Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase

Infection and Immunity

Volumn 69, Issue 10, 2001, Pages 6156-6164

  Hayashi, T ^a   Rao, S P ^a   Takabayashi, K ^a   Van Uden, J H ^a   Kornbluth, R S ^a   Baird, S M ^a   Taylor, M W ^a   Carson, D A ^a   Catanzaro, A ^a   Raz, E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BACTERIAL DNA; BETA INTERFERON; CLARITHROMYCIN; GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 12; NITRIC OXIDE; OLIGODEOXYNUCLEOTIDE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOSTIMULATION; MACROPHAGE; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM AVIUM; NONHUMAN; PRIORITY JOURNAL; TH1 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTI-BACTERIAL AGENTS; CELLS, CULTURED; CLARITHROMYCIN; DISEASE MODELS, ANIMAL; DNA; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INTERFERON TYPE II; INTERFERON-ALPHA; INTERFERON-BETA; INTERLEUKIN-12; MACROPHAGES; MICE; MICE, KNOCKOUT; MONOCYTES; MYCOBACTERIUM AVIUM; NADPH OXIDASE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OLIGODEOXYRIBONUCLEOTIDES; T-LYMPHOCYTES; THIONUCLEOTIDES; TRYPTOPHAN OXYGENASE; TUBERCULOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034832968     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.10.6156-6164.2001     Document Type: Article

References (55)

1. Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages
2. Tumour necrosis factor-alpha (TNF-alpha) in the host resistance to mycobacteria of distinct virulence
3. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
4. Tryptophan depletion as a mechanism of gamma interferon-mediated chlamydial persistence
5. Differential mechanisms of intracellular killing of Mycobacterium avium and Listeria monocytogenes by activated human and murine macrophages. The role of nitric oxide
6. Interaction of Mycobacterium avium complex with human macrophages: Roles of membrane receptors and serum proteins
7. Interferon-induced indoleamine 2:3-dioxygenase activity inhibits Chlamydia psittaci replication in human macrophages
8. The impact of Mycobacterium avium complex bacteremia and its treatment on survival of AIDS patients - A prospective study
9. Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism
10. Predictive value of CD4 lymphocyte numbers for the development of opportunistic infections and malignancies in HIV-infected persons
11. IFN-gamma activated indoleamine 2:3-dioxygenase activity in human cells is an antiparasitic and an antibacterial effector mechanism
12. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection
13. IL-12 promotes drug-induced clearance of Mycobacterium avium infection in mice
14. The immunology of mycobacterial diseases
15. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
16. Perspectives series: Host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity
17. Induction of IL-1 beta, IL-6, TNF-alpha, GM-CSF and G-CSF in human macrophages by smooth transparent and smooth opaque colonial variants of Mycobacterium avium
18. Analysis of interferon-gamma resistant mutants that are possibly defective in their signaling mechanism
19. In vitro response of murine alveolar and peritoneal macrophages to Mycobactedum intracellulare
20. Apoptosis of human monocytes and macrophages by Mycobacterium avium sonicate
21. Role of CD40 ligand in Mycobacterium avium infection
22. Mycobacterium avium complex infection in the acquired immunodeficiency syndrome
23. Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation
24. Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection
25. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
26. Protection of mice from Mycobacterium avium infection by recombinant interleukin-12
27. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
28. CpG motifs in bacterial DNA trigger direct B-cell activation
29. The role of CpG dinucleotides in DNA vaccines
30. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
31. Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds
32. Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences
33. Recommendations on prophylaxis and therapy for disseminated Mycobacterium avium complex disease in patients infected with the human immunodeficiency virus. Public Health Service Task Force on Prophylaxis and Therapy for Mycobacterium avium Complex
34. Characterization and growth in human macrophages of Mycobacterium avium complex strains isolated from the blood of patients with acquired immunodeficiency syndrome
35. Role of oxidants in microbial pathophysiology
36. Inhibition of T cell proliferation by macrophage tryptophan catabolism
37. Prevention of allogeneic fetal rejection by tryptophan catabolism
38. Survival of human macrophages infected with Mycobacterium avium intracellulare correlates with increased production of tumor necrosis factor-alpha and IL-6
39. Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare
40. Macrophage control of mycobacterial growth induced by picolinic acid is dependent on host cell apoptosis
41. Inhibition of growth of Toxoplasma gondii in cultured fibroblasts by human recombinant gamma interferon
42. 3 on human monocytes and monocyte-derived macrophages
43. Nutrition, growth and metabolism
44. Immunostimutatory DNA sequences function as T helper-1-promoting adjuvants
45. Mechanisms generating functionally heterogeneous macrophages: Chaos revisited
46. Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria
47. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
48. Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-alpha-mediated shock
49. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase
50. Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells
51. Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms
52. Differential expression of inducible nitric oxide synthase gene by alveolar and peritoneal macrophages in lipopolysaccharide-hyporesponsive C3H/HeJ mice
53. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth
54. Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway
55. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis