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Volumn 4, Issue 2, 2002, Pages 165-168

Efficient semisynthesis of a tetraphosphorylated analogue of the type I TGFβ receptor

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR 1; PHOSPHOPROTEIN; RESIN; SERINE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; THREONINE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

EID: 0037165313     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol016859i     Document Type: Article
Times cited : (53)

References (24)
  • 3
    • 0034990891 scopus 로고    scopus 로고
    • For a recent review, see: Muir, T. W. Synlett 2001, 6, 733-740.
    • (2001) Synlett , vol.6 , pp. 733-740
    • Muir, T.W.1
  • 11
    • 11244304930 scopus 로고    scopus 로고
    • note
    • The final yield of homogeneous GS4 was further reduced because GS4 and GS4* could only be partially resolved on preparative scale HPLC, even using optimized gradients and elevated temperatures.
  • 12
    • 11244316875 scopus 로고    scopus 로고
    • In contrast with the present model study, Backes and Ellman did not observe significant S-alkylation in a Met-containing dipeptide (ref 7b)
    • In contrast with the present model study, Backes and Ellman did not observe significant S-alkylation in a Met-containing dipeptide (ref 7b).
  • 13
    • 11244255970 scopus 로고    scopus 로고
    • 4
    • 4
  • 14
    • 11244281525 scopus 로고    scopus 로고
    • note
    • 2.
  • 15
    • 11244327107 scopus 로고    scopus 로고
    • Addition of 350 mM 1,6-hexanediol was found to reduce nonspecific aggregation to 25% of total protein, as compared to 60% in its absence
    • Addition of 350 mM 1,6-hexanediol was found to reduce nonspecific aggregation to 25% of total protein, as compared to 60% in its absence.
  • 16
    • 11244265352 scopus 로고    scopus 로고
    • note
    • In a typical ligation reaction, 3 μmol of GS4-Nle (7.5 mg) was mixed with 218 nmol of TβR-1Δ (7.5 mg) in 4.5 mL of 100 mM Hepes pH 8.0, 100 mM okadaic acid, 0.5 mM NaCl, 350 mM 1,6 hexanediol, and 50 mM MESNA at 4 °C for 16 h.
  • 17
    • 11244315773 scopus 로고    scopus 로고
    • note
    • 32P]ATP. The level of Smad phosphorylation was analyzed by SDS-PAGE and autoradiography.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.