Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin

Journal of Investigative Dermatology

Volumn 129, Issue 12, 2009, Pages 2795-2804

  Gudjonsson, Johann E ^a   Ding, Jun ^b   Li, Xing ^b   Nair, Rajan P ^a   Tejasvi, Trilokraj ^a   Qin, Zhaohui S ^b   Ghosh, Debashis ^c   Aphale, Abhishek ^a   Gumucio, Deborah L ^b   Voorhees, John J ^a   Abecasis, Goncalo R ^b   Elder, James T ^a,d  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; TRANSCRIPTION FACTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; BIOLOGY; BIOSYNTHESIS; CYTOLOGY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; KERATINOCYTE; LIPID METABOLISM; MALE; METABOLISM; MIDDLE AGED; PROMOTER REGION; PSORIASIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN;

ADOLESCENT; ADULT; AGED; COMPUTATIONAL BIOLOGY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; KERATINOCYTES; LIPID METABOLISM; LIPIDS; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; PSORIASIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; YOUNG ADULT;

EID: 79959361260     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.173     Document Type: Article

References (54)

1. Aberg KM, Man MQ, Gallo RL, Ganz T, Crumrine D, Brown BE et al. (2008) Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol 128:917-25
2. Bowcock AM, Shannon W, Du F, Duncan J, Cao K, Aftergut K et al. (2001) Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum Mol Genet 10:1793-805
3. Braun-Falco O. (1971) Dynamics of Growth and Regression in Psoriatic Lesions: Alterations in the skin from Normal into a Psoriatic Lesion, and during Regression of Psoriatic Lesions. Stanford University Press: Stanford, California, 215-37
4. Candi E, Schmidt R, Melino G (2005) The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol 6:328-40
5. Cheng JB, Russell DW (2004) Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. J Biol Chem 279:37789-97
6. Conrad C, Boyman O, Tonel G, Tun-Kyi A, Laggner U, de Fougerolles A et al. (2007) Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med 13:836-42
7. Cunningham BA, Moncur JT, Huntington JT, KinlawWB (1998) "Spot 14" protein: a metabolic integrator in normal and neoplastic cells. Thyroid 8:815-25
8. de Guzman Strong C, Wertz PW, Wang C, Yang F, Meltzer PS, Andl T et al. (2006) Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol 175:661-70
9. de Jongh GJ, Zeeuwen PL, Kucharekova M, Pfundt R, van der Valk PG, Blokx W et al. (2005) High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis. J Invest Dermatol 125:1163-73
10. Detmar M, Brown LF, Claffey KP, Yeo KT, Kocher O, Jackman RW et al. (1994) Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med 180:1141-6
11. Dumont M, Luu-The V, Dupont E, Pelletier G, Labrie F (1992) Characterization, expression, and immunohistochemical localization of 3 betahydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skin. J Invest Dermatol 99:415-21
12. Elder JT, Fisher GJ, Lindquist PB, Bennett GL, Pittelkow MR, Coffey RJ Jr et al. (1989) Overexpression of transforming growth factor alpha in psoriatic epidermis. Science 243:811-4
13. Ghadially R, Reed JT, Elias PM (1996) Stratum corneum structure and function correlates with phenotype in psoriasis. J Invest Dermatol 107:558-64
14. Gladman DD (1994) Natural history of psoriatic arthritis. Baillieres Clin Rheumatol 8:379-94
15. Gudjonsson JE, Aphale A, Grachtchouk M, Ding J, Nair RP, Wang T et al. (2009) Lack of evidence for activation of the hedgehog pathway in psoriasis. J Invest Dermatol 129:635-40
16. Gudjonsson JE, Elder JT (2007) Psoriasis. In: (Wolff K Goldsmith LA, Katz SI, Gilchrest BA, Paller AM, Leffell DJ, eds). Fitzpatrick's Dermatology in General Medicine, Vol. 1 McGraw-Hill: New York, 169-94
17. Gudjonsson JE, Johnston A, Sigmundsdottir H, Valdimarsson H (2004) Immunopathogenic mechanisms in psoriasis. Clin Exp Immunol 135:1-8
18. Gupta MA, Schork NJ, Gupta AK, Kirkby S, Ellis CN (1993) Suicidal ideation in psoriasis. Int J Dermatol 32:188-90
19. Harder J, Schroder JM (2002) RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. J Biol Chem 277:46779-84
20. Headington JT, Gupta AK, Goldfarb MT, Nickoloff BJ, Hamilton TA, Ellis CN et al. (1989) A morphometric and histologic study of the scalp in psoriasis. Paradoxical sebaceous gland atrophy and decreased hair shaft diameters without alopecia. Arch Dermatol 125:639-42
21. Hudson TJ (2006) Skin barrier function and allergic risk. Nat Genet 38: 399-400
22. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31:e15
23. Jakobsson A,Westerberg R, Jacobsson A (2006) Fatty acid elongases in mammals: their regulation and roles in metabolism. Prog Lipid Res 45:237-49
