Ectopic expression of wnt-5a in human renal cell carcinoma cells suppresses in vitro growth and telomerase activity

Tumor Biology

Volumn 19, Issue 4, 1998, Pages 244-252

  Olson, Daniel J ^a   Oshimura, Mitsuo ^b   Otte, Arie P ^c   Kumar, Rakesh ^d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b TOTTORI UNIVERSITY   (Japan)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

Anti oncogene; Chromosome 3p deletion; Differentiation; Kidney cancer

Indexed keywords

TELOMERASE;

ARTICLE; CANCER CELL; CELL GROWTH; CHROMOSOME 3P; ENZYME ACTIVITY; GENE LOSS; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0031821881     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000030014     Document Type: Article

References (38)

1. Yokota J, Tsukada Y, Nakajima T, Gotoh M, Shimosato Y, Mori N, Tsunokawa Y, Sugimura T, Terada M: Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix. Cancer Res 1989;49:3598-3601.
2. Ehlen T, Dubeau L: Loss of heterozygosity on chromosomal segments 3p, 6q, and 11p in human ovarian cancers. Oncogene 1990;5:219-223.
3. el-Naggar AK, Lee MS, Wang G, Luna MA, Goepfert H, Batsakis JG: Polymerase chain reaction-based restriction fragment length polymorphism analysis of the short arm of chromosome 3 in primary head and neck squamous cell carcinoma. Cancer 1993;72:881-886.
4. Brauch H, Tory K, Kotler F, Gazdar AF, Pettengill OS, Johnson B, Graziano S, Winton T, Buys CH, Sorenson GD: Molecular mapping of deletion sites in the short arm of chromosome 3 in human lung cancer. Genes Chrom Cancer 1990;1:240-246.
5. Ponder B: Gene losses in human tumors. Nature 1988;335:400-402.
6. Klingelhutz AJ, Wu S-Q, Bookland E, Reznikoff CA: Allelic 3p deletions in high-grade carcinomas after transformation in vitro of human uroepithelial cells. Genes Chrom Cancer 1991;3:346-357.
7. Wu S-Q, Storer BE, Bookland EA, Klingelhutz AJ, Gilchrist KW, Meisner LF, Oyasu R, Reznikoff CA: Nonrandom chromosome losses in stepwise neoplastic transformation in vitro of human uroepithelial cells. Cancer Res 1991;51: 3323-3326.
8. Siden TS, Golembieski W, Kumlien J, Smith DI: Physical map of small cell lung cancer deletion region on short arm of human chromosome 3 (3p 13-22) based on radiation fusion hybrid analysis. Somatic Cell Mol Genet 1994;20:121-132.
9. Chen L-C, Matsumura K, Deng G, Kurisu W, Ljung BM, Lerman MI, Waldman FM, Smith HS: Deletion of two separate regions on chromosome 3p in breast cancers. Cancer Res 1994;54:3021-3024.
10. Klingelhutz AJ, Wu S-Q, Huang J, Reznikoff CA: Loss of 3p13-p21.2 in tumorigenic reversion of a hybrid between isogenic nontumorigenic and tumorigenic human uroepithelial cells. Cancer Res 1992;52:1631-1634.
11. Zhao WP, Gnarra JR, Liu S, Knutsen T, Linehan WM, Whang-Peng J: Renal cell carcinoma. Cytogenetic analysis of tumors and cell lines. Cancer Genet Cytogenet 1995;82:128-139.
12. Yoshida MA, Ohyashiki K, Ochi H, Gibas Z, Pontes JE, Prout GR Jr, Huben R, Sandberg AA: Cytogenetic studies of tumor tissue from patients with nonfamilial renal cell carcinoma. Cancer Res 1986;46: 2139-2147.
13. Brauch H, Pomer S, Hieronymus T, Schadt T, Lohrke H, Komitowski D: Genetic alterations in sporadic renal-cell carcinoma: Molecular analyses of tumor suppressor gene harboring chromosomal regions 3p, 5q, and 17p. World J Urol 1994;12: 162-168.
14. Foster K, Crossney PA, Cairns P, Hetherington JW, Richards FM, Jones MH, Bentley E, Affara NA, Ferguson-Smith MA, Maher ER: Molecular genetic investigation of sporadic renal cell carcinoma: Analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22. Br J Cancer 1994;69:230-234.
15. Presti JC, Reuter VE, Cordon-Cardo C, Mazumdar M, Fair WR, Jhanwar SC: Allelic deletions in renal tumors: Histopathological correlations. Cancer Res 1993;53:5780-5783.
