메뉴 건너뛰기




Volumn 1, Issue 9, 2009, Pages 1671-1681

Leveraging therapeutic potential of multi-targeted siRNA inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; DOUBLE STRANDED RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOSOME; MATRIX METALLOPROTEINASE; PROTAMINE; RIBONUCLEASE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; VASCULOTROPIN RECEPTOR;

EID: 77953445954     PISSN: 17568919     EISSN: None     Source Type: Journal    
DOI: 10.4155/fmc.09.131     Document Type: Review
Times cited : (7)

References (92)
  • 1
    • 84904737592 scopus 로고    scopus 로고
    • Early initiation of antiretroviral therapy results in decreased morbidity and mortality among patients with TB and HIV
    • Tabarsi P, Saber-Tehrani AS, Baghaei P et al. Early initiation of antiretroviral therapy results in decreased morbidity and mortality among patients with TB and HIV. J. Int. AIDS Soc. 12(1), 14 (2009).
    • (2009) J. Int. AIDS Soc. , vol.12 , Issue.1 , pp. 14
    • Tabarsi, P.1    Saber-Tehrani, A.S.2    Baghaei, P.3
  • 2
    • 73549087233 scopus 로고    scopus 로고
    • Pharmacokinetics and drug-drug interactions of antiretrovirals: An update
    • DOI:10.1016/j.antiviral.2009.07.017. Epub ahead of print
    • Dickinson L, Khoo S, Back D. Pharmacokinetics and drug-drug interactions of antiretrovirals: an update. Antiviral Res. DOI:10.1016/j.antiviral.2009.07. 017 (2009) (Epub ahead of print).
    • (2009) Antiviral Res
    • Dickinson, L.1    Khoo, S.2    Back, D.3
  • 3
    • 3142615372 scopus 로고    scopus 로고
    • The RNAi revolution
    • Novina CD, Sharp PA. The RNAi revolution. Nature 430(6996), 161-164 (2004).
    • (2004) Nature , vol.430 , Issue.6996 , pp. 161-164
    • Novina, C.D.1    Sharp, P.A.2
  • 4
    • 38449100230 scopus 로고    scopus 로고
    • A protocol for designing siRNAs with high functionality and specificity
    • Birmingham A, Anderson E, Sullivan K et al. A protocol for designing siRNAs with high functionality and specificity. Nat. Protoc. 2(9), 2068-2078 (2007).
    • (2007) Nat. Protoc. , vol.2 , Issue.9 , pp. 2068-2078
    • Birmingham, A.1    Anderson, E.2    Sullivan, K.3
  • 5
    • 65949091600 scopus 로고    scopus 로고
    • Stringent testing identifies highly potent and escape-proof anti-HIV short hairpin RNAs
    • von Eije KJ, Ter Brake O, Berkhout B. Stringent testing identifies highly potent and escape-proof anti-HIV short hairpin RNAs. J. Gene Med. 11(6), 459-467 (2009).
    • (2009) J. Gene Med. , vol.11 , Issue.6 , pp. 459-467
    • Von Eije, K.J.1    Ter Brake, O.2    Berkhout, B.3
  • 6
    • 11144239376 scopus 로고    scopus 로고
    • Poliovirus escape from RNA interference: Short interfering RNA-target recognition and implications for therapeutic approaches
    • Gitlin L, Stone JK, Andino R. Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approaches. J. Virol. 79(2), 1027-1035 (2005).
    • (2005) J. Virol. , vol.79 , Issue.2 , pp. 1027-1035
    • Gitlin, L.1    Stone, J.K.2    Andino, R.3
  • 7
    • 9644275599 scopus 로고    scopus 로고
    • Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor-pathway genes; Therapeutic strategy for herpetic stromal keratitis
    • Kim BQ, Tang QQ, Rouse BT. Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor-pathway genes; therapeutic strategy for herpetic stromal keratitis. Am. J. Pathol. 165(6), 2177-2184 (2004).
    • (2004) Am. J. Pathol. , vol.165 , Issue.6 , pp. 2177-2184
    • Kim, B.Q.1    Tang, Q.Q.2    Rouse, B.T.3
  • 8
    • 23844474160 scopus 로고    scopus 로고
    • Antibody mediated in vivo delivery of small interfering RNA via cell surface receptors
    • Song EW, Zhu P, Lee SK et al. Antibody mediated in vivo delivery of small interfering RNA via cell surface receptors. Nature Biotechnol. 23(6), 709-717 (2005).
    • (2005) Nature Biotechnol , vol.23 , Issue.6 , pp. 709-717
    • Song, E.W.1    Zhu, P.2    Lee, S.K.3
  • 9
    • 34548586960 scopus 로고    scopus 로고
    • RNA interferencemediated targeting of urokinase plasminogen activator receptor and matrix metalloproteinase-9 gene expression in the IOMM-Lee malignant meningioma cellline inhibits tumor growth, tumor cell invasion and angiogenesis
    • Tummalapalli P, Gondi CS, Dinh DH, Gujrati M, Rao JS. RNA interferencemediated targeting of urokinase plasminogen activator receptor and matrix metalloproteinase-9 gene expression in the IOMM-Lee malignant meningioma cellline inhibits tumor growth, tumor cell invasion and angiogenesis. Int. J. Oncol. 31, 5-17 (2007).
