladino, M. A.; Anderson, K. C. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell, 2005, 8, 407-419.
-
(2005)
Cancer Cell
, vol.8
, pp. 407-419
-
-
Chauhan, D.1
Catley, L.2
Li, G.3
Podar, K.4
Hideshima, T.5
Velankar, M.6
Mitsiades, C.7
Mitsiades, N.8
Yasui, H.9
Letai, A.10
Ovaa, H.11
Berkers, C.12
Nicholson, B.13
Chao, T.H.14
Neuteboom, S.T.15
Richardson, P.16
Palladino, M.A.17
Anderson, K.C.18
-
74
-
-
0036015847
-
Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome
-
Groll, M.; Nazif, T.; Huber, R.; Bogyo, M. Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome. Chem. Biol., 2002, 9, 655-662.
-
(2002)
Chem. Biol.
, vol.9
, pp. 655-662
-
-
Groll, M.1
Nazif, T.2
Huber, R.3
Bogyo, M.4
-
75
-
-
71749110782
-
The 26 S proteasome: From basic mechanisms to drug targeting
-
Navon, A.; Ciechanover, A. The 26 S proteasome: from basic mechanisms to drug targeting. J. Biol. Chem., 2009, 284, 33713-33718.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 33713-33718
-
-
Navon, A.1
Ciechanover, A.2
-
76
-
-
38949125853
-
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
-
Chauhan, D.; Singh, A.; Brahmandam, M.; Podar, K.; Hideshima, T.; Richardson, P.; Munshi, N.; Palladino, M. A.; Anderson, K. C. Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood, 2008, 111, 1654-1664.
-
(2008)
Blood
, vol.111
, pp. 1654-1664
-
-
Chauhan, D.1
Singh, A.2
Brahmandam, M.3
Podar, K.4
Hideshima, T.5
Richardson, P.6
Munshi, N.7
Palladino, M.A.8
Anderson, K.C.9
-
77
-
-
33646841837
-
Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate
-
Kisselev, A. F.; Callard, A.; Goldberg, A. L. Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate. J. Biol. Chem., 2006, 281, 8582-8590.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 8582-8590
-
-
Kisselev, A.F.1
Callard, A.2
Goldberg, A.L.3
-
78
-
-
70349290496
-
Roles of P67/MetAP2 as a tumor suppressor
-
Datta, B. Roles of P67/MetAP2 as a tumor suppressor. Biochim. Biophys. Acta. 2009, 1796, 281-2892.
-
(2009)
Biochim. Biophys. Acta.
, vol.1796
, pp. 281-2892
-
-
Datta, B.1
-
79
-
-
13044300888
-
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2
-
Griffith, E. C.; Su, Z.; Niwayama, S.; Ramsay, C. A.; Chang, Y. H.; Liu, J. O. Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2. Proc. Natl. Acad. Sci. USA, 1998, 95, 15183-15188.
-
(1998)
Proc. Natl. Acad. Sci. USA.
, vol.95
, pp. 15183-15188
-
-
Griffith, E.C.1
Su, Z.2
Niwayama, S.3
Ramsay, C.A.4
Chang, Y.H.5
Liu, J.O.6
-
80
-
-
1542274566
-
A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases
-
Brdlik, C. M.; Crews, C. M. A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases. J. Biol. Chem., 2004, 279, 9475-9480.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 9475-9480
-
-
Brdlik, C.M.1
Crews, C.M.2
-
81
-
-
0038344159
-
Reactivity of functional groups on the protein surface: Development of epoxide probes for protein labeling
-
Chen, G.; Heim, A.; Riether, D.; Yee, D.; Milgrom, Y.; Gawinowicz, M. A.; Sames, D. Reactivity of functional groups on the protein surface: development of epoxide probes for protein labeling. J. Am. Chem. Soc., 2003, 125, 8130-8133.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 8130-8133
-
-
Chen, G.1
Heim, A.2
Riether, D.3
Yee, D.4
Milgrom, Y.5
Gawinowicz, M.A.6
Sames, D.7
-
82
-
-
1842865013
-
Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities
-
Mizui, Y.; Sakai, T.; Iwata, M.; Uenaka, T.; Okamoto, K.; Shimizu, H.; Yamori, T.; Yoshimatsu, K.; Asada, M. Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities. J Antibiot. (Tokyo), 2004, 57, 188-196.
-
(2004)
J Antibiot. (Tokyo)
, vol.57
, pp. 188-196
-
-
Mizui, Y.1
Sakai, T.2
Iwata, M.3
Uenaka, T.4
Okamoto, K.5
Shimizu, H.6
Yamori, T.7
Yoshimatsu, K.8
Asada, M.9
-
83
-
-
34548104659
-
Splicing factor SF3b as a target of the antitumor natural product pladienolide
-
Kotake, Y.; Sagane, K.; Owa, T.; Mimori-Kiyosue, Y.; Shimizu, H.; Uesugi, M.; Ishihama, Y.; Iwata, M.; Mizui, Y. Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat. Chem. Biol., 2007, 3, 570-575.
