-
1
-
-
0037069929
-
Chemotherapy: Targeting the mitochondrial cell death pathway
-
Debatin KM, Poncet D, Kroemer G (2002) Chemotherapy: targeting the mitochondrial cell death pathway. Oncogene 21:8786-8803
-
(2002)
Oncogene
, vol.21
, pp. 8786-8803
-
-
Debatin, K.M.1
Poncet, D.2
Kroemer, G.3
-
2
-
-
0033135406
-
Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction
-
Wesselborg S, Engels IH, Rossmann E, Los M, Schulze-Osthoff K (1999) Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction. Blood 93:3053-3063
-
(1999)
Blood
, vol.93
, pp. 3053-3063
-
-
Wesselborg, S.1
Engels, I.H.2
Rossmann, E.3
Los, M.4
Schulze-Osthoff, K.5
-
3
-
-
0034699353
-
Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis
-
Engels IH, Stepczynska A, Stroh C, Lauber K, Berg C, Schwenzer R, Wajant H, Janicke RU, Porter AG, Belka C, Gregor M, Schulze Osthoff K, Wesselborg S (2000) Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene 19:4563-4573
-
(2000)
Oncogene
, vol.19
, pp. 4563-4573
-
-
Engels, I.H.1
Stepczynska, A.2
Stroh, C.3
Lauber, K.4
Berg, C.5
Schwenzer, R.6
Wajant, H.7
Janicke, R.U.8
Porter, A.G.9
Belka, C.10
Gregor, M.11
Schulze Osthoff, K.12
Wesselborg, S.13
-
4
-
-
0034708169
-
Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis
-
Belka C, Rudner J, Wesselborg S, Stepczynska A, Marini P, Lepple-Wienhues A, Faltin H, Bamberg M, Budach W, Schulze-Osthoff K (2000) Differential role of caspase-8 and BID activation during radiation- and CD95-induced apoptosis. Oncogene 19:1181-1190
-
(2000)
Oncogene
, vol.19
, pp. 1181-1190
-
-
Belka, C.1
Rudner, J.2
Wesselborg, S.3
Stepczynska, A.4
Marini, P.5
Lepple-Wienhues, A.6
Faltin, H.7
Bamberg, M.8
Budach, W.9
Schulze-Osthoff, K.10
-
5
-
-
0242410719
-
p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa
-
Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, Ausserlechner MJ, Adams JM, Strasser A (2003) p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa. Science 302:1036-1038
-
(2003)
Science
, vol.302
, pp. 1036-1038
-
-
Villunger, A.1
Michalak, E.M.2
Coultas, L.3
Mullauer, F.4
Bock, G.5
Ausserlechner, M.J.6
Adams, J.M.7
Strasser, A.8
-
6
-
-
0031036872
-
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
-
Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275:1129-1132
-
(1997)
Science
, vol.275
, pp. 1129-1132
-
-
Yang, J.1
Liu, X.2
Bhalla, K.3
Kim, C.N.4
Ibrado, A.M.5
Cai, J.6
Peng, T.I.7
Jones, D.P.8
Wang, X.9
-
7
-
-
29144508618
-
Ion channels in cell proliferation and apoptotic cell death
-
Lang F, Foller M, Lang KS, Lang PA, Ritter M, Gulbins E, Vereninov A, Huber SM (2005) Ion channels in cell proliferation and apoptotic cell death. J Membr Biol 205:147-157
-
(2005)
J Membr Biol
, vol.205
, pp. 147-157
-
-
Lang, F.1
Foller, M.2
Lang, K.S.3
Lang, P.A.4
Ritter, M.5
Gulbins, E.6
Vereninov, A.7
Huber, S.M.8
-
8
-
-
0032432557
-
Use of intracellular pH and annexin-V flow cytometric assays to monitor apoptosis and its suppression by bcl-2 over-expression in hybridoma cell culture
-
Ishaque A, Al-Rubeai M (1998) Use of intracellular pH and annexin-V flow cytometric assays to monitor apoptosis and its suppression by bcl-2 over-expression in hybridoma cell culture. J Immunol Methods 221:43-57