    • (2007) Int. J. Oncol. , vol.31 , pp. 5-17
    • Tummalapalli, P.1    Gondi, C.S.2    Dinh, D.H.3    Gujrati, M.4    Rao, J.S.5
  • 10
    • 68049144915 scopus 로고    scopus 로고
    • Daul targeting of EphA2 and FAK in overian carcinoma
    • Shahzad MM, Lu C, Lee JW et al. Daul targeting of EphA2 and FAK in overian carcinoma. Cancer Biol. Ther. 8(11), 1027-1034 (2009).
    • (2009) Cancer Biol. Ther. , vol.8 , Issue.11 , pp. 1027-1034
    • Shahzad, M.M.1    Lu, C.2    Lee, J.W.3
  • 11
    • 22144489833 scopus 로고    scopus 로고
    • RNAi: The nuts and bolts of the RISC machine
    • Filipowicz W. RNAi: the nuts and bolts of the RISC machine. Cell 122(1), 17-20 (2005).
    • (2005) Cell , vol.122 , Issue.1 , pp. 17-20
    • Filipowicz, W.1
  • 12
    • 58749113430 scopus 로고    scopus 로고
    • A three-dimensional view of the molecular machinery of RNA interference
    • Jinek M, Doudna JA. A three-dimensional view of the molecular machinery of RNA interference. Nature 457(7228), 405-412 (2009).
    • (2009) Nature , vol.457 , Issue.7228 , pp. 405-412
    • Jinek, M.1    Doudna, J.A.2
  • 13
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond SM, Bernstein E, Beach D, Hannon GJ. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404(6775), 293-296 (2000).
    • (2000) Nature , vol.404 , Issue.6775 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 14
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101(1), 25-33 (2000).
    • (2000) Cell , vol.101 , Issue.1 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 15
    • 34547115237 scopus 로고    scopus 로고
    • Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA
    • Kok KH, Ng MH, Ching YP, Jin DY. Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J. Biol. Chem. 282(24), 17649-17657 (2007).
    • (2007) J. Biol. Chem. , vol.282 , Issue.24 , pp. 17649-17657
    • Kok, K.H.1    Ng, M.H.2    Ching, Y.P.3    Jin, D.Y.4
  • 16
    • 23644433363 scopus 로고    scopus 로고
    • TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
    • Chendrimada TP, Gregory RI, Kumaraswamy E et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436(7051), 740-744 (2005).
    • (2005) Nature , vol.436 , Issue.7051 , pp. 740-744
    • Chendrimada, T.P.1    Gregory, R.I.2    Kumaraswamy, E.3
  • 17
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir SM, Lendeckel W, Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15(2), 188-200 (2001).
    • (2001) Genes Dev , vol.15 , Issue.2 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 18
    • 1842816517 scopus 로고    scopus 로고
    • Distinct roles for Drosophila dicer-1 and dicer-2 in the siRNA/miRNA silencing pathways
    • Lee YS, Nakahara K, Pham JW et al. Distinct roles for Drosophila dicer-1 and dicer-2 in the siRNA/miRNA silencing pathways. Cell 117(1), 69-81 (2004).
    • (2004) Cell , vol.117 , Issue.1 , pp. 69-81
    • Lee, Y.S.1    Nakahara, K.2    Pham, J.W.3
  • 19
    • 2342626647 scopus 로고    scopus 로고
    • The RNA-induced silencing complex is a Mg2+-dependent endonuclease
    • Schwarz DS, Tomari Y, Zamore PD. The RNA-induced silencing complex is a Mg2+-dependent endonuclease. Curr. Biol. 14(9), 787-791 (2004).
    • (2004) Curr. Biol. , vol.14 , Issue.9 , pp. 787-791
    • Schwarz, D.S.1    Tomari, Y.2    Zamore, P.D.3
  • 20
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • Khvorova A, Reynolds A, Jayasena SD. Functional siRNAs and miRNAs exhibit strand bias. Cell 115(2), 209-216 (2003).
    • (2003) Cell , vol.115 , Issue.2 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 21
    • 58749096360 scopus 로고    scopus 로고
    • On the road to reading the RNA-interference code
    • Siomi H, Siomi MC. On the road to reading the RNA-interference code. Nature 457, 396-404 (2009)
    • (2009) Nature , vol.457 , pp. 396-404
    • Siomi, H.1    Siomi, M.C.2
  • 22
    • 0035798415 scopus 로고    scopus 로고
    • ATP requirements and small interfering RNA structure in the RNA interference pathway
    • Nykanen A, Haley B, Zamore PD. ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell 107(3), 309-321 (2001).
    • (2001) Cell , vol.107 , Issue.3 , pp. 309-321
    • Nykanen, A.1    Haley, B.2    Zamore, P.D.3
  • 23
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • Martinez J, Patkaniowska A, Urlaub H, Luhrmann R, Tuschl T. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 110(5), 563-574 (2002).
