LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of wnt signaling

Journal of Biological Chemistry

Volumn 284, Issue 1, 2009, Pages 381-388

  Terrand, Jérome ^a   Bruban, Véronique ^a   Zhou, Li ^e   Gong, Wanfeng ^a   Asmar, Zeina El ^a   May, Petra ^b   Zurhove, Kai ^b   Haffner, Philipp ^b   Philippe, Claude ^a   Woldt, Estelle ^a   Matz, Rachel L ^a   Gracia, Céline ^a   Metzger, Daniel ^c   Auwerx, Johan ^d   Herz, Joachim ^a,e   Boucher, Philippe ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b UNIVERSITY OF FREIBURG   (Germany)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d INSTITUT CLINIQUE DE LA SOURIS   (France)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTE DIFFERENTIATION; ADIPOSE TISSUES; CELL SURFACES; CHOLESTEROL ACCUMULATION; LIPID METABOLISMS; LIPOPROTEIN RECEPTOR (LDLR);

ACIDS; BIOCHEMISTRY; CELL CULTURE; CELL MEMBRANES; ESTERS; FATTY ACIDS; MODULATION; SIGNALING;

CHOLESTEROL;

ACETYL COENZYME A CARBOXYLASE; CELL SURFACE RECEPTOR; CHOLESTEROL; CHOLESTEROL ESTER; FATTY ACID; LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEIN LRP1; UNCLASSIFIED DRUG; WNT5A PROTEIN;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL SURFACE; CONTROLLED STUDY; FATTY ACID SYNTHESIS; LIPID METABOLISM; LIPID STORAGE; LIPOGENESIS; LIPOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETYL-COA CARBOXYLASE; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CHOLESTEROL; FATTY ACIDS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LIPID METABOLISM; LIVER; MICE; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS; RECEPTORS, LDL; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS; WNT PROTEINS;

MUS;

EID: 58649104220     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806538200     Document Type: Article

References (35)

1. Rosen, E. D., and MacDougald, O. A. (2006) Nat. Rev. Mol. Cell. Biol. 7, 885-896
2. Rosen, E. D., Walkey, C. J., Puigserver, P., and Spiegelman, B. M. (2000) Genes Dev. 14, 1293-1307
3. Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K., Milstone, D. S., Spiegelman, B. M., and Mortensen, R. M. (1999) Mol. Cell 4, 611-617
4. Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., and Spiegelman, B. M. (1994) Genes Dev. 8, 1224-1234
5. Schoonjans, K., Peinado-Onsurbe, J., Lefebvre, A. M., Heyman, R. A., Briggs, M., Deeb, S., Staels, B., and Auwerx, J. (1996) EMBO J. 15, 5336-5348
6. Zimmermann, R., Strauss, J. G., Haemmerle, G., Schoiswohl, G., Birner- Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., and Zechner, R. (2004) Science 306, 1383-1386
7. Schweiger, M., Schreiber, R., Haemmerle, G., Lass, A., Fledelius, C., Jacob-sen, P., Tornqvist, H., Zechner, R., and Zimmermann, R. (2006) J. Biol. Chem. 281, 40236-40241
8. Herz, J., and Hui, D. Y. (2004) Curr. Opin. Lipidol. 15, 175-181
9. Herz, J., and Strickland, D. K. (2001) J.Clin. Invest. 108, 779-784
10. Lillis, A. P., Mikhailenko, I., and Strickland, D. K. (2005) J Thromb Hae- most 3, 1884-1893
11. Boucher, P., Gotthardt, M., Li, W. P., Anderson, R. G., and Herz, J. (2003) Science 300, 329-332
12. Boucher, P., Liu, P., Gotthardt, M., Hiesberger, T., Anderson, R. G., and Herz, J. (2002) J. Biol. Chem. 277, 15507-15513
13. Imai, T., Takakuwa, R., Marchand, S., Dentz, E., Bornert, J. M., Messaddeq, N., Wendling, O., Mark, M., Desvergne, B., Wahli, W., Chambon, P., and Metzger, D. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 4543-4547
14. Rohlmann, A., Gotthardt, M., Willnow, T. E., Hammer, R. E., and Herz, J. (1996) Nat Biotechnol 14, 1562-1565
15. Ishibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E., and Herz, J. (1993) J.Clin. Investig. 92, 883-893
16. Hofmann, S. M., Zhou, L., Perez-Tilve, D., Greer, T., Grant, E., Wancata, L., Thomas, A., Pfluger, P. T., Basford, J. E., Gilham, D., Herz, J., Tschop, M. H., and Hui, D. Y. (2007) J. Clin. Investig. 117, 3271-3282
17. Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., and MacDougald, O. A. (2000) Science 289, 950-953
18. Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., 3rd, and Nusse, R. (2003) Nature 423, 448 - 452
19. Deleted in proof
20. Kudo, N., Barr, A. J., Barr, R. L., Desai, S., and Lopaschuk, G. D. (1995) J. Biol. Chem. 270, 17513-17520
21. Student, A. K., Hsu, R. Y., and Lane, M. D. (1980) J. Biol. Chem. 255, 4745-4750
22. Fujino, T., Asaba, H., Kang, M. J., Ikeda, Y., Sone, H., Takada, S., Kim, D. H., Ioka, R. X., Ono, M., Tomoyori, H., Okubo, M., Murase, T., Ka-mataki, A., Yamamoto, J., Magoori, K., Takahashi, S., Miyamoto, Y., Oishi, H., Nose, M., Okazaki, M., Usui, S., Imaizumi, K., Yanagisawa, M., Sakai, J., and Yamamoto, T. T. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 229 -234
23. Mermelstein, C. S., Portilho, D. M., Mendes, F. A., Costa, M. L., and Abreu, J. G. (2007) Differentiation 75, 184-192
24. Deleted in proof
25. Kahn, B. B., Alquier, T., Carling, D., and Hardie, D. G. (2005) Cell Metab. 1, 15-25
26. Ross, S. E., Erickson, R. L., Hemati, N., and MacDougald, O. A. (1999) Mol. Cell. Biol. 19, 8433-8441
27. Imai, T., Jiang, M., Chambon, P., and Metzger, D. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 224-228
28. He, W., Barak, Y., Hevener, A., Olson, P., Liao, D., Le, J., Nelson, M., Ong, E., Olefsky, J. M., and Evans, R. M. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 15712-15717
29. Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., and Brown, M. S. (1998) Genes Dev. 12, 3182-3194
30. Bhanot, P., Brink, M., Samos, C. H., Hsieh, J. C., Wang, Y., Macke, J. P., Andrew, D., Nathans, J., and Nusse, R. (1996) Nature 382, 225-230
31. Deleted in proof
32. Deleted in proof
33. Deleted in proof
34. Orena, S. J., Torchia, A. J., and Garofalo, R. S. (2000) J. Biol. Chem. 275, 15765-15772
35. Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A., and Wakil, S. J. (2001) Science 291, 2613-2616