-
(1998)
J Immunol Methods
, vol.221
, pp. 43-57
-
-
Ishaque, A.1
Al-Rubeai, M.2
-
9
-
-
0027278822
-
Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification
-
Barry MA, Reynolds JE, Eastman A (1993) Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification. Cancer Res 53:2349-2357
-
(1993)
Cancer Res
, vol.53
, pp. 2349-2357
-
-
Barry, M.A.1
Reynolds, J.E.2
Eastman, A.3
-
10
-
-
0030048987
-
Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification
-
Gottlieb RA, Nordberg J, Skowronski E, Babior BM (1996) Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc Natl Acad Sci USA 93:654-658
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 654-658
-
-
Gottlieb, R.A.1
Nordberg, J.2
Skowronski, E.3
Babior, B.M.4
-
11
-
-
0030985808
-
Intracellular acidification induces apoptosis by stimulating ICE-like protease activity
-
Furlong IJ, Ascaso R, Lopez Rivas A, Collins MK (1997) Intracellular acidification induces apoptosis by stimulating ICE-like protease activity. J Cell Sci 110:653-661
-
(1997)
J Cell Sci
, vol.110
, pp. 653-661
-
-
Furlong, I.J.1
Ascaso, R.2
Lopez Rivas, A.3
Collins, M.K.4
-
12
-
-
0032568602
-
Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes
-
Szabo I, Lepple-Wienhues A, Kaba KN, Zoratti M, Gulbins E, Lang F (1998) Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes. Proc Natl Acad Sci USA 95:6169-6174
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6169-6174
-
-
Szabo, I.1
Lepple-Wienhues, A.2
Kaba, K.N.3
Zoratti, M.4
Gulbins, E.5
Lang, F.6
-
13
-
-
0031050545
-
Role of acid/base homeostasis in the suppression of apoptosis in haemopoietic cells by v-Abl protein tyrosine kinase
-
Chen Q, Benson RS, Whetton AD, Brant SR, Donowitz M, Montrose MH, Dive C, Watson AJ (1997) Role of acid/base homeostasis in the suppression of apoptosis in haemopoietic cells by v-Abl protein tyrosine kinase. J Cell Sci 110:379-387
-
(1997)
J Cell Sci
, vol.110
, pp. 379-387
-
-
Chen, Q.1
Benson, R.S.2
Whetton, A.D.3
Brant, S.R.4
Donowitz, M.5
Montrose, M.H.6
Dive, C.7
Watson, A.J.8
-
14
-
-
0028813378
-
Apoptosis in an interleukin-2-dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification. Role of the Na(+)/H(+)-antiport
-
Li J, Eastman A (1995) Apoptosis in an interleukin-2-dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification. Role of the Na(+)/H(+)-antiport. J Biol Chem 270:3203-3211
-
(1995)
J Biol Chem
, vol.270
, pp. 3203-3211
-
-
Li, J.1
Eastman, A.2
-
15
-
-
0029046006
-
Apoptosis induced by IL-2 withdrawal is associated with an intracellular acidification
-
Rebollo A, Gomez J, Martinez de Aragon A, Lastres P, Silva A, Perez-Sala D (1995) Apoptosis induced by IL-2 withdrawal is associated with an intracellular acidification. Exp Cell Res 218:581-585
-
(1995)
Exp Cell Res
, vol.218
, pp. 581-585
-
-
Rebollo, A.1
Gomez, J.2
Martinez de Aragon, A.3
Lastres, P.4
Silva, A.5
Perez-Sala, D.6
-
16
-
-
0032856998
-
Regulation of acidification and apoptosis by SHP-1 and Bcl-2
-