    • (2002) Cell , vol.110 , Issue.5 , pp. 563-574
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Luhrmann, R.4    Tuschl, T.5
  • 24
    • 0035839109 scopus 로고    scopus 로고
    • Argonaute2, a link between genetic and biochemical analyses of RNAi
    • Hammond SM, Boettcher S, Caudy AA, Kobayashi R, Hannon GJ. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293(5532), 1146-1150 (2001).
    • (2001) Science , vol.293 , Issue.5532 , pp. 1146-1150
    • Hammond, S.M.1    Boettcher, S.2    Caudy, A.A.3    Kobayashi, R.4    Hannon, G.J.5
  • 25
    • 3142729150 scopus 로고    scopus 로고
    • Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
    • Okamura K, Ishizuka A, Siomi H, Siomi MC. Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev. 18(14), 1655-1666 (2004).
    • (2004) Genes Dev , vol.18 , Issue.14 , pp. 1655-1666
    • Okamura, K.1    Ishizuka, A.2    Siomi, H.3    Siomi, M.C.4
  • 26
    • 15844371219 scopus 로고    scopus 로고
    • Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein
    • Ma JB, Yuan YR, Meister G, Pei Y, Tuschl T, Patel DJ. Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature 434(7033), 666-670 (2005).
    • (2005) Nature , vol.434 , Issue.7033 , pp. 666-670
    • Ma, J.B.1    Yuan, Y.R.2    Meister, G.3    Pei, Y.4    Tuschl, T.5    Patel, D.J.6
  • 27
    • 21244451435 scopus 로고    scopus 로고
    • Crystal structures of RNase H bound to an RNA/DNA hybrid: Substrate specificity and metal-dependent catalysis
    • Nowotny M, Gaidamakov SA, Crouch RJ, Yang W. Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis. Cell 121(7), 1005-1016 (2005).
    • (2005) Cell , vol.121 , Issue.7 , pp. 1005-1016
    • Nowotny, M.1    Gaidamakov, S.A.2    Crouch, R.J.3    Yang, W.4
  • 28
    • 34250638746 scopus 로고    scopus 로고
    • SiRNAs in drug discovery: Target validation and beyond
    • Natt F. siRNAs in drug discovery: target validation and beyond. Curr. Opin. Mol. Ther. 9(3), 242-247 (2007).
    • (2007) Curr. Opin. Mol. Ther. , vol.9 , Issue.3 , pp. 242-247
    • Natt, F.1
  • 29
    • 34347391035 scopus 로고    scopus 로고
    • Utilizing RNA interference to enhance cancer drug discovery
    • Iorns E, Lord CJ, Turner N, Ashworth A. Utilizing RNA interference to enhance cancer drug discovery. Nat. Rev. Drug Discov. 6(7), 556-568 (2007).
    • (2007) Nat. Rev. Drug Discov. , vol.6 , Issue.7 , pp. 556-568
    • Iorns, E.1    Lord, C.J.2    Turner, N.3    Ashworth, A.4
  • 30
    • 0037089135 scopus 로고    scopus 로고
    • Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor
    • Holen T, Amarzguioui M, Wiiger MT, Babaie E, Prydz H. Positional effects of short interfering RNAs targeting the human coagulation trigger tissue factor. Nucleic Acids Res. 30(8), 1757-1766 (2002).
    • (2002) Nucleic Acids Res , vol.30 , Issue.8 , pp. 1757-1766
    • Holen, T.1    Amarzguioui, M.2    Wiiger, M.T.3    Babaie, E.4    Prydz, H.5
  • 32
    • 3042736199 scopus 로고    scopus 로고
    • Prophylactic and therapeutic effects of small interfering RNA targeting SARS-coronavirus
    • Zheng BJ. Prophylactic and therapeutic effects of small interfering RNA targeting SARS-coronavirus. Antiviral Therapy 9, 365-374 (2004).
    • (2004) Antiviral Therapy , vol.9 , pp. 365-374
    • Zheng, B.J.1
  • 33
    • 24744466699 scopus 로고    scopus 로고
    • Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque
    • Li BJ. Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nat. Med. 11(9), 944-951 (2005).
    • (2005) Nat. Med. , vol.11 , Issue.9 , pp. 944-951
    • Li, B.J.1
  • 34
    • 34548548614 scopus 로고    scopus 로고
    • Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC
    • Castanotto D, Sakurai K, Lingeman R et al. Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC. Nucleic Acids Res. 35(15), 5154-5164 (2007).
    • (2007) Nucleic Acids Res , vol.35 , Issue.15 , pp. 5154-5164
    • Castanotto, D.1    Sakurai, K.2    Lingeman, R.3
  • 35
    • 33745299723 scopus 로고    scopus 로고
    • Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
    • Grimm D, Streetz KL, Jopling CL et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441(7092), 537-541 (2006).
