Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-κB-dependent IL-6 expression in human monocytes

Journal of Immunology

Volumn 162, Issue 8, 1999, Pages 4893-4902

  Tuyt, Leonore M L ^a   Dokter, Wim H A ^a,b   Birkenkamp, Kim ^a   Koopmans, Sicco B ^a   Lummen, Chantal ^a   Kruijer, Wiebe ^a   Vellenga, Edo ^a,c  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b AKZO NOBEL CENTRAL RESEARCH   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; OKADAIC ACID; PHOSPHOTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; BINDING AFFINITY; CELL FUNCTION; CELL ISOLATION; DNA BINDING; ENZYME REGULATION; GENE ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION INITIATION;

CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; DOWN-REGULATION; ENZYME ACTIVATION; HUMANS; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B; OKADAIC ACID; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-RAF; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0033561678     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Van Snick, J. 1990. Interleukin 6: an overview. Annu. Rev. Immunol. 8:253.
2. Akira, S., H. Isshiki, T. Nakajima, S. Kinoshita, Y. Nishio, S. Natsuka, and T. Kishimoto. 1992. Regulation of expression of the interleukin-6 gene: structure and function of the transcription factor NF-1L6. Ciba Found. Symp. 167:47.
3. Dokter, W. H. A., S. B. Koopmans, and E. Vellenga. 1996. Effects of IL-10 and IL-4 on LPS-induced transcription factors (AP-1, NF-1L6 and NF-κB) which are involved in IL-6 regulation. Leukemia 10:1308.
4. Tuyt, L. M. L., H. De Wit, S. B. Koopmans, S. J. Sierdsema, and E. Vellenga. 1996. Effects of IL-3 and LPS on transcription factors involved in the regulation of IL-6 mRNA. Br. J. Hematol. 92:521.
5. Shimizu, H., K. Mitomo, T. Watanabe, S. I. Okamoto, and K. I. Yamamoto. 1990. Involvement of a NF-κB like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines. Mol. Cell. Biol. 10:561.
6. Libermann, T. A., and D. Baltimore. 1990. Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol. Cell. Biol. 10:2327.
7. Zhang, Y. H., J. X. Lin, and J. Vilcek. 1990. Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a κB-like sequence. Mol. Cell. Biol. 10:3818.
8. Akira, S., and T. Kishimoto. 1997. NF-IL6 and NF-KB in cytokine gene regulation. Adv. Immunol. 65:1.
9. Grimm, S., and P. A. Baeuerle. 1993. The inducible transcription factor NF-κB: structure-function relationship of its protein subunits. Biochem. J. 290:297.
10. Matsusaka, T., K. Fujikawa, Y. Nishio, N. Mukaida, K. Matsushima, T. Kishimoto, and S. Akira. 1990. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci. USA 90:10193.
11. Dendorfer, U., P. Oettgen, and T. A. Libermann. 1994. Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Mol. Cell. Biol. 14:4443.
12. Su, B., and M. Karin. 1996. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8:402.
13. Treisman, R. 1996. Regulation of transcription by MAP kinase cascades. Curr. Opin. Immunol. 8:205.
14. RSK) phosphorylates the N-terminal regulatory domain of IκBα and stimulates its degradation in vitro. J. Biol. Chem. 272:21281.
15. Briant, L., V. Robert-Hebmann, V. Sivan, A. Brunet, J. Pouyssegur, and C. Devaux. 1998. Involvement of extracellular signal-regulated kinase module in HIV-mediated CD4 signals controlling activation of nuclear factor-κB and AP-1 transcription factors. J. Immunol. 160:1875.
16. Coso, O. A., M. Chiariello, J. C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. S. Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137.
17. Dérijard, B., M. Hibi, I.-H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R. J. Davis. 1994. JNK1 : a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025.
18. Fanger, G. R., P. Gerwins, C. Widmann, M. B. Jarpe, and G. L. Johnson. 1997. MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases? Curr. Opin. Genet. Dev. 7:67.
19. Ho, H.-Y., H.-H. Lee, and M.-Z. Lai. 1997. Overexpression of mitogen-activated protein kinase kinase kinase reversed cAMP inhibition of NF-κB in T cells. Eur. J. Immunol. 27:222.