Thangaraju M, Sharma K, Leber B, Andrews DW, Shen SH, Srikant CB (1999) Regulation of acidification and apoptosis by SHP-1 and Bcl-2. J Biol Chem 274:29549-29557
-
(1999)
J Biol Chem
, vol.274
, pp. 29549-29557
-
-
Thangaraju, M.1
Sharma, K.2
Leber, B.3
Andrews, D.W.4
Shen, S.H.5
Srikant, C.B.6
-
17
-
-
0035808388
-
Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells
-
Hirpara JL, Clement MV, Pervaiz S (2001) Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells. J Biol Chem 276:514-521
-
(2001)
J Biol Chem
, vol.276
, pp. 514-521
-
-
Hirpara, J.L.1
Clement, M.V.2
Pervaiz, S.3
-
18
-
-
0034737646
-
Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis
-
Liu D, Martino G, Thangaraju M, Sharma M, Halwani F, Shen SH, Patel YC, Srikant CB (2000) Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis. J Biol Chem 275:9244-9250
-
(2000)
J Biol Chem
, vol.275
, pp. 9244-9250
-
-
Liu, D.1
Martino, G.2
Thangaraju, M.3
Sharma, M.4
Halwani, F.5
Shen, S.H.6
Patel, Y.C.7
Srikant, C.B.8
-
19
-
-
1442327911
-
Early and late apoptosis events in human transformed and non-transformed colonocytes are independent on intracellular acidification
-
Wenzel U, Daniel H (2004) Early and late apoptosis events in human transformed and non-transformed colonocytes are independent on intracellular acidification. Cell Physiol Biochem 14:65-76
-
(2004)
Cell Physiol Biochem
, vol.14
, pp. 65-76
-
-
Wenzel, U.1
Daniel, H.2
-
20
-
-
4544246352
-
Alterations of intracellular pH homeostasis in apoptosis: Origins and roles
-
Lagadic-Gossmann D, Huc L, Lecureur V (2004) Alterations of intracellular pH homeostasis in apoptosis: origins and roles. Cell Death Differ 11:953-961
-
(2004)
Cell Death Differ
, vol.11
, pp. 953-961
-
-
Lagadic-Gossmann, D.1
Huc, L.2
Lecureur, V.3
-
21
-
-
0033776271
-
Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
-
Matsuyama S, Llopis J, Deveraux QL, Tsien RY, Reed JC (2000) Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol 2:318-325
-
(2000)
Nat Cell Biol
, vol.2
, pp. 318-325
-
-
Matsuyama, S.1
Llopis, J.2
Deveraux, Q.L.3
Tsien, R.Y.4
Reed, J.C.5
-
22
-
-
14344272939
-
Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide
-
Roy S, Bayly CI, Gareau Y, Houtzager VM, Kargman S, Keen SL, Rowland K, Seiden IM, Thornberry NA, Nicholson DW (2001) Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide. Proc Natl Acad Sci USA 98:6132-6137
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6132-6137
-
-
Roy, S.1
Bayly, C.I.2
Gareau, Y.3
Houtzager, V.M.4
Kargman, S.5
Keen, S.L.6
Rowland, K.7
Seiden, I.M.8
Thornberry, N.A.9
Nicholson, D.W.10
-
23
-
-
0034523187
-
Mitochondria-dependent apoptosis and cellular pH regulation
-
Matsuyama S, Reed JC (2000) Mitochondria-dependent apoptosis and cellular pH regulation. Cell Death Differ 7:1155-1165
-
(2000)
Cell Death Differ
, vol.7
, pp. 1155-1165
-
-
Matsuyama, S.1
Reed, J.C.2
-
24
-
-
29144506662
-
Ion channels and cancer
-
Kunzelmann K (2005) Ion channels and cancer. J Membr Biol 205:159-173
-
(2005)
J Membr Biol
, vol.205
, pp. 159-173
-
-
Kunzelmann, K.1
-
25
-
-
29144445147
-
2+ signaling, intracellular pH and cell volume in cell proliferation
-
2+ signaling, intracellular pH and cell volume in cell proliferation. J Membr Biol 205:129-137