    • (2006) Nature , vol.441 , Issue.7092 , pp. 537-541
    • Grimm, D.1    Streetz, K.L.2    Jopling, C.L.3
  • 36
    • 0037685280 scopus 로고    scopus 로고
    • Expression profiling reveals off-target gene regulation by RNAi
    • Jackson AL, Bartz SR, Schelter J et al. Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. 21(6), 635-637 (2003).
    • (2003) Nat. Biotechnol. , vol.21 , Issue.6 , pp. 635-637
    • Jackson, A.L.1    Bartz, S.R.2    Schelter, J.3
  • 37
    • 33646188259 scopus 로고    scopus 로고
    • 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets
    • Birmingham A, Anderson EM, Reynolds A et al. 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat. Methods. 3(3), 199-204 (2006).
    • (2006) Nat. Methods. , vol.3 , Issue.3 , pp. 199-204
    • Birmingham, A.1    Anderson, E.M.2    Reynolds, A.3
  • 38
    • 23344438420 scopus 로고    scopus 로고
    • SiRNA-mediated off-target gene silencing triggered by a 7 nt complementation
    • Lin X, Ruan X, Anderson MG et al. siRNA-mediated off-target gene silencing triggered by a 7 nt complementation. Nucleic Acids Res. 33(14), 4527-4535 (2005).
    • (2005) Nucleic Acids Res , vol.33 , Issue.14 , pp. 4527-4535
    • Lin, X.1    Ruan, X.2    Anderson, M.G.3
  • 39
    • 39449097277 scopus 로고    scopus 로고
    • Overcoming the innate immune response to small interfering RNA
    • Judge A, MacLachlan I. Overcoming the innate immune response to small interfering RNA. Hum. Gene Ther. 19(2), 111-124 (2008).
    • (2008) Hum. Gene Ther. , vol.19 , Issue.2 , pp. 111-124
    • Judge, A.1    MacLachlan, I.2
  • 40
    • 10744219688 scopus 로고    scopus 로고
    • Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells
    • Scacheri PC, Rozenblatt-Rosen O, Caplen NJ et al. Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc. Natl Acad. Sci. USA 101(7), 1892-1897 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.7 , pp. 1892-1897
    • Scacheri, P.C.1    Rozenblatt-Rosen, O.2    Caplen, N.J.3
  • 41
    • 67149115119 scopus 로고    scopus 로고
    • Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
    • Khan AA, Betel D, Miller ML, Sander C, Leslie CS, Marks DS. Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat. Biotechnol. 27(6), 549-555 (2009)
    • (2009) Nat. Biotechnol. , vol.27 , Issue.6 , pp. 549-555
    • Khan, A.A.1    Betel, D.2    Miller, M.L.3    Sander, C.4    Leslie, C.S.5    Marks, D.S.6
  • 42
    • 70350130799 scopus 로고    scopus 로고
    • Comparative assessment of siRNA and shRNA off target effects: What is slowing clinical development
    • Rao DD, Senzer N, Cleary MA, Nemunaitis J. Comparative assessment of siRNA and shRNA off target effects: what is slowing clinical development. Cancer Gene Ther. 16(11), 807-809. (2009).
    • (2009) Cancer Gene Ther , vol.16 , Issue.11 , pp. 807-809
    • Rao, D.D.1    Senzer, N.2    Cleary, M.A.3    Nemunaitis, J.4
  • 43
    • 34247873185 scopus 로고    scopus 로고
    • Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies
    • Kittler R, Surendranath V, Heninger AK et al. Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies. Nat. Methods 4(4), 337-344 (2007).
    • (2007) Nat. Methods , vol.4 , Issue.4 , pp. 337-344
    • Kittler, R.1    Surendranath, V.2    Heninger, A.K.3
  • 44
    • 54949095836 scopus 로고    scopus 로고
    • Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation
    • Robbins M, Judge A, Ambegia E et al. Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. Hum. Gene Ther. 19(10), 991-999 (2008).
    • (2008) Hum. Gene Ther. , vol.19 , Issue.10 , pp. 991-999
    • Robbins, M.1    Judge, A.2    Ambegia, E.3
  • 45
    • 33745614074 scopus 로고    scopus 로고
    • Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing
    • Jackson AL, Burchard J, Leake D et al. Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA 12(7), 1197-1205 (2006).
    • (2006) RNA , vol.12 , Issue.7 , pp. 1197-1205
    • Jackson, A.L.1    Burchard, J.2    Leake, D.3
  • 46
    • 42449091989 scopus 로고    scopus 로고
    • Functional dissection of siRNA sequence by systematic DNA substitution: Modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect
    • Ui-Tei K, Naito Y, Zenno S et al. Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. Nucleic Acids Res. 36(7), 2136-2151 (2008).
    • (2008) Nucleic Acids Res , vol.36 , Issue.7 , pp. 2136-2151
    • Ui-Tei, K.1    Naito, Y.2    Zenno, S.3
  • 47
    • 0036752785 scopus 로고    scopus 로고
    • RNAi in human cells: Basic structural and functional features of small interfering RNA
    • Chiu YL, Rana TM. RNAi in human cells: basic structural and functional features of small interfering RNA. Mol. Cell 10(3), 549-561 (2002).