20. Lee, F. S., J. Hagler, Z. J. Chen, and T. Maniatis. 1997. Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213.
21. Cohen, P., C. F. B. Holmes, and Y. Tsukitani. 1990. Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem. Sci. 15:98.
22. Sung, S. J., and J. A. Walters. 1993. Stimulation of interleukin-1α and interleukin-1β production in human monocytes by protein phosphatase 1 and 2A inhibitors. J. Biol. Chem. 268:5802.
23. Sung, S. J., J. A. Walters, and S. M. Fu. 1992. Stimulation of tumor necrosis factor a production in human monocytes by inhibitors of protein phosphatase 1 and 2A. J. Exp. Med. 176:897.
24. Kitamura, T., T. Tange, T. Terasawa, S. Chiba, T. Kuwaki, K. Miyagawa, Y.-F. Piao, K. Miyazono, A. Urabe, and F. Takaku. 1989. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, 1L-3, or erythropoietin. J. Cell. Physiol. 140:323.
25. Alessi, D. R., A. Cuenda, P. Cohen, D. T. Dudley, and A. R. Saltiel. 1995. PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:27489.
26. Dokter, W. H. A., M. T. Esselink, M. R. Halie, and E. Vellenga. 1993. Interleukin-4 inhibits the lipopolysaccharide-induced expression of c-Jun and c-Fos messenger RNA and activator protein-1 binding activity in human monocytes. Blood 81:337.
27. Schreiber, E., P. Matthias, M. M. Müller, and W. Scaffner. 1989. Rapid detection of octamer binding proteins with 'mini extracts,' prepared from a small number of cells. Nucleic Acids Res. 17:6419.
28. Smith, S. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31.
29. Kharbanda, S., R. Datta, E. Rubin, T. Nakamura, R. Hass, and D. Kufe. 1992. Regulation of c-jun expression during induction of monocytic differentiation by okadaic acid. Cell Growth Differ. 3:391.
30. Hurme, M., and S. Matikainen. 1993. Okadaic acid, a phosphatase inhibitor, enhances the phorbol ester-induced interleukin-1β expression via an AP-1-mediated mechanism. Scand. J. Immunol. 38:570.
31. Amaral, M. C., A. M. Casillas, and A. E. Nel. 1993. Contrasting effects of two tumour promoters, phorbol myristate acetate and okadaic acid, on T-cell responses and activation of p42 MAP-kinase/ERK-2. Immunology 79:24.
32. Casillas, A. M., M. C. Amaral, S. Chegini-Farahani, and A. E. Nel. 1993. Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase: ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate. Biochem. J. 290:545.
33. Hardwick, S. J., L. Hegyi, K. Clare, N. S. Law, K. L. Carpenter, M. J. Mitchinson, and J. N. Skepper. 1996. Apoptosis in human monocyte-macrophages exposed to oxidized low density lipoprotein. J. Pathol. 179:294.
34. Schmitz, M. L., and P. A. Baeuerle. 1991. The p65 subunit is responsible for he strong transcription activating potential of NF-κB. EMBO J. 10:3805.
35. Schaap, D., J. van der Wal, L. R. Howe, C. J. Marshall, and W. J. van Bitterswijk. 1993. A dominant-negative mutant of rafblocks mitogen-activated protein kinase activation by growth factors and oncogenic p21 ras. J. Biol. Chem. 268:20232.
36. Gupta, S., D. Campbell, B. Dérijard, and R. J. Davis. 1995. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267:389.
37. Stein, B., A. S. Baldwin, Jr., D. W. Ballard, W. C. Greene, P. Angel, and P. Herrlich. 1993. Cross-coupling of the NF-κB p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J. 12:3879.
38. Brown, E. J., M. W. Albers, T. B. Shin, K. Ichikawa, C. T. Keith, W. S. Lane, and S. L. Schreiber. 1994. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369:756.