-
(2005)
J Membr Biol
, vol.205
, pp. 129-137
-
-
Schreiber, R.1
-
26
-
-
0029906431
-
BCL-2 and MCL-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine
-
Reynolds JE, Li J, Craig RW, Eastman A (1996) BCL-2 and MCL-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine. Exp Cell Res 225:430-436
-
(1996)
Exp Cell Res
, vol.225
, pp. 430-436
-
-
Reynolds, J.E.1
Li, J.2
Craig, R.W.3
Eastman, A.4
-
27
-
-
0033020267
-
Cytoplasmic acidification is not an effector mechanism of VP16 or DEX-induced apoptosis in CEM T leukaemia cells
-
Benson RS, Dive C, Watson AJ (1999) Cytoplasmic acidification is not an effector mechanism of VP16 or DEX-induced apoptosis in CEM T leukaemia cells. J Cell Sci 112(Pt 11):1755-1760
-
(1999)
J Cell Sci
, vol.112
, Issue.PART 11
, pp. 1755-1760
-
-
Benson, R.S.1
Dive, C.2
Watson, A.J.3
-
28
-
-
0033608168
-
Intracellular acidification during apoptosis can occur in the absence of a nucleus
-
Wolf CM, Eastman A (1999) Intracellular acidification during apoptosis can occur in the absence of a nucleus. Biochem Biophys Res Commun 254:821-827
-
(1999)
Biochem Biophys Res Commun
, vol.254
, pp. 821-827
-
-
Wolf, C.M.1
Eastman, A.2
-
30
-
-
0024595839
-
Arginine vasopressin enhances pHi regulation in the presence of HCO3-by stimulating three acid-base transport systems
-
Ganz MB, Boyarsky G, Sterzel RB, Boron WF (1989) Arginine vasopressin enhances pHi regulation in the presence of HCO3-by stimulating three acid-base transport systems. Nature 337:648-651
-
(1989)
Nature
, vol.337
, pp. 648-651
-
-
Ganz, M.B.1
Boyarsky, G.2
Sterzel, R.B.3
Boron, W.F.4
-
31
-
-
0033825432
-
Inhibition of Jurkat-T-lymphocyte Na+/H+-exchanger by CD95(Fas/Apo-1)-receptor stimulation
-
Lang F, Madlung J, Bock J, Lukewille U, Kaltenbach S, Lang KS, Belka C, Wagner CA, Lang HJ, Gulbins E, Lepple-Wienhues A (2000) Inhibition of Jurkat-T-lymphocyte Na+/H+-exchanger by CD95(Fas/Apo-1)-receptor stimulation. Pflugers Arch 440:902-907
-
(2000)
Pflugers Arch
, vol.440
, pp. 902-907
-
-
Lang, F.1
Madlung, J.2
Bock, J.3
Lukewille, U.4
Kaltenbach, S.5
Lang, K.S.6
Belka, C.7
Wagner, C.A.8
Lang, H.J.9
Gulbins, E.10
Lepple-Wienhues, A.11
-
32
-
-
0035839575
-
The adapter protein Apaf-1 is proteolytically processed during apoptosis
-
Lauber K, Appel HA, Schlosser SF, Gregor M, Schulze Osthoff K, Wesselborg S (2001) The adapter protein Apaf-1 is proteolytically processed during apoptosis. J Biol Chem 276:29772-29781
-
(2001)
J Biol Chem
, vol.276
, pp. 29772-29781
-
-
Lauber, K.1
Appel, H.A.2
Schlosser, S.F.3
Gregor, M.4
Schulze Osthoff, K.5
Wesselborg, S.6
-
33
-
-
0032126479
-
Death of tumor cells after intracellular acidification is dependent on stress-activated protein kinases (SAPK/JNK) pathway activation and cannot be inhibited by Bcl-2 expression or interleukin 1beta-converting enzyme inhibition
-
Zanke BW, Lee C, Arab S, Tannock IF (1998) Death of tumor cells after intracellular acidification is dependent on stress-activated protein kinases (SAPK/JNK) pathway activation and cannot be inhibited by Bcl-2 expression or interleukin 1beta-converting enzyme inhibition. Cancer Res 58:2801-2808