    • (2002) Mol. Cell , vol.10 , Issue.3 , pp. 549-561
    • Chiu, Y.L.1    Rana, T.M.2
  • 48
  • 49
    • 38049161918 scopus 로고    scopus 로고
    • RNAi for treating hepatitis B viral infection
    • Chen Y, Cheng G, Mahato RI. RNAi for treating hepatitis B viral infection. Pharm. Res. 25(1), 72-86 (2008).
    • (2008) Pharm. Res. , vol.25 , Issue.1 , pp. 72-86
    • Chen, Y.1    Cheng, G.2    Mahato, R.I.3
  • 50
    • 0026334457 scopus 로고
    • Nucleotide sequence and mutation rate of the H strain of hepatitis C virus
    • Ogata N, Alter HJ, Miller RH, Purcell RH. Nucleotide sequence and mutation rate of the H strain of hepatitis C virus. Proc. Natl Acad. Sci. USA 88(8), 3392-3396 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , Issue.8 , pp. 3392-3396
    • Ogata, N.1    Alter, H.J.2    Miller, R.H.3    Purcell, R.H.4
  • 51
    • 0026726857 scopus 로고
    • Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: Variability and stability
    • Okamoto H, Kojima M, Okada S et al. Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability. Virology 190(2), 894-899 (1992).
    • (1992) Virology , vol.190 , Issue.2 , pp. 894-899
    • Okamoto, H.1    Kojima, M.2    Okada, S.3
  • 52
    • 0033598717 scopus 로고    scopus 로고
    • Mutation rates among RNA viruses
    • Drake JW, Holland JJ. Mutation rates among RNA viruses. Proc. Natl Acad. Sci. USA 96(24), 13910-13913 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , Issue.24 , pp. 13910-13913
    • Drake, J.W.1    Holland, J.J.2
  • 53
    • 0022477122 scopus 로고
    • Measurement of the mutation rates of animal viruses: Influenza A virus and poliovirus type 1
    • Parvin JD, Moscona A, Pan WT, Leider JM, Palese P. Measurement of the mutation rates of animal viruses: influenza A virus and poliovirus type 1. J. Virol. 59(2), 377-383 (1986).
    • (1986) J. Virol. , vol.59 , Issue.2 , pp. 377-383
    • Parvin, J.D.1    Moscona, A.2    Pan, W.T.3    Leider, J.M.4    Palese, P.5
  • 54
    • 0028358840 scopus 로고
    • Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis
    • Enomoto N, Kurosaki M, Tanaka Y, Marumo F, Sato C. Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis. J. Gen. Virol. 75, 1361-1369 (1994).
    • (1994) J. Gen. Virol. , vol.75 , pp. 1361-1369
    • Enomoto, N.1    Kurosaki, M.2    Tanaka, Y.3    Marumo, F.4    Sato, C.5
  • 55
    • 34250617883 scopus 로고    scopus 로고
    • Genetic diversity of the hepatitis C virus: Impact and issues in the antiviral therapy
    • Guillou-Guillemette HL, Vallet S, Gaudy-Graffin C et al. Genetic diversity of the hepatitis C virus: impact and issues in the antiviral therapy. World J. Gastroenterol. 13(17), 2416-2426 (2007).
    • (2007) World J. Gastroenterol. , vol.13 , Issue.17 , pp. 2416-2426
    • Guillou-Guillemette, H.L.1    Vallet, S.2    Gaudy-Graffin, C.3
  • 56
    • 0037173613 scopus 로고    scopus 로고
    • Short interfering RNA confers intracellular antiviral immunity in human cells
    • Gitlin L, Karelsky S, Andino R. Short interfering RNA confers intracellular antiviral immunity in human cells. Nature 418(6896), 430-434 (2002).
    • (2002) Nature , vol.418 , Issue.6896 , pp. 430-434
    • Gitlin, L.1    Karelsky, S.2    Andino, R.3
  • 57
    • 18744382144 scopus 로고    scopus 로고
    • Hepatitis C virus replicons escape RNA interference induced by a short interfering RNA directed against the NS5b coding region
    • Wilson JA, Richardson CD. Hepatitis C virus replicons escape RNA interference induced by a short interfering RNA directed against the NS5b coding region. J. Virol. 79(11), 7050-7058 (2005).
    • (2005) J. Virol. , vol.79 , Issue.11 , pp. 7050-7058
    • Wilson, J.A.1    Richardson, C.D.2
  • 58
    • 33750062855 scopus 로고    scopus 로고
    • SiRNA-resistance in treated HCV replicon cells is correlated with the development of specific HCV mutations
    • Konishi M, Wu CH, Kaito M et al. siRNA-resistance in treated HCV replicon cells is correlated with the development of specific HCV mutations. J. Viral Hepat. 13(11), 756-761 (2006).
    • (2006) J. Viral Hepat. , vol.13 , Issue.11 , pp. 756-761
    • Konishi, M.1    Wu, C.H.2    Kaito, M.3
  • 59
    • 33746210111 scopus 로고    scopus 로고
    • Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration
    • Nishitsuji H, Kohara M, Kannagi M, Masuda T. Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration. J. Virol. 80(15), 7658-7666 (2006).