24. Jiang WG, Watkins G, Douglas-Jones A, Mansel RE (2006) Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer. Prostaglandins Leukot Essent Fatty Acids 74:235-45
25. Johnston A, Gudjonsson JE, Sigmundsdottir H, Love TJ, Valdimarsson H (2004) Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M proteins are largely restricted to skinhoming CD8(+) T cells. Clin Exp Immunol 138:83-93
26. Kinlaw WB, Tron P, Friedmann AS (1992) Nuclear localization and hepatic zonation of rat "spot 14" protein: immunohistochemical investigation employing anti-fusion protein antibodies. Endocrinology 131:3120-2
27. Klemp P, Staberg B (1983) Cutaneous blood flow in psoriasis. J Invest Dermatol 81:503-6
28. Kragballe K, Desjarlais L, Duell EA, Voorhees JJ (1986) In vitro synthesis of 12-hydroxy-eicosatetraenoic acid is increased in uninvolved psoriatic epidermis. J Invest Dermatol 87:47-52
29. Krueger GG, Bergstresser PR, Lowe NJ, Voorhees JJ, Weinstein GD (1984) Psoriasis. J Am Acad Dermatol 11:937-47
30. Kulski JK, Kenworthy W, Bellgard M, Taplin R, Okamoto K, Oka A et al. (2005) Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signals. J Mol Med 83:964-75
31. Leigh IM, Nasaria H, Purkis PE, McKay IA, Bowden PE, Riddle PN (1995) Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro. Br J Dermatol 133:501-11
32. Lewis RA, Austen KF (1984) The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions, and pharmacology. J Clin Invest 73:889-97
33. Marshall D, Hardman MJ, Nield KM, Byrne C (2001) Differentially expressed late constituents of the epidermal cornified envelope. Proc Natl Acad Sci USA 98:13031-6
34. Nair RP, Ruether A, Stuart PE, Jenisch S, Tejasvi T, Hiremagalore R et al. (2008) Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol 128:1653-61
35. Nair RP, Stuart PE, Nistor I, Hiremagalore R, Chia NV, Jenisch S et al. (2006) Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet 78:827-51
36. Nickoloff BJ, Karabin GD, Barker JN, Griffiths CE, Sarma V, Mitra RS et al. (1991) Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis. Am J Pathol 138:129-40
37. Nickoloff BJ, Wrone-Smith T (1999) Injection of pre-psoriatic skin with CD4+ T cells induces psoriasis. Am J Pathol 155:145-58
38. Nonomura K, Yamanishi K, Yasuno H, Nara K, Hirose S (1994) Up-regulation of elafin/SKALP gene expression in psoriatic epidermis. J Invest Dermatol 103:88-91
39. Oren A, Ganz T, Liu L, Meerloo T (2003) In human epidermis, beta-defensin 2 is packaged in lamellar bodies. Exp Mol Pathol 74:180-2
40. Pei Z, Jia Z, Watkins PA (2006) The second member of the human and murine bubblegum family is a testis-and brainstem-specific acyl-CoA synthetase. J Biol Chem 281:6632-41
41. Romanowska M, al Yacoub N, Seidel H, Donandt S, Gerken H, Phillip S et al. (2008) PPARdelta enhances keratinocyte proliferation in psoriasis and induces heparin-binding EGF-like growth factor. J Invest Dermatol 128:110-24
42. Sander HM, Morris LF, Phillips CM, Harrison PE, Menter A (1993) The annual cost of psoriasis. J Am Acad Dermatol 28:422-5
43. Schaeffer L, Gohlke H, Muller M, Heid IM, Palmer LJ, Kompauer I et al. (2006) Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet 15:1745-56
44. Schwartzman ML, Balazy M, Masferrer J, Abraham NG, McGiff JC, Murphy RC (1987) 12(R)-hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+, K+-ATPase in the cornea. Proc Natl Acad Sci USA 84:8125-9
45. Segre JA, Bauer C, Fuchs E (1999) Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet 22:356-60
46. Shi Y, Hon M, Evans RM (2002) The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc Natl Acad Sci USA 99:2613-8
47. Simard J, Ricketts ML, Gingras S, Soucy P, Feltus FA, Melner MH (2005) Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family. Endocr Rev 26:525-82
48. Watkins PA (1997) Fatty acid activation. Prog Lipid Res 36:55-83
49. Westerberg R, Tvrdik P, Unden AB, Mansson JE, Norlen L, Jakobsson A et al. (2004) Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem 279:5621-9
50. Wilkinson DI (1971) Lipid Metabolism in Psoriasis, Vol Standford University Press: Stanford, 277-85
51. Wilson CL, Dean D, Lane EB, Dawber RP, Leigh IM (1994) Keratinocyte differentiation in psoriatic scalp: morphology and expression of epithelial keratins. Br J Dermatol 131:191-200
52. Zhao XP, Elder JT (1997) Positional cloning of novel skin-specific genes from the human epidermal differentiation complex. Genomics 45:250-8
53. Zhou X, Krueger JG, Kao MC, Lee E, Du F, Menter A et al. (2003) Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array. Physiol Genomics 13:69-78
54. Ziboh VA, Casebolt TL, Marcelo CL, Voorhees JJ (1984) Biosynthesis of lipoxygenase products by enzyme preparations from normal and psoriatic skin. J Invest Dermatol 83:426-30