39. Karin, M., Z. G. Liu, and Zandi, E. 1997. AP-1 function and regulation. Curr. Opin. Cell. Biol. 9:240.
40. Hirano, T. 1998. Interleukin 6 and its receptor: ten years later. Int. Rev. Immunol. 16:249.
41. Sonoda, Y., T. Kashahara, Y. Yamaguchi, K. Kuno, K. Matsishima, and N. Mukaida. 1997. Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline: possible role of mitogen-activated protein kinase on the okadaic acid-induced NF-κB activation. J. Biol. Chem. 272:15366.
42. Schouten, G. J., A. C. O. Vertegaal, S. T. Whiteside, A. Israël, M. Toebes, J. C. Dorsman, A. J. van der Eb, and A. Zantema. 1997. IκBα is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. EMBO J. 16:3133.
43. Mercurio, F., H. Zhu, B. W. Murray, A. Shevchenko, B. L. Bennett, J. W. Li, D. B. Young, M. Barbosa, M. Mann, A. Manning, et al. 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860.
44. Woronicz, J. D., X. Gao, Z. Cao, M. Rothe, and D. V. Goeddel. 1997. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278:866.
45. Zandi, E., D. M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin. 1997. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91:243.
46. Schmitz, M. L., M. A. dos Santos Silva, and P. A. Baeuerle. 1995. Transactivalion domain 2 (TA2) of p65 NF-κB: similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells. J. Biol. Chem. 270:15576.
47. Zhong, H., H. SuYang, H. Erdjument-Bromage, P. Tempst, and S. Ghosh. 1997. The transcriptional activity of NF-κB is regulated by the IκB-associated PKAc subunit through a cyclic AMP-independent mechanism. Cell 89:413.
48. Gerritsen, M. E., A. J. Williams, A. S. Neish, S. Moore, Y. Shi, and T. Collins. 1997. CREB-binding protein/p300 are transcriptional coactivators of p65. Proc. Natl Acad. Sci. USA 94:2927.
49. Zhong, H., R. Voll, and S. Ghosh. 1998. Phosphorylation of NF-κB p65 regulates its transcriptional activity. In Keystone Symposia on Specificity in Signal Transduction. No. 008.
50. Bird, T. A., K. Schooley, S. K. Dower, H. Hagen, and G. D. Virca. 1997. Activation of nuclear transcription factor NF-κB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit. J. Biol. Chem. 272:32606.
51. Brown, P. H., T. K. Chen, and M. J. Birrer. 1994. Mechanism of action of a dominant-negative mutant of c-Jun. Oncogene 9:791.
52. Li, J.-J., M. H. Vousden, R. Schlegel, and N. H. Colbum. 1996. AP-1 and NF-κB transactivation in E6/E7 immortalized human keratinocytes. Proc. Am. Assoc. Cancer Res. 37:531.
53. Berra, E., M. T. Diaz-Meco, J. Lozano, S. Frutos, M. M. Munico, P. Sanchez, L. Sanz, and J. Moscat. 1995. Evidence for a role of MEK and MAPK during signal transduction by protein kinase Cζ. EMBO J. 14:6157.
54. Min, W., and J. S. Pober. 1997. TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-κB and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways. J. Immunol. 159:3508.
55. Vanden Berghe, W., S. Plaisance, E. Boone, K. De Bosscher, M. L. Schmitz, W. Fiers, and G. Haegeman. 1998. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem. 273:3285.
56. Keyse, S. M. 1995. An emerging family of dual specificity MAP kinase phosphatases. Biochim. Biophys. Acta 1265:152.
57. Groom, L. A., A. A. Sneddon, D. R. Alessi, S. Dowd, and S. M. Keyse. 1996. Differential regulation of the MAP, SAP and RK/p38 kinases by Pystl, a novel cytosolic dual-specificity phosphatase. EMBO J. 15:3621.
58. Ishibashi, T., D. P. Bottaro, P. Michieli, C. A. Kelley, and S. A. Aaronson. 1995. A novel dual specificity phosphatase induced by serum stimulation and heat shock. J. Biol. Chem. 269:29897.
59. Rohan, P. J., P. Davis, C. A. Moskaluk, M. Kerans, H. Krutzsch, U. Siebenlist, and K. Kelly. 1991 PAC-1:a mitogen-induced nuclear protein tyrosine phosphatase. Science 259:1763.