    • (2006) J. Virol. , vol.80 , Issue.15 , pp. 7658-7666
    • Nishitsuji, H.1    Kohara, M.2    Kannagi, M.3    Masuda, T.4
  • 60
    • 0142124143 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 escape from RNA interference
    • Boden D, Pusch O, Lee F, Tucker L, Ramratnam B. Human immunodeficiency virus type 1 escape from RNA interference. J. Virol. 77(21), 11531-11535 (2003).
    • (2003) J. Virol. , vol.77 , Issue.21 , pp. 11531-11535
    • Boden, D.1    Pusch, O.2    Lee, F.3    Tucker, L.4    Ramratnam, B.5
  • 61
    • 1242319384 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 escapes from RNA interferencemediated inhibition
    • Das AT, Brummelkamp TR, Westerhout EM et al. Human immunodeficiency virus type 1 escapes from RNA interferencemediated inhibition. J. Virol. 78(5), 2601-2605 (2004).
    • (2004) J. Virol. , vol.78 , Issue.5 , pp. 2601-2605
    • Das, A.T.1    Brummelkamp, T.R.2    Westerhout, E.M.3
  • 62
    • 33751001588 scopus 로고    scopus 로고
    • Silencing of HIV-1 with RNA interference: A multiple shRNA approach
    • ter Brake O, Konstantinova P, Ceylan M, Berkhout B. Silencing of HIV-1 with RNA interference: a multiple shRNA approach. Mol. Ther. 14(6), 883-892 (2006).
    • (2006) Mol. Ther. , vol.14 , Issue.6 , pp. 883-892
    • Ter Brake, O.1    Konstantinova, P.2    Ceylan, M.3    Berkhout, B.4
  • 63
    • 30344474936 scopus 로고    scopus 로고
    • Sequence homology required by human immunodeficiency virus type 1 to escape from short interfering RNAs
    • Sabariegos R, Gimenez-Barcons M, Tapia N, Clotet B, Martinez MA. Sequence homology required by human immunodeficiency virus type 1 to escape from short interfering RNAs. J. Virol. 80(2), 571-577 (2006).
    • (2006) J. Virol. , vol.80 , Issue.2 , pp. 571-577
    • Sabariegos, R.1    Gimenez-Barcons, M.2    Tapia, N.3    Clotet, B.4    Martinez, M.A.5
  • 64
    • 32444432596 scopus 로고    scopus 로고
    • Novel Pol II fusion promoter directs human immunodeficiency virus type 1-inducible coexpression of a short hairpin RNA and protein
    • Unwalla HJ, Li HT, Bahner I, Li MJ, Kohn D, Rossi JJ. Novel Pol II fusion promoter directs human immunodeficiency virus type 1-inducible coexpression of a short hairpin RNA and protein. J. Virol. 80(4), 1863-1873 (2006).
    • (2006) J. Virol. , vol.80 , Issue.4 , pp. 1863-1873
    • Unwalla, H.J.1    Li, H.T.2    Bahner, I.3    Li, M.J.4    Kohn, D.5    Rossi, J.J.6
  • 65
    • 13844320402 scopus 로고    scopus 로고
    • HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome
    • Westerhout EM, Ooms M, Vink M, Das AT, Berkhout B. HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome. Nucleic Acids Res. 33(2), 796-804 (2005).
    • (2005) Nucleic Acids Res , vol.33 , Issue.2 , pp. 796-804
    • Westerhout, E.M.1    Ooms, M.2    Vink, M.3    Das, A.T.4    Berkhout, B.5
  • 66
    • 55249098418 scopus 로고    scopus 로고
    • HIV evades RNA interference directed at TAR by an indirect compensatory mechanism
    • Leonard JN, Shah PS, Burnett JC, Schaffer DV. HIV evades RNA interference directed at TAR by an indirect compensatory mechanism. Cell Host Microbe 4(5), 484-494 (2008).
    • (2008) Cell Host Microbe , vol.4 , Issue.5 , pp. 484-494
    • Leonard, J.N.1    Shah, P.S.2    Burnett, J.C.3    Schaffer, D.V.4
  • 67
    • 40149092147 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference
    • von Eije KJ, ter Brake O, Berkhout B. Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference. J. Virol. 82(6), 2895-2903 (2008).
    • (2008) J. Virol. , vol.82 , Issue.6 , pp. 2895-2903
    • Von Eije, K.J.1    Ter Brake, O.2    Berkhout, B.3
  • 68
    • 0036066508 scopus 로고    scopus 로고
    • SiRNA-directed inhibition of HIV-1 infection
    • Novina CD, Murray MF, Dykxhoorn DM et al. siRNA-directed inhibition of HIV-1 infection. Nat. Med. 8(7), 681-686 (2002).
