Evidence for altered wnt signaling in psoriatic skin

Journal of Investigative Dermatology

Volumn 130, Issue 7, 2010, Pages 1849-1859

  Gudjonsson, Johann E ^a   Johnston, Andrew ^a   Stoll, Stefan W ^a   Riblett, Mary B ^a   Xing, Xianying ^a   Kochkodan, James J ^a   Ding, Jun ^b   Nair, Rajan P ^a   Aphale, Abhishek ^a   Voorhees, John J ^a   Elder, James T ^a,c  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; AXIN 2; BETA CATENIN; FRIZZLED 2 PROTEIN; FRIZZLED 5 PROTEIN; FRIZZLED PROTEIN; GAMMA INTERFERON; INTERLEUKIN 1ALPHA; MESSENGER RNA; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WNT INHIBITORY FACTOR 1; WNT5A PROTEIN;

ADULT; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC CODE; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PSORIASIS; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BIOPSY; CELLS, CULTURED; CYTOKINES; DOWN-REGULATION; FRIZZLED RECEPTORS; GENE EXPRESSION PROFILING; HOMEOSTASIS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KERATINOCYTES; PROTO-ONCOGENE PROTEINS; PSORIASIS; RECEPTORS, G-PROTEIN-COUPLED; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION; WNT PROTEINS;

EID: 77953616665     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.67     Document Type: Article

References (62)