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 570-575
-
-
Kotake, Y.1
Sagane, K.2
Owa, T.3
Mimori-Kiyosue, Y.4
Shimizu, H.5
Uesugi, M.6
Ishihama, Y.7
Iwata, M.8
Mizui, Y.9
-
84
-
-
73849090207
-
Identification and characterization of molecular targets of natural products by mass spectrometry
-
Cheng, K. W.; Wong, C. C.; Wang, M.; He, Q. Y.; Chen, F. Identification and characterization of molecular targets of natural products by mass spectrometry. Mass Spectrom. Rev., 29, 126-155.
-
Mass Spectrom. Rev.
, vol.29
, pp. 126-155
-
-
Cheng, K.W.1
Wong, C.C.2
Wang, M.3
He, Q.Y.4
Chen, F.5
-
85
-
-
70449634957
-
Predicting new molecular targets for known drugs
-
Keiser, M. J.; Setola, V.; Irwin, J. J.; Laggner, C.; Abbas, A. I.; Hufeisen, S. J.; Jensen, N. H.; Kuijer, M. B.; Matos, R. C.; Tran, T. B.; Whaley, R.; Glennon, R. A.; Hert, J.; Thomas, K. L.; Edwards, D. D.; Shoichet, B. K.; Roth, B. L. Predicting new molecular targets for known drugs. Nature, 2009, 462, 175-181.
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
Setola, V.2
Irwin, J.J.3
Laggner, C.4
Abbas, A.I.5
Hufeisen, S.J.6
Jensen, N.H.7
Kuijer, M.B.8
Matos, R.C.9
Tran, T.B.10
Whaley, R.11
Glennon, R.A.12
Hert, J.13
Thomas, K.L.14
Edwards, D.D.15
Shoichet, B.K.16
Roth, B.L.17
-
86
-
-
0041973445
-
Can an in silico drug-target search method be used to probe potential mechanisms of medicinal plant ingredients?
-
Chen, X.; Ung, C. Y.; Chen, Y. Can an in silico drug-target search method be used to probe potential mechanisms of medicinal plant ingredients? Nat. Prod. Rep., 2003, 20, 432-444.
-
(2003)
Nat. Prod. Rep.
, vol.20
, pp. 432-444
-
-
Chen, X.1
Ung, C.Y.2
Chen, Y.3
-
87
-
-
0036635291
-
Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
-
Capdeville, R.; Buchdunger, E.; Zimmermann, J.; Matter, A. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug. Nat. Rev. Drug Discov., 2002, 1, 493-502.
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 493-502
-
-
Capdeville, R.1
Buchdunger, E.2
Zimmermann, J.3
Matter, A.4
-
88
-
-
33846219417
-
Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
-
Byrd, J. C.; Lin, T. S.; Dalton, J. T.; Wu, D.; Phelps, M. A.; Fischer, B.; Moran, M.; Blum, K. A.; Rovin, B.; Brooker- McEldowney, M.; Broering, S.; Schaaf, L. J.; Johnson, A. J.; Lucas, D. M.; Heerema, N. A.; Lozanski, G.; Young, D. C.; Suarez, J. R.; Colevas, A. D.; Grever, M. R. Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood, 2007, 109, 399-404.
-
(2007)
Blood
, vol.109
, pp. 399-404
-
-
Byrd, J.C.1
Lin, T.S.2
Dalton, J.T.3
Wu, D.4
Phelps, M.A.5
Fischer, B.6
Moran, M.7
Blum, K.A.8
Rovin, B.9
Brooker-McEldowney, M.10
Broering, S.11
Schaaf, L.J.12
Johnson, A.J.13
Lucas, D.M.14
Heerema, N.A.15
Lozanski, G.16
Young, D.C.17
Suarez, J.R.18
Colevas, A.D.19
Grever, M.R.20
more..
-
89
-
-
24944450694
-
Protein-reactive natural products
-
Drahl, C.; Cravatt, B. F.; Sorensen, E. J. Protein-reactive natural products. Angew Chem. Int. Ed. Engl., 2005, 44, 5788-5809.
-
(2005)
Angew Chem. Int. Ed. Engl.
, vol.44
, pp. 5788-5809
-
-
Drahl, C.1
Cravatt, B.F.2
Sorensen, E.J.3
-
90
-
-
22244488279
-
Methionine aminopeptidases type I and type II are essential to control cell proliferation
-
Bernier, S. G.; Taghizadeh, N.; Thompson, C. D.; Westlin, W. F.; Hannig, G. Methionine aminopeptidases type I and type II are essential to control cell proliferation. J Cell Biochem., 2005, 95, 1191-1203.
-
(2005)
J Cell Biochem
, vol.95
, pp. 1191-1203
-
-
Bernier, S.G.1
Taghizadeh, N.2
Thompson, C.D.3
Westlin, W.F.4
Hannig, G.5
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