    • (2002) Nat. Med. , vol.8 , Issue.7 , pp. 681-686
    • Novina, C.D.1    Murray, M.F.2    Dykxhoorn, D.M.3
  • 69
    • 0036900140 scopus 로고    scopus 로고
    • RNA interference of HIV replication
    • Martinez MA, Clotet B, Este JA. RNA interference of HIV replication. Trends Immunol. 23(12), 559-561 (2002).
    • (2002) Trends Immunol , vol.23 , Issue.12 , pp. 559-561
    • Martinez, M.A.1    Clotet, B.2    Este, J.A.3
  • 70
    • 34447548962 scopus 로고    scopus 로고
    • RNAi-mediated knockdown of target genes: A promising strategy for pancreatic cancer research
    • Chang H. RNAi-mediated knockdown of target genes: a promising strategy for pancreatic cancer research. Cancer Gene Ther. 14(8), 677-685 (2007)
    • (2007) Cancer Gene Ther , vol.14 , Issue.8 , pp. 677-685
    • Chang, H.1
  • 71
    • 43249091971 scopus 로고    scopus 로고
    • RNA interference and cancer: Endogenous pathways and therapeutic approaches
    • Dykxhoorn DM, Chowdhury D, Lieberman J. RNA interference and cancer: endogenous pathways and therapeutic approaches. Adv. Exp. Med. Biol. 615, 299-329 (2008).
    • (2008) Adv. Exp. Med. Biol. , vol.615 , pp. 299-329
    • Dykxhoorn, D.M.1    Chowdhury, D.2    Lieberman, J.3
  • 72
    • 41849137252 scopus 로고    scopus 로고
    • Harnessing the RNA interference pathway to advance treatment and prevention of hepatocellular carcinoma
    • Arbuthnot P, Thompson LJ. Harnessing the RNA interference pathway to advance treatment and prevention of hepatocellular carcinoma. World J. Gastroenterol. 14(11), 1670-1681 (2008).
    • (2008) World J. Gastroenterol. , vol.14 , Issue.11 , pp. 1670-1681
    • Arbuthnot, P.1    Thompson, L.J.2
  • 73
    • 14844320045 scopus 로고    scopus 로고
    • Modulation of angiogenesis pathway using siRNA for gene function validation and novel therapeutics
    • Lu PY, Xie FY, Woodle M. Modulation of angiogenesis pathway using siRNA for gene function validation and novel therapeutics. Trends Mol. Med. 11(3), 104-113 (2005).
    • (2005) Trends Mol. Med. , vol.11 , Issue.3 , pp. 104-113
    • Lu, P.Y.1    Xie, F.Y.2    Woodle, M.3
  • 75
    • 70449732503 scopus 로고    scopus 로고
    • Matrix Metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer
    • Roy R, Yang J, Moses MA. Matrix Metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer. J. Clin. Oncol. 27(31), 5287-5297 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.31 , pp. 5287-5297
    • Roy, R.1    Yang, J.2    Moses, M.A.3
  • 76
    • 54249092645 scopus 로고    scopus 로고
    • Antiangiogenic therapy in brain tumors
    • Lakka SS, Rao JS. Antiangiogenic therapy in brain tumors. Expert Rev. Neurother. 8(1), 1457-1473 (2008).
    • (2008) Expert Rev. Neurother. , vol.8 , Issue.1 , pp. 1457-1473
    • Lakka, S.S.1    Rao, J.S.2
  • 77
    • 66749086832 scopus 로고    scopus 로고
    • Integrin-mediated regulation of neurovascular development, physiology and disease
    • McCarty JH. Integrin-mediated regulation of neurovascular development, physiology and disease. Cell Adh. Migr. 3(2), 211-215 (2009).
    • (2009) Cell Adh. Migr. , vol.3 , Issue.2 , pp. 211-215
    • McCarty, J.H.1
  • 78
    • 58149330982 scopus 로고    scopus 로고
    • Meta-analysis of gene expression profiles in breast cancer: Toward a unified understanding of breast cancer subtyping and prognosis signatures
    • Wirapati P, Sotiriou C, Kunkel S et al. Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res. 10(4), R65 (2008).