16. Presti JC, Moch H, Reuter VE, Cordon-Cardo C, Waldman FM: Renal cell carcinoma genetic analysis by comparative genomic hybridization and restriction length polymorphism analysis. J Urol 1996;156:281-285.
17. Anglard P, Trahan E, Liu S, Latif F, Merino MJ, Lerman MI, Zbar B, Linehan WM: Molecular and cellular characterization of human renal cell carcinoma cell lines. Cancer Res 1992;52:348-356.
18. Zbar B, Brauch H, Talmadge C, Linehan M: Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 1987;327:721-724.
19. Yamakawa K, Monta R, Takahashi E, Hori T, Ishakawa J, Nakamura Y: A detailed mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Res 1991;51:4707-4711.
20. Sanchez Y, el-Naggar A, Pathak S, Killary AM: A tumor suppressor locus within 3p14-p12 mediates rapid cell death of renal cell carcinoma in vivo. Proc Natl Acad Sci USA 1994;91:3383-3387.
21. Wilhelm M, Bugert P, Kenck C, Staehler G, Kovacs G: Terminal deletion of chromosome 3p sequences in nonpapillary renal cell carcinomas: A breakpoint cluster between loci D3S1285 and D3S1603. Cancer Res 1995;55:5383-5385.
22. Olson DJ, Papkoff JL: Regulated expression of wnt family members during proliferation of C57MG mammary cells. Cell Growth Differ 1994;5:197-206.
23. Huguet EL, Smith K, Bicknell R, Harris AL: Regulation of wnt-5a mRNA expression in human mammary epithelial cells by cell shape, confluence, and hepatocyte growth factor. J Biol Chem 1995;270:12851-12856.
24. Clark CC, Cohen I, Eichstetter I, Cannizzaro LA, McPherson JD, Wasmuth JJ, Iozzo RV: Molecular cloning of the human proto-oncogene wnt-5a and mapping of the gene (wnt-5a) to chromosome 3p14-p21. Genomics 1993;18:249-260.
25. Lejeune S, Huguet EL, Hamby A, Poulsom R, Harris AL: wnt-5a cloning, expression, and up-regulation in human primary breast cancers. Clin Cancer Res 1995;1:215-222.
26. Olson DJ, Gibo D, Saggers G, Debinski W, Kumar R: Reversion of uroepithelial cell tumorigenesis by the ectopic expression of human wnt-5a. Cell Growth Differ 1997;8:417-423.
27. Yoshida MA, Shimizu M, Ikeuchi T, Tonomura A, Yokota J, Oshimura M: In vitro growth suppression and morphological change in a human renal cell carcinoma cell line by the introduction of normal chromosome 3 via microcell fusion. Mol Carcinog 1994;9:114-121.
28. Ohmura H, Tahara H, Suzuki M, Ide T, Shimizu M, Yoshida MA, Tahara E, Shay JW, Barrett JC, Oshimura M: Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Ipn J Cancer Res 1995;86: 899-904.
29. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
30. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW: Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-2015.
31. Zhu X, Kumar R, Mandal M, Sharma N, Sharma HW, Dhingra U, Sokoloski JA, Hsiao R, Narayanan R: Cell-cycle-dependent modulation of telomerase activity in tumor cells. Proc Natl Acad Sci USA 1996;93:6091-6095.
32. Broccoli D, Godley LA, Donehower LA, Varmus HE, LeLange T: Telomerase activation in mouse mammary tumors: Lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol Cell Biol 1996;16:3765-3772.
33. Brown AMC, Wildin RS, Prendergast TJ, Varmus HE: A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line. Cell 1986;461001-1009.
34. Iozzo RV, Eichstetter I, Danielson KG. Aberrant expression of the growth factor wnt-5a in human malignancy. Cancer Res 1995;55:3495-3499.
35. Harley CB and Villeponteau B: Telomere and telomerase in aging and cancer. Curr Opin Genet Dev 1995;5:249-255.
36. Counter CM, Avilian AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S: Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBOJ 1992;11:1921-1929.
37. Sharma HW, Sokoloski JA, Perez JR, Maltese JY, Sartorelli AC, Stem CA, Nichols G, Khaled Z, Telang NT, Narayanan R: Differentiation of immortal cells inhibits telomerase activity. Proc Natl Acad Sci USA 1995;92:12343-12346.
38. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR: Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995;14:2140-2148.