-
(1998)
Cancer Res
, vol.58
, pp. 2801-2808
-
-
Zanke, B.W.1
Lee, C.2
Arab, S.3
Tannock, I.F.4
-
34
-
-
12444288591
-
Type I and type II reactions in TRAIL-induced apoptosis - results from dose-response studies
-
Rudner J, Jendrossek V, Lauber K, Daniel PT, Wesselborg S, Belka C (2005) Type I and type II reactions in TRAIL-induced apoptosis - results from dose-response studies. Oncogene 24:130-140
-
(2005)
Oncogene
, vol.24
, pp. 130-140
-
-
Rudner, J.1
Jendrossek, V.2
Lauber, K.3
Daniel, P.T.4
Wesselborg, S.5
Belka, C.6
-
35
-
-
0034123026
-
Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: A potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release
-
Slee EA, Keogh SA, Martin SJ (2000) Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release. Cell Death Differ 7:556-565
-
(2000)
Cell Death Differ
, vol.7
, pp. 556-565
-
-
Slee, E.A.1
Keogh, S.A.2
Martin, S.J.3
-
36
-
-
0037376221
-
Renal tubular epithelial cell apoptosis is associated with caspase cleavage of the NHE1 Na+/H+ exchanger
-
Wu KL, Khan S, Lakhe-Reddy S, Wang L, Jarad G, Miller RT, Konieczkowski M, Brown AM, Sedor JR, Schelling JR (2003) Renal tubular epithelial cell apoptosis is associated with caspase cleavage of the NHE1 Na+/H+ exchanger. Am J Physiol Renal Physiol 284:F829-839
-
(2003)
Am J Physiol Renal Physiol
, vol.284
-
-
Wu, K.L.1
Khan, S.2
Lakhe-Reddy, S.3
Wang, L.4
Jarad, G.5
Miller, R.T.6
Konieczkowski, M.7
Brown, A.M.8
Sedor, J.R.9
Schelling, J.R.10
-
37
-
-
0032536771
-
Two CD95 (APO-1/Fas) signaling pathways
-
Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH, Peter ME (1998) Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17:1675-1687
-
(1998)
EMBO J
, vol.17
, pp. 1675-1687
-
-
Scaffidi, C.1
Fulda, S.2
Srinivasan, A.3
Friesen, C.4
Li, F.5
Tomaselli, K.J.6
Debatin, K.M.7
Krammer, P.H.8
Peter, M.E.9
-
38
-
-
0034662989
-
Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis
-
Maeno E, Ishizaki Y, Kanaseki T, Hazama A, Okada Y (2000) Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc Natl Acad Sci USA 97:9487-9492
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9487-9492
-
-
Maeno, E.1
Ishizaki, Y.2
Kanaseki, T.3
Hazama, A.4
Okada, Y.5
-
39
-
-
4444374080
-
Cl-channel blockers NPPB and niflumic acid blunt Ca(2+)-induced erythrocyte 'apoptosis'. Cell Physiol
-
Myssina S, Lang PA, Kempe DS, Kaiser S, Huber SM, Wieder T, Lang F (2004) Cl-channel blockers NPPB and niflumic acid blunt Ca(2+)-induced erythrocyte 'apoptosis'. Cell Physiol Biochem 14:241-248
-
(2004)
Biochem
, vol.14
, pp. 241-248
-
-
Myssina, S.1
Lang, P.A.2
Kempe, D.S.3
Kaiser, S.4
Huber, S.M.5
Wieder, T.6
Lang, F.7
-
40
-
-
33745821268
-
Cytosolic acidification and lysosomal alkalinization during TNF-alpha induced apoptosis in U937 cells
-
Nilsson C, Johansson U, Johansson AC, Kagedal K, Ollinger K (2006) Cytosolic acidification and lysosomal alkalinization during TNF-alpha induced apoptosis in U937 cells. Apoptosis 11:1149-1159
-
(2006)
Apoptosis
, vol.11
, pp. 1149-1159
-
-
Nilsson, C.1
Johansson, U.2
Johansson, A.C.3
Kagedal, K.4
Ollinger, K.5
|