    • (2008) Breast Cancer Res , vol.10 , Issue.4
    • Wirapati, P.1    Sotiriou, C.2    Kunkel, S.3
  • 80
    • 35348905119 scopus 로고    scopus 로고
    • RNAi-mediatged downregulation of urokinase plasminogen activator receptor and matrix metalloprotease-9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth
    • Kunigal S, Lakka SS, Gondi CS, Estes N, Rao JS. RNAi-mediatged downregulation of urokinase plasminogen activator receptor and matrix metalloprotease-9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth. Int. J. Cancer 121, 2307-2316 (2007)
    • (2007) Int. J. Cancer , vol.121 , pp. 2307-2316
    • Kunigal, S.1    Lakka, S.S.2    Gondi, C.S.3    Estes, N.4    Rao, J.S.5
  • 81
    • 20444470108 scopus 로고    scopus 로고
    • Specific interference of uPAR and MMP-9 gene expression induced by double-stranded RNA results in decreased invasion, tumor growth and angiogenesis in gliomas
    • Lakka SS, Gondi CS, Dinh DH et al. Specific interference of uPAR and MMP-9 gene expression induced by double-stranded RNA results in decreased invasion, tumor growth and angiogenesis in gliomas. J. Biol. Chem. 280, 21882-21892 (2005)
    • (2005) J. Biol. Chem. , vol.280 , pp. 21882-21892
    • Lakka, S.S.1    Gondi, C.S.2    Dinh, D.H.3
  • 82
    • 34547134691 scopus 로고    scopus 로고
    • Intraperitoneal injection of an hpRNA-expressing plasmid targeting uPAR and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice
    • Gondi CS, Lakka SS, Dinh DH, Olivero WC, Gujrati M, Rao JS. Intraperitoneal injection of an hpRNA-expressing plasmid targeting uPAR and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice. Clin. Cancer Res. 13, 4051-4060 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 4051-4060
    • Gondi, C.S.1    Lakka, S.S.2    Dinh, D.H.3    Olivero, W.C.4    Gujrati, M.5    Rao, J.S.6
  • 83
    • 58149179443 scopus 로고    scopus 로고
    • UPA/ uPAR downregulation inhibits radiationinduced migration, invasion and angiogenesis in IOMM-Lee meningioma cells and decreases tumor growth in vivo
    • Kargiotis O, Chetty C, Gogineni V et al. uPA/ uPAR downregulation inhibits radiationinduced migration, invasion and angiogenesis in IOMM-Lee meningioma cells and decreases tumor growth in vivo. Int. J. Oncol. 33(5), 937-947 (2008).
    • (2008) Int. J. Oncol. , vol.33 , Issue.5 , pp. 937-947
    • Kargiotis, O.1    Chetty, C.2    Gogineni, V.3
  • 84
    • 2942718949 scopus 로고    scopus 로고
    • Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis
    • Lakka SS, Gondi CS, Yanamandra N et al. Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. Oncogene 23, 4681-4689 (2004).
    • (2004) Oncogene , vol.23 , pp. 4681-4689
    • Lakka, S.S.1    Gondi, C.S.2    Yanamandra, N.3
  • 85
    • 9144231998 scopus 로고    scopus 로고
    • RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas
    • Gondi CS, Lakka SS, Dinh DH, Olivero WC, Gujrati M, Rao JS. RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas. Oncogene 23, 8486-8496 (2004).
    • (2004) Oncogene , vol.23 , pp. 8486-8496
    • Gondi, C.S.1    Lakka, S.S.2    Dinh, D.H.3    Olivero, W.C.4    Gujrati, M.5    Rao, J.S.6
  • 86
    • 24744464786 scopus 로고    scopus 로고
    • Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo
    • Takeshita F, Minakuchi Y, Nagahara S et al. Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc. Natl Acad. Sci. USA 102, 12177-12182 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 12177-12182
    • Takeshita, F.1    Minakuchi, Y.2    Nagahara, S.3
  • 87
    • 0347036244 scopus 로고    scopus 로고
    • Alnylam Pharmaceuticals Inc. (Nasdaq: ALNY), April 3
    • News Release. Alnylam Pharmaceuticals Inc. (Nasdaq: ALNY), April 3, 2009.
    • (2009) News Release
  • 88
    • 49049114293 scopus 로고    scopus 로고
    • Multitarget siRNA inhibition of antiapoptotic genes (XIAP, BCL2, BCL-X(L)) in bladder cancer cells
    • Kunze D, Wuttig D, Fuessel S et al. Multitarget siRNA inhibition of antiapoptotic genes (XIAP, BCL2, BCL-X(L)) in bladder cancer cells. Anticancer Res. 28(4B), 2259-2263 (2008).
    • (2008) Anticancer Res , vol.28 , Issue.4 B , pp. 2259-2263
    • Kunze, D.1    Wuttig, D.2    Fuessel, S.3
  • 89
    • 67949120217 scopus 로고    scopus 로고
    • Dual knockdown of N-ras and epiregulin synergistically suppressed the growth of human hepatoma cells
    • Zhao M, He HW, Sun HX et al. Dual knockdown of N-ras and epiregulin synergistically suppressed the growth of human hepatoma cells. Biochem. Biophys. Res. Commun. 387(2), 239-244 (2009).
    • (2009) Biochem. Biophys. Res. Commun. , vol.387 , Issue.2 , pp. 239-244
    • Zhao, M.1    He, H.W.2    Sun, H.X.3
  • 91
    • 55549114663 scopus 로고    scopus 로고
    • 5′-triphosphate-siRNA: Turning gene silencing and Rig-I activation against melanoma
    • Poeck H. 5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat. Med. 14(11), 1256-1263 (2008).
    • (2008) Nat. Med. , vol.14 , Issue.11 , pp. 1256-1263
    • Poeck, H.1
  • 92
    • 67650479404 scopus 로고    scopus 로고
    • Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug
    • MacDiarmid JA. Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug. Nat. Biotechnol. 27(7), 643-654 (2009).
    • (2009) Nat. Biotechnol. , vol.27 , Issue.7 , pp. 643-654
    • MacDiarmid, J.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.