1. Ahumada A, Slusarski DC, Liu X et al. (2002) Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP. Science 298: 2006-2010
2. Belso N, Szell M, Pivarcsi A et al. (2008) Differential expression of D-type cyclins in HaCaT keratinocytes and in psoriasis. J Invest Dermatol 128:634-642
3. Blumenthal A, Ehlers S, Lauber J et al. (2006) The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood 108:965-973
4. Cargill M, Schrodi SJ, Chang M et al. (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 80:273-290
5. Cheng CW, Yeh JC, Fan TP et al. (2008) Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem Biophys Res Commun 365:285-290
6. Chew AL, Bennett A, Smith CH et al. (2004) Successful treatment of severe psoriasis and psoriatic arthritis with adalimumab. Br J Dermatol 151:492-496
7. Cook PW, Pittelkow MR, Keeble WW et al. (1992) Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas. Cancer Res 52:3224-3227
8. Detmar M, Brown LF, Claffey KP et al. (1994) Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med 180:1141-1146
9. Elder JT, Fisher GJ, Lindquist PB et al. (1989) Overexpression of transforming growth factor alpha in psoriatic epidermis. Science 243: 811-814
10. Gottlieb AB, Chamian F, Masud S et al. (2005) TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques. J Immunol 175:2721-2729
11. Gudjonsson JE, Aphale A, Grachtchouk M et al. (2009a) Lack of evidence for activation of the hedgehog pathway in psoriasis. J Invest Dermatol 129:635-640
12. Gudjonsson JE, Ding J, Li X et al. (2009b) Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin. J Invest Dermatol 129: 2795-2804
13. Gudjonsson JE, Johnston A, Dyson M et al. (2007) Mouse models of psoriasis. J Invest Dermatol 127:1292-1308
14. Hampton PJ, Ross OK, Reynolds NJ (2007) Increased nuclear beta-catenin in suprabasal involved psoriatic epidermis. Br J Dermatol 157:1168-1177
15. He X, Saint-Jeannet JP, Wang Y et al. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275: 1652-1654
16. Hern S, Mortimer PS (2007) In vivo quantification of microvessels in clinically uninvolved psoriatic skin and in normal skin. Br J Dermatol 156:1224-1229
17. Hertle MD, Kubler MD, Leigh IM et al. (1992) Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis. J Clin Invest 89:1892-1901
18. Hsieh JC, Kodjabachian L, Rebbert ML et al. (1999) A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature 398:431-436
19. Ito M, Yang Z, Andl T et al. (2007) Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature 447:316-320
20. Jho EH, Zhang T, Domon C et al. (2002) Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol 22:1172-1183
21. Katoh M (2007) WNT signaling pathway and stem cell signaling network. Clin Cancer Res 13:4042-4045
22. Kawakami K, Hirata H, Yamamura S et al. (2009) Functional significance of Wnt inhibitory factor-1 gene in kidney cancer. Cancer Res 69:8603-8610
23. Kawano Y, Kypta R (2003) Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116:2627-2634
24. Kohn AD, Moon RT (2005) Wnt and calcium signaling: beta-catenin- independent pathways. Cell Calcium 38:439-446
25. Krueger GG, Langley RG, Leonardi C et al. (2007) A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med 356:580-592
26. Kuhl M, Sheldahl LC, Park M et al. (2000) The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet 16:279-283
27. Kurayoshi M, Yamamoto H, Izumi S et al. (2007) Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem J 402:515-523
28. Kuroda K, Sapadin A, Shoji T et al. (2001) Altered expression of angiopoietins and Tie2 endothelium receptor in psoriasis. J Invest Dermatol 116:713-720
29. Laborda J (1991) 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res 19:3998
30. Lee RT, Briggs WH, Cheng GC et al. (1997) Mechanical deformation promotes secretion of IL-1 alpha and IL-1 receptor antagonist. J Immunol 159:5084-5088
31. Leigh IM, Navsaria H, Purkis PE et al. (1995) Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro. Br J Dermatol 133:501-511
32. Leigh IM, Pulford KA, Ramaekers FC et al. (1985) Psoriasis: maintenance of an intact monolayer basal cell differentiation compartment in spite of hyperproliferation. Br J Dermatol 113:53-64
33. Leonardi CL, Powers JL, Matheson RT et al. (2003) Etanercept as monotherapy in patients with psoriasis. N Engl J Med 349:2014-2022
34. Liu G, Bafico A, Aaronson SA (2005) The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncano-nical Wnts. Mol Cell Biol 25:3475-3482
35. Logan CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20:781-810
36. Lowes MA, Bowcock AM, Krueger JG (2007) Pathogenesis and therapy of psoriasis. Nature 445:866-873
37. Lu W, Yamamoto V, Ortega B et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119:97-108
38. Mansbridge JN, Knapp AM, Strefling AM (1984) Evidence for an alternative pathway of keratinocyte maturation in psoriasis from an antigen found in psoriatic but not normal epidermis. J Invest Dermatol 83: 296-301
39. Masckauchan TN, Agalliu D, Vorontchikhina M et al. (2006) Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol Biol Cell 17:5163-5172
40. Mikels AJ, Nusse R (2006) Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol 4:e115
41. Nair RP, Duffin KC, Helms C et al. (2009) Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet 41:199-204
42. Nestle FO, Conrad C, Tun-Kyi A et al. (2005) Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med 202:135-143
43. Oishi I, Suzuki H, Onishi N et al. (2003) The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8:645-654
44. Olson DJ, Oshimura M, Otte AP et al. (1998) Ectopic expression of wnt-5a in human renal cell carcinoma cells suppresses in vitro growth and telomerase activity. Tumour Biol 19:244-252
45. Prasad CP, Gupta SD, Rath G et al. (2007) Wnt signaling pathway in invasive ductal carcinoma of the breast: relationship between beta-catenin, dishevelled and cyclin D1 expression. Oncology 73:112-117
46. Reischl J, Schwenke S, Beekman JM et al. (2007) Increased expression of Wnt5a in psoriatic plaques. J Invest Dermatol 127:163-169
47. Romanowska M, Evans A, Kellock D et al. (2009) Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon. PLoS ONE 4:e5354
48. Sen M, Ghosh G (2008) Transcriptional outcome of Wnt-Frizzled signal transduction in inflammation: evolving concepts. J Immunol 181:4441-4445
49. Slusarski DC, Corces VG, Moon RT (1997) Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 390:410-413
50. Stoll SW, Elder JT (1998) Retinoid regulation of heparin-binding EGF-like growth factor gene expression in human keratinocytes and skin. Exp Dermatol 7:391-397
51. Stoll SW, Kansra S, Peshick S et al. (2001) Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. Neoplasia 3:339-350
52. Tao Q, Yokota C, Puck H et al. (2005) Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell 120:857-871
53. Urakami S, Shiina H, Enokida H et al. (2006) Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway. Clin Cancer Res 12:383-391
54. Uyemura K, Yamamura M, Fivenson DF et al. (1993) The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response. J Invest Dermatol 101:701-705
55. Valdimarsson H, Baker BS, Jonsdottir I et al. (1995) Psoriasis: a T-cell-mediated autoimmune disease induced by streptococcal superantigens? Immunol Today 16:145-149
56. van Amerongen R, Mikels A, Nusse R (2008) Alternative wnt signaling is initiated by distinct receptors. Sci Signal 1:re9
57. Voskas D, Jones N, Van Slyke P et al. (2005) A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice. Am J Pathol 166:843-855
58. Wehrli M, Dougan ST, Caldwell K et al. (2000) arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 407: 527-530
59. Weinstein GD, McCullough JL, Ross PA (1985) Cell kinetic basis for pathophysiology of psoriasis. J Invest Dermatol 85:579-583
60. Wright NA, Camplejohn RS (eds)(1983) Psoriasis: Cell Proliferation. Churchill Livingstone: Edinburgh, London, Melbourne and New York
61. Yamazaki F, Aragane Y, Kawada A et al. (2001) Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma. Br J Dermatol 145:771-777
62. Zaba LC, Cardinale I, Gilleaudeau P et al. (2007) Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med 